Anodyne; Anthelmintic; Antispasmodic; Antitumor; Diuretic; Febrifuge; Hallucinogenic; Hypnotic; Mydriatic; Narcotic; Sedative
Turkey; Afghanistan; Italy; Turkmenistan; Nepal; Mongolia; France; Ireland; Norway; Uzbekistan; Australia; Iran; Algeria; China; Belgium; Germany; Iraq; Kazakhstan; Spain; Ukraine; Netherlands; Denmark; Poland; Finland; United States; Morocco; Sweden; Belarus; Japan; Switzerland; New Zealand; Russia; Bulgaria; Pakistan; Romania; Albania; Portugal; Myanmar; South Africa; Tunisia; India; United Kingdom; Austria; Greece; Hungary; Tajikistan
Ingredient ID: NPC97820
Ingredient ID: NPC97212
Ingredient ID: NPC93433
Ingredient ID: NPC92146
Ingredient ID: NPC90984
Ingredient ID: NPC85811
Ingredient ID: NPC84281
Ingredient ID: NPC83062
Ingredient ID: NPC80851
Ingredient ID: NPC69699
Ingredient ID: NPC69496
Ingredient ID: NPC55285
Ingredient ID: NPC54511
Ingredient ID: NPC53463
Ingredient ID: NPC475443
Ingredient ID: NPC473829
Ingredient ID: NPC473559
Ingredient ID: NPC4683
Ingredient ID: NPC46780
Ingredient ID: NPC40005
Ingredient ID: NPC36609
Ingredient ID: NPC33541
Ingredient ID: NPC330426
Ingredient ID: NPC328960
Ingredient ID: NPC327013
Ingredient ID: NPC324403
Ingredient ID: NPC323787
Ingredient ID: NPC310904
Ingredient ID: NPC295983
Ingredient ID: NPC291027
Ingredient ID: NPC287708
Ingredient ID: NPC273260
Ingredient ID: NPC270278
Ingredient ID: NPC267466
Ingredient ID: NPC265160
Ingredient ID: NPC261831
Ingredient ID: NPC255452
Ingredient ID: NPC248142
Ingredient ID: NPC242162
Ingredient ID: NPC234378
Ingredient ID: NPC233910
Ingredient ID: NPC227451
Ingredient ID: NPC222039
Ingredient ID: NPC218109
Ingredient ID: NPC216630
Ingredient ID: NPC211401
Ingredient ID: NPC209970
Ingredient ID: NPC209773
Ingredient ID: NPC209596
Ingredient ID: NPC204385
Ingredient ID: NPC203064
Ingredient ID: NPC200302
Ingredient ID: NPC195749
Ingredient ID: NPC194435
Ingredient ID: NPC193830
Ingredient ID: NPC190558
Ingredient ID: NPC181153
Ingredient ID: NPC17936
Ingredient ID: NPC178263
Ingredient ID: NPC176599
Ingredient ID: NPC173810
Ingredient ID: NPC172518
Ingredient ID: NPC171551
Ingredient ID: NPC169485
Ingredient ID: NPC166179
Ingredient ID: NPC161229
Ingredient ID: NPC154165
Ingredient ID: NPC153413
Ingredient ID: NPC151003
Ingredient ID: NPC146197
Ingredient ID: NPC142753
Ingredient ID: NPC142458
Ingredient ID: NPC140302
Ingredient ID: NPC135174
Ingredient ID: NPC132923
Ingredient ID: NPC131969
Ingredient ID: NPC126878
Ingredient ID: NPC124626
Ingredient ID: NPC120426
Ingredient ID: NPC118353
Ingredient ID: NPC117351
Ingredient ID: NPC116631
Ingredient ID: NPC100478
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
Therapeutic Target | Small molecule receptor (family A GPCR) | CHRM5 | Muscarinic acetylcholine receptor M5 | P08912 | CHEMBL2035 |
Therapeutic Target | Small molecule receptor (family A GPCR) | CHRM1 | Muscarinic acetylcholine receptor M1 | P11229 | CHEMBL216 |
Therapeutic Target | Small molecule receptor (family A GPCR) | CHRM2 | Muscarinic acetylcholine receptor M2 | P08172 | CHEMBL211 |
Therapeutic Target | Small molecule receptor (family A GPCR) | CHRM3 | Muscarinic acetylcholine receptor M3 | P20309 | CHEMBL245 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 5 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00638196 | Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS | multiple sclerosis | Oleic Acid (NPC261831) | NP level |
NCT01792310 | A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours | glioma | Oleic Acid (NPC261831) | NP level |
NCT01929044 | Efficacy of Buscopan® in Comparison With 654-II (Anisodamine) in Acute Gastric or Intestinal Pain | intestinal disease | Anisodamine (NPC69496) | NP level |
NCT02442440 | Anisodamine Critically Ill SeptIc Shock | septic shock | Anisodamine (NPC69496) | NP level |
NCT01661764 | Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention | colorectal adenoma | Oleic Acid (NPC261831) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
CHRM3,OR51E2,FABP5,CHRM2,CHRM1
|
Peptic ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA61 |
CHRM5,CHRM3,CHRM2,CHRM1
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
CHRM1,CHRM2,CHRM3,CHRM5
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
CHRM3,FABP5,OR51E2,FABP4
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
FABP5,PPARA,OR51E2,FABP4
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CHRM3,OR51E2,FABP4,FABP5
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CHRM3,OR51E2,FABP5,CHRM2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
CHRM3,CHRM2,CHRM5
|
Sebaceous gland disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED91 |
CHRM1,CHRM3,CHRM2
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
CHRM1,CHRM3,CHRM5
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
PPARA,CHRM5,CHRM1
|
Abnormal micturitionDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF50 |
CHRM2,CHRM1,CHRM5
|
Functional bladder disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GC50 |
CHRM1,CHRM5,CHRM3
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
FABP5,OR51E2,FABP5
|
Respiratory system diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB40-CB7Z |
CHRM2,CHRM3
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
CHRM1,CHRM5
|
DyslipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80-5C81 |
CHRM1,PPARA
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
CHRM5,CHRM1
|
Tonus and reflex abnormalityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB47 |
CHRM5,CHRM3
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
PPARA
FABP4 |
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CHRM1,FABP5
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CHRM1,FABP5
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
OR51E2,FABP5
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
CHRM5,FABP4
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CHRM5,CHRM1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2,FABP5
|
Cognition symptoms/signs/clinical symptonDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB21 |
CHRM5
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARA
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
CHRM1
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
CHRM1
|
Sjogren syndromeDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A43 |
CHRM3
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
CHRM5
|
NystagmusDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C84 |
CHRM5
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
PPARA
|
Schizoaffective disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A21 |
CHRM1
|
Anterior uveitisDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A96 |
CHRM5
|
General examinationDisease Category: 24.Factors influencing health status or contact with health servicesDisease ICD-11 Code: QA00 |
CHRM5
|
Epileptic encephalopathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A62 |
CHRM1
|
HyperlipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARA
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
CHRM1
|
CoughDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD12 |
CHRM5
|
Female pelvic painDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA34 |
CHRM5
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
CHRM5
|
Intellectual development disorderDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD90 |
CHRM1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
CHRM1
|
Corneal diseaseDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A76-9A78 |
CHRM1
|
Brain diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70-8E61 |
CHRM5
|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
CHRM1
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
CHRM1
|
GoutDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA25 |
PPARA
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
PPARA
|
PancreatitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC31-DC34 |
CHRM5
|
GastritisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA42 |
CHRM5
|
Nausea/vomitingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD90 |
CHRM3
|
Dystonic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A02 |
CHRM1
|
Oesophagus motility disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA21 |
CHRM5
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
CHRM1
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
PPARA
|
HyperhidrosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EE00 |
CHRM1
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
CHRM1
|
Infectious gastroenteritis/colitisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A40 |
CHRM5
|
PolyuriaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF55 |
CHRM5
|
UrgencyDisease Category: NADisease ICD-11 Code: N.A. |
CHRM5
|
Central and peripheral nervous diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04-8E7Z |
CHRM5
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
PPARA
|
Digestive system diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DE2Z |
CHRM5
|
Gastric ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA60 |
CHRM1
|
Appearance/behaviour symptomDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB23 |
CHRM5
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PPARA
|
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
CHRM5
|
Muscle disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB32-FB3Z |
CHRM2
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
NCT01661764
|
Septic shockDisease Category: X.Extension CodesDisease ICD-11 Code: XS26 |
NCT02442440
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
NCT00638196
|
Diseases of the digestive system, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DE2Z |
NCT01929044
|
Glioma, malignantDisease Category: X.Extension CodesDisease ICD-11 Code: XH4RQ3 |
NCT01792310
|
Hypertrophic cardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43.1 |
CHRM3
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
FABP5
|
Malignant neoplasms of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
FABP4
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
OR51E2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
OR51E2
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
OR51E2
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
FABP4
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
CHRM5
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
FABP4
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
FABP5
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
FABP5
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CHRM1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
FABP5
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
OR51E2
|
Malignant neoplasm of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
FABP4
|