Collective Molecular Activities of the Plant: Juglans Regia
Country/Region:
Turkey; Israel; Italy; Portugal; Lebanon; India; Jordan; Chile; China; Argentina; Iraq; SpainTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCM; HomeopathyMedicinal Functions:
Alterative; Anodyne; Antiinflammatory; Astringent; Bach; Blood purifier; Cancer; Depurative; Detergent; Diuretic; Laxative; Lithontripic; Miscellany; Pectoral; Skin; Stimulant; Vermifuge
Turkey; Italy; India; Nepal; France; Argentina; Israel; Algeria; Jordan; Chile; Belgium; China; Iraq; Spain; Ukraine; Libya; Morocco; Switzerland; Russia; Bulgaria; Romania; Albania; Portugal; Mexico; Tunisia; South Africa; Lebanon; United Kingdom; Austria; Greece; Hungary
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
213 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
124 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
123 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99734
Ingredient ID: NPC96286
Ingredient ID: NPC95615
Ingredient ID: NPC94167
Ingredient ID: NPC93888
Ingredient ID: NPC92774
Ingredient ID: NPC91114
Ingredient ID: NPC8793
Ingredient ID: NPC85813
Ingredient ID: NPC81010
Ingredient ID: NPC74539
Ingredient ID: NPC73143
Ingredient ID: NPC71460
Ingredient ID: NPC68670
Ingredient ID: NPC68492
Ingredient ID: NPC67250
Ingredient ID: NPC67037
Ingredient ID: NPC65562
Ingredient ID: NPC64434
Ingredient ID: NPC62045
Ingredient ID: NPC6095
Ingredient ID: NPC59650
Ingredient ID: NPC5891
Ingredient ID: NPC56699
Ingredient ID: NPC56145
Ingredient ID: NPC55412
Ingredient ID: NPC54925
Ingredient ID: NPC5326
Ingredient ID: NPC490427
Ingredient ID: NPC490424
Ingredient ID: NPC489908
Ingredient ID: NPC489907
Ingredient ID: NPC488382
Ingredient ID: NPC488381
Ingredient ID: NPC488380
Ingredient ID: NPC488379
Ingredient ID: NPC488378
Ingredient ID: NPC488377
Ingredient ID: NPC488376
Ingredient ID: NPC488375
Ingredient ID: NPC488374
Ingredient ID: NPC488373
Ingredient ID: NPC488372
Ingredient ID: NPC488371
Ingredient ID: NPC488370
Ingredient ID: NPC488369
Ingredient ID: NPC488368
Ingredient ID: NPC488367
Ingredient ID: NPC488366
Ingredient ID: NPC488365
Ingredient ID: NPC48623
Ingredient ID: NPC45663
Ingredient ID: NPC44260
Ingredient ID: NPC43945
Ingredient ID: NPC424
Ingredient ID: NPC39426
Ingredient ID: NPC35699
Ingredient ID: NPC32977
Ingredient ID: NPC328680
Ingredient ID: NPC328447
Ingredient ID: NPC32817
Ingredient ID: NPC327254
Ingredient ID: NPC323909
Ingredient ID: NPC322714
Ingredient ID: NPC321447
Ingredient ID: NPC321320
Ingredient ID: NPC320323
Ingredient ID: NPC319252
Ingredient ID: NPC318804
Ingredient ID: NPC317480
Ingredient ID: NPC317429
Ingredient ID: NPC317120
Ingredient ID: NPC31034
Ingredient ID: NPC307963
Ingredient ID: NPC307670
Ingredient ID: NPC304309
Ingredient ID: NPC302857
Ingredient ID: NPC301585
Ingredient ID: NPC300326
Ingredient ID: NPC299010
Ingredient ID: NPC295644
Ingredient ID: NPC294902
Ingredient ID: NPC294548
Ingredient ID: NPC293344
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC288963
Ingredient ID: NPC28657
Ingredient ID: NPC285989
Ingredient ID: NPC285893
Ingredient ID: NPC285829
Ingredient ID: NPC285196
Ingredient ID: NPC284285
Ingredient ID: NPC282229
Ingredient ID: NPC282120
Ingredient ID: NPC281972
Ingredient ID: NPC281686
Ingredient ID: NPC281131
Ingredient ID: NPC280905
Ingredient ID: NPC280749
Ingredient ID: NPC274613
Ingredient ID: NPC272614
Ingredient ID: NPC269980
Ingredient ID: NPC269919
Ingredient ID: NPC269440
Ingredient ID: NPC265305
Ingredient ID: NPC264779
Ingredient ID: NPC264537
Ingredient ID: NPC261831
Ingredient ID: NPC257124
Ingredient ID: NPC250769
Ingredient ID: NPC243509
Ingredient ID: NPC242580
Ingredient ID: NPC239067
Ingredient ID: NPC237812
Ingredient ID: NPC23622
Ingredient ID: NPC235751
Ingredient ID: NPC233827
Ingredient ID: NPC230301
Ingredient ID: NPC226453
Ingredient ID: NPC225710
Ingredient ID: NPC223727
Ingredient ID: NPC221144
Ingredient ID: NPC220765
Ingredient ID: NPC217781
Ingredient ID: NPC217649
Ingredient ID: NPC216630
Ingredient ID: NPC216297
Ingredient ID: NPC215894
Ingredient ID: NPC215008
Ingredient ID: NPC209970
Ingredient ID: NPC208793
Ingredient ID: NPC208553
Ingredient ID: NPC203468
Ingredient ID: NPC201284
Ingredient ID: NPC200872
Ingredient ID: NPC200684
Ingredient ID: NPC200561
Ingredient ID: NPC20045
Ingredient ID: NPC199072
Ingredient ID: NPC198658
Ingredient ID: NPC196924
Ingredient ID: NPC19620
Ingredient ID: NPC193694
Ingredient ID: NPC189438
Ingredient ID: NPC188428
Ingredient ID: NPC187993
Ingredient ID: NPC187770
Ingredient ID: NPC187605
Ingredient ID: NPC187262
Ingredient ID: NPC185755
Ingredient ID: NPC18335
Ingredient ID: NPC179037
Ingredient ID: NPC178134
Ingredient ID: NPC17810
Ingredient ID: NPC174246
Ingredient ID: NPC174213
Ingredient ID: NPC173638
Ingredient ID: NPC172419
Ingredient ID: NPC171736
Ingredient ID: NPC170960
Ingredient ID: NPC169749
Ingredient ID: NPC168707
Ingredient ID: NPC1682
Ingredient ID: NPC167400
Ingredient ID: NPC166525
Ingredient ID: NPC165257
Ingredient ID: NPC164646
Ingredient ID: NPC164329
Ingredient ID: NPC162742
Ingredient ID: NPC159334
Ingredient ID: NPC15912
Ingredient ID: NPC158147
Ingredient ID: NPC157338
Ingredient ID: NPC156654
Ingredient ID: NPC156461
Ingredient ID: NPC152451
Ingredient ID: NPC150950
Ingredient ID: NPC149184
Ingredient ID: NPC148215
Ingredient ID: NPC147983
Ingredient ID: NPC146197
Ingredient ID: NPC142770
Ingredient ID: NPC14079
Ingredient ID: NPC13914
Ingredient ID: NPC137958
Ingredient ID: NPC136814
Ingredient ID: NPC136785
Ingredient ID: NPC136188
Ingredient ID: NPC136014
Ingredient ID: NPC134847
Ingredient ID: NPC130683
Ingredient ID: NPC128410
Ingredient ID: NPC128030
Ingredient ID: NPC126791
Ingredient ID: NPC126759
Ingredient ID: NPC126681
Ingredient ID: NPC124530
Ingredient ID: NPC122414
Ingredient ID: NPC121817
Ingredient ID: NPC121372
Ingredient ID: NPC120649
Ingredient ID: NPC120635
Ingredient ID: NPC116474
Ingredient ID: NPC11433
Ingredient ID: NPC113914
Ingredient ID: NPC113733
Ingredient ID: NPC113665
Ingredient ID: NPC113212
Ingredient ID: NPC112890
Ingredient ID: NPC110899
Ingredient ID: NPC109221
Ingredient ID: NPC108288
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2B6 | Cytochrome P450 2B6 | P20813 | CHEMBL4729 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A2 | Norepinephrine transporter | P23975 | CHEMBL222 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A3 | Dopamine transporter | Q01959 | CHEMBL238 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A4 | Serotonin transporter | P31645 | CHEMBL228 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 2830 | |
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | macular degeneration | Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract | Beta Carotene (NPC17810);Ascorbate (NPC187770) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2,ESR1
NCT03522922,NCT03090048 |
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT03083470
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
KDR,AKR1B1,DPP4,HTR2A,HTR2C,PPARA,FFAR1,INSR,NR3C1
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute kidney failure, stage unspecifiedDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB60.Z |
NCT05084196
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
SRC,IDO1,MAPT,TOP2A,PIM1,NFKB1,TP53
NCT01842139,NCT00329498,NCT00184054 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00640094,NCT00781404,NCT02929888
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
