Collective Molecular Activities of the Plant: Saussurea Involucrata
Plant ID: NPO18671
Plant Latin Name: Saussurea Involucrata
Taxonomy Genus: Saussurea
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
200489
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMChina
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
85 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
44 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
47 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98356
Ingredient ID: NPC93201
Ingredient ID: NPC92774
Ingredient ID: NPC83508
Ingredient ID: NPC81775
Ingredient ID: NPC76336
Ingredient ID: NPC70744
Ingredient ID: NPC6984
Ingredient ID: NPC68517
Ingredient ID: NPC67462
Ingredient ID: NPC50898
Ingredient ID: NPC4982
Ingredient ID: NPC49074
Ingredient ID: NPC47993
Ingredient ID: NPC37548
Ingredient ID: NPC37331
Ingredient ID: NPC314267
Ingredient ID: NPC309355
Ingredient ID: NPC303090
Ingredient ID: NPC302857
Ingredient ID: NPC300776
Ingredient ID: NPC296266
Ingredient ID: NPC294902
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC28913
Ingredient ID: NPC284948
Ingredient ID: NPC283790
Ingredient ID: NPC281131
Ingredient ID: NPC279121
Ingredient ID: NPC278068
Ingredient ID: NPC264779
Ingredient ID: NPC259896
Ingredient ID: NPC250553
Ingredient ID: NPC248056
Ingredient ID: NPC241498
Ingredient ID: NPC240646
Ingredient ID: NPC237532
Ingredient ID: NPC234193
Ingredient ID: NPC233533
Ingredient ID: NPC230301
Ingredient ID: NPC228074
Ingredient ID: NPC226250
Ingredient ID: NPC22602
Ingredient ID: NPC224389
Ingredient ID: NPC224386
Ingredient ID: NPC223549
Ingredient ID: NPC219068
Ingredient ID: NPC218109
Ingredient ID: NPC216330
Ingredient ID: NPC215435
Ingredient ID: NPC211132
Ingredient ID: NPC211028
Ingredient ID: NPC210040
Ingredient ID: NPC210003
Ingredient ID: NPC208223
Ingredient ID: NPC208203
Ingredient ID: NPC20791
Ingredient ID: NPC206800
Ingredient ID: NPC206095
Ingredient ID: NPC20505
Ingredient ID: NPC203500
Ingredient ID: NPC200184
Ingredient ID: NPC197250
Ingredient ID: NPC195000
Ingredient ID: NPC194665
Ingredient ID: NPC189142
Ingredient ID: NPC182606
Ingredient ID: NPC179950
Ingredient ID: NPC179694
Ingredient ID: NPC176740
Ingredient ID: NPC174597
Ingredient ID: NPC171280
Ingredient ID: NPC170476
Ingredient ID: NPC167976
Ingredient ID: NPC166442
Ingredient ID: NPC16157
Ingredient ID: NPC144485
Ingredient ID: NPC142753
Ingredient ID: NPC142703
Ingredient ID: NPC139548
Ingredient ID: NPC115786
Ingredient ID: NPC115674
Ingredient ID: NPC1075
Ingredient ID: NPC105025
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Therapeutic Target | Enzyme | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 37 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
| NCT01438320 | Q-Trial in Patients With Hepatitis C | chronic hepatitis C virus infection | Quercetin (NPC20791) | NP level |
| NCT01705652 | Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients | prostate cancer | Rutin (NPC176740) | NP level |
| NCT01708278 | Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) | chronic obstructive pulmonary disease | Quercetin (NPC20791) | NP level |
| NCT01720147 | Quercetin in Children With Fanconi Anemia; a Pilot Study | Fanconi anemia | Quercetin (NPC20791) | NP level |
| NCT01839344 | Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes. | type 2 diabetes mellitus | Quercetin (NPC20791) | NP level |
| NCT01912820 | Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery | prostate adenocarcinoma | Quercetin (NPC20791) | NP level |
| NCT02136342 | Phase 1 Trial of Chlorogenic Acid in Patients With Advanced Cancer | cancer | Chlorogenic Acid (NPC302857) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
KDR,DPP4,AURKB,AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53,AURKB,FLT3,NFKB1,PIM1,GSK3B,AXL,KDM1A,SRC
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
THPO,NPSR1,CA7,TTR,MMP12,CA12,MMP9,MMP1,TSHR,AURKB,CA9,F2,ACHE,AKR1B10,CDK1,XDH
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ALOX5,CYP1B1,NPSR1,CA7,TTR,ALOX15,APP,ABCG2,SNCA,PIM1,RECQL,DPP4,POLB,HIF1A,MMP1,CA2,MMP2,AXL,AURKB,CA9,F2,MET,ACHE,AKR1B10,XDH
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,TTR,ALOX15
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
MMP9,MMP12,NPSR1,MMP1,NOX4,AURKB,CYP19A1,F2,MET,CDK1,ALOX15
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
HIF1A
|
Ageing associated decline in intrinsic capacityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG2A |
NCT05422885,NCT04946383
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
