CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Tripterospermum Japonicum

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO18560
Plant Latin Name: Tripterospermum Japonicum
Taxonomy Genus: Tripterospermum
Taxonomy Family: Gentianaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

26 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

20 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

8 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC87419

Ingredient ID: NPC55707

Ingredient ID: NPC41083

Ingredient ID: NPC34908

Ingredient ID: NPC32710

Ingredient ID: NPC312636

Ingredient ID: NPC308379

Ingredient ID: NPC289668

Ingredient ID: NPC28657

Ingredient ID: NPC278976

Ingredient ID: NPC27781

Ingredient ID: NPC270908

Ingredient ID: NPC261809

Ingredient ID: NPC257347

Ingredient ID: NPC242755

Ingredient ID: NPC226464

Ingredient ID: NPC20300

Ingredient ID: NPC192040

Ingredient ID: NPC164574

Ingredient ID: NPC162742

Ingredient ID: NPC162656

Ingredient ID: NPC157192

Ingredient ID: NPC151480

Ingredient ID: NPC140310

Ingredient ID: NPC125637

Ingredient ID: NPC106770

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Nuclear hormone receptor subfamily 1	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	4

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00009841	Gene Therapy in Treating Patients With Advanced Head and Neck Cancer	head and neck malignant neoplasia	Cholesterol (NPC28657)	NP level
NCT04359823	DSAP Treatment Comparison	porokeratosis	Cholesterol (NPC28657)	NP level
NCT00965068	Cholesterol in ASD: Characterization and Treatment	Asperger syndrome;autism	Cholesterol (NPC28657)	NP level
NCT00272844	Treatment of the Cholesterol Defect in Smith-Lemli-Opitz Syndrome	Smith-Lemli-Opitz syndrome	Cholesterol (NPC28657)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Multiple sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A40	RORC
Crohn disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD70	RORC
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	RORC
Autoimmune disease Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40-4A45	RORC
Lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	RORC
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	RORC
Head and neck cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D42	NCT00009841
Autism spectrum disorder without disorder of intellectual development and with mild or no impairment of functional language Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A02.0	NCT00965068
Porokeratoses Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED52	NCT04359823
Autism spectrum disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A02	NCT00965068
Disorders of cholesterol synthesis Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C52.10	NCT00272844
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	RORC
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	RORC
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	RORC
Tetralogy of Fallot Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA88.2	RORC

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Tripterospermum Japonicum

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

26 All known Ingredients in Total

20 Ingredients with Acceptable Bioavailablity

8 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Multiple sclerosis

Crohn disease

Psoriasis

Autoimmune disease

Lung cancer

Solid tumour/cancer

Head and neck cancer

Autism spectrum disorder without disorder of intellectual development and with mild or no impairment of functional language

Porokeratoses

Autism spectrum disorder

Disorders of cholesterol synthesis

Carcinosarcoma of uterus

Serous cystadenoma,borderline malignancy of ovary

Pheochromocytoma

Tetralogy of Fallot

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities