CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Selinum Libanotis

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO18424
Plant Latin Name: Selinum Libanotis
Taxonomy Genus: Selinum
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

104 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

86 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

61 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC86144

Ingredient ID: NPC83297

Ingredient ID: NPC78790

Ingredient ID: NPC74080

Ingredient ID: NPC73818

Ingredient ID: NPC70744

Ingredient ID: NPC69712

Ingredient ID: NPC55715

Ingredient ID: NPC45242

Ingredient ID: NPC43732

Ingredient ID: NPC43246

Ingredient ID: NPC35961

Ingredient ID: NPC35627

Ingredient ID: NPC310532

Ingredient ID: NPC308198

Ingredient ID: NPC305944

Ingredient ID: NPC29883

Ingredient ID: NPC291426

Ingredient ID: NPC285315

Ingredient ID: NPC283823

Ingredient ID: NPC283468

Ingredient ID: NPC280291

Ingredient ID: NPC278525

Ingredient ID: NPC2770

Ingredient ID: NPC276195

Ingredient ID: NPC275110

Ingredient ID: NPC274613

Ingredient ID: NPC27410

Ingredient ID: NPC267396

Ingredient ID: NPC264870

Ingredient ID: NPC261206

Ingredient ID: NPC253746

Ingredient ID: NPC252032

Ingredient ID: NPC251387

Ingredient ID: NPC249194

Ingredient ID: NPC245561

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Ingredient ID: NPC243469

Ingredient ID: NPC24101

Ingredient ID: NPC24019

Ingredient ID: NPC236443

Ingredient ID: NPC234918

Ingredient ID: NPC230301

Ingredient ID: NPC230214

Ingredient ID: NPC229991

Ingredient ID: NPC22481

Ingredient ID: NPC223956

Ingredient ID: NPC221653

Ingredient ID: NPC220540

Ingredient ID: NPC219913

Ingredient ID: NPC218652

Ingredient ID: NPC214869

Ingredient ID: NPC214001

Ingredient ID: NPC211192

Ingredient ID: NPC210434

Ingredient ID: NPC205421

Ingredient ID: NPC204607

Ingredient ID: NPC203719

Ingredient ID: NPC199990

Ingredient ID: NPC199965

Ingredient ID: NPC195058

Ingredient ID: NPC192135

Ingredient ID: NPC190827

Ingredient ID: NPC189903

Ingredient ID: NPC189470

Ingredient ID: NPC184026

Ingredient ID: NPC180199

Ingredient ID: NPC17814

Ingredient ID: NPC17599

Ingredient ID: NPC174726

Ingredient ID: NPC171317

Ingredient ID: NPC167400

Ingredient ID: NPC164627

Ingredient ID: NPC161187

Ingredient ID: NPC159418

Ingredient ID: NPC158088

Ingredient ID: NPC155838

Ingredient ID: NPC155098

Ingredient ID: NPC152212

Ingredient ID: NPC152106

Ingredient ID: NPC150043

Ingredient ID: NPC14818

Ingredient ID: NPC146694

Ingredient ID: NPC146137

Ingredient ID: NPC145727

Ingredient ID: NPC141765

Ingredient ID: NPC136508

Ingredient ID: NPC135006

Ingredient ID: NPC133862

Ingredient ID: NPC131192

Ingredient ID: NPC119535

Ingredient ID: NPC117423

Ingredient ID: NPC117237

Ingredient ID: NPC116349

Ingredient ID: NPC114102

Ingredient ID: NPC113733

Ingredient ID: NPC112575

Ingredient ID: NPC111888

Ingredient ID: NPC110899

Ingredient ID: NPC110865

Ingredient ID: NPC110396

Ingredient ID: NPC107374

Ingredient ID: NPC105501

Ingredient ID: NPC101679

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

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Search:

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Hydrolase	CDA	Cytidine deaminase	P32320	CHEMBL4502
Therapeutic Target	Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Therapeutic Target	Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Therapeutic Target	Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Therapeutic Target	Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Therapeutic Target	Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Therapeutic Target	Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Therapeutic Target	Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Therapeutic Target	Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Therapeutic Target	Small molecule receptor (family A GPCR)	HTR5A	Serotonin 5a (5-HT5a) receptor	P47898	CHEMBL3426

Showing 1 to 10 of 19 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	79

Clinical trial details

Show entries

Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00000461	Harvard Atherosclerosis Reversibility Project (HARP)	Myocardial Ischemia	Niacin (NPC167400)	NP level
NCT00000482	Coronary Drug Project	Myocardial Ischemia;myocardial infarction	Niacin (NPC167400)	NP level
NCT00000512	Familial Atherosclerosis Treatment Study	Myocardial Ischemia	Niacin (NPC167400)	NP level
NCT00000553	HDL-Atherosclerosis Treatment Study (HATS)	Myocardial Ischemia	Niacin (NPC167400)	NP level
NCT00000599	Cholesterol-Lowering Atherosclerosis Study (CLAS)	carotid artery disease;cerebral atherosclerosis;Myocardial Ischemia	Niacin (NPC167400)	NP level
NCT00062556	Effect of Niacin ER/Lovastatin on Peak Walking Time & Claudication Onset Time in Patients With Intermittent Claudication	intermittent vascular claudication	Niacin (NPC167400)	NP level
NCT00071266	The Dose Response of Niacin ER/Lovastatin on Peak Walking Time (PWT) in Patients With Intermittent Claudication - TROPIC	intermittent vascular claudication	Niacin (NPC167400)	NP level
NCT00080275	Evaluation of the Safety & Efficacy of a Combination of Niacin ER & Simvastatin in Patients With Dyslipidemia (OCEANS)	Hypercholesterolemia	Niacin (NPC167400)	NP level
NCT00082251	Safety & Efficacy of a Combination Niacin ER/Simvastatin in Patients With Dyslipidemia: A Dose-Ranging Study - SEACOAST	Hypercholesterolemia	Niacin (NPC167400)	NP level
NCT00111891	An Investigational Drug Study Evaluating a Novel Approach to Treat Dyslipidemia (0524A-032)	Disorder of lipid metabolism	Niacin (NPC167400)	NP level

Showing 1 to 10 of 79 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Show entries

Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Abortion Disease Category: 18.Pregnancy, childbirth or the puerperium Disease ICD-11 Code: JA00	DRD1
Acne vulgaris Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED80	MMP2
Acute ischaemic heart disease, unspecified Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA4Z	NCT00855257
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	CREBBP
Acute respiratory distress syndrome Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB00	F3
Acute upper respiratory infection Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA07	DRD2
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	F2,CDA,HTR2B,CA9,MMP9,CA12,CA7
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	CA14,F2,HTR7,MMP2,CA2,HTR2B,CA9,HCAR2,SNCA,DRD2,DRD1,CA7
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	F2,MMP9,DRD1
Allergic/hypersensitivity disorder Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A80-4A8Z	DRD5,DRD2,DRD1

Showing 1 to 10 of 180 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Selinum Libanotis

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

104 All known Ingredients in Total

86 Ingredients with Acceptable Bioavailablity

61 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Abortion

Acne vulgaris

Acute ischaemic heart disease, unspecified

Acute myeloid leukaemia

Acute respiratory distress syndrome

Acute upper respiratory infection

Adenocarcinoma of bronchus or lung

Adenocarcinoma of pancreas

Adenocarcinoma of stomach

Allergic/hypersensitivity disorder

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities