Collective Molecular Activities of the Plant: Medicago Sativa
Plant ID: NPO18321
Plant Latin Name: Medicago Sativa
Taxonomy Genus: Medicago
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
3879
Plant-of-the-World-Online:
30234961-2
Country/Region:
China; Argentina; India; Turkmenistan; ChileTraditional Medicine System:
Unani; TCM; Homeopathy; AyurvedaMedicinal Functions:
Anodyne; Antibacterial; Antiscorbutic; Aperient; Diuretic; Emetic; Febrifuge; Haemostatic; Hypoglycaemic; Nutritive; Stimulant; Tonic
Brazil; Afghanistan; Italy; Bangladesh; Sudan; Nepal; Mongolia; France; Somalia; Ireland; Argentina; Bolivia; Norway; Ecuador; Turkmenistan; Uzbekistan; Saudi Arabia; Australia; Iran; Algeria; Cuba; Turkey; Venezuela; Austria; Russia; United States; Guatemala; China; Chile; Oman; Belgium; Germany; Dominican Republic; Iraq; Kazakhstan; Spain; Ukraine; Netherlands; Libya; Denmark; Poland; Finland; New Caledonia; Mauritius; Morocco; Sweden; Belarus; Switzerland; Uruguay; New Zealand; Yemen; Haiti; Bulgaria; Pakistan; Romania; Albania; Angola; Portugal; Chad; Mexico; Egypt; Tajikistan; South Africa; India; Peru; United Kingdom; Tunisia; Djibouti; Colombia; Greece; Sri Lanka; Hungary; Cyprus
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
91 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
60 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
47 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98555
Ingredient ID: NPC98304
Ingredient ID: NPC94167
Ingredient ID: NPC93888
Ingredient ID: NPC85813
Ingredient ID: NPC84226
Ingredient ID: NPC76145
Ingredient ID: NPC73143
Ingredient ID: NPC71371
Ingredient ID: NPC68889
Ingredient ID: NPC63318
Ingredient ID: NPC62045
Ingredient ID: NPC59650
Ingredient ID: NPC56198
Ingredient ID: NPC55412
Ingredient ID: NPC53028
Ingredient ID: NPC490427
Ingredient ID: NPC490424
Ingredient ID: NPC489907
Ingredient ID: NPC424
Ingredient ID: NPC41326
Ingredient ID: NPC39426
Ingredient ID: NPC36882
Ingredient ID: NPC34764
Ingredient ID: NPC328447
Ingredient ID: NPC322339
Ingredient ID: NPC320323
Ingredient ID: NPC318724
Ingredient ID: NPC318696
Ingredient ID: NPC315672
Ingredient ID: NPC312713
Ingredient ID: NPC305741
Ingredient ID: NPC299781
Ingredient ID: NPC295697
Ingredient ID: NPC294548
Ingredient ID: NPC293714
Ingredient ID: NPC291428
Ingredient ID: NPC288241
Ingredient ID: NPC279865
Ingredient ID: NPC279661
Ingredient ID: NPC278363
Ingredient ID: NPC269919
Ingredient ID: NPC2660
Ingredient ID: NPC258957
Ingredient ID: NPC257885
Ingredient ID: NPC242580
Ingredient ID: NPC24219
Ingredient ID: NPC240336
Ingredient ID: NPC236709
Ingredient ID: NPC236340
Ingredient ID: NPC234560
Ingredient ID: NPC234106
Ingredient ID: NPC230085
Ingredient ID: NPC229113
Ingredient ID: NPC226690
Ingredient ID: NPC21547
Ingredient ID: NPC209560
Ingredient ID: NPC208448
Ingredient ID: NPC20791
Ingredient ID: NPC206924
Ingredient ID: NPC206500
Ingredient ID: NPC201284
Ingredient ID: NPC200015
Ingredient ID: NPC192040
Ingredient ID: NPC18950
Ingredient ID: NPC189436
Ingredient ID: NPC187770
Ingredient ID: NPC183845
Ingredient ID: NPC181574
Ingredient ID: NPC180871
Ingredient ID: NPC180781
Ingredient ID: NPC17810
Ingredient ID: NPC174246
Ingredient ID: NPC1682
Ingredient ID: NPC167400
Ingredient ID: NPC16087
Ingredient ID: NPC159630
Ingredient ID: NPC158756
Ingredient ID: NPC157857
Ingredient ID: NPC150950
Ingredient ID: NPC147983
Ingredient ID: NPC142597
Ingredient ID: NPC1397
Ingredient ID: NPC138113
Ingredient ID: NPC136014
Ingredient ID: NPC130683
Ingredient ID: NPC127624
Ingredient ID: NPC125935
Ingredient ID: NPC120635
Ingredient ID: NPC119724
Ingredient ID: NPC112890
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 491 | |
 Plant level | 2 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Ascorbate (NPC187770) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction | Beta Carotene (NPC17810);Ascorbate (NPC187770);Folic Acid (NPC147983);Pyridoxine (NPC269919) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Folic Acid (NPC147983);Pyridoxine (NPC269919);Beta Carotene (NPC17810) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
NCT03522922,NCT03090048 |
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
KDR,FFAR1,DPP4,AURKB
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT,SRC,PIM1,AXL,FLT3,AURKB,TP53
NCT01842139,NCT00184054,NCT00329498 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888
|
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT03624270
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT03718507,NCT04404387
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
NPSR1,CA12,BLM,CA7,SLCO1B1,NR1I2,AURKB,GPR35,CDK1,XDH,AKR1C3,CYP2C9,NQO1,TSHR
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
