CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Isodon Adenolomus

Example Image

PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO18055
Plant Latin Name: Isodon Adenolomus
Taxonomy Genus: Isodon
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: 662903
Plant-of-the-World-Online: 915107-1

Used in Medicines

Unknown.

Geographical Distribution

China

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

90 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

83 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

38 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC94141

Ingredient ID: NPC88945

Ingredient ID: NPC84786

Ingredient ID: NPC75457

Ingredient ID: NPC71074

Ingredient ID: NPC66333

Ingredient ID: NPC63841

Ingredient ID: NPC52289

Ingredient ID: NPC473352

Ingredient ID: NPC471093

Ingredient ID: NPC470172

Ingredient ID: NPC470171

Ingredient ID: NPC470170

Ingredient ID: NPC470169

Ingredient ID: NPC470168

Ingredient ID: NPC470167

Ingredient ID: NPC470166

Ingredient ID: NPC45462

Ingredient ID: NPC4051

Ingredient ID: NPC329302

Ingredient ID: NPC328973

Ingredient ID: NPC328613

Ingredient ID: NPC328350

Ingredient ID: NPC327331

Ingredient ID: NPC327205

Ingredient ID: NPC326960

Ingredient ID: NPC326871

Ingredient ID: NPC326480

Ingredient ID: NPC326456

Ingredient ID: NPC326432

Ingredient ID: NPC325433

Ingredient ID: NPC325334

Ingredient ID: NPC324883

Ingredient ID: NPC324374

Ingredient ID: NPC324044

Ingredient ID: NPC323878

Ingredient ID: NPC323617

Ingredient ID: NPC323319

Ingredient ID: NPC323270

Ingredient ID: NPC322681

Ingredient ID: NPC321423

Ingredient ID: NPC320465

Ingredient ID: NPC320451

Ingredient ID: NPC320436

Ingredient ID: NPC320370

Ingredient ID: NPC320284

Ingredient ID: NPC320176

Ingredient ID: NPC319272

Ingredient ID: NPC319242

Ingredient ID: NPC318957

Ingredient ID: NPC318834

Ingredient ID: NPC318744

Ingredient ID: NPC318337

Ingredient ID: NPC317616

Ingredient ID: NPC302462

Ingredient ID: NPC293454

Ingredient ID: NPC28804

Ingredient ID: NPC286880

Ingredient ID: NPC249078

Ingredient ID: NPC248068

Ingredient ID: NPC247928

Ingredient ID: NPC246229

Ingredient ID: NPC243354

Ingredient ID: NPC230691

Ingredient ID: NPC229752

Ingredient ID: NPC225518

Ingredient ID: NPC22502

Ingredient ID: NPC224878

Ingredient ID: NPC223573

Ingredient ID: NPC217156

Ingredient ID: NPC210327

Ingredient ID: NPC198868

Ingredient ID: NPC194273

Ingredient ID: NPC191899

Ingredient ID: NPC186054

Ingredient ID: NPC182442

Ingredient ID: NPC176130

Ingredient ID: NPC17165

Ingredient ID: NPC157929

Ingredient ID: NPC152966

Ingredient ID: NPC152152

Ingredient ID: NPC142167

Ingredient ID: NPC132668

Ingredient ID: NPC127046

Ingredient ID: NPC126707

Ingredient ID: NPC11917

Ingredient ID: NPC111845

Ingredient ID: NPC110364

Ingredient ID: NPC109813

Ingredient ID: NPC107385

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

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Search:

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Oxidoreductase	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Therapeutic Target	Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253

Showing 1 to 2 of 2 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials

Clinical trial details

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Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
No data available in table

Showing 0 to 0 of 0 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Show entries

Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	HSD11B1
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	CNR2,HSD11B1
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	HSD11B1
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	CNR2
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	CNR2
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	HSD11B1
Crohn disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD70	CNR2 HSD11B1
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	CNR2
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	CNR2,HSD11B1
General pain disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E43	CNR2

Showing 1 to 10 of 28 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Isodon Adenolomus

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

90 All known Ingredients in Total

83 Ingredients with Acceptable Bioavailablity

38 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Acute diabete complication

Adenocarcinoma of pancreas

Alzheimer disease

Atopic eczema

Attention deficit hyperactivity disorder

Carpal tunnel syndrome

Crohn disease

Cytomegaloviral disease

Diffuse large B-cell lymphomas

General pain disorder

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities