Collective Molecular Activities of the Plant: Agrimonia Pilosa
Plant ID: NPO18007
Plant Latin Name: Agrimonia Pilosa
Taxonomy Genus: Agrimonia
Taxonomy Family: Rosaceae
Plant External Links:
NCBI TaxonomyDB:
74656
Plant-of-the-World-Online:
n.a.
Country/Region:
China; South Korea; India; RussiaTraditional Medicine System:
Indian Folk; TCMMedicinal Functions:
Analgesic; Antibacterial; Antiinflammatory; Antipyretic; Astringent; Cardiotonic; Haemostatic; Hypoglycaemic; Vasoconstrictor; Vermifuge
India; South Korea; China; Russia
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
206 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
133 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
105 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99886
Ingredient ID: NPC9880
Ingredient ID: NPC98204
Ingredient ID: NPC96630
Ingredient ID: NPC96286
Ingredient ID: NPC94118
Ingredient ID: NPC89069
Ingredient ID: NPC88789
Ingredient ID: NPC87828
Ingredient ID: NPC85813
Ingredient ID: NPC85550
Ingredient ID: NPC84030
Ingredient ID: NPC82115
Ingredient ID: NPC76145
Ingredient ID: NPC75158
Ingredient ID: NPC7491
Ingredient ID: NPC73577
Ingredient ID: NPC71074
Ingredient ID: NPC68889
Ingredient ID: NPC67986
Ingredient ID: NPC66681
Ingredient ID: NPC61477
Ingredient ID: NPC60556
Ingredient ID: NPC58478
Ingredient ID: NPC56023
Ingredient ID: NPC5515
Ingredient ID: NPC53720
Ingredient ID: NPC52230
Ingredient ID: NPC51758
Ingredient ID: NPC51700
Ingredient ID: NPC51189
Ingredient ID: NPC50898
Ingredient ID: NPC479794
Ingredient ID: NPC479793
Ingredient ID: NPC47946
Ingredient ID: NPC47521
Ingredient ID: NPC46380
Ingredient ID: NPC46330
Ingredient ID: NPC45603
Ingredient ID: NPC43114
Ingredient ID: NPC424
Ingredient ID: NPC39633
Ingredient ID: NPC38751
Ingredient ID: NPC36835
Ingredient ID: NPC36653
Ingredient ID: NPC36061
Ingredient ID: NPC35519
Ingredient ID: NPC34764
Ingredient ID: NPC34440
Ingredient ID: NPC324696
Ingredient ID: NPC323434
Ingredient ID: NPC322655
Ingredient ID: NPC32222
Ingredient ID: NPC321036
Ingredient ID: NPC320283
Ingredient ID: NPC319108
Ingredient ID: NPC318533
Ingredient ID: NPC317111
Ingredient ID: NPC3155
Ingredient ID: NPC311816
Ingredient ID: NPC310478
Ingredient ID: NPC309182
Ingredient ID: NPC308218
Ingredient ID: NPC306990
Ingredient ID: NPC306207
Ingredient ID: NPC301585
Ingredient ID: NPC300649
Ingredient ID: NPC297643
Ingredient ID: NPC297222
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Ingredient ID: NPC290437
Ingredient ID: NPC290189
Ingredient ID: NPC288932
Ingredient ID: NPC288645
Ingredient ID: NPC288537
Ingredient ID: NPC287550
Ingredient ID: NPC284731
Ingredient ID: NPC283655
Ingredient ID: NPC281131
Ingredient ID: NPC280965
Ingredient ID: NPC279121
Ingredient ID: NPC275463
Ingredient ID: NPC272902
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Ingredient ID: NPC26974
Ingredient ID: NPC26960
Ingredient ID: NPC26906
Ingredient ID: NPC268469
Ingredient ID: NPC26600
Ingredient ID: NPC265636
Ingredient ID: NPC264779
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Ingredient ID: NPC264207
Ingredient ID: NPC263542
Ingredient ID: NPC261831
Ingredient ID: NPC261619
Ingredient ID: NPC260619
Ingredient ID: NPC259733
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Ingredient ID: NPC248726
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Ingredient ID: NPC22708
Ingredient ID: NPC225710
Ingredient ID: NPC2251
Ingredient ID: NPC223468
Ingredient ID: NPC223148
Ingredient ID: NPC222065
Ingredient ID: NPC219876
Ingredient ID: NPC218918
Ingredient ID: NPC216630
Ingredient ID: NPC214909
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Ingredient ID: NPC21372
Ingredient ID: NPC209970
Ingredient ID: NPC209846
Ingredient ID: NPC209275
Ingredient ID: NPC20791
Ingredient ID: NPC20742
Ingredient ID: NPC206050
Ingredient ID: NPC20306
Ingredient ID: NPC201844
Ingredient ID: NPC196490
Ingredient ID: NPC194206
Ingredient ID: NPC193180
Ingredient ID: NPC192962
Ingredient ID: NPC19240
Ingredient ID: NPC190810
Ingredient ID: NPC190043
Ingredient ID: NPC189853
Ingredient ID: NPC189142
Ingredient ID: NPC189036
Ingredient ID: NPC187602
Ingredient ID: NPC187061
Ingredient ID: NPC184049
Ingredient ID: NPC184028
Ingredient ID: NPC183811
Ingredient ID: NPC182840
Ingredient ID: NPC182102
Ingredient ID: NPC18208
Ingredient ID: NPC180871
Ingredient ID: NPC180840
Ingredient ID: NPC180684
Ingredient ID: NPC179950
Ingredient ID: NPC179024
Ingredient ID: NPC178223
Ingredient ID: NPC178134
Ingredient ID: NPC176740
Ingredient ID: NPC176309
Ingredient ID: NPC175987
Ingredient ID: NPC174490
Ingredient ID: NPC173637
Ingredient ID: NPC167385
Ingredient ID: NPC166894
Ingredient ID: NPC16157
Ingredient ID: NPC160601
Ingredient ID: NPC160156
Ingredient ID: NPC15970
Ingredient ID: NPC157781
Ingredient ID: NPC15658
Ingredient ID: NPC155182
Ingredient ID: NPC154186
Ingredient ID: NPC147343
Ingredient ID: NPC14682
Ingredient ID: NPC146197
Ingredient ID: NPC14576
Ingredient ID: NPC144023
Ingredient ID: NPC143639
Ingredient ID: NPC142415
Ingredient ID: NPC142252
Ingredient ID: NPC139546
Ingredient ID: NPC139545
Ingredient ID: NPC139029
Ingredient ID: NPC138347
Ingredient ID: NPC13789
Ingredient ID: NPC136091
Ingredient ID: NPC135391
Ingredient ID: NPC135088
Ingredient ID: NPC133671
Ingredient ID: NPC132142
Ingredient ID: NPC131809
Ingredient ID: NPC126240
Ingredient ID: NPC124876
Ingredient ID: NPC120926
Ingredient ID: NPC117493
Ingredient ID: NPC116775
Ingredient ID: NPC109945
Ingredient ID: NPC109813
Ingredient ID: NPC106250
Ingredient ID: NPC105557
Ingredient ID: NPC104569
Ingredient ID: NPC10251
Ingredient ID: NPC101285
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLC22A6 | Solute carrier family 22 member 6 | Q4U2R8 | CHEMBL1641347 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 71 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT00299559 | Kinetics of Etheric Oils, Smart Textiles vs. Ointment | common cold | Menthol (NPC223468) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791);Ellagic Acid (NPC178134) | NP level |
| NCT00607945 | Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Linoleic Acid (NPC85813) | NP level |
| NCT00638196 | Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS | multiple sclerosis | Oleic Acid (NPC261831) | NP level |
| NCT00908791 | Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue | breast cancer | Linoleic Acid (NPC85813) | NP level |
| NCT00951158 | A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors | neoplasm | Linoleic Acid (NPC85813) | NP level |
| NCT01119534 | Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin | Cough | Menthol (NPC223468) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
INSR,HSD11B1,FFAR1,AKR1B1,DPP4,PTPN1,AURKB,KDR,PPARA
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,PTPRC,AXL,PIM1,AURKB,SRC,KDM1A,GSK3B,RELA,TP53,FLT3
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
RELA,NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,CA7,MMP12,XDH,AKR1C3,AURKB,AKR1B10,CDK1,CYP2C9,MMP9,MMP1,GPR35,TTR,CA12,THPO,NPSR1,TSHR
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
FABP3,ACHE,CA7,CISD1,POLB,DPP4,LMNA,CA2,XDH,AKR1C3,HSD17B2,RECQL,TEK,AURKB,CYP1B1,AKR1B10,FFAR4,HIF1A,CYP2C9,MMP1,NUAK1,CNR2,TTR,MET,OR51E2,PTPRC,PTPN1,ALOX15,PIM1,HSD11B1,ABCG2,AXL,FUT7,ALOX5,NPSR1,CDC25B,MMP2,CES1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,TTR,OR51E2,FABP5,ALOX15
NCT01912820 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
