Collective Molecular Activities of the Plant: Berberis Vulgaris
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PLANiTS DNA barcode
Taxonomic Information
Plant ID: NPO17909
Plant Latin Name: Berberis Vulgaris
Taxonomy Genus: Berberis
Taxonomy Family: Berberidaceae
Plant External Links:
NCBI TaxonomyDB:
258209
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary
Overview of Ingredients
19 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
9 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
14 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC78359
Ingredient ID: NPC7715
Ingredient ID: NPC53069
Ingredient ID: NPC49075
Ingredient ID: NPC480592
Ingredient ID: NPC480591
Ingredient ID: NPC480590
Ingredient ID: NPC480589
Ingredient ID: NPC47298
Ingredient ID: NPC4669
Ingredient ID: NPC300481
Ingredient ID: NPC251735
Ingredient ID: NPC248109
Ingredient ID: NPC200388
Ingredient ID: NPC199402
Ingredient ID: NPC181796
Ingredient ID: NPC16452
Ingredient ID: NPC117785
Ingredient ID: NPC116007
Classification of Human Proteins Collectively Targeted by the Plant
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Therapeutic Target | Hydrolase | BCHE | Butyrylcholinesterase | P06276 | CHEMBL1914 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Serine protease | CELA1 | Elastase 1 | Q9UNI1 | CHEMBL3000 |
| Therapeutic Target | Serine protease | PREP | Prolyl endopeptidase | P48147 | CHEMBL3202 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical Trials Summary
Overview
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 42 | |
 Plant level | 1 | |
Clinical trial details
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01039194 | Drug-Drug Interaction to Study the Effect of BMS-708163 on Pharmacokinetics (PK) of Galantamine Extended Release (ER) | Alzheimer disease | Galantamine (NPC78359) | NP level |
| NCT02082756 | Effects of Berberine Hydrochloride and Bifidobacterium in Prediabetes Prevention and Treatment | prediabetes syndrome | Berberine (NPC53069) | NP level |
| NCT03281096 | A Research of Berberine Hydrochloride to Prevent Colorectal Adenomas in Patients With Previous Colorectal Cancer | colorectal adenoma | Berberine (NPC53069) | NP level |
| NCT02084004 | Effects of Berberine Hydrochloride and Bifidobacterium in Diabetes Mellitus Prevention and Treatment | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
| NCT00750529 | Alzheimer and Sleep | Alzheimer disease | Galantamine (NPC78359) | NP level |
| NCT01100775 | Effects of Galantamine on Cognition | schizophrenia | Galantamine (NPC78359) | NP level |
| NCT03124355 | Vagal Stimulation in POTS | orthostatic hypotension | Galantamine (NPC78359) | NP level |
| NCT01548638 | Effect of Galantamine on Smoking Abstinence | nicotine dependence | Galantamine (NPC78359) | NP level |
| NCT04084847 | Berberis Vulgaris Consumption and Blood Pressure | Blood Pressure|Cardiovascular Risk Factor|Lipid Profile | Berberis Vulgaris | Plant level As single plant |
| NCT00633282 | Role of Pioglitazone and Berberine in Treatment of Non-Alcoholic Fatty Liver Disease | non-alcoholic fatty liver disease | Berberine (NPC53069) | NP level |
| NCT01677754 | A Study of RO4602522 in Participants With Moderate Severity Alzheimer Disease on Background Alzheimer Disease Therapy | Alzheimer disease | Galantamine (NPC78359) | NP level |
| NCT00969696 | Galantamine Effects on Cognitive Function in Marijuana Users | memory impairment | Galantamine (NPC78359) | NP level |
| NCT01372306 | Galantamine Bioequivalence Study of Dr. Reddy's Under Fed Condition | Fish-eye disease | Galantamine (NPC78359) | NP level |
| NCT02374567 | Pharmacovigilance in Gerontopsychiatric Patients | anxiety;depressive disorder;schizophrenia;Dementia | Galantamine (NPC78359) | NP level |
| NCT01012167 | Oxytocin or Galantamine Versus Placebo for the Treatment of Negative Symptoms and Cognitive Impairments in Schizophrenia | schizophrenia | Galantamine (NPC78359) | NP level |
| NCT02226185 | Study of Berberine Hydrochloride in Prevention of Colorectal Adenomas Recurrence | colorectal adenoma | Berberine (NPC53069) | NP level |
| NCT00000172 | Evaluation of Galantamine in the Treatment of Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
| NCT00645190 | A Randomized, Double-blind, Flexible Dose, Multicenter Study to Evaluate the Effectiveness and Safety of Galantamine IR in Mild to Moderate Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
| NCT00230997 | Safety and Efficacy of Galantamine in Patients With Dementia With Lewy Bodies | Lewy body dementia | Galantamine (NPC78359) | NP level |
| NCT00679627 | A Study of Galantamine Used to Treat Patients With Mild to Moderate Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
| NCT03384784 | Effect of Galantamine on Inflammation and Cognition | HIV infection | Galantamine (NPC78359) | NP level |
| NCT02248636 | Cholinesterase Inhibitor Discontinuation | Dementia | Galantamine (NPC78359) | NP level |
| NCT02234752 | Galantamine and Memantine Combination for Cognitive Impairments in Schizophrenia | schizoaffective disorder;schizophrenia | Galantamine (NPC78359) | NP level |
| NCT02548832 | Bezafibrate Plus Berberine in Mixed Dyslipidemia | Combined hyperlipidemia | Berberine (NPC53069) | NP level |
| NCT03333265 | Primary Chemoprevention of Familial Adenomatous Polyposis With Berberine Hydrochloride | colorectal adenoma | Berberine (NPC53069) | NP level |
| NCT00082602 | Safety and Tolerability Study of Extended Release (ER) Galantamine in Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
| NCT00425009 | Therapeutic Effects of Berberine in Patients With Type 2 Diabetes | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
| NCT00252603 | Galantamine Versus Placebo in Childhood Autism | autism | Galantamine (NPC78359) | NP level |
| NCT00309725 | A Cardiac Safety Study of Galantamine in the Treatment of Alzheimer's Disease. | Alzheimer disease | Galantamine (NPC78359) | NP level |
| NCT00814801 | An Efficacy and Safety Study of Galantamine for the Treatment of Patients With Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
| NCT03486496 | Gefitinib and Berberine in the First-line Treatment of Lung Adenocarcinoma With EGFR Mutation | lung adenocarcinoma | Berberine (NPC53069) | NP level |
| NCT00301574 | An Efficacy and Safety Study of Galantamine for the Treatment of Patients With Alzheimer's Disease. | Alzheimer disease | Galantamine (NPC78359) | NP level |
| NCT02861261 | A Study on the Efficacy and Gut Microbiota of Berberine and Probiotics in Patients With Newly Diagnosed Type 2 Diabetes | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
| NCT01417429 | Galantamine Effects on Nicotine Responses in Smokers | nicotine dependence | Galantamine (NPC78359) | NP level |
| NCT02365285 | Racial Differences in Vagal Control of Glucose Homeostasis | obesity | Galantamine (NPC78359) | NP level |
| NCT00814658 | The Use of Galantamine (Reminyl ER) in Patients With MIXed Dementia: Effects on Cognition and Quality of Life | Dementia | Galantamine (NPC78359) | NP level |
| NCT00509067 | Use of Galantamine and CDP-choline (Citicoline) to Treat Adults With Schizophrenia | schizophrenia | Galantamine (NPC78359) | NP level |
| NCT00035191 | A Placebo-controlled Trial to Evaluate the Safety and Efficacy of Galantamine in the Treatment of Vascular Dementia | vascular dementia | Galantamine (NPC78359) | NP level |
| NCT00304629 | Long-term Safety and Efficacy of Galantamine in Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
| NCT00463879 | Galantamine for Cognitive Deficits in Schizophrenia | schizophrenia | Galantamine (NPC78359) | NP level |
| NCT01669538 | Effect of Galantamine on Short-term Abstinence | nicotine dependence | Galantamine (NPC78359) | NP level |
| NCT00809835 | Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse | cocaine dependence | Galantamine (NPC78359) | NP level |
| NCT02872857 | Subarachnoid Hemorrhage Recovery And Galantamine | subarachnoid hemorrhage | Galantamine (NPC78359) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
NCT00463879,NCT00509067,NCT02374567,NCT01100775,NCT01012167,NCT02234752
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
ACHE
NCT02248636,NCT00814658,NCT02374567,NCT00230997 |
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CYP1B1,ACHE,LMNA,BCHE
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
ACHE,BCHE,PREP
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
NCT02226185,NCT03281096,NCT03333265
|
Nicotine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4A |
NCT01417429,NCT01669538,NCT01548638
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
NCT00425009,NCT02084004,NCT02861261
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
CELA1,ACHE,BCHE
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CYP1B1,CELA1,ACHE
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CYP1B1,LMNA,CELA1
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
ACHE,BCHE
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
ACHE,BCHE
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA,ACHE
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
LMNA,BCHE
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA,ACHE
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
ACHE,BCHE
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
BCHE,ACHE
NCT00309725,NCT00082602,NCT01677754,NCT00679627,NCT00304629,NCT00814801,NCT00301574,NCT00750529,NCT00000172,NCT01039194,NCT00645190 |
Blood PressureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA2Z-BA00.Z |
NCT04084847
|
Inflammatory spondyloarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA92 |
CELA1
|
Oesophageal/gastroduodenal disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD90 |
ACHE
|
Ulcerative colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD71 |
CELA1
|
Psoriatic arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA21 |
CELA1
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
CELA1
|
Pyoderma gangrenosumDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EB21 |
CELA1
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
ACHE
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
PREP
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
ACHE
|
Alpha-1-antitrypsin deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C5A |
CELA1
|
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
ACHE
|
Eexposure to noxious substances harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE61 |
BCHE
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
PREP
|
Acute bronchitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA42 |
CELA1
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ACHE
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
CELA1
|
Parasitic worm infestationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F90 |
ACHE
|
Tonus and reflex abnormalityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB47 |
BCHE
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
ACHE
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
CELA1
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
PREP
|
Anterior uveitisDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A96 |
CELA1
|
PediculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G00 |
ACHE
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
CELA1
|
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT03486496
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
NCT02365285
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
NCT00252603
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
NCT02374567
|
Mixed hyperlipidaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80.2 |
NCT02548832
|
Dementia due to cerebrovascular diseaseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D81 |
NCT00035191
|
Orthostatic hypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA21 |
NCT03124355
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
NCT00633282
|
Intermediate hyperglycaemia, unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A40.Z |
NCT02082756
|
Schizoaffective disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A21 |
NCT02234752
|
Cocaine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C45 |
NCT00809835
|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT03384784
|
Subarachnoid haemorrhageDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B01 |
NCT02872857
|
Age-associated cognitive declineDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB21.0 |
NCT00969696
|
Depressive disorders, unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A7Z |
NCT02374567
|
HypoalphalipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C81.0 |
NCT01372306
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
PREP
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
ACHE
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
BCHE
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
ACHE
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
ACHE
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ACHE
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
ACHE
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CYP1B1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
CYP1B1
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
CYP1B1
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
ACHE
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
BCHE
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
Plant-Targeted Human Disease Network
>> Targets derived from weak experimental activities
