CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Cephalonoplos Segetum

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO17811
Plant Latin Name: Cephalonoplos Segetum
Taxonomy Genus: Cephanonoplos
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 41543
Plant-of-the-World-Online: n.a.

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

103 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

100 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

40 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC99638

Ingredient ID: NPC91702

Ingredient ID: NPC90083

Ingredient ID: NPC85045

Ingredient ID: NPC81781

Ingredient ID: NPC80241

Ingredient ID: NPC71553

Ingredient ID: NPC67012

Ingredient ID: NPC66819

Ingredient ID: NPC66436

Ingredient ID: NPC66292

Ingredient ID: NPC63238

Ingredient ID: NPC57119

Ingredient ID: NPC55349

Ingredient ID: NPC50408

Ingredient ID: NPC49603

Ingredient ID: NPC36108

Ingredient ID: NPC35437

Ingredient ID: NPC33675

Ingredient ID: NPC31279

Ingredient ID: NPC312713

Ingredient ID: NPC310905

Ingredient ID: NPC310208

Ingredient ID: NPC309053

Ingredient ID: NPC30668

Ingredient ID: NPC301585

Ingredient ID: NPC301043

Ingredient ID: NPC296301

Ingredient ID: NPC295998

Ingredient ID: NPC29008

Ingredient ID: NPC287926

Ingredient ID: NPC287660

Ingredient ID: NPC28681

Ingredient ID: NPC284135

Ingredient ID: NPC282703

Ingredient ID: NPC277700

Ingredient ID: NPC275152

Ingredient ID: NPC274356

Ingredient ID: NPC270989

Ingredient ID: NPC268377

Ingredient ID: NPC261661

Ingredient ID: NPC257872

Ingredient ID: NPC252552

Ingredient ID: NPC251040

Ingredient ID: NPC24815

Ingredient ID: NPC245076

Ingredient ID: NPC244441

Ingredient ID: NPC243749

Ingredient ID: NPC243259

Ingredient ID: NPC240308

Ingredient ID: NPC238737

Ingredient ID: NPC237254

Ingredient ID: NPC232316

Ingredient ID: NPC230828

Ingredient ID: NPC229383

Ingredient ID: NPC227217

Ingredient ID: NPC227002

Ingredient ID: NPC225840

Ingredient ID: NPC222986

Ingredient ID: NPC219671

Ingredient ID: NPC21867

Ingredient ID: NPC218197

Ingredient ID: NPC215975

Ingredient ID: NPC21563

Ingredient ID: NPC212015

Ingredient ID: NPC210969

Ingredient ID: NPC210674

Ingredient ID: NPC210489

Ingredient ID: NPC20674

Ingredient ID: NPC204120

Ingredient ID: NPC203924

Ingredient ID: NPC20387

Ingredient ID: NPC203831

Ingredient ID: NPC197318

Ingredient ID: NPC194996

Ingredient ID: NPC192961

Ingredient ID: NPC190629

Ingredient ID: NPC187616

Ingredient ID: NPC186556

Ingredient ID: NPC184733

Ingredient ID: NPC183987

Ingredient ID: NPC181869

Ingredient ID: NPC178284

Ingredient ID: NPC174727

Ingredient ID: NPC17240

Ingredient ID: NPC170779

Ingredient ID: NPC166348

Ingredient ID: NPC16272

Ingredient ID: NPC161405

Ingredient ID: NPC159805

Ingredient ID: NPC141529

Ingredient ID: NPC135479

Ingredient ID: NPC129570

Ingredient ID: NPC128208

Ingredient ID: NPC127233

Ingredient ID: NPC124042

Ingredient ID: NPC12362

Ingredient ID: NPC119949

Ingredient ID: NPC115663

Ingredient ID: NPC112237

Ingredient ID: NPC106739

Ingredient ID: NPC106221

Ingredient ID: NPC104308

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

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Search:

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Other cytosolic protein	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Showing 1 to 1 of 1 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	1

Clinical trial details

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Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT01378143	Using OCZ103-OS in Patients With Unresectable and Locally Recurrent or Metastatic Colorectal Cancer Undergoing Standard Chemotherapy	colorectal carcinoma	Ethane (NPC71553)	NP level

Showing 1 to 1 of 1 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Show entries

Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	MAPT
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	SGMS2
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	MAPT
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	SGMS2
Choreiform disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A01	MAPT
Colorectal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B91	NCT01378143
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	MAPT,MAPT
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	MAPT
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	MAPT
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	SGMS2

Showing 1 to 10 of 15 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Cephalonoplos Segetum

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

103 All known Ingredients in Total

100 Ingredients with Acceptable Bioavailablity

40 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Acute myeloid leukaemia

Adenocarcinoma of pancreas

Alzheimer disease

Carpal tunnel syndrome

Choreiform disorder

Colorectal cancer

Hepatocellular carcinoma of liver

Malignant neoplasms of biliary tract, distal bile duct

Malignant neoplasms of thymus

Mesothelioma of pleura

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities