Collective Molecular Activities of the Plant: Pinus Sylvestris
Plant ID: NPO17593
Plant Latin Name: Pinus Sylvestris
Taxonomy Genus: Pinus
Taxonomy Family: Pinaceae
Plant External Links:
NCBI TaxonomyDB:
3349
Plant-of-the-World-Online:
n.a.
Country/Region:
Turkey; Finland; India; Sweden; China; Spain; BulgariaTraditional Medicine System:
Sowa-Rigpa; TCM; HomeopathyMedicinal Functions:
Antirheumatic; Antiseptic; Aromatherapy; Bach; Balsamic; Diuretic; Expectorant
Turkey; Finland; India; Sweden; China; Spain; Bulgaria
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
174 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
93 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
68 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9874
Ingredient ID: NPC95126
Ingredient ID: NPC91386
Ingredient ID: NPC90105
Ingredient ID: NPC86753
Ingredient ID: NPC86438
Ingredient ID: NPC80807
Ingredient ID: NPC80600
Ingredient ID: NPC80374
Ingredient ID: NPC79499
Ingredient ID: NPC79391
Ingredient ID: NPC78946
Ingredient ID: NPC78026
Ingredient ID: NPC77974
Ingredient ID: NPC76296
Ingredient ID: NPC76145
Ingredient ID: NPC72422
Ingredient ID: NPC72017
Ingredient ID: NPC71853
Ingredient ID: NPC70744
Ingredient ID: NPC70100
Ingredient ID: NPC68779
Ingredient ID: NPC68617
Ingredient ID: NPC68014
Ingredient ID: NPC67571
Ingredient ID: NPC66399
Ingredient ID: NPC65942
Ingredient ID: NPC64123
Ingredient ID: NPC58841
Ingredient ID: NPC58190
Ingredient ID: NPC57788
Ingredient ID: NPC50763
Ingredient ID: NPC48744
Ingredient ID: NPC48107
Ingredient ID: NPC47844
Ingredient ID: NPC43436
Ingredient ID: NPC42676
Ingredient ID: NPC40147
Ingredient ID: NPC39896
Ingredient ID: NPC37468
Ingredient ID: NPC37288
Ingredient ID: NPC36616
Ingredient ID: NPC3649
Ingredient ID: NPC35741
Ingredient ID: NPC33090
Ingredient ID: NPC329043
Ingredient ID: NPC329007
Ingredient ID: NPC32553
Ingredient ID: NPC317758
Ingredient ID: NPC311881
Ingredient ID: NPC307574
Ingredient ID: NPC307506
Ingredient ID: NPC307110
Ingredient ID: NPC307050
Ingredient ID: NPC299937
Ingredient ID: NPC299856
Ingredient ID: NPC299529
Ingredient ID: NPC297727
Ingredient ID: NPC297011
Ingredient ID: NPC29598
Ingredient ID: NPC295946
Ingredient ID: NPC294952
Ingredient ID: NPC293908
Ingredient ID: NPC293017
Ingredient ID: NPC292722
Ingredient ID: NPC291789
Ingredient ID: NPC290016
Ingredient ID: NPC289688
Ingredient ID: NPC288436
Ingredient ID: NPC287301
Ingredient ID: NPC280642
Ingredient ID: NPC278434
Ingredient ID: NPC273991
Ingredient ID: NPC269613
Ingredient ID: NPC268862
Ingredient ID: NPC268342
Ingredient ID: NPC263281
Ingredient ID: NPC26314
Ingredient ID: NPC261093
Ingredient ID: NPC26080
Ingredient ID: NPC251102
Ingredient ID: NPC250482
Ingredient ID: NPC249340
Ingredient ID: NPC246581
Ingredient ID: NPC246202
Ingredient ID: NPC246162
Ingredient ID: NPC246005
Ingredient ID: NPC244776
Ingredient ID: NPC244442
Ingredient ID: NPC243728
Ingredient ID: NPC242898
Ingredient ID: NPC241784
Ingredient ID: NPC238809
Ingredient ID: NPC237207
Ingredient ID: NPC23682
Ingredient ID: NPC23678
Ingredient ID: NPC236202
Ingredient ID: NPC232375
Ingredient ID: NPC232227
Ingredient ID: NPC228346
Ingredient ID: NPC227632
Ingredient ID: NPC224390
Ingredient ID: NPC223834
Ingredient ID: NPC222001
Ingredient ID: NPC219876
Ingredient ID: NPC219480
Ingredient ID: NPC218943
Ingredient ID: NPC218792
Ingredient ID: NPC217650
Ingredient ID: NPC215647
Ingredient ID: NPC212866
Ingredient ID: NPC211336
Ingredient ID: NPC210532
Ingredient ID: NPC21002
Ingredient ID: NPC206280
Ingredient ID: NPC203719
Ingredient ID: NPC197285
Ingredient ID: NPC191327
Ingredient ID: NPC191271
Ingredient ID: NPC188238
Ingredient ID: NPC18816
Ingredient ID: NPC187272
Ingredient ID: NPC187169
Ingredient ID: NPC186616
Ingredient ID: NPC185768
Ingredient ID: NPC182453
Ingredient ID: NPC18229
Ingredient ID: NPC181664
Ingredient ID: NPC178919
Ingredient ID: NPC178815
Ingredient ID: NPC178582
Ingredient ID: NPC173883
Ingredient ID: NPC172469
Ingredient ID: NPC172195
Ingredient ID: NPC169468
Ingredient ID: NPC165219
Ingredient ID: NPC163332
Ingredient ID: NPC163326
Ingredient ID: NPC163191
Ingredient ID: NPC162521
Ingredient ID: NPC15658
Ingredient ID: NPC156304
Ingredient ID: NPC15518
Ingredient ID: NPC15482
Ingredient ID: NPC153854
Ingredient ID: NPC152600
Ingredient ID: NPC151439
Ingredient ID: NPC150361
Ingredient ID: NPC148615
Ingredient ID: NPC148174
Ingredient ID: NPC142871
Ingredient ID: NPC141733
Ingredient ID: NPC140201
Ingredient ID: NPC139397
Ingredient ID: NPC138370
Ingredient ID: NPC138113
Ingredient ID: NPC130754
Ingredient ID: NPC13033
Ingredient ID: NPC128248
Ingredient ID: NPC12640
Ingredient ID: NPC125665
Ingredient ID: NPC116272
Ingredient ID: NPC114239
Ingredient ID: NPC113614
Ingredient ID: NPC112959
Ingredient ID: NPC111929
Ingredient ID: NPC111275
Ingredient ID: NPC111212
Ingredient ID: NPC108811
Ingredient ID: NPC107815
Ingredient ID: NPC10716
Ingredient ID: NPC107091
Ingredient ID: NPC100844
Ingredient ID: NPC100340
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Therapeutic Target | Enzyme | KARS1 | Lysyl-tRNA synthetase | Q15046 | CHEMBL5575 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Oxidoreductase | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Therapeutic Target | Oxidoreductase | HSD17B3 | Estradiol 17-beta-dehydrogenase 3 | P37058 | CHEMBL4234 |
| Therapeutic Target | Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Therapeutic Target | Transcription factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Therapeutic Target | Unclassified protein | SNCA | Alpha-synuclein | P37840 | CHEMBL6152 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 3 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT04392622 | d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma | xerostomia | Limonene (NPC76145) | NP level |
| NCT04853082 | Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution | Hepatic steatosis | Limonene (NPC76145) | NP level |
| NCT05432284 | Behavioral Pharmacology of THC and Beta-Myrcene | cannabis dependence | Myrcene (NPC138113) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,NPSR1,CA7
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
SNCA,NPSR1,CA7
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
NPSR1,CYP19A1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SNCA
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA12
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
TP53
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
TP53
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
