Collective Molecular Activities of the Plant: Acacia Adunca
Unknown.
Australia; India
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
258 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
63 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
86 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99088
Ingredient ID: NPC99069
Ingredient ID: NPC98583
Ingredient ID: NPC97578
Ingredient ID: NPC97444
Ingredient ID: NPC96403
Ingredient ID: NPC96229
Ingredient ID: NPC93155
Ingredient ID: NPC92999
Ingredient ID: NPC9259
Ingredient ID: NPC92338
Ingredient ID: NPC91957
Ingredient ID: NPC91431
Ingredient ID: NPC90643
Ingredient ID: NPC88391
Ingredient ID: NPC87061
Ingredient ID: NPC86856
Ingredient ID: NPC85799
Ingredient ID: NPC85345
Ingredient ID: NPC81870
Ingredient ID: NPC81803
Ingredient ID: NPC81010
Ingredient ID: NPC76939
Ingredient ID: NPC76733
Ingredient ID: NPC76241
Ingredient ID: NPC76078
Ingredient ID: NPC75467
Ingredient ID: NPC74238
Ingredient ID: NPC73959
Ingredient ID: NPC73666
Ingredient ID: NPC7300
Ingredient ID: NPC71686
Ingredient ID: NPC70367
Ingredient ID: NPC6702
Ingredient ID: NPC66812
Ingredient ID: NPC65142
Ingredient ID: NPC64381
Ingredient ID: NPC62965
Ingredient ID: NPC61990
Ingredient ID: NPC61446
Ingredient ID: NPC59692
Ingredient ID: NPC59005
Ingredient ID: NPC58350
Ingredient ID: NPC58190
Ingredient ID: NPC57788
Ingredient ID: NPC56340
Ingredient ID: NPC55917
Ingredient ID: NPC54653
Ingredient ID: NPC5360
Ingredient ID: NPC50364
Ingredient ID: NPC47941
Ingredient ID: NPC45782
Ingredient ID: NPC44892
Ingredient ID: NPC44209
Ingredient ID: NPC43381
Ingredient ID: NPC42683
Ingredient ID: NPC41748
Ingredient ID: NPC39351
Ingredient ID: NPC38851
Ingredient ID: NPC37793
Ingredient ID: NPC37725
Ingredient ID: NPC37644
Ingredient ID: NPC37393
Ingredient ID: NPC34864
Ingredient ID: NPC34763
Ingredient ID: NPC34125
Ingredient ID: NPC32807
Ingredient ID: NPC32643
Ingredient ID: NPC313179
Ingredient ID: NPC312800
Ingredient ID: NPC311233
Ingredient ID: NPC307147
Ingredient ID: NPC307064
Ingredient ID: NPC306159
Ingredient ID: NPC305471
Ingredient ID: NPC303646
Ingredient ID: NPC303422
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Ingredient ID: NPC302787
Ingredient ID: NPC301221
Ingredient ID: NPC300326
Ingredient ID: NPC29883
Ingredient ID: NPC297848
Ingredient ID: NPC296058
Ingredient ID: NPC295314
Ingredient ID: NPC295230
Ingredient ID: NPC294558
Ingredient ID: NPC293378
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Ingredient ID: NPC291938
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Ingredient ID: NPC285472
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Ingredient ID: NPC278299
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Ingredient ID: NPC277867
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Ingredient ID: NPC275759
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Ingredient ID: NPC27373
Ingredient ID: NPC270698
Ingredient ID: NPC270578
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Ingredient ID: NPC268079
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Ingredient ID: NPC26474
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Ingredient ID: NPC263233
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Ingredient ID: NPC260342
Ingredient ID: NPC259722
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Ingredient ID: NPC249191
Ingredient ID: NPC248943
Ingredient ID: NPC248573
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Ingredient ID: NPC24642
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Ingredient ID: NPC242107
Ingredient ID: NPC242028
Ingredient ID: NPC238254
Ingredient ID: NPC236997
Ingredient ID: NPC236709
Ingredient ID: NPC236264
Ingredient ID: NPC236202
Ingredient ID: NPC235469
Ingredient ID: NPC235341
Ingredient ID: NPC235260
Ingredient ID: NPC234905
Ingredient ID: NPC234719
Ingredient ID: NPC234578
Ingredient ID: NPC234489
Ingredient ID: NPC233467
Ingredient ID: NPC233388
Ingredient ID: NPC231926
Ingredient ID: NPC230301
Ingredient ID: NPC22941
Ingredient ID: NPC228496
Ingredient ID: NPC226809
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Ingredient ID: NPC225977
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Ingredient ID: NPC224297
Ingredient ID: NPC224205
Ingredient ID: NPC223654
Ingredient ID: NPC222692
Ingredient ID: NPC219876
Ingredient ID: NPC216980
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Ingredient ID: NPC215135
Ingredient ID: NPC214910
Ingredient ID: NPC213968
Ingredient ID: NPC213607
Ingredient ID: NPC212387
Ingredient ID: NPC209779
Ingredient ID: NPC20791
Ingredient ID: NPC207516
Ingredient ID: NPC204932
Ingredient ID: NPC203230
Ingredient ID: NPC202742
Ingredient ID: NPC201562
Ingredient ID: NPC201170
Ingredient ID: NPC198031
Ingredient ID: NPC196817
Ingredient ID: NPC196791
Ingredient ID: NPC195355
Ingredient ID: NPC194376
Ingredient ID: NPC19388
Ingredient ID: NPC193541
Ingredient ID: NPC193078
Ingredient ID: NPC189620
Ingredient ID: NPC188899
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Ingredient ID: NPC187676
Ingredient ID: NPC186518
Ingredient ID: NPC185230
Ingredient ID: NPC183523
Ingredient ID: NPC18185
Ingredient ID: NPC180508
Ingredient ID: NPC180144
Ingredient ID: NPC179950
Ingredient ID: NPC179789
Ingredient ID: NPC179702
Ingredient ID: NPC17810
Ingredient ID: NPC178059
Ingredient ID: NPC177941
Ingredient ID: NPC176025
Ingredient ID: NPC175378
Ingredient ID: NPC171794
Ingredient ID: NPC170016
Ingredient ID: NPC169749
Ingredient ID: NPC169468
Ingredient ID: NPC168579
Ingredient ID: NPC165686
Ingredient ID: NPC165136
Ingredient ID: NPC164622
Ingredient ID: NPC164487
Ingredient ID: NPC163091
Ingredient ID: NPC163090
Ingredient ID: NPC161700
Ingredient ID: NPC161571
Ingredient ID: NPC160512
Ingredient ID: NPC159664
Ingredient ID: NPC15962
Ingredient ID: NPC159095
Ingredient ID: NPC158540
Ingredient ID: NPC15658
Ingredient ID: NPC154656
Ingredient ID: NPC154362
Ingredient ID: NPC152127
Ingredient ID: NPC15109
Ingredient ID: NPC150670
Ingredient ID: NPC149209
Ingredient ID: NPC147934
Ingredient ID: NPC147155
Ingredient ID: NPC147020
Ingredient ID: NPC146972
Ingredient ID: NPC146953
Ingredient ID: NPC14442
Ingredient ID: NPC143852
Ingredient ID: NPC1429
Ingredient ID: NPC142415
Ingredient ID: NPC142153
Ingredient ID: NPC137634
Ingredient ID: NPC136473
Ingredient ID: NPC136064
Ingredient ID: NPC134140
Ingredient ID: NPC133671
Ingredient ID: NPC133209
Ingredient ID: NPC131957
Ingredient ID: NPC126791
Ingredient ID: NPC126029
Ingredient ID: NPC125755
Ingredient ID: NPC125579
Ingredient ID: NPC124295
Ingredient ID: NPC118752
Ingredient ID: NPC11727
Ingredient ID: NPC114179
Ingredient ID: NPC1135
Ingredient ID: NPC113366
Ingredient ID: NPC11128
Ingredient ID: NPC111134
Ingredient ID: NPC108811
Ingredient ID: NPC108303
Ingredient ID: NPC108212
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 96 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction;Myocardial Ischemia | Beta Carotene (NPC17810) | NP level |
| NCT00006202 | Lutein for Age-Related Macular Degeneration | macular degeneration | Lutein (NPC313179) | NP level |
| NCT00029289 | Effects of Lutein in Retinitis Pigmentosa | retinitis pigmentosa | Lutein (NPC313179) | NP level |
| NCT00098969 | UMCC 2003-064 Resveratrol in Preventing Cancer in Healthy Participants | neoplasm | Resveratrol (NPC161571) | NP level |
| NCT00121589 | Lutein/Zeaxanthin and Omega-3 Supplementation in Persons Over Age 60 | macular degeneration | Lutein (NPC313179) | NP level |
| NCT00249951 | Alkaline Citrate Treatment to Lower the Risk of Nephrocalcinosis in Preterm Infants | Nephrocalcinosis | Citric Acid (NPC293378) | NP level |
| NCT00256334 | Resveratrol for Patients With Colon Cancer | malignant colon neoplasm | Resveratrol (NPC161571) | NP level |
| NCT00275418 | Beta Carotene From Natural Source for Patients With Non-Active Crohn's Disease | Crohn's disease | Beta Carotene (NPC17810) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PTPN1,KDR,AKR1B1,AURKB,DPP4
|
Acute kidney failure, stage unspecifiedDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB60.Z |
NCT04342975
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
FLT3,AXL,KDM1A,TOP2A,PTPRC,TP53,PIM1,NFKB1,SRC,BCL2,AURKB
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
NPSR1,CA7,CA12,TRPA1,SLCO1B1,AURKB,CA9,F2,TOP2A,ACHE,AKR1B10,CDK1,XDH
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ALOX5,CYP1B1,PGD,NPSR1,CA7,CA14,ALOX15,CES1,ABCG2,SNCA,PIM1,RECQL,CDC25B,XDH,DPP4,PTPN1,PTPRC,PTGS2,POLB,DRD1,CA2,TRPA1,LMNA,AXL,CYP2C19,AURKB,CA9,F2,MET,ACHE,AKR1B10,PTGS1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
