Collective Molecular Activities of the Plant: Ribes Nigrum
Country/Region:
Lebanon; Finland; India; Russia; ChinaTraditional Medicine System:
Indian Folk; TCMMedicinal Functions:
Antidiarrhoeal; Antirheumatic; Diaphoretic; Diuretic; Febrifuge; Miscellany
Italy; India; France; Ireland; Norway; Belarus; China; Belgium; Germany; Ukraine; Netherlands; Denmark; Poland; Finland; United States; Sweden; Switzerland; Russia; Bulgaria; Romania; South Africa; Lebanon; United Kingdom; Austria; Hungary
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
162 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
84 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
84 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99734
Ingredient ID: NPC98356
Ingredient ID: NPC96576
Ingredient ID: NPC94167
Ingredient ID: NPC93888
Ingredient ID: NPC93633
Ingredient ID: NPC90112
Ingredient ID: NPC8962
Ingredient ID: NPC88566
Ingredient ID: NPC87439
Ingredient ID: NPC85813
Ingredient ID: NPC84955
Ingredient ID: NPC84908
Ingredient ID: NPC81010
Ingredient ID: NPC77672
Ingredient ID: NPC76145
Ingredient ID: NPC75521
Ingredient ID: NPC72527
Ingredient ID: NPC71141
Ingredient ID: NPC69445
Ingredient ID: NPC64176
Ingredient ID: NPC62045
Ingredient ID: NPC60761
Ingredient ID: NPC60151
Ingredient ID: NPC55412
Ingredient ID: NPC5447
Ingredient ID: NPC54435
Ingredient ID: NPC5413
Ingredient ID: NPC491218
Ingredient ID: NPC490454
Ingredient ID: NPC490453
Ingredient ID: NPC490438
Ingredient ID: NPC490435
Ingredient ID: NPC490427
Ingredient ID: NPC490424
Ingredient ID: NPC490408
Ingredient ID: NPC490392
Ingredient ID: NPC490352
Ingredient ID: NPC490322
Ingredient ID: NPC490242
Ingredient ID: NPC490188
Ingredient ID: NPC490160
Ingredient ID: NPC489907
Ingredient ID: NPC489902
Ingredient ID: NPC424
Ingredient ID: NPC41676
Ingredient ID: NPC39426
Ingredient ID: NPC37793
Ingredient ID: NPC37468
Ingredient ID: NPC3649
Ingredient ID: NPC34908
Ingredient ID: NPC34764
Ingredient ID: NPC34241
Ingredient ID: NPC33908
Ingredient ID: NPC328447
Ingredient ID: NPC32674
Ingredient ID: NPC322752
Ingredient ID: NPC317291
Ingredient ID: NPC317120
Ingredient ID: NPC316518
Ingredient ID: NPC314329
Ingredient ID: NPC313179
Ingredient ID: NPC307517
Ingredient ID: NPC300017
Ingredient ID: NPC299529
Ingredient ID: NPC29883
Ingredient ID: NPC296337
Ingredient ID: NPC294902
Ingredient ID: NPC294548
Ingredient ID: NPC293378
Ingredient ID: NPC290319
Ingredient ID: NPC284720
Ingredient ID: NPC281131
Ingredient ID: NPC280943
Ingredient ID: NPC278068
Ingredient ID: NPC277867
Ingredient ID: NPC269980
Ingredient ID: NPC269919
Ingredient ID: NPC268862
Ingredient ID: NPC265305
Ingredient ID: NPC264145
Ingredient ID: NPC261831
Ingredient ID: NPC259293
Ingredient ID: NPC255042
Ingredient ID: NPC251501
Ingredient ID: NPC251256
Ingredient ID: NPC247266
Ingredient ID: NPC243990
Ingredient ID: NPC242580
Ingredient ID: NPC240431
Ingredient ID: NPC237365
Ingredient ID: NPC229415
Ingredient ID: NPC226453
Ingredient ID: NPC225710
Ingredient ID: NPC22229
Ingredient ID: NPC221903
Ingredient ID: NPC219876
Ingredient ID: NPC216105
Ingredient ID: NPC2121
Ingredient ID: NPC208793
Ingredient ID: NPC20791
Ingredient ID: NPC203468
Ingredient ID: NPC201284
Ingredient ID: NPC200561
Ingredient ID: NPC199072
Ingredient ID: NPC198658
Ingredient ID: NPC197087
Ingredient ID: NPC195265
Ingredient ID: NPC194861
Ingredient ID: NPC194081
Ingredient ID: NPC190974
Ingredient ID: NPC189436
Ingredient ID: NPC188238
Ingredient ID: NPC187770
Ingredient ID: NPC184643
Ingredient ID: NPC184560
Ingredient ID: NPC180871
Ingredient ID: NPC179950
Ingredient ID: NPC17810
Ingredient ID: NPC178026
Ingredient ID: NPC176740
Ingredient ID: NPC176730
Ingredient ID: NPC175987
Ingredient ID: NPC174246
Ingredient ID: NPC169749
Ingredient ID: NPC168855
Ingredient ID: NPC168579
Ingredient ID: NPC1682
Ingredient ID: NPC167400
Ingredient ID: NPC161700
Ingredient ID: NPC161393
Ingredient ID: NPC160789
Ingredient ID: NPC151620
Ingredient ID: NPC150950
Ingredient ID: NPC149821
Ingredient ID: NPC149198
Ingredient ID: NPC14867
Ingredient ID: NPC147983
Ingredient ID: NPC147156
Ingredient ID: NPC142103
Ingredient ID: NPC140454
Ingredient ID: NPC137958
Ingredient ID: NPC137887
Ingredient ID: NPC136531
Ingredient ID: NPC133671
Ingredient ID: NPC131372
Ingredient ID: NPC130683
Ingredient ID: NPC126741
Ingredient ID: NPC125755
Ingredient ID: NPC121373
Ingredient ID: NPC119866
Ingredient ID: NPC116775
Ingredient ID: NPC115216
Ingredient ID: NPC114648
Ingredient ID: NPC114517
Ingredient ID: NPC11433
Ingredient ID: NPC114239
Ingredient ID: NPC11119
Ingredient ID: NPC109813
Ingredient ID: NPC108455
Ingredient ID: NPC107840
Ingredient ID: NPC106381
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2B6 | Cytochrome P450 2B6 | P20813 | CHEMBL4729 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A3 | Dopamine transporter | Q01959 | CHEMBL238 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A2 | Norepinephrine transporter | P23975 | CHEMBL222 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A4 | Serotonin transporter | P31645 | CHEMBL228 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 602 | |
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810);Ascorbate (NPC187770) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Beta Carotene (NPC17810);Pyridoxine (NPC269919);Folic Acid (NPC147983) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction | Beta Carotene (NPC17810);Folic Acid (NPC147983);Ascorbate (NPC187770);Pyridoxine (NPC269919) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1,MMP2
NCT03522922,NCT03090048 |
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB,TYR
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,PPARA,NR3C1,AURKB,DPP4,FFAR1,KDR
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AXL,TOP2A,SRC,PIM1,MAPT,FLT3,KDM1A,TP53,AURKB,NFKB1
NCT00184054,NCT00329498 |
Acute painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG31 |
SLC6A2
|
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT03624270
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
