Collective Molecular Activities of the Plant: Prunella Vulgaris
Plant ID: NPO17494
Plant Latin Name: Prunella Vulgaris
Taxonomy Genus: Prunella
Taxonomy Family: Lamiaceae
Plant External Links:
NCBI TaxonomyDB:
39358
Plant-of-the-World-Online:
n.a.
Country/Region:
China; Finland; IndiaTraditional Medicine System:
Indian Folk; TCMMedicinal Functions:
Alterative; Antibacterial; Antibiotic; Antidiarrhoeal; Antipyretic; Antiseptic; Antispasmodic; Astringent; Carminative; Diuretic; Febrifuge; Hypotensive; Stomachic; Styptic; Tonic; Vermifuge; Vulnerary
India; Finland; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
120 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
66 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
59 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95090
Ingredient ID: NPC93503
Ingredient ID: NPC93241
Ingredient ID: NPC88789
Ingredient ID: NPC84319
Ingredient ID: NPC836
Ingredient ID: NPC81010
Ingredient ID: NPC79520
Ingredient ID: NPC7947
Ingredient ID: NPC79407
Ingredient ID: NPC78551
Ingredient ID: NPC74855
Ingredient ID: NPC73453
Ingredient ID: NPC70744
Ingredient ID: NPC70388
Ingredient ID: NPC68889
Ingredient ID: NPC67761
Ingredient ID: NPC66769
Ingredient ID: NPC63126
Ingredient ID: NPC62469
Ingredient ID: NPC61
Ingredient ID: NPC53545
Ingredient ID: NPC52021
Ingredient ID: NPC51758
Ingredient ID: NPC51700
Ingredient ID: NPC49615
Ingredient ID: NPC478264
Ingredient ID: NPC478263
Ingredient ID: NPC45727
Ingredient ID: NPC43728
Ingredient ID: NPC40552
Ingredient ID: NPC32977
Ingredient ID: NPC328825
Ingredient ID: NPC327117
Ingredient ID: NPC323787
Ingredient ID: NPC322726
Ingredient ID: NPC322523
Ingredient ID: NPC318892
Ingredient ID: NPC318785
Ingredient ID: NPC317652
Ingredient ID: NPC317111
Ingredient ID: NPC311666
Ingredient ID: NPC307335
Ingredient ID: NPC302857
Ingredient ID: NPC29976
Ingredient ID: NPC298886
Ingredient ID: NPC295777
Ingredient ID: NPC295700
Ingredient ID: NPC294902
Ingredient ID: NPC293343
Ingredient ID: NPC290613
Ingredient ID: NPC290191
Ingredient ID: NPC29
Ingredient ID: NPC288537
Ingredient ID: NPC288089
Ingredient ID: NPC281131
Ingredient ID: NPC279121
Ingredient ID: NPC278976
Ingredient ID: NPC277907
Ingredient ID: NPC275463
Ingredient ID: NPC272343
Ingredient ID: NPC26960
Ingredient ID: NPC264711
Ingredient ID: NPC259733
Ingredient ID: NPC258672
Ingredient ID: NPC255662
Ingredient ID: NPC255463
Ingredient ID: NPC246708
Ingredient ID: NPC243728
Ingredient ID: NPC243702
Ingredient ID: NPC2421
Ingredient ID: NPC230301
Ingredient ID: NPC227363
Ingredient ID: NPC226794
Ingredient ID: NPC222084
Ingredient ID: NPC218355
Ingredient ID: NPC218109
Ingredient ID: NPC215894
Ingredient ID: NPC212607
Ingredient ID: NPC211801
Ingredient ID: NPC210215
Ingredient ID: NPC209279
Ingredient ID: NPC20791
Ingredient ID: NPC207325
Ingredient ID: NPC205600
Ingredient ID: NPC205579
Ingredient ID: NPC199052
Ingredient ID: NPC197066
Ingredient ID: NPC196561
Ingredient ID: NPC196070
Ingredient ID: NPC195019
Ingredient ID: NPC194586
Ingredient ID: NPC194416
Ingredient ID: NPC189142
Ingredient ID: NPC184078
Ingredient ID: NPC18074
Ingredient ID: NPC179950
Ingredient ID: NPC1788
Ingredient ID: NPC176740
Ingredient ID: NPC171495
Ingredient ID: NPC1682
Ingredient ID: NPC167976
Ingredient ID: NPC167289
Ingredient ID: NPC163866
Ingredient ID: NPC158371
Ingredient ID: NPC156654
Ingredient ID: NPC142753
Ingredient ID: NPC142415
Ingredient ID: NPC138932
Ingredient ID: NPC138113
Ingredient ID: NPC135088
Ingredient ID: NPC133671
Ingredient ID: NPC130577
Ingredient ID: NPC129165
Ingredient ID: NPC117193
Ingredient ID: NPC116794
Ingredient ID: NPC113733
Ingredient ID: NPC112866
Ingredient ID: NPC108494
Ingredient ID: NPC1075
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 41 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
| NCT01438320 | Q-Trial in Patients With Hepatitis C | chronic hepatitis C virus infection | Quercetin (NPC20791) | NP level |
| NCT01705652 | Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients | prostate cancer | Rutin (NPC176740) | NP level |
| NCT01708278 | Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) | chronic obstructive pulmonary disease | Quercetin (NPC20791) | NP level |
| NCT01720147 | Quercetin in Children With Fanconi Anemia; a Pilot Study | Fanconi anemia | Quercetin (NPC20791) | NP level |
| NCT01839344 | Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes. | type 2 diabetes mellitus | Quercetin (NPC20791) | NP level |
| NCT01912820 | Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery | prostate adenocarcinoma | Quercetin (NPC20791) | NP level |
| NCT02136342 | Phase 1 Trial of Chlorogenic Acid in Patients With Advanced Cancer | cancer | Chlorogenic Acid (NPC302857) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4,PTPN1,AURKB,AKR1B1,KDR
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AXL,PIM1,NFKB1,AURKB,PTPRC,FLT3,RELA,TP53,KDM1A,GSK3B,SRC
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
RELA,NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,CA7,MMP12,XDH,AURKB,AKR1B10,CDK1,F2,MMP9,MMP1,CA12,NPSR1,TSHR
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,CA7,DPP4,POLB,CA2,XDH,RECQL,AURKB,AKR1B10,CYP1B1,HIF1A,F2,MMP1,SNCA,MET,PTPRC,PTPN1,ALOX15,PIM1,ABCG2,AXL,NPSR1,ALOX5,CA14,CDC25B,MMP2,CES1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,ALOX15
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
MMP12,AURKB,CDK1,F2,MMP9,MMP1,NOX4,MET,CYP19A1,ALOX15,NPSR1,CDC25B
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
HIF1A
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
