Collective Molecular Activities of the Plant: Benincasa Hispida
Plant ID: NPO17336
Plant Latin Name: Benincasa Hispida
Taxonomy Genus: Benincasa
Taxonomy Family: Cucurbitaceae
Plant External Links:
NCBI TaxonomyDB:
102211
Plant-of-the-World-Online:
n.a.
Country/Region:
Thailand; Indonesia; India; ChinaTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; Kampo; TCMMedicinal Functions:
Anthelmintic; Antiperiodic; Aphrodisiac; Cancer; Demulcent; Diuretic; Expectorant; Febrifuge; Laxative; Salve; Tonic; VD
India; Indonesia; China; Thailand
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
164 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
103 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
84 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98777
Ingredient ID: NPC98583
Ingredient ID: NPC94583
Ingredient ID: NPC94167
Ingredient ID: NPC92117
Ingredient ID: NPC91409
Ingredient ID: NPC91239
Ingredient ID: NPC90701
Ingredient ID: NPC87828
Ingredient ID: NPC86947
Ingredient ID: NPC8651
Ingredient ID: NPC85813
Ingredient ID: NPC85270
Ingredient ID: NPC84279
Ingredient ID: NPC78946
Ingredient ID: NPC76145
Ingredient ID: NPC76128
Ingredient ID: NPC76112
Ingredient ID: NPC75097
Ingredient ID: NPC70622
Ingredient ID: NPC69071
Ingredient ID: NPC68953
Ingredient ID: NPC66913
Ingredient ID: NPC63027
Ingredient ID: NPC62086
Ingredient ID: NPC57380
Ingredient ID: NPC52370
Ingredient ID: NPC5029
Ingredient ID: NPC49074
Ingredient ID: NPC489907
Ingredient ID: NPC44260
Ingredient ID: NPC424
Ingredient ID: NPC41080
Ingredient ID: NPC39333
Ingredient ID: NPC38851
Ingredient ID: NPC36959
Ingredient ID: NPC36490
Ingredient ID: NPC36061
Ingredient ID: NPC36002
Ingredient ID: NPC35344
Ingredient ID: NPC328447
Ingredient ID: NPC317201
Ingredient ID: NPC313047
Ingredient ID: NPC312929
Ingredient ID: NPC308738
Ingredient ID: NPC305843
Ingredient ID: NPC304452
Ingredient ID: NPC301585
Ingredient ID: NPC301384
Ingredient ID: NPC299964
Ingredient ID: NPC294548
Ingredient ID: NPC288411
Ingredient ID: NPC288089
Ingredient ID: NPC282923
Ingredient ID: NPC278525
Ingredient ID: NPC278329
Ingredient ID: NPC271385
Ingredient ID: NPC269919
Ingredient ID: NPC264779
Ingredient ID: NPC264145
Ingredient ID: NPC261831
Ingredient ID: NPC261147
Ingredient ID: NPC26080
Ingredient ID: NPC259976
Ingredient ID: NPC254847
Ingredient ID: NPC248949
Ingredient ID: NPC248668
Ingredient ID: NPC248520
Ingredient ID: NPC248047
Ingredient ID: NPC247364
Ingredient ID: NPC243728
Ingredient ID: NPC242582
Ingredient ID: NPC242580
Ingredient ID: NPC241055
Ingredient ID: NPC232924
Ingredient ID: NPC232189
Ingredient ID: NPC230301
Ingredient ID: NPC230085
Ingredient ID: NPC229036
Ingredient ID: NPC226803
Ingredient ID: NPC225710
Ingredient ID: NPC22481
Ingredient ID: NPC223951
Ingredient ID: NPC221134
Ingredient ID: NPC218988
Ingredient ID: NPC216752
Ingredient ID: NPC216630
Ingredient ID: NPC216216
Ingredient ID: NPC214251
Ingredient ID: NPC214165
Ingredient ID: NPC211722
Ingredient ID: NPC211608
Ingredient ID: NPC211342
Ingredient ID: NPC209970
Ingredient ID: NPC209011
Ingredient ID: NPC203468
Ingredient ID: NPC199875
Ingredient ID: NPC198865
Ingredient ID: NPC198440
Ingredient ID: NPC197087
Ingredient ID: NPC194677
Ingredient ID: NPC190036
Ingredient ID: NPC189470
Ingredient ID: NPC188563
Ingredient ID: NPC187770
Ingredient ID: NPC186944
Ingredient ID: NPC185072
Ingredient ID: NPC184615
Ingredient ID: NPC181448
Ingredient ID: NPC179024
Ingredient ID: NPC178851
Ingredient ID: NPC17810
Ingredient ID: NPC177465
Ingredient ID: NPC176740
Ingredient ID: NPC175542
Ingredient ID: NPC175313
Ingredient ID: NPC168829
Ingredient ID: NPC168409
Ingredient ID: NPC168255
Ingredient ID: NPC1682
Ingredient ID: NPC167400
Ingredient ID: NPC166963
Ingredient ID: NPC160512
Ingredient ID: NPC159630
Ingredient ID: NPC159106
Ingredient ID: NPC154920
Ingredient ID: NPC152451
Ingredient ID: NPC150950
Ingredient ID: NPC149700
Ingredient ID: NPC147983
Ingredient ID: NPC146973
Ingredient ID: NPC146837
Ingredient ID: NPC146197
Ingredient ID: NPC142811
Ingredient ID: NPC142632
Ingredient ID: NPC142063
Ingredient ID: NPC141777
Ingredient ID: NPC141003
Ingredient ID: NPC14079
Ingredient ID: NPC139029
Ingredient ID: NPC138466
Ingredient ID: NPC13789
Ingredient ID: NPC136014
Ingredient ID: NPC130683
Ingredient ID: NPC130315
Ingredient ID: NPC128792
Ingredient ID: NPC128457
Ingredient ID: NPC123953
Ingredient ID: NPC122792
Ingredient ID: NPC120635
Ingredient ID: NPC117862
Ingredient ID: NPC116628
Ingredient ID: NPC115723
Ingredient ID: NPC115119
Ingredient ID: NPC114746
Ingredient ID: NPC114526
Ingredient ID: NPC114239
Ingredient ID: NPC113650
Ingredient ID: NPC112890
Ingredient ID: NPC112355
Ingredient ID: NPC109813
Ingredient ID: NPC108455
Ingredient ID: NPC105004
Ingredient ID: NPC101649
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Therapeutic Target | Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 491 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract | Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | macular degeneration | Beta Carotene (NPC17810);Ascorbate (NPC187770) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction | Pyridoxine (NPC269919);Ascorbate (NPC187770);Folic Acid (NPC147983);Beta Carotene (NPC17810) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Ascorbate (NPC187770) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Folic Acid (NPC147983);Pyridoxine (NPC269919);Beta Carotene (NPC17810) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1,MMP2
NCT03522922 |
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
FFAR1,CNR1,PPARA
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
BCL2
NCT00184054,NCT00329498,NCT01842139 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888
|
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT03624270
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT03718507,NCT04404387
|
Acute viral hepatitisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50 |
NCT00108589
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
