Collective Molecular Activities of the Plant: Ipomoea Nil
Country/Region:
India; LaosTraditional Medicine System:
Indian Folk; Unani; Ayurveda; SiddhaMedicinal Functions:
Anthelmintic; Antifungal; Antispasmodic; Antitumor; Diuretic; Hallucinogenic; Laxative; Parasiticide
Brazil; Madagascar; Bangladesh; Sudan; Guinea; Nepal; Costa Rica; Bahamas; Ethiopia; Tanzania; Peru; Laos; Argentina; Bolivia; Cameroon; Cote d'Ivoire; Ecuador; Ghana; Saudi Arabia; Australia; Cuba; Venezuela; Zambia; Suriname; Guatemala; Zimbabwe; China; Vietnam; Thailand; Dominican Republic; Belize; United States; Sierra Leone; Nigeria; Eritrea; Netherlands; Uganda; Pakistan; Trinidad and Tobago; Philippines; Indonesia; New Caledonia; Mauritius; Sri Lanka; Uruguay; French Guiana; Guyana; Yemen; Haiti; Jamaica; Seychelles; Myanmar; Chad; Equatorial Guinea; Mexico; India; South Africa; Senegal; Congo; Colombia; Greece; Paraguay; Namibia; Nicaragua; Comoros
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
96 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
77 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
50 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9848
Ingredient ID: NPC95381
Ingredient ID: NPC91589
Ingredient ID: NPC9117
Ingredient ID: NPC8452
Ingredient ID: NPC81010
Ingredient ID: NPC79056
Ingredient ID: NPC76548
Ingredient ID: NPC70744
Ingredient ID: NPC66004
Ingredient ID: NPC65326
Ingredient ID: NPC64848
Ingredient ID: NPC60814
Ingredient ID: NPC5459
Ingredient ID: NPC51700
Ingredient ID: NPC50526
Ingredient ID: NPC479107
Ingredient ID: NPC479106
Ingredient ID: NPC479105
Ingredient ID: NPC479104
Ingredient ID: NPC479102
Ingredient ID: NPC479101
Ingredient ID: NPC479100
Ingredient ID: NPC479099
Ingredient ID: NPC479098
Ingredient ID: NPC47654
Ingredient ID: NPC40432
Ingredient ID: NPC37696
Ingredient ID: NPC37423
Ingredient ID: NPC35961
Ingredient ID: NPC34770
Ingredient ID: NPC34103
Ingredient ID: NPC32977
Ingredient ID: NPC3295
Ingredient ID: NPC312017
Ingredient ID: NPC309320
Ingredient ID: NPC305205
Ingredient ID: NPC300017
Ingredient ID: NPC299151
Ingredient ID: NPC298180
Ingredient ID: NPC294902
Ingredient ID: NPC293399
Ingredient ID: NPC292510
Ingredient ID: NPC289774
Ingredient ID: NPC288537
Ingredient ID: NPC286946
Ingredient ID: NPC278102
Ingredient ID: NPC278021
Ingredient ID: NPC273858
Ingredient ID: NPC272392
Ingredient ID: NPC270070
Ingredient ID: NPC265932
Ingredient ID: NPC264711
Ingredient ID: NPC261012
Ingredient ID: NPC247553
Ingredient ID: NPC244669
Ingredient ID: NPC243728
Ingredient ID: NPC24284
Ingredient ID: NPC233335
Ingredient ID: NPC232028
Ingredient ID: NPC230301
Ingredient ID: NPC228346
Ingredient ID: NPC225710
Ingredient ID: NPC224420
Ingredient ID: NPC222125
Ingredient ID: NPC216827
Ingredient ID: NPC216630
Ingredient ID: NPC210434
Ingredient ID: NPC207294
Ingredient ID: NPC205217
Ingredient ID: NPC203198
Ingredient ID: NPC201562
Ingredient ID: NPC19757
Ingredient ID: NPC195749
Ingredient ID: NPC192638
Ingredient ID: NPC192436
Ingredient ID: NPC185632
Ingredient ID: NPC177393
Ingredient ID: NPC169119
Ingredient ID: NPC165159
Ingredient ID: NPC164609
Ingredient ID: NPC164574
Ingredient ID: NPC161557
Ingredient ID: NPC158175
Ingredient ID: NPC158079
Ingredient ID: NPC153572
Ingredient ID: NPC152101
Ingredient ID: NPC151907
Ingredient ID: NPC143168
Ingredient ID: NPC142415
Ingredient ID: NPC141765
Ingredient ID: NPC134451
Ingredient ID: NPC121867
Ingredient ID: NPC115207
Ingredient ID: NPC113927
Ingredient ID: NPC1075
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Isomerase | TOP2A | DNA topoisomerase II alpha | P11388 | CHEMBL1806 |
| Therapeutic Target | Isomerase | PTGES | Prostaglandin E synthase | O14684 | CHEMBL5658 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 892 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00001300 | A Randomized Study of the Effect of Adjuvant Chemotherapy With Doxorubicin and Ifosfamide With Mesna in the Treatment of High-Grade Adult Extremity Soft Tissue Sarcoma | sarcoma | Doxorubicin (NPC261012) | NP level |
| NCT00001339 | A Study of Combination Chemotherapy and Surgical Resection in the Treatment of Adrenocortical Carcinoma: Continuous Infusion Doxorubicin, Vincristine and Etoposide With Daily Mitotane Before and After Surgical Resection | carcinoma | Doxorubicin (NPC261012) | NP level |
| NCT00001384 | A Pilot Trial of AC (Adriamycin, Cyclophosphamide) Chemotherapy With G-CSF (Granulocyte Colony-Stimulating Factor) Followed by Infusional Taxol (Paclitaxel) as Adjuvant Treatment for High Risk Stage II and Stage III Breast Cancer Patients | breast cancer | Doxorubicin (NPC261012) | NP level |
| NCT00001498 | A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With Peripheral Blood Progenitor Cell Support, and Intensification With Paclitaxel and Doxorubicin for Patients With High-Risk Breast Cancer | breast cancer | Doxorubicin (NPC261012) | NP level |
| NCT00002105 | Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma | Kaposi's sarcoma | Doxorubicin (NPC261012) | NP level |
| NCT00002318 | A Comparison of DOX-SL Versus Adriamycin Plus Bleomycin Plus Vincristine in the Treatment of Severe AIDS-Related Kaposi's Sarcoma | Kaposi's sarcoma | Doxorubicin (NPC261012) | NP level |
| NCT00002557 | Combination Chemotherapy in Patients With Advanced or Recurrent Mycosis Fungoides | lymphoma | Doxorubicin (NPC261012) | NP level |
| NCT00002565 | Combination Chemotherapy in Treating Patients With Intermediate-Grade or Immunoblastic Non-Hodgkin's Lymphoma | lymphoma | Doxorubicin (NPC261012) | NP level |
| NCT00002707 | Chemotherapy in Treating Women With Breast Cancer That Can Be Surgically Removed | breast cancer | Doxorubicin (NPC261012) | NP level |
| NCT00003150 | Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Older Patients With Non-Hodgkin's Lymphoma | lymphoma | Doxorubicin (NPC261012) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PTPN1,AKR1B1,AURKA
|
Acute leukaemias of ambiguous lineageDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A61 |
NCT02419755
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PTPRC,AURKA,TOP2A,XIAP,RELA,NFKB1
NCT03860844,NCT03059615 |
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1,RELA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
PTGES,TOP2A,F2,CYP2D6,AKR1B10,GPR84,CA9,CA12,AURKA,MMP9,TSHR,MMP1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
AURKA,CA2,RECQL,AKR1B10,MPEG1,F2,MMP1,PTGES,GPR84,SNCA,CA9,OR51E2,PTPRC,PTPN1,MMP2,DHCR7,FUT7,ALOX5,CDC25B,LMNA,CES1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2,FABP5
NCT02560051 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
TOP2A,F2,GPR84,AURKA,MMP9,CDC25B,MMP1
NCT04047004 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
