Collective Molecular Activities of the Plant: Vitis Vinifera
Plant ID: NPO17024
Plant Latin Name: Vitis Vinifera
Taxonomy Genus: Vitis
Taxonomy Family: Vitaceae
Plant External Links:
NCBI TaxonomyDB:
29760
Plant-of-the-World-Online:
n.a.
Country/Region:
Turkey; Israel; Italy; India; Lebanon; United States; China; Jordan; Thailand; SpainTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCMMedicinal Functions:
Analgesic; Antiinflammatory; Astringent; Bach; Demulcent; Diuretic; Hepatic; Laxative; Lithontripic; Miscellany; Skin; Stomachic
Turkey; Israel; Italy; Lebanon; India; United States; Jordan; Thailand; China; Spain
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
660 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
388 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
288 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99088
Ingredient ID: NPC99069
Ingredient ID: NPC98583
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Ingredient ID: NPC146953
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Ingredient ID: NPC143852
Ingredient ID: NPC1429
Ingredient ID: NPC142415
Ingredient ID: NPC142153
Ingredient ID: NPC13991
Ingredient ID: NPC139047
Ingredient ID: NPC137958
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Ingredient ID: NPC136473
Ingredient ID: NPC136064
Ingredient ID: NPC136014
Ingredient ID: NPC134584
Ingredient ID: NPC134252
Ingredient ID: NPC134140
Ingredient ID: NPC133671
Ingredient ID: NPC133209
Ingredient ID: NPC131957
Ingredient ID: NPC131642
Ingredient ID: NPC130683
Ingredient ID: NPC12904
Ingredient ID: NPC126791
Ingredient ID: NPC126681
Ingredient ID: NPC126029
Ingredient ID: NPC125755
Ingredient ID: NPC125579
Ingredient ID: NPC124295
Ingredient ID: NPC122962
Ingredient ID: NPC120649
Ingredient ID: NPC119090
Ingredient ID: NPC118752
Ingredient ID: NPC118534
Ingredient ID: NPC11727
Ingredient ID: NPC116775
Ingredient ID: NPC115708
Ingredient ID: NPC11433
Ingredient ID: NPC114270
Ingredient ID: NPC114179
Ingredient ID: NPC113733
Ingredient ID: NPC1135
Ingredient ID: NPC113366
Ingredient ID: NPC112941
Ingredient ID: NPC112890
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Ingredient ID: NPC112242
Ingredient ID: NPC11128
Ingredient ID: NPC111134
Ingredient ID: NPC110899
Ingredient ID: NPC110704
Ingredient ID: NPC110107
Ingredient ID: NPC108811
Ingredient ID: NPC108303
Ingredient ID: NPC108218
Ingredient ID: NPC108212
Ingredient ID: NPC106770
Ingredient ID: NPC106551
Ingredient ID: NPC104195
Ingredient ID: NPC103387
Ingredient ID: NPC10251
Ingredient ID: NPC100842
Ingredient ID: NPC100809
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 766 | |
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | macular degeneration | Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract | Beta Carotene (NPC17810);Ascorbate (NPC187770) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2,ESR1
NCT03522922,NCT03090048,NCT02126657 |
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB,TYR
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
FFAR1,AURKB,AKR1B1,KDR,DPP4,PTPN1,PPARA
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute kidney failure, stage unspecifiedDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB60.Z |
NCT04342975
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
SRC,MAPT,KDM1A,FLT3,TOP2A,NFKB1,AXL,PTPRC,TP53,GSK3B,PIM1,AURKB,BCL2
NCT00184054,NCT02472626,NCT00329498,NCT01842139 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
