Myanmar; South Africa; Mongolia; China; Japan; South Korea; Russia
Ingredient ID: NPC98872
Ingredient ID: NPC94101
Ingredient ID: NPC91580
Ingredient ID: NPC83699
Ingredient ID: NPC8203
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Ingredient ID: NPC327707
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Ingredient ID: NPC316995
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Ingredient ID: NPC309183
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Ingredient ID: NPC305946
Ingredient ID: NPC304423
Ingredient ID: NPC302930
Ingredient ID: NPC298936
Ingredient ID: NPC298395
Ingredient ID: NPC297071
Ingredient ID: NPC296837
Ingredient ID: NPC290598
Ingredient ID: NPC288630
Ingredient ID: NPC288328
Ingredient ID: NPC279461
Ingredient ID: NPC2789
Ingredient ID: NPC27786
Ingredient ID: NPC275463
Ingredient ID: NPC265077
Ingredient ID: NPC257362
Ingredient ID: NPC254968
Ingredient ID: NPC246654
Ingredient ID: NPC242580
Ingredient ID: NPC233395
Ingredient ID: NPC233122
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Ingredient ID: NPC230920
Ingredient ID: NPC227925
Ingredient ID: NPC227139
Ingredient ID: NPC224883
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Ingredient ID: NPC200684
Ingredient ID: NPC197396
Ingredient ID: NPC192864
Ingredient ID: NPC192744
Ingredient ID: NPC192638
Ingredient ID: NPC192570
Ingredient ID: NPC188309
Ingredient ID: NPC187021
Ingredient ID: NPC182502
Ingredient ID: NPC180391
Ingredient ID: NPC178383
Ingredient ID: NPC176085
Ingredient ID: NPC176025
Ingredient ID: NPC175972
Ingredient ID: NPC167240
Ingredient ID: NPC165993
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Ingredient ID: NPC155156
Ingredient ID: NPC154865
Ingredient ID: NPC154592
Ingredient ID: NPC153344
Ingredient ID: NPC149203
Ingredient ID: NPC148693
Ingredient ID: NPC131709
Ingredient ID: NPC126029
Ingredient ID: NPC119555
Ingredient ID: NPC114822
Ingredient ID: NPC110823
Ingredient ID: NPC110699
Ingredient ID: NPC107271
Ingredient ID: NPC102128
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Therapeutic Target | Transferase | GSTP1 | Glutathione S-transferase Pi | P09211 | CHEMBL3902 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 3 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT01880866 | (-)-Epicatechin and Pulmonary Arterial Hypertension | pulmonary arterial hypertension | (-)-Epicatechin (NPC126029) | NP level |
NCT01856868 | Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study) | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
NCT03236662 | (-)- Epicatechin Becker Muscular Dystrophy | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
GSTP1,CES1,LMNA,SNCA
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
GSTP1,HSD17B10,ALPL
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
HSD17B10,GSTP1,LMNA
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
GSTP1,LMNA,SNCA
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
GSTP1,SNCA,LMNA
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
NFKB1,GSTP1
|
Becker muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70.0 |
NCT01856868,NCT03236662
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
GSTP1,ALPL
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
GSTP1,LMNA
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
NFKB1,HSD17B10
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SNCA
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
GSTP1
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
GSTP1
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
NFKB1
|
Parasitic infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D0Y-1G2Z |
ALPL
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
CES1
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
NFKB1
|
Skin and skin-structure infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G0Z |
NFKB1
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
NFKB1
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
SNCA
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
NFKB1
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
NFKB1
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
GSTP1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
GSTP1
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
NFKB1
|
Peroxisomal diseaseDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C57 |
CES1
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
NFKB1
|
Colon cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
ALPL
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NFKB1
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
NFKB1
|
Genetic prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E02 |
ALPL
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
NFKB1
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
NFKB1
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
NFKB1
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
CES1
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Synthesis disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52-5C59 |
CES1
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
NCT01880866
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
ALPL
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
SNCA
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
ALPL
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
ALPL
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
GSTP1
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
ALPL
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
NFKB1
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
GSTP1
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
ALPL
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
ALPL
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
SNCA
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
SNCA
|