Collective Molecular Activities of the Plant: Codonopsis Pilosula
Plant ID: NPO16741
Plant Latin Name: Codonopsis Pilosula
Taxonomy Genus: Codonopsis
Taxonomy Family: Campanulaceae
Plant External Links:
NCBI TaxonomyDB:
86864
Plant-of-the-World-Online:
n.a.
Collective Molecular Activities of the Plant: Codonopsis Pilosula
Plant ID: NPO16741
Plant Latin Name: Codonopsis Pilosula
Taxonomy Genus: Codonopsis
Taxonomy Family: Campanulaceae
Plant External Links:
NCBI TaxonomyDB:
86864
Plant-of-the-World-Online:
n.a.
Country/Region:
Thailand; South Korea; ChinaTraditional Medicine System:
TCMThailand; South Korea; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
237 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
152 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
90 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98858
Ingredient ID: NPC97444
Ingredient ID: NPC96576
Ingredient ID: NPC93633
Ingredient ID: NPC90112
Ingredient ID: NPC8962
Ingredient ID: NPC89422
Ingredient ID: NPC88759
Ingredient ID: NPC88686
Ingredient ID: NPC88481
Ingredient ID: NPC87439
Ingredient ID: NPC84955
Ingredient ID: NPC84938
Ingredient ID: NPC84908
Ingredient ID: NPC84462
Ingredient ID: NPC84398
Ingredient ID: NPC84158
Ingredient ID: NPC84024
Ingredient ID: NPC81511
Ingredient ID: NPC79056
Ingredient ID: NPC78551
Ingredient ID: NPC78080
Ingredient ID: NPC77672
Ingredient ID: NPC76145
Ingredient ID: NPC76074
Ingredient ID: NPC75521
Ingredient ID: NPC75158
Ingredient ID: NPC75037
Ingredient ID: NPC73306
Ingredient ID: NPC72527
Ingredient ID: NPC72024
Ingredient ID: NPC71145
Ingredient ID: NPC64176
Ingredient ID: NPC63941
Ingredient ID: NPC60761
Ingredient ID: NPC54435
Ingredient ID: NPC51820
Ingredient ID: NPC5130
Ingredient ID: NPC48564
Ingredient ID: NPC46838
Ingredient ID: NPC44512
Ingredient ID: NPC44328
Ingredient ID: NPC41676
Ingredient ID: NPC41538
Ingredient ID: NPC39633
Ingredient ID: NPC38069
Ingredient ID: NPC37793
Ingredient ID: NPC37132
Ingredient ID: NPC3649
Ingredient ID: NPC34700
Ingredient ID: NPC34241
Ingredient ID: NPC34103
Ingredient ID: NPC33908
Ingredient ID: NPC32674
Ingredient ID: NPC323806
Ingredient ID: NPC321027
Ingredient ID: NPC320799
Ingredient ID: NPC320086
Ingredient ID: NPC315459
Ingredient ID: NPC311987
Ingredient ID: NPC310437
Ingredient ID: NPC308749
Ingredient ID: NPC307517
Ingredient ID: NPC305660
Ingredient ID: NPC300228
Ingredient ID: NPC300017
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Ingredient ID: NPC299529
Ingredient ID: NPC299008
Ingredient ID: NPC29883
Ingredient ID: NPC298048
Ingredient ID: NPC29680
Ingredient ID: NPC293714
Ingredient ID: NPC293378
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Ingredient ID: NPC28913
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Ingredient ID: NPC277867
Ingredient ID: NPC276465
Ingredient ID: NPC27501
Ingredient ID: NPC274613
Ingredient ID: NPC270077
Ingredient ID: NPC268862
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Ingredient ID: NPC264145
Ingredient ID: NPC26229
Ingredient ID: NPC260995
Ingredient ID: NPC260052
Ingredient ID: NPC259293
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Ingredient ID: NPC258130
Ingredient ID: NPC254848
Ingredient ID: NPC254159
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Ingredient ID: NPC251256
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Ingredient ID: NPC247266
Ingredient ID: NPC243990
Ingredient ID: NPC242580
Ingredient ID: NPC240431
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Ingredient ID: NPC239406
Ingredient ID: NPC237812
Ingredient ID: NPC237365
Ingredient ID: NPC236579
Ingredient ID: NPC231944
Ingredient ID: NPC23049
Ingredient ID: NPC230301
Ingredient ID: NPC229786
Ingredient ID: NPC229646
Ingredient ID: NPC22903
Ingredient ID: NPC227250
Ingredient ID: NPC227211
Ingredient ID: NPC225783
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Ingredient ID: NPC225467
Ingredient ID: NPC223455
Ingredient ID: NPC222628
Ingredient ID: NPC222538
Ingredient ID: NPC22229
Ingredient ID: NPC220523
Ingredient ID: NPC216105
Ingredient ID: NPC21566
Ingredient ID: NPC215377
Ingredient ID: NPC214608
Ingredient ID: NPC212195
Ingredient ID: NPC2121
Ingredient ID: NPC211519
Ingredient ID: NPC209971
Ingredient ID: NPC209054
Ingredient ID: NPC20791
Ingredient ID: NPC204759
Ingredient ID: NPC202967
Ingredient ID: NPC202956
Ingredient ID: NPC198658
Ingredient ID: NPC197978
Ingredient ID: NPC197811
Ingredient ID: NPC19756
Ingredient ID: NPC196924
Ingredient ID: NPC196776
Ingredient ID: NPC195265
Ingredient ID: NPC194861
Ingredient ID: NPC193335
Ingredient ID: NPC192944
Ingredient ID: NPC192695
Ingredient ID: NPC190974
Ingredient ID: NPC189206
Ingredient ID: NPC188238
Ingredient ID: NPC186653
Ingredient ID: NPC185339
Ingredient ID: NPC185189
Ingredient ID: NPC184643
Ingredient ID: NPC182571
Ingredient ID: NPC181153
Ingredient ID: NPC180133
Ingredient ID: NPC179950
Ingredient ID: NPC179694
Ingredient ID: NPC179365
Ingredient ID: NPC178026
Ingredient ID: NPC177874
Ingredient ID: NPC177726
Ingredient ID: NPC176730
Ingredient ID: NPC173651
Ingredient ID: NPC169749
Ingredient ID: NPC168855
Ingredient ID: NPC168579
Ingredient ID: NPC167400
Ingredient ID: NPC163866
Ingredient ID: NPC161700
Ingredient ID: NPC161393
Ingredient ID: NPC160789
Ingredient ID: NPC15698
Ingredient ID: NPC156630
Ingredient ID: NPC156461
Ingredient ID: NPC154401
Ingredient ID: NPC154186
Ingredient ID: NPC154185
Ingredient ID: NPC152759
Ingredient ID: NPC152451
Ingredient ID: NPC1507
Ingredient ID: NPC149198
Ingredient ID: NPC148825
Ingredient ID: NPC14867
Ingredient ID: NPC147156
Ingredient ID: NPC143586
Ingredient ID: NPC142691
Ingredient ID: NPC142103
Ingredient ID: NPC140454
Ingredient ID: NPC137887
Ingredient ID: NPC136996
Ingredient ID: NPC136531
Ingredient ID: NPC135353
Ingredient ID: NPC133966
Ingredient ID: NPC133961
Ingredient ID: NPC133671
Ingredient ID: NPC131524
Ingredient ID: NPC131372
Ingredient ID: NPC130683
Ingredient ID: NPC130628
Ingredient ID: NPC130444
Ingredient ID: NPC129206
Ingredient ID: NPC129165
Ingredient ID: NPC127122
Ingredient ID: NPC126759
Ingredient ID: NPC126681
Ingredient ID: NPC125755
Ingredient ID: NPC123175
Ingredient ID: NPC122962
Ingredient ID: NPC119949
Ingredient ID: NPC119866
Ingredient ID: NPC118004
Ingredient ID: NPC116775
Ingredient ID: NPC115216
Ingredient ID: NPC114648
Ingredient ID: NPC114239
Ingredient ID: NPC113219
Ingredient ID: NPC11119
Ingredient ID: NPC110895
Ingredient ID: NPC109813
Ingredient ID: NPC108612
Ingredient ID: NPC107840
Ingredient ID: NPC10781
Ingredient ID: NPC107482
Ingredient ID: NPC106381
Ingredient ID: NPC10636
Ingredient ID: NPC10183
Ingredient ID: NPC100980
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 223 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000553 | HDL-Atherosclerosis Treatment Study (HATS) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000599 | Cholesterol-Lowering Atherosclerosis Study (CLAS) | carotid artery disease;cerebral atherosclerosis;Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00005658 | Glycine to Treat Psychotic Disorders in Children | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00062556 | Effect of Niacin ER/Lovastatin on Peak Walking Time & Claudication Onset Time in Patients With Intermittent Claudication | intermittent vascular claudication | Niacin (NPC167400) | NP level |
| NCT00071266 | The Dose Response of Niacin ER/Lovastatin on Peak Walking Time (PWT) in Patients With Intermittent Claudication - TROPIC | intermittent vascular claudication | Niacin (NPC167400) | NP level |
| NCT00080275 | Evaluation of the Safety & Efficacy of a Combination of Niacin ER & Simvastatin in Patients With Dyslipidemia (OCEANS) | Hypercholesterolemia | Niacin (NPC167400) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4,KDR,AURKB
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53,AURKB,SRC,KDM1A,AXL,PIM1,FLT3,TOP2A
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04588441,NCT03718507
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT00284323,NCT01747174
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
