Plant ID: NPO16614
Plant Latin Name: Zanthoxylum Spinosum
Taxonomy Genus: Zanthoxylum
Taxonomy Family: Rutaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
270788-2
Unknown.
Jamaica
Ingredient ID: NPC99462
Ingredient ID: NPC98179
Ingredient ID: NPC95204
Ingredient ID: NPC88445
Ingredient ID: NPC76336
Ingredient ID: NPC71553
Ingredient ID: NPC5478
Ingredient ID: NPC52223
Ingredient ID: NPC51146
Ingredient ID: NPC50427
Ingredient ID: NPC43822
Ingredient ID: NPC33320
Ingredient ID: NPC308817
Ingredient ID: NPC297114
Ingredient ID: NPC287457
Ingredient ID: NPC281835
Ingredient ID: NPC281356
Ingredient ID: NPC276761
Ingredient ID: NPC275856
Ingredient ID: NPC263446
Ingredient ID: NPC261537
Ingredient ID: NPC253574
Ingredient ID: NPC247553
Ingredient ID: NPC243509
Ingredient ID: NPC234536
Ingredient ID: NPC224816
Ingredient ID: NPC224543
Ingredient ID: NPC202131
Ingredient ID: NPC189625
Ingredient ID: NPC188327
Ingredient ID: NPC178055
Ingredient ID: NPC171263
Ingredient ID: NPC15819
Ingredient ID: NPC155882
Ingredient ID: NPC153115
Ingredient ID: NPC152329
Ingredient ID: NPC142415
Ingredient ID: NPC138305
Ingredient ID: NPC11890
Ingredient ID: NPC117731
Ingredient ID: NPC111347
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 | Cytochrome P450 family 2 | CYP2A13 | Cytochrome P450 2A13 | Q16696 | CHEMBL3542436 |
Cytochrome P450 | Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Therapeutic Target | Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
Therapeutic Target | Surface antigen | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 21 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00054600 | Safety and Efficacy Study of Photopheresis With UVADEX to Prevent Graft-versus-Host Disease | graft versus host disease | Methoxsalen (NPC33320) | NP level |
NCT02524847 | Methoxsalen and Extracorporeal Photopheresis (ECP) for the Treatment of Pediatric Participants With Steroid Refractory Acute Graft Versus Host Disease | acute graft vs. host disease | Methoxsalen (NPC33320) | NP level |
NCT00533195 | Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis | atopic eczema | Bergapten (NPC74539) | NP level |
NCT00056355 | Extracorporeal Photopheresis to Maintain Symptoms Remission During Steroid Withdrawal in Patients With Steroid-Dependent Crohn's Disease | Crohn's disease | Methoxsalen (NPC33320) | NP level |
NCT01686594 | PUVA Maintenance Therapy in Mycosis Fungoides | mycosis fungoides | Methoxsalen (NPC33320) | NP level |
NCT00054613 | Safety and Efficacy Study of Photopheresis Plus Standard Therapy to Treat Chronic Graft-versus-Host Disease | graft versus host disease | Methoxsalen (NPC33320) | NP level |
NCT04986605 | Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic Sclerosis | diffuse scleroderma | Methoxsalen (NPC33320) | NP level |
NCT00221000 | Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthritis | rheumatoid arthritis | Methoxsalen (NPC33320) | NP level |
NCT00030589 | Chemotherapy and Photodynamic Therapy in Treating Patients With Cutaneous T-Cell Lymphoma | lymphoma | Methoxsalen (NPC33320) | NP level |
NCT00221026 | Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Crohn's Disease | Crohn's disease | Methoxsalen (NPC33320) | NP level |
NCT01378143 | Using OCZ103-OS in Patients With Unresectable and Locally Recurrent or Metastatic Colorectal Cancer Undergoing Standard Chemotherapy | colorectal carcinoma | Ethane (NPC71553) | NP level |
NCT03512756 | A Randomized Phase 2/3 Multi-Center Study of SM-88 in Patients With Metastatic Pancreatic Cancer | pancreatic carcinoma | Methoxsalen (NPC33320) | NP level |
NCT00282503 | Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Acute Graft Versus-Host Disease | acute graft vs. host disease | Methoxsalen (NPC33320) | NP level |
NCT00004359 | Phase II Pilot Study of Extracorporeal Phototherapy for Epidermolysis Bullosa Acquisita | epidermolysis bullosa acquisita | Methoxsalen (NPC33320) | NP level |
NCT00005092 | Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer | leukemia;multiple myeloma;myelodysplastic syndrome | Psoralen (NPC51146) | NP level |
NCT00930566 | Extracorporal Photopheresis Pilot Study | lymphoid neoplasm | Methoxsalen (NPC33320) | NP level |
NCT00639717 | Addition of Etanercept and Extracorporeal Photopheresis (ECP) to Standard Graft-Versus-Host Disease (GVHD) Prophylaxis in Stem Cell Transplant | graft versus host disease | Methoxsalen (NPC33320) | NP level |
NCT00056056 | Ultraviolet Light Therapy Using Methoxsalen With or Without Bexarotene in Treating Patients With Mycosis Fungoides | lymphoma | Methoxsalen (NPC33320) | NP level |
NCT04291261 | Extracorporal Photopheresis With UVADEX Plus Standard Steroid Treatment for High Risk Acute Graft-versus-host Disease | acute graft vs. host disease | Methoxsalen (NPC33320) | NP level |
NCT03778996 | SM-88 Maintenance Therapy for Advanced Ewing's Sarcoma and as Salvage Therapy for Sarcoma | Ewing sarcoma | Methoxsalen (NPC33320) | NP level |
NCT03563040 | Study of Photopheresis in the Treatment of Erythrodermic MF and SS | Sezary's disease;mycosis fungoides | Methoxsalen (NPC33320) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CES1,CYP1B1,CA9,CDC25B,PTPN1,AKR1B10,PTPRC,ACHE
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CA9,CA12,AKR1B10,CA9,CA12,CDC25B,AKR1B10
|
Graft-versus-host diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4B24 |
NCT00639717,NCT00054613,NCT04291261,NCT00054600,NCT00282503,NCT02524847
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CYP2A13,CA9,CA12,AKR1B10,PTPRC,CYP1A2
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
CA9,CA12,PTPN1,ACHE,F3
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
CA9,ACHE,AKR1B10,CA9,PTPRC
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
CA9,CA12,CDC25B,AKR1B10,PTPRC
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CYP1B1,CA9,AKR1B10,PTPRC,ACHE
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CYP1B1,CA9,CA12,AKR1B10,PTPRC
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
PTPRC,CA9
NCT00030589,NCT00056056 |
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA9,CA12,ACHE,AKR1B10
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CYP2A6,CYP2A13,CA9,CA12
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
CDC25B,CA12,ACHE,PTPRC
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
CA12,CA9,F3
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA12,CA9,PTPN1
|
Mycosis fungoidesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B01 |
CYP2A6
NCT01686594,NCT03563040 |
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CYP2A13,CA9,AKR1B10
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
CDC25B,PTPN1,AKR1B10
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
CA9,CA12,AKR1B10
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CYP1A1,CA9,CDC25B
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
CA12,CA9,AKR1B10
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CYP1A1,ACHE,KDM4E
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
CYP1A1,ACHE,F3
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CYP1A1,CA9,AKR1B10
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP1A1,CA12,CYP1A2
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
CYP2A6
AKR1B10 |
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
NCT00056355,NCT00221026
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
CA9,F3
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
CA12,AKR1B10
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
CDC25B,ACHE
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CA9,CYP1A2
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CYP1A1,CA9
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CA12,CYP1B1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CA9,CA12
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ACHE
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
PTPN1
|
Nasopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
CDC25B
|
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
ACHE
|
Synthesis disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52-5C59 |
CES1
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
CES1
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
PTPRC
|
Metabolic disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5D2Z |
PTPN1
|
Ophthalmic devices/implants/grafts injuryDisease Category: 23.External causes of morbidity or mortalityDisease ICD-11 Code: PK97 |
PTPN1
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
F3
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
PTPN1
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
CA9
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PTPN1
|
Oesophageal/gastroduodenal disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD90 |
ACHE
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
CDC25B
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
PTPN1
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
ACHE
|
Diffuse large B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
PTPRC
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F3
|
PediculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G00 |
ACHE
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA12
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
ACHE
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
ACHE
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PTPRC
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
ACHE
|
Transplanted organ/tissueDisease Category: 24.Factors influencing health status or contact with health servicesDisease ICD-11 Code: QB63 |
PTPRC
|
Parasitic worm infestationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F90 |
ACHE
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
ACHE
|
BCR-ABL1-negative chronic myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A41 |
PTPRC
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
CES1
|
Transplant rejectionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE84 |
PTPRC
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
ACHE
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE
|
Peroxisomal diseaseDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C57 |
CES1
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA12
|
Malignant neoplasm of pancreas, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.Z |
NCT03512756
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
NCT01378143
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT04986605
|
LeukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60-2B33 |
NCT00005092
|
Sezary syndromeDisease Category: X.Extension CodesDisease ICD-11 Code: XH8HN3 |
NCT03563040
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
NCT00221000
|
Epidermolysis bullosa acquisitaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EB43 |
NCT00004359
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NCT00533195
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
NCT00005092
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
NCT00005092
|
Neoplasms of haematopoietic or lymphoid tissues, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B3Z |
NCT00930566
|
Ewing sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B52 |
NCT03778996
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
CYP1A1
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
ACHE
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
ACHE
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
CA12
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
CYP2A13
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CDC25B
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
CA9
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
CYP1A1
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
ACHE
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
F3
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
PTPRC
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
ACHE
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
F3
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
CYP1B1
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
CYP1B1
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
ACHE
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
AKR1B10
|