Collective Molecular Activities of the Plant: Avena Sativa
Plant ID: NPO16509
Plant Latin Name: Avena Sativa
Taxonomy Genus: Avena
Taxonomy Family: Poaceae
Plant External Links:
NCBI TaxonomyDB:
4498
Plant-of-the-World-Online:
n.a.
Country/Region:
Turkey; Canada; Madagascar; Italy; South Africa; India; Lebanon; United States; Zimbabwe; Jordan; Swaziland; Angola; China; SpainTraditional Medicine System:
Indian Folk; TCM; HomeopathyMedicinal Functions:
Anticholesterolemic; Antidiarrhoeal; Antirheumatic; Antiseborrheic; Antispasmodic; Cancer; Cardiac; Diuretic; Emollient; Hypoglycaemic; Nervine; Nutritive; Poultice; Stimulant
Canada; Turkey; Madagascar; Italy; South Africa; Lebanon; India; United States; Zimbabwe; China; Angola; Swaziland; Jordan; Spain
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
115 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
93 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
78 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95589
Ingredient ID: NPC94167
Ingredient ID: NPC93888
Ingredient ID: NPC85813
Ingredient ID: NPC81930
Ingredient ID: NPC81414
Ingredient ID: NPC81010
Ingredient ID: NPC78312
Ingredient ID: NPC76336
Ingredient ID: NPC74599
Ingredient ID: NPC62045
Ingredient ID: NPC60151
Ingredient ID: NPC59650
Ingredient ID: NPC5502
Ingredient ID: NPC52472
Ingredient ID: NPC50496
Ingredient ID: NPC50315
Ingredient ID: NPC491218
Ingredient ID: NPC490427
Ingredient ID: NPC490351
Ingredient ID: NPC490332
Ingredient ID: NPC490321
Ingredient ID: NPC490288
Ingredient ID: NPC489928
Ingredient ID: NPC489907
Ingredient ID: NPC4294
Ingredient ID: NPC424
Ingredient ID: NPC39064
Ingredient ID: NPC34908
Ingredient ID: NPC33666
Ingredient ID: NPC328447
Ingredient ID: NPC317120
Ingredient ID: NPC313955
Ingredient ID: NPC309330
Ingredient ID: NPC300326
Ingredient ID: NPC300059
Ingredient ID: NPC29883
Ingredient ID: NPC295644
Ingredient ID: NPC294902
Ingredient ID: NPC294548
Ingredient ID: NPC293628
Ingredient ID: NPC291473
Ingredient ID: NPC290319
Ingredient ID: NPC287287
Ingredient ID: NPC281686
Ingredient ID: NPC27836
Ingredient ID: NPC273019
Ingredient ID: NPC272614
Ingredient ID: NPC269980
Ingredient ID: NPC269919
Ingredient ID: NPC265305
Ingredient ID: NPC263495
Ingredient ID: NPC260569
Ingredient ID: NPC260000
Ingredient ID: NPC245346
Ingredient ID: NPC242580
Ingredient ID: NPC23962
Ingredient ID: NPC237812
Ingredient ID: NPC230479
Ingredient ID: NPC226453
Ingredient ID: NPC226027
Ingredient ID: NPC222889
Ingredient ID: NPC221411
Ingredient ID: NPC220765
Ingredient ID: NPC219913
Ingredient ID: NPC219143
Ingredient ID: NPC213876
Ingredient ID: NPC210267
Ingredient ID: NPC209560
Ingredient ID: NPC208793
Ingredient ID: NPC20791
Ingredient ID: NPC203719
Ingredient ID: NPC203468
Ingredient ID: NPC202431
Ingredient ID: NPC201844
Ingredient ID: NPC199072
Ingredient ID: NPC197087
Ingredient ID: NPC193989
Ingredient ID: NPC193536
Ingredient ID: NPC189436
Ingredient ID: NPC185755
Ingredient ID: NPC17810
Ingredient ID: NPC174246
Ingredient ID: NPC1682
Ingredient ID: NPC167400
Ingredient ID: NPC160353
Ingredient ID: NPC158079
Ingredient ID: NPC156751
Ingredient ID: NPC156654
Ingredient ID: NPC15658
Ingredient ID: NPC152451
Ingredient ID: NPC150950
Ingredient ID: NPC147983
Ingredient ID: NPC146422
Ingredient ID: NPC141765
Ingredient ID: NPC140753
Ingredient ID: NPC140154
Ingredient ID: NPC137958
Ingredient ID: NPC136014
Ingredient ID: NPC135539
Ingredient ID: NPC134452
Ingredient ID: NPC133183
Ingredient ID: NPC130683
Ingredient ID: NPC126918
Ingredient ID: NPC126681
Ingredient ID: NPC126409
Ingredient ID: NPC126029
Ingredient ID: NPC125449
Ingredient ID: NPC121522
Ingredient ID: NPC118429
Ingredient ID: NPC11433
Ingredient ID: NPC112890
Ingredient ID: NPC111888
Ingredient ID: NPC110899
Ingredient ID: NPC109699
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A2 | Norepinephrine transporter | P23975 | CHEMBL222 |
| Drug Transporter | SLC superfamily of solute carriers | SLC6A3 | Dopamine transporter | Q01959 | CHEMBL238 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Therapeutic Target | 5HT3 receptor | HTR3A | Serotonin 3a (5-HT3a) receptor | P46098 | CHEMBL1899 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 507 | |
 Plant level | 2 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction | Folic Acid (NPC147983);Pyridoxine (NPC269919);Beta Carotene (NPC17810) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Pyridoxine (NPC269919);Folic Acid (NPC147983);Beta Carotene (NPC17810) | NP level |
| NCT00000553 | HDL-Atherosclerosis Treatment Study (HATS) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,HTR2A,HTR2C,AKR1B1,KDR,FFAR1
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AURKB,TP53,SRC,PIM1,NFKB1,AXL,FLT3
NCT01842139 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888
|
Acute painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG31 |
SLC6A2
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT03718507
|
Acute upper respiratory infectionDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA07 |
DRD3,DRD2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
