Collective Molecular Activities of the Plant: Amomum Xanthioides
Plant ID: NPO1631
Plant Latin Name: Amomum Xanthioides
Taxonomy Genus: Amomum
Taxonomy Family: Zingiberaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Country/Region:
Thailand; Vietnam; India; China; LaosTraditional Medicine System:
Kampo; Indian Folk; TCM; Ayurveda; SiddhaIndia; Vietnam; China; Thailand; Laos
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
141 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
125 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
66 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9880
Ingredient ID: NPC96630
Ingredient ID: NPC95675
Ingredient ID: NPC89069
Ingredient ID: NPC87828
Ingredient ID: NPC84030
Ingredient ID: NPC81500
Ingredient ID: NPC78551
Ingredient ID: NPC76765
Ingredient ID: NPC76145
Ingredient ID: NPC75158
Ingredient ID: NPC71703
Ingredient ID: NPC71506
Ingredient ID: NPC70291
Ingredient ID: NPC68889
Ingredient ID: NPC67986
Ingredient ID: NPC66577
Ingredient ID: NPC61828
Ingredient ID: NPC61779
Ingredient ID: NPC61769
Ingredient ID: NPC60556
Ingredient ID: NPC60288
Ingredient ID: NPC57877
Ingredient ID: NPC54264
Ingredient ID: NPC51758
Ingredient ID: NPC51189
Ingredient ID: NPC50629
Ingredient ID: NPC45727
Ingredient ID: NPC44751
Ingredient ID: NPC43635
Ingredient ID: NPC43453
Ingredient ID: NPC43114
Ingredient ID: NPC40249
Ingredient ID: NPC3936
Ingredient ID: NPC38278
Ingredient ID: NPC36408
Ingredient ID: NPC34764
Ingredient ID: NPC32762
Ingredient ID: NPC325439
Ingredient ID: NPC325196
Ingredient ID: NPC319957
Ingredient ID: NPC3155
Ingredient ID: NPC310194
Ingredient ID: NPC309182
Ingredient ID: NPC308297
Ingredient ID: NPC308218
Ingredient ID: NPC307011
Ingredient ID: NPC304885
Ingredient ID: NPC300649
Ingredient ID: NPC299724
Ingredient ID: NPC298062
Ingredient ID: NPC297844
Ingredient ID: NPC297527
Ingredient ID: NPC293343
Ingredient ID: NPC292952
Ingredient ID: NPC290613
Ingredient ID: NPC290437
Ingredient ID: NPC290189
Ingredient ID: NPC29
Ingredient ID: NPC289366
Ingredient ID: NPC287550
Ingredient ID: NPC287331
Ingredient ID: NPC286774
Ingredient ID: NPC284731
Ingredient ID: NPC283655
Ingredient ID: NPC277917
Ingredient ID: NPC276707
Ingredient ID: NPC274012
Ingredient ID: NPC26906
Ingredient ID: NPC260000
Ingredient ID: NPC258672
Ingredient ID: NPC254293
Ingredient ID: NPC252230
Ingredient ID: NPC249009
Ingredient ID: NPC247786
Ingredient ID: NPC241838
Ingredient ID: NPC240009
Ingredient ID: NPC239039
Ingredient ID: NPC237705
Ingredient ID: NPC235976
Ingredient ID: NPC232375
Ingredient ID: NPC231738
Ingredient ID: NPC230301
Ingredient ID: NPC227670
Ingredient ID: NPC227378
Ingredient ID: NPC223468
Ingredient ID: NPC219400
Ingredient ID: NPC218918
Ingredient ID: NPC216630
Ingredient ID: NPC214909
Ingredient ID: NPC214584
Ingredient ID: NPC211567
Ingredient ID: NPC210831
Ingredient ID: NPC209970
Ingredient ID: NPC209275
Ingredient ID: NPC200740
Ingredient ID: NPC197896
Ingredient ID: NPC196490
Ingredient ID: NPC190810
Ingredient ID: NPC189036
Ingredient ID: NPC188238
Ingredient ID: NPC187061
Ingredient ID: NPC180871
Ingredient ID: NPC180684
Ingredient ID: NPC179950
Ingredient ID: NPC179103
Ingredient ID: NPC178223
Ingredient ID: NPC177112
Ingredient ID: NPC176309
Ingredient ID: NPC175987
Ingredient ID: NPC173996
Ingredient ID: NPC173637
Ingredient ID: NPC166894
Ingredient ID: NPC166362
Ingredient ID: NPC15970
Ingredient ID: NPC157298
Ingredient ID: NPC156461
Ingredient ID: NPC152989
Ingredient ID: NPC152005
Ingredient ID: NPC150465
Ingredient ID: NPC148303
Ingredient ID: NPC147343
Ingredient ID: NPC14682
Ingredient ID: NPC141777
Ingredient ID: NPC13991
Ingredient ID: NPC139546
Ingredient ID: NPC139337
Ingredient ID: NPC138113
Ingredient ID: NPC136232
Ingredient ID: NPC131981
Ingredient ID: NPC131769
Ingredient ID: NPC126240
Ingredient ID: NPC120926
Ingredient ID: NPC115469
Ingredient ID: NPC114239
Ingredient ID: NPC114011
Ingredient ID: NPC111888
Ingredient ID: NPC109813
Ingredient ID: NPC108494
Ingredient ID: NPC105557
Ingredient ID: NPC100445
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Therapeutic Target | Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA2A | Adenosine A2a receptor | P29274 | CHEMBL251 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 54 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00179010 | AMP as a Better Delivery System of Adenosine | ischemia | Adenosine (NPC156461) | NP level |
| NCT00284323 | Salvage: Postconditioning With Adenosine for STEMI | ST Elevation Myocardial Infarction | Adenosine (NPC156461) | NP level |
| NCT00298636 | Dose-Response of Adenosine for Perioperative Pain | pain | Adenosine (NPC156461) | NP level |
| NCT00299559 | Kinetics of Etheric Oils, Smart Textiles vs. Ointment | common cold | Menthol (NPC223468) | NP level |
| NCT00349921 | Clonidine Versus Adenosine to Treat Neuropathic Pain | pain | Adenosine (NPC156461) | NP level |
| NCT00565188 | Application of ATP Infusions in Palliative Home Care | cancer | Adenosine (NPC156461) | NP level |
| NCT00580905 | Role of Adenosine in the Release of VEGF and Cytokines | inflammation | Adenosine (NPC156461) | NP level |
| NCT00590070 | THE REOPEN-AMI STUDY - Intracoronary Nitroprusside Versus Adenosine in Acute Myocardial Infarction | myocardial infarction | Adenosine (NPC156461) | NP level |
| NCT00612521 | Prophylactic Intra-coronary Adenosine to Prevent Post Coronary Artery Stenting Myonecrosis | coronary stenosis | Adenosine (NPC156461) | NP level |
| NCT00714103 | 8-Chloro-Adenosine in Chronic Lymphocytic Leukemia | chronic lymphocytic leukemia | Adenosine (NPC156461) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
KDM1A
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04588441
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT00284323,NCT01747174
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA7,CA12,F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CYP1B1,CA7,OR51E2,CNR2,ADORA2A,LMNA,ADORA3,F2,CA2
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2,FABP5
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
