Collective Molecular Activities of the Plant: Rhodiola Rosea
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PLANiTS DNA barcode
Taxonomic Information
Plant ID: NPO16239
Plant Latin Name: Rhodiola Rosea
Taxonomy Genus: Rhodiola
Taxonomy Family: Crassulaceae
Plant External Links:
NCBI TaxonomyDB:
203015
Plant-of-the-World-Online:
n.a.
Used in Medicines
Country/Region:
Canada; France; Sweden; Germany; Norway; RussiaTraditional Medicine System:
Medicinal Functions:
Adaptogen; Antidepressant; Stomachic; TB
Geographical Distribution
Canada; France; Sweden; Germany; Norway; Russia
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary
Overview of Ingredients
50 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
16 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
26 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC88803
Ingredient ID: NPC8573
Ingredient ID: NPC81010
Ingredient ID: NPC77531
Ingredient ID: NPC74899
Ingredient ID: NPC66299
Ingredient ID: NPC66172
Ingredient ID: NPC55715
Ingredient ID: NPC50898
Ingredient ID: NPC476405
Ingredient ID: NPC4574
Ingredient ID: NPC40974
Ingredient ID: NPC325196
Ingredient ID: NPC324740
Ingredient ID: NPC324579
Ingredient ID: NPC323907
Ingredient ID: NPC318803
Ingredient ID: NPC31496
Ingredient ID: NPC300017
Ingredient ID: NPC295082
Ingredient ID: NPC292465
Ingredient ID: NPC29023
Ingredient ID: NPC279121
Ingredient ID: NPC27208
Ingredient ID: NPC266746
Ingredient ID: NPC247957
Ingredient ID: NPC233409
Ingredient ID: NPC231834
Ingredient ID: NPC229397
Ingredient ID: NPC225731
Ingredient ID: NPC224103
Ingredient ID: NPC218262
Ingredient ID: NPC210003
Ingredient ID: NPC207928
Ingredient ID: NPC20791
Ingredient ID: NPC18603
Ingredient ID: NPC181465
Ingredient ID: NPC176740
Ingredient ID: NPC169733
Ingredient ID: NPC167400
Ingredient ID: NPC156934
Ingredient ID: NPC155477
Ingredient ID: NPC150480
Ingredient ID: NPC140052
Ingredient ID: NPC133671
Ingredient ID: NPC133403
Ingredient ID: NPC130449
Ingredient ID: NPC126136
Ingredient ID: NPC121654
Ingredient ID: NPC116775
Classification of Human Proteins Collectively Targeted by the Plant
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Metallo protease | MMP12 | Matrix metalloproteinase 12 | P39900 | CHEMBL4393 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Therapeutic Target | Oxidoreductase | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
| Therapeutic Target | Oxidoreductase | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | P14061 | CHEMBL3181 |
| Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Therapeutic Target | Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Therapeutic Target | Protein Kinase | AXL | Tyrosine-protein kinase receptor UFO | P30530 | CHEMBL4895 |
| Therapeutic Target | Protein Kinase | IGF1R | Insulin-like growth factor I receptor | P08069 | CHEMBL1957 |
| Therapeutic Target | Protein Kinase | MKNK2 | MAP kinase signal-integrating kinase 2 | Q9HBH9 | CHEMBL4204 |
| Therapeutic Target | Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
| Therapeutic Target | Protein Kinase | YES1 | Tyrosine-protein kinase YES | P07947 | CHEMBL2073 |
| Therapeutic Target | Protein Kinase | MKNK1 | MAP kinase-interacting serine/threonine-protein kinase MNK1 | Q9BUB5 | CHEMBL4718 |
| Therapeutic Target | Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
| Therapeutic Target | Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Therapeutic Target | Protein Kinase | CDK1 | Cyclin-dependent kinase 1 | P06493 | CHEMBL308 |
| Therapeutic Target | Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Therapeutic Target | Protein Kinase | MET | Hepatocyte growth factor receptor | P08581 | CHEMBL3717 |
| Therapeutic Target | Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Therapeutic Target | Secreted protein | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
| Therapeutic Target | Secreted protein | TTR | Transthyretin | P02766 | CHEMBL3194 |
| Therapeutic Target | Serine protease | DPP4 | Dipeptidyl peptidase IV | P27487 | CHEMBL284 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HCAR2 | Hydroxycarboxylic acid receptor 2 | Q8TDS4 | CHEMBL3785 |
| Therapeutic Target | Transcription factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Therapeutic Target | Transcription factor | AHR | Aryl hydrocarbon receptor | P35869 | CHEMBL3201 |
Clinical Trials Summary
Overview
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 98 | |
 Plant level | 4 | |
Clinical trial details
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00080275 | Evaluation of the Safety & Efficacy of a Combination of Niacin ER & Simvastatin in Patients With Dyslipidemia (OCEANS) | Hypercholesterolemia | Niacin (NPC167400) | NP level |
| NCT00796887 | Randomized, Controlled Trial of Extended-Release Niacin (Niaspan®) to Augment Subacute Ischemic Stroke Recovery | Ischemic stroke | Niacin (NPC167400) | NP level |
| NCT00961636 | A Long-term Study of ERN/LRPT (Extended Release Niacin/Laropiprant [MK0524A]) in Patients With Dyslipidemia (0524A-102) | Disorder of lipid metabolism | Niacin (NPC167400) | NP level |
| NCT00289900 | Lipid Efficacy and Safety in Participants With Mixed Hyperlipidemia (MK-0524B-024) | Combined hyperlipidemia | Niacin (NPC167400) | NP level |
| NCT01104519 | A Study of Niaspan on Endothelium-Dependent and Endothelium-Independent Vascular Reactivity (0000-093) | Disorder of lipid metabolism | Niacin (NPC167400) | NP level |
| NCT03866174 | A Study of Psilocybin for Major Depressive Disorder (MDD) | major depressive disorder | Niacin (NPC167400) | NP level |
| NCT00630877 | Evaluation of a Flushing ASsessment Tool (FAST) in Subjects Receiving Niacin Extended-release Plus Aspirin | Disorder of lipid metabolism | Niacin (NPC167400) | NP level |
| NCT01583647 | A Study of Extended-release (ER) Niacin/Laropiprant in Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0524A-158) | familial hypercholesterolemia | Niacin (NPC167400) | NP level |
| NCT04853199 | Quercetin In The Treatment Of SARS-COV 2 | COVID-19 | Quercetin (NPC20791) | NP level |
| NCT00533312 | MK0524A Clinical Efficacy Study (0524A-026)(COMPLETED) | Hypercholesterolemia | Niacin (NPC167400) | NP level |
| NCT00000599 | Cholesterol-Lowering Atherosclerosis Study (CLAS) | carotid artery disease;cerebral atherosclerosis;Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT01705652 | Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients | prostate cancer | Rutin (NPC176740) | NP level |
| NCT01321034 | Effect of Niacin in the Lipoprotein (a) Concentration | Hypercholesterolemia | Niacin (NPC167400) | NP level |
| NCT00150722 | High-Density Lipoprotein (HDL) Modulation and Endothelial Function | atherosclerosis | Niacin (NPC167400) | NP level |
| NCT00269204 | Lipid Efficacy/Tolerability Study (0524A-020) | Combined hyperlipidemia | Niacin (NPC167400) | NP level |
| NCT04851821 | The Effectiveness of Phytotherapy in SARS-COV2(COVID-19) | COVID-19 | Quercetin (NPC20791) | NP level |
| NCT01912820 | Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery | prostate adenocarcinoma | Quercetin (NPC20791) | NP level |
| NCT01071291 | Effects of Niaspan™ on High-density Lipoprotein (HDL) in Healthy Male Subjects (0000-069) | Disorder of lipid metabolism | Niacin (NPC167400) | NP level |
| NCT01426438 | Endothelial Function, Lipoproteins, and Inflammation With Low HDL Cholesterol in HIV: ER Niacin Versus Fenofibrate | HIV-1 infection | Niacin (NPC167400) | NP level |
| NCT01368328 | Effect of the Chromium Nicotinate on Type 2 Diabetes | type 2 diabetes mellitus | Niacin (NPC167400) | NP level |
| NCT00804843 | Merck Carotid Atherosclerosis Trial (MK-0000-111)(COMPLETED) | carotid atherosclerosis | Niacin (NPC167400) | NP level |
| NCT05452772 | 5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder | nicotine dependence | Niacin (NPC167400) | NP level |
| NCT00170404 | TB Nutrition, Immunology and Epidemiology | tuberculosis | Niacin (NPC167400) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT00120289 | Niacin Plus Statin to Prevent Vascular Events | stroke;atherosclerosis;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT01984073 | Effects of Niacin On Fatty Acid Trapping | Disorder of lipid metabolism | Niacin (NPC167400) | NP level |
| NCT00082251 | Safety & Efficacy of a Combination Niacin ER/Simvastatin in Patients With Dyslipidemia: A Dose-Ranging Study - SEACOAST | Hypercholesterolemia | Niacin (NPC167400) | NP level |
| NCT04677049 | Study of Niacin in Glioblastoma | glioblastoma multiforme | Niacin (NPC167400) | NP level |
| NCT00269217 | Lipid Efficacy Study (0524B-022)(COMPLETED) | Combined hyperlipidemia;Hypercholesterolemia | Niacin (NPC167400) | NP level |
| NCT01438320 | Q-Trial in Patients With Hepatitis C | chronic hepatitis C virus infection | Quercetin (NPC20791) | NP level |
| NCT00062556 | Effect of Niacin ER/Lovastatin on Peak Walking Time & Claudication Onset Time in Patients With Intermittent Claudication | intermittent vascular claudication | Niacin (NPC167400) | NP level |
| NCT00378833 | Tolerability of MK0524A Versus Niacin Extended-Release (0524A-054) | Hypercholesterolemia;hyperlipidemia | Niacin (NPC167400) | NP level |
| NCT00664287 | Extended Release (ER) Niacin/Laropiprant Add on Study (0524A-082) | Disorder of lipid metabolism | Niacin (NPC167400) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT05456022 | Therapeutic Efficacy of Quercetin Versus Its Encapsulated Nanoparticle on Tongue Squamous Cell Carcinoma Cell Line | mouth neoplasm | Quercetin (NPC20791) | NP level |
| NCT01720095 | Niapsan as Add -on Therapy to Antipsychotic Treatment in First Episode Psychosis | psychosis | Niacin (NPC167400) | NP level |
| NCT00485758 | Extended Niacin/Laropiprant in Patients With Type 2 Diabetes (0524A-069) | type 2 diabetes mellitus | Niacin (NPC167400) | NP level |
| NCT00111891 | An Investigational Drug Study Evaluating a Novel Approach to Treat Dyslipidemia (0524A-032) | Disorder of lipid metabolism | Niacin (NPC167400) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT05276895 | Effect of Natural Senolytic Agents & NLRP3 Inhibitors on Osteoarthritis | osteoarthritis | Quercetin (NPC20791) | NP level |
| NCT00384293 | Carotid IMT (Intima Media Thickening) Study (0524A-041)(TERMINATED) | familial hypercholesterolemia | Niacin (NPC167400) | NP level |
| NCT02226484 | Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD? | gastroesophageal reflux disease | Quercetin (NPC20791) | NP level |
| NCT01054508 | Effect of Tredaptive on Serum Lipoproteins and Inflammatory Markers | Hypercholesterolemia | Niacin (NPC167400) | NP level |
| NCT00500045 | Retrospective Study of the Effectiveness and Safety of Niacin and Steroid Eye Drops for Retinal Vein Occlusions | retinal vein occlusion | Niacin (NPC167400) | NP level |
| NCT00536237 | MK0524A Phase IIb Study (0524A-011)(COMPLETED) | Flushing | Niacin (NPC167400) | NP level |
| NCT01221402 | Effect of Extended-Release Niacin on Saphenous Vein Graft Atherosclerosis | atherosclerosis | Niacin (NPC167400) | NP level |
| NCT00300365 | Pioglitazone vs Placebo in Combination With Niacin Extended Release on Low HDL | metabolic syndrome | Niacin (NPC167400) | NP level |
| NCT00000553 | HDL-Atherosclerosis Treatment Study (HATS) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT02737033 | Effects of 800mg of Rhodiola Rosea in Attention in Adults With Attention-Deficit/Hyperactivity Disorder | Attention Deficit Hyperactivity Disorder | Rhodiola Rosea | Plant level As single plant |
| NCT04733534 | An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer | childhood cancer | Quercetin (NPC20791) | NP level |
| NCT00944645 | MK0524A Bioequivalence Study (0524A-059) | Disorder of lipid metabolism | Niacin (NPC167400) | NP level |
| NCT01098318 | Rhodiola Rosea Therapy of Major Depressive Disorder | Depression | Rhodiola Rosea | Plant level As single plant |
| NCT00943124 | MK0524B Bioequivalence Study (0524B-070) | Disorder of lipid metabolism | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT01083329 | Effect of Nicotinic Acid on Adipose Tissue Inflammation in Obese Subjects | obesity | Niacin (NPC167400) | NP level |
| NCT00652431 | Assessment of Interaction Between Vytorin and Niaspan in Healthy Subjects (P04955AM2) | Hypercholesterolemia;hyperlipidemia | Niacin (NPC167400) | NP level |
| NCT04630964 | The Effect of Psilocybin on MDD Symptom Severity and Synaptic Density | major depressive disorder | Niacin (NPC167400) | NP level |
| NCT00071266 | The Dose Response of Niacin ER/Lovastatin on Peak Walking Time (PWT) in Patients With Intermittent Claudication - TROPIC | intermittent vascular claudication | Niacin (NPC167400) | NP level |
| NCT05062486 | A Study to Evaluate the Safety and Efficacy of RQC for AMD | age-related macular degeneration | Quercetin (NPC20791) | NP level |
| NCT01278992 | Rhodiola Rosea for Mental and Physical Fatigue | Fatigue | Rhodiola Rosea | Plant level As single plant |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
| NCT01839344 | Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes. | type 2 diabetes mellitus | Quercetin (NPC20791) | NP level |
| NCT00626392 | Study to Evaluate the EFFECTS of Acetylsalicylic Acid (ASA) on Niaspan®-Induced Flushing in Subjects With Dyslipidemia | Disorder of lipid metabolism | Niacin (NPC167400) | NP level |
| NCT00533611 | Effect of MK0524A on Flushing Caused by Niacin (0524A-056) | Flushing | Niacin (NPC167400) | NP level |
| NCT02702492 | PAK4 and NAMPT in Patients With Solid Malignancies or NHL (PANAMA) | non-Hodgkins lymphoma | Niacin (NPC167400) | NP level |
| NCT00769132 | A Study to Evaluate the Effects of Extended Release (ER) Niacin/Laropiprant, Laropiprant, ER Niacin, and Placebo on Urinary Prostanoid Metabolites in Subjects With High Cholesterol (0524A-075)(COMPLETED) | Hypercholesterolemia | Niacin (NPC167400) | NP level |
| NCT03943459 | Sirtuin-1 and Advanced Glycation End-products in Postmenopausal Women With Coronary Disease | coronary artery disease | Quercetin (NPC20791) | NP level |
| NCT01720147 | Quercetin in Children With Fanconi Anemia; a Pilot Study | Fanconi anemia | Quercetin (NPC20791) | NP level |
| NCT02018965 | Niacin on Immune Activation : a Proof-of-concept Study | HIV infection | Niacin (NPC167400) | NP level |
| NCT00728910 | Combined Effects of Non-statin Treatments on Apolipoprotein A-I Up-Regulation (CENTAUR): A Feasibility Study | Disorder of lipid metabolism | Niacin (NPC167400) | NP level |
| NCT03989271 | Biological Effects of Quercetin in COPD | chronic obstructive pulmonary disease | Quercetin (NPC20791) | NP level |
| NCT03510715 | An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia | Hypercholesterolemia | Niacin (NPC167400) | NP level |
| NCT04907253 | Quercetin in Coronary Artery By-pass Surgery | coronary artery disease | Quercetin (NPC20791) | NP level |
| NCT04946383 | Safety and Effectivness of Quercetin & Dasatinib on Epigenetic Aging | aging | Quercetin (NPC20791) | NP level |
| NCT05422885 | Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease | aging | Quercetin (NPC20791) | NP level |
| NCT02890992 | An 8-Week Dose-Finding Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia | Disorder of lipid metabolism | Niacin (NPC167400) | NP level |
| NCT00152893 | To Determine if Chromium Nicotinate Supplementation Will Improve Insulin Resistance in HIV Patients With Metabolic Abnormalities | HIV infection | Niacin (NPC167400) | NP level |
| NCT00397657 | Comparative Study of the Effect of Ezetimibe Versus Extended-Release Niacin on Atherosclerosis | atherosclerosis | Niacin (NPC167400) | NP level |
| NCT00376584 | Effect of an Investigational Compound on Tolerability of Extended Release Niacin (0524A-023)(COMPLETED) | Disorder of lipid metabolism;hyperlipidemia | Niacin (NPC167400) | NP level |
| NCT03752918 | The Effects of MDMA on Prefrontal and Amygdala Activation in PTSD. | post-traumatic stress disorder | Niacin (NPC167400) | NP level |
| NCT00957359 | Psilocybin Cancer Anxiety Study | cancer | Niacin (NPC167400) | NP level |
| NCT00203476 | A Prospective, Open Label Comparison of Ezetimibe, Niacin, and Colestipol as Adjunct Therapy in Lipid Reduction | Hypercholesterolemia;hyperlipidemia | Niacin (NPC167400) | NP level |
| NCT00855257 | Assessment of Endothelial Vasomotricity After Treatment by Nicotinic Acid in Acute Coronary Syndrome | acute coronary syndrome | Niacin (NPC167400) | NP level |
| NCT00536510 | Effect of MK0524A on Cholesterol Levels (0524A-048) | Hypercholesterolemia;hyperlipidemia | Niacin (NPC167400) | NP level |
| NCT04703361 | Effects of Ketones and Niacin in Heart Failure Patients | systolic heart failure | Niacin (NPC167400) | NP level |
| NCT03685773 | The Role of Hepatic Denervation in the Dysregulation of Glucose Metabolism in Liver Transplant Recipients | type 2 diabetes mellitus | Niacin (NPC167400) | NP level |
| NCT03540758 | Regulation of Endogenous Glucose Production by Central KATP Channels | type 2 diabetes mellitus | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00493064 | To Study the Effectiveness and Safety of Niacin and a Topical Steroid Eye Drop to Treat Retinal Vein Occlusions | retinal vein occlusion | Niacin (NPC167400) | NP level |
| NCT00508989 | Niacin to Improve Blood Flow in People With Sickle Cell Disease | sickle cell anemia | Niacin (NPC167400) | NP level |
| NCT00618995 | A Study to Evaluate the Effects of ER Niacin/Laropiprant, Laropiprant, ER Niacin, and Placebo on Urinary Prostanoid Metabolites (0524A-079)(COMPLETED) | type 2 diabetes mellitus | Niacin (NPC167400) | NP level |
| NCT01005303 | Micronutrient Supplementation in Patients With Heart Failure | heart failure | Niacin (NPC167400) | NP level |
| NCT00271817 | To Evaluate Ezetimibe/Simvastatin and Niacin (Extended Release Tablet) in Patients With Type IIa or Type IIb Hyperlipidemia (0653A-091)(COMPLETED) | Hypercholesterolemia | Niacin (NPC167400) | NP level |
| NCT02109614 | Early Aortic Valve Lipoprotein(a) Lowering Trial | aortic stenosis | Niacin (NPC167400) | NP level |
| NCT02848131 | Senescence in Chronic Kidney Disease | chronic kidney disease | Quercetin (NPC20791) | NP level |
| NCT00903617 | Study to Test GSK256073 in Patients With Dyslipidemia | Disorder of lipid metabolism | Niacin (NPC167400) | NP level |
| NCT01708278 | Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) | chronic obstructive pulmonary disease | Quercetin (NPC20791) | NP level |
| NCT01071525 | The Effect of Niacin Administration on Oxidative Stress in Patients With Hypercholesterolmia, as Measured by the Use of a Novel Biomarker | Hypercholesterolemia | Niacin (NPC167400) | NP level |
| NCT03356483 | Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study. | obsessive-compulsive disorder | Niacin (NPC167400) | NP level |
| NCT03510884 | An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia | Disorder of lipid metabolism | Niacin (NPC167400) | NP level |
| NCT00127218 | High-Density Lipoprotein (HDL) Cholesterol Increased Plaque Stabilization in the Elderly | atherosclerosis | Niacin (NPC167400) | NP level |
| NCT02737020 | Rhodiola Rosea in Adults With Attention Deficit/Hyperactivity Disorder | Attention Deficit/Hyperactivity Disorder | Rhodiola Rosea | Plant level As single plant |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
ALOX5,CDK1,FLT3,MMP12,EGFR,MET,IGF1R,AXL,KDR
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CA12,CSNK2A3,DPP4,CA2,HCAR2,MET,CYP1B1,KDR,CYP19A1
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
MET,MKNK2,KDR,FLT3,MKNK1,TP53,EGFR,IGF1R
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
CA4,MMP12,ACHE,XDH,CA2,TTR,MET,NOX4
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CDK1,NOX4,AURKB,MMP12,NPSR1,ALOX15,CYP19A1,MET
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CDK1,AKR1B1,AURKB,HSD17B1,CA2,CYP1A2,CYP2C9,TTR
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CA12,AURKB,CA2,HCAR2,MET,CYP1A1,CYP1A2,TTR
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
PIM1,AXL,GSK3B,SRC,AURKB,TP53,FLT3
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
MKNK2,KDR,CSNK2A1,EGFR,MKNK1,IGF1R,MET
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
DPP4
NCT01839344,NCT03540758,NCT03685773,NCT01368328,NCT00485758,NCT00618995 |
HyperlipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
NCT00376584,NCT00384293,NCT00652431,NCT00378833,NCT01583647,NCT00536510,NCT00203476
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
NOX4,MMP12,HCAR2,TYR,NPSR1,MET,CYP1A1
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
CDK1,AURKB,MMP12,ALOX15,ACHE,NPSR1,NOX4
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
THPO,CA2,ACHE,ALOX15,CYP2C9,ESR2,CYP1A1
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
FLT3,AXL,IGF1R,AHR,SRC,KDR
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
CDK1,FLT3,SRC,DPP4,TP53,AURKB
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
KDR,SRC,TP53,HIF1A,EGFR,MET
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
DPP4,AXL,ACHE,HCAR2,CYP19A1,MET
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
CA12,CDK1,AURKB,MMP12,XDH,HSD17B1
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
DPP4,CA4,SRC,CA2,ACHE,HSD17B1
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
CA4,AKR1B1,ACHE,CA2,MET
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
FLT3,MET,TP53,SRC,KDR
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE,FLT3,MET,ESR2,KDR
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
DPP4,ALOX5,FLT3,AHR
MMP12 |
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
AXL,EGFR,TP53,AHR,KDR
|
Coronary atherosclerosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA80 |
NCT00397657,NCT01221402,NCT00120289,NCT00150722,NCT00127218
|
Ischaemic heart diseases, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA6Z |
NCT00000482,NCT00000512,NCT00000553,NCT00000599,NCT00000461
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
DPP4,NOX4,AKR1B1,MMP12,FLT3
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
EGFR,AXL,XDH,CYP19A1,HIF1A
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CA12,CDK1,THPO,AURKB,MMP12
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
AXL,ACHE,HCAR2,MET,HSD17B2
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
TP53,HCAR2,MET,DPP4
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
MMP12,MET,KDR,EGFR
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
SRC,AXL,EGFR,TP53
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
IGF1R,EGFR,SRC,TP53
|
Peritoneal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C51 |
SRC,TP53,FLT3,KDR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
KDR,AURKB,DPP4,AKR1B1
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
TYR,MET,KDR,EGFR
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
EGFR,HIF1A,MKNK2,MKNK1
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
ABCG2,AKR1B1,ALOX5,CA2
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
AKR1B1,IGF1R,ACHE,ALOX5
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
TP53,KDR,MET,EGFR
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA12,CYP2C9,CA4,CA2
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
THPO,DPP4
NCT00120289,NCT00000482 |
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
MET,EGFR,TP53,KDR
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
CA2,XDH
NCT01005303,NCT04703361 |
NADisease Category: NADisease ICD-11 Code: NA |
NOX4,MET
NCT00062556,NCT00071266 |
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
KDR,SRC,HCAR2,MET
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
ALOX15,TTR,NOX4
NCT01912820 |
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
AURKB,MMP12,NPSR1,NOX4
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
NOX4,IGF1R,ABCG2,TTR
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
DPP4,THPO,CYP1B1,NOX4
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
KDR,MET,EGFR
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
AURKB,ESR2
NCT01705652 |
Pleomorphic sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B54 |
KDR,MET,SRC
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA12,CA4,CA2
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
FLT3,KDR,EGFR
|
Nasopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
CDK1,ALOX5,EGFR
|
Metastatic lymph node neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60 |
KDR,MET,EGFR
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
SRC,GSK3B,FLT3
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
CA4,MMP12,ALOX5
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
GSK3B,SRC,ACHE
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
KDR,AHR,ALOX5
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
IGF1R,XDH
NCT02848131 |
Mixed hyperlipidaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80.2 |
NCT00289900,NCT00269204,NCT00269217
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
CDK1,CYP1A1,HCAR2
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
MMP12,HCAR2,NOX4
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
CA12,CDK1,HSD17B2
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
ACHE,YES1,CYP1A1
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
AXL,MET,FLT3
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
MMP12,AHR,NOX4
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
KDR,CSNK2A1,MKNK2,HIF1A,IGF1R,MKNK1,APEX1,XDH,CA2,AURKB,MET,CA12,CDK1,AHR,PIM1,EGFR,FLT3,YES1,GSK3B,ALOX5,TP53,CA4,AXL,POLB,SRC
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
RECQL,EGFR,XDH,FLT3,AHR,APEX1,MET,CA12,CDK1,TDP1,AURKB,HCAR2,TYR,PIM1,KDR,CA7,HSD17B2,DPP4,SRC,MMP12,CSNK2A2,ALOX15,ALOX5,AXL
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
RECQL,THPO,HSD17B10,EGFR,ACHE,AHR,APEX1,MET,PSMB5,CA12,CDK1,TDP1,TP53,AURKB,AKR1B1,KDR,ESR2,SRC,CISD1,CSNK2A2,CSNK2A1,AXL,NOX4
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
RECQL,POLB,ACHE,XDH,TTR,MET,AURKB,HCAR2,PIM1,CYP1B1,CA7,HSD17B2,DPP4,CISD1,CA2,NPSR1,ALOX15,ALOX5,CYP2C9,AXL,ABCG2,HIF1A
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
ALOX12,XDH,AHR,APEX1,MET,PSMB5,CA12,CSNK2A3,TDP1,TP53,HCAR2,YES1,CYP1A2,HSD17B2,CISD1,MMP12,CA2,ALOX15,ALOX5,CSNK2A1,NOX4
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
ALOX12,ACHE,XDH,AHR,TTR,MET,HIF1A,CA12,CDK1,CA4,AKR1B1,KDR,HSD17B2,DPP4,TST,RAD52,NPSR1,ALOX5,CYP2C9,ABCG2,NOX4
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
POLB,HSD17B10,XDH,MET,PSMB5,TDP1,TP53,AKR1B1,AURKB,HCAR2,YES1,CA7,HSD17B2,DPP4,CISD1,MMP12,CA2,NPSR1,ALOX15,CYP19A1
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
NCT02737020,NCT02737033
|
Metabolic disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5D2Z |
DPP4
NCT00300365 |
Thyroid cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10 |
MET,KDR
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
ESR2,HCAR2
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
CYP19A1,AKR1B1
|
Hepatitis virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50-1E51 |
ESR2,EGFR
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
THPO
NCT00120289 |
Endometrial cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76 |
SRC,TP53
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
FLT3,CDK1
|
Cushing syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A70 |
ESR2,CYP19A1
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
XDH,ALOX5
|
Gastrointestinal stromal tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5B |
SRC,KDR
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
FLT3,ALOX5
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
SRC,ALOX5
|
Fallopian tube cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C74 |
TP53,SRC
|
IschemiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B10-8B11 |
SRC,EGFR
|
Unspecific body region injuryDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND56 |
EGFR,MET
|
OsteosarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B51 |
SRC,GSK3B
|
Motor neuron diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60 |
SRC,IGF1R
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
ALOX5,AHR
|
RetinopathyDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B71 |
IGF1R,APEX1
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
IGF1R,ALOX5
|
BCR-ABL1-negative chronic myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A41 |
FLT3,SRC
|
Malignant digestive organ neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C11 |
KDR,SRC
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
HCAR2
NCT00796887 |
Cervical cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C77 |
TP53,SRC
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04851821,NCT04853199
|
coronary artery diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Y-BA8Z |
NCT04907253,NCT03943459
|
Ageing associated decline in intrinsic capacityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG2A |
NCT04946383,NCT05422885
|
FlushingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME64.4 |
NCT00533611,NCT00536237
|
Single episode depressive disorder, severe, without psychotic symptomsDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70.3 |
NCT04630964,NCT03866174
|
Retinal vascular occlusionDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B74 |
NCT00500045,NCT00493064
|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT02018965,NCT00152893
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
NCT01708278,NCT03989271
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT00957359,NCT04733534
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
MMP12,HCAR2
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
PIM1,CYP2C9
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
AXL,ACHE
|
Dengue fever, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D2Z |
ABCG2,AURKB
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
CA4,ABCG2
|
Pneumonia due to PseudomonasaeruginosaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40.05 |
DPP4,MMP12
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
MMP12,CYP1A1
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
ABCG2,CYP1B1
|
Lyme borreliosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C1G |
MET,HCAR2
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
HCAR2
NCT01071291,NCT00728910,NCT00630877,NCT01104519,NCT00111891,NCT01984073,NCT02890992,NCT00903617,NCT00943124,NCT00664287,NCT03510884,NCT00626392,NCT00376584,NCT00944645,NCT00961636 |
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
ALOX12,IGF1R,HIF1A,CSNK2A3,CDK1,CA4,TP53,AKR1B1,AURKB,ESR2,SRC,MMP12,ALOX5,CSNK2A1,NOX4
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA12,IGF1R,MET,MKNK2,CA2,ESR2,SRC,CYP19A1,AXL,KDR,CDK1,EGFR,CA4,MKNK1
|
HypercholesterolaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80.0 |
NCT00378833,NCT00269217,NCT00652431,NCT00533312,NCT03510715,NCT01054508,NCT00080275,NCT01321034,NCT00769132,NCT00203476,NCT00271817,NCT00082251,NCT01071525,NCT00536510
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
HSD17B10,ACHE,FLT3,APEX1,PSMB5,AKR1B1,HCAR2,CYP1B1,HSD17B2,DPP4,CISD1,MMP12,ALOX15,CYP2C9
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CA12,CDK1,CA4,AURKB,MMP12,CYP19A1,NOX4,CA12,CDK1,SRC,AURKB,MMP12,CYP19A1
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
ALOX5,AURKB,ACHE,XDH,TYR,MET,CYP19A1,CYP2C9,AURKB,MMP12,ALOX5
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,CDK1,THPO,AURKB,MMP12,ACHE,XDH,NPSR1,CA7,CYP2C9,TTR
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CDK1,AURKB,MMP12,CA2,HCAR2,XDH,NPSR1,ALOX15,CYP2C9,HSD17B2,CYP1A1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CA12,CDK1,DPP4,NOX4,CA4,AURKB,MMP12,MET,CA7,CYP19A1,HSD17B2
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
CA12,CDK1,CA4,SRC,AKR1B1,AURKB,MMP12,IGF1R,CYP19A1,NOX4
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
CA12,CDK1,ALOX12,AURKB,HSD17B1,MMP12,XDH,NPSR1,CA7,CYP2C9
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CA12,DPP4,MMP12,HCAR2,XDH,CYP1B1,CA7,ALOX5,MET,NOX4
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
NCT01098318
|
FatigueDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG22 |
NCT01278992
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
HIF1A
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
ACHE
|
GoutDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA25 |
XDH
|
Hypopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6D |
EGFR
|
Duodenal ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA63 |
CA2
|
SepsisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G40-1G41 |
ESR2
|
FilariasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F66 |
ALOX5
|
Epidermal dysplasiasDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK90 |
SRC
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CA2
|
CardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43 |
TTR
|
Metastatic biliary tract neoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C14-2C17 |
EGFR
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
ABCG2
|
Ischemic heart diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40-BA6Z |
MET
|
Biliary tract cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C17 |
MET
|
Extraocular muscle disorderDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C82 |
IGF1R
|
Phakomatoses/hamartoneoplastic syndromeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD2D |
FLT3
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
LeiomyosarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B58 |
SRC
|
Malignant mesenchymal neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5D-2B5Y |
EGFR
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
SRC
|
Prostate hyperplasiaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA90 |
ESR2
|
Menopausal disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA30 |
ESR2
|
Transplanted organ/tissueDisease Category: 24.Factors influencing health status or contact with health servicesDisease ICD-11 Code: QB63 |
FLT3
|
Parasitic worm infestationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F90 |
ACHE
|
Unspecified viral infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D9Z |
FLT3
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
CA2
|
Inflammatory arthropathyDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA2Z |
FLT3
|
MastocytosisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A21 |
FLT3
|
Synovial sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B5A |
SRC
|
Colon cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
EGFR
|
DyslipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80-5C81 |
HCAR2
|
Myotonic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71 |
GSK3B
|
Coronavirus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D92 |
CSNK2A1
|
Ureteral cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C92 |
AHR
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
HIF1A
|
Inborn purine/pyrimidine/nucleotide metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C55 |
XDH
|
Carcinoid syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B10 |
ALOX5
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
EGFR
|
Ocular cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D00-2D07 |
APEX1
|
EncephalopathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E47 |
XDH
|
Diabetic foot ulcerDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD54 |
EGFR
|
Mineral deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B5K |
XDH
|
Metastatic malignant neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D50-2E09 |
AXL
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
ACHE
|
Testicular cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80 |
EGFR
|
Fragile X chromosomeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD55 |
GSK3B
|
Multiple structural anomalies syndromeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD2F |
IGF1R
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
DPP4
|
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
ACHE
|
Metastatic digestive system neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D8Y |
SRC
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
ALOX5
|
Diffuse large B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
FLT3
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
AKR1B1
|
OesophagitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA24 |
CYP19A1
|
Ovarian dysfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80 |
TP53
|
LiposarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B59 |
TP53
|
Esophageal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
TP53
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
AKR1B1
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
CYP19A1
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
AKR1B1
|
Transplant rejectionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE84 |
TP53
|
PediculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G00 |
ACHE
|
Skin postprocedural disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EL8Y |
EGFR
|
ThyrotoxicosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A02 |
IGF1R
|
Metastatic liver/bile duct neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D80 |
TP53
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
TP53
|
Lip/oral cavity/pharynx neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6E |
TP53
|
Oesophageal/gastroduodenal disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD90 |
ACHE
|
Vasomotor/allergic rhinitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA08 |
ESR2
|
Spinal cord/cranial nerve neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A02 |
EGFR
|
Intracerebral haemorrhageDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B00 |
EGFR
|
Human immunodeficiency virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C60-1C62 |
FLT3
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ACHE
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB90-DB9Z |
MET
|
Bone/articular cartilage neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F7B |
FLT3
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
ACHE
|
Urethral cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C93 |
EGFR
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
DPP4
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
CA2
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
ESR2
|
Chronic myelomonocytic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A40 |
FLT3
|
Kidney failureDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB60-GB6Z |
TP53
|
Digestive organ benign neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E92 |
KDR
|
AmyloidosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5D00 |
TTR
|
Malignant neoplasms of other or unspecified parts of mouthDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B66 |
NCT05456022
|
Congenital aplastic anaemiaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A70.0 |
NCT01720147
|
Malignant lymphoma, not elsewhere classifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33.5 |
NCT02702492
|
Gastro-oesophageal reflux diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA22 |
NCT02226484
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
NCT05276895
|
Macular degenerationDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B75 |
NCT05062486
|
Cerebrovascular diseases, unspecifiedDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B2Z |
NCT00000599
|
Follicular lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A80 |
NCT00455416
|
Human immunodeficiency virus type 1Disease Category: X.Extension CodesDisease ICD-11 Code: XN8LD |
NCT01426438
|
Asymptomatic stenosis of intracranial or extracranial arteryDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD55 |
NCT00000599
|
Nicotine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4A |
NCT05452772
|
Aortic valve stenosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB70 |
NCT02109614
|
HIV-infected patients with tuberculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1B10-1B14 |
NCT00170404
|
Sickle-cell disorderDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A51 |
NCT00508989
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Glioblastoma, primary, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH0MB1 |
NCT04677049
|
Chronic hepatitis CDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E51.1 |
NCT01438320
|
Schizophrenia or other primary psychotic disorders, unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A2Z |
NCT01720095
|
Cystic fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA25 |
NCT01348204
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
NCT01083329
|
Lichen planusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA91 |
NCT01375101
|
Atherosclerotic chronic arterial occlusive disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD40.Z |
NCT00804843
|
Post-traumatic stress disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B40 |
NCT03752918
|
Obsessive-compulsive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B20 |
NCT03356483
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
MMP12
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
CYP1A1
|
KeratoconusDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A78.50 |
CA4
|
Pre-eclampsiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA24 |
CA4
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
NOX4
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
MMP12
|
Dilated cardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43.0 |
ABCG2
|
Malaria, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F4Z |
HCAR2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
Plant-Targeted Human Disease Network
>> Targets derived from weak experimental activities
