Collective Molecular Activities of the Plant: Actaea Cimicifuga
Country/Region:
IndiaTraditional Medicine System:
Indian FolkIndia; Kazakhstan; China; Mongolia; South Africa
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
201 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
136 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
120 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99886
Ingredient ID: NPC97260
Ingredient ID: NPC96835
Ingredient ID: NPC96630
Ingredient ID: NPC94885
Ingredient ID: NPC92788
Ingredient ID: NPC90232
Ingredient ID: NPC89422
Ingredient ID: NPC89069
Ingredient ID: NPC84030
Ingredient ID: NPC82295
Ingredient ID: NPC78500
Ingredient ID: NPC75158
Ingredient ID: NPC73385
Ingredient ID: NPC70744
Ingredient ID: NPC70741
Ingredient ID: NPC68889
Ingredient ID: NPC68842
Ingredient ID: NPC68438
Ingredient ID: NPC67761
Ingredient ID: NPC67180
Ingredient ID: NPC66681
Ingredient ID: NPC66655
Ingredient ID: NPC65871
Ingredient ID: NPC60253
Ingredient ID: NPC59581
Ingredient ID: NPC59570
Ingredient ID: NPC54733
Ingredient ID: NPC53884
Ingredient ID: NPC53720
Ingredient ID: NPC51758
Ingredient ID: NPC49151
Ingredient ID: NPC49150
Ingredient ID: NPC478630
Ingredient ID: NPC478629
Ingredient ID: NPC478628
Ingredient ID: NPC478627
Ingredient ID: NPC478626
Ingredient ID: NPC478625
Ingredient ID: NPC478624
Ingredient ID: NPC478623
Ingredient ID: NPC478622
Ingredient ID: NPC478621
Ingredient ID: NPC478620
Ingredient ID: NPC478619
Ingredient ID: NPC478618
Ingredient ID: NPC47768
Ingredient ID: NPC46221
Ingredient ID: NPC45270
Ingredient ID: NPC45249
Ingredient ID: NPC43728
Ingredient ID: NPC42471
Ingredient ID: NPC4079
Ingredient ID: NPC38497
Ingredient ID: NPC3780
Ingredient ID: NPC37644
Ingredient ID: NPC37145
Ingredient ID: NPC37084
Ingredient ID: NPC36108
Ingredient ID: NPC312328
Ingredient ID: NPC310478
Ingredient ID: NPC308418
Ingredient ID: NPC308218
Ingredient ID: NPC301696
Ingredient ID: NPC301585
Ingredient ID: NPC300326
Ingredient ID: NPC29939
Ingredient ID: NPC29929
Ingredient ID: NPC298504
Ingredient ID: NPC294902
Ingredient ID: NPC294697
Ingredient ID: NPC293391
Ingredient ID: NPC292924
Ingredient ID: NPC292792
Ingredient ID: NPC292346
Ingredient ID: NPC291517
Ingredient ID: NPC291255
Ingredient ID: NPC289609
Ingredient ID: NPC287643
Ingredient ID: NPC287550
Ingredient ID: NPC286987
Ingredient ID: NPC286904
Ingredient ID: NPC284731
Ingredient ID: NPC284409
Ingredient ID: NPC283932
Ingredient ID: NPC283655
Ingredient ID: NPC283081
Ingredient ID: NPC278782
Ingredient ID: NPC278683
Ingredient ID: NPC277907
Ingredient ID: NPC271535
Ingredient ID: NPC26906
Ingredient ID: NPC265853
Ingredient ID: NPC264779
Ingredient ID: NPC262505
Ingredient ID: NPC26116
Ingredient ID: NPC261080
Ingredient ID: NPC259134
Ingredient ID: NPC258671
Ingredient ID: NPC257124
Ingredient ID: NPC25542
Ingredient ID: NPC255042
Ingredient ID: NPC253524
Ingredient ID: NPC250013
Ingredient ID: NPC246214
Ingredient ID: NPC239880
Ingredient ID: NPC239147
Ingredient ID: NPC236355
Ingredient ID: NPC235059
Ingredient ID: NPC233533
Ingredient ID: NPC228059
Ingredient ID: NPC226250
Ingredient ID: NPC223468
Ingredient ID: NPC221383
Ingredient ID: NPC219969
Ingredient ID: NPC219113
Ingredient ID: NPC217226
Ingredient ID: NPC216630
Ingredient ID: NPC216127
Ingredient ID: NPC214584
Ingredient ID: NPC212660
Ingredient ID: NPC211363
Ingredient ID: NPC209279
Ingredient ID: NPC208936
Ingredient ID: NPC208075
Ingredient ID: NPC206132
Ingredient ID: NPC204120
Ingredient ID: NPC202494
Ingredient ID: NPC201844
Ingredient ID: NPC196490
Ingredient ID: NPC194586
Ingredient ID: NPC193252
Ingredient ID: NPC191758
Ingredient ID: NPC190961
Ingredient ID: NPC190771
Ingredient ID: NPC189036
Ingredient ID: NPC188813
Ingredient ID: NPC187061
Ingredient ID: NPC186098
Ingredient ID: NPC186045
Ingredient ID: NPC183683
Ingredient ID: NPC182840
Ingredient ID: NPC18205
Ingredient ID: NPC180871
Ingredient ID: NPC180684
Ingredient ID: NPC179505
Ingredient ID: NPC179265
Ingredient ID: NPC1788
Ingredient ID: NPC178382
Ingredient ID: NPC178223
Ingredient ID: NPC176309
Ingredient ID: NPC175342
Ingredient ID: NPC174368
Ingredient ID: NPC171783
Ingredient ID: NPC170814
Ingredient ID: NPC169222
Ingredient ID: NPC168855
Ingredient ID: NPC166894
Ingredient ID: NPC1656
Ingredient ID: NPC165163
Ingredient ID: NPC164706
Ingredient ID: NPC163556
Ingredient ID: NPC161617
Ingredient ID: NPC161097
Ingredient ID: NPC159606
Ingredient ID: NPC155263
Ingredient ID: NPC154792
Ingredient ID: NPC154186
Ingredient ID: NPC152899
Ingredient ID: NPC151675
Ingredient ID: NPC150420
Ingredient ID: NPC149355
Ingredient ID: NPC14917
Ingredient ID: NPC147787
Ingredient ID: NPC147601
Ingredient ID: NPC147343
Ingredient ID: NPC14682
Ingredient ID: NPC14432
Ingredient ID: NPC139546
Ingredient ID: NPC137949
Ingredient ID: NPC137153
Ingredient ID: NPC135353
Ingredient ID: NPC135077
Ingredient ID: NPC134967
Ingredient ID: NPC133600
Ingredient ID: NPC130059
Ingredient ID: NPC12987
Ingredient ID: NPC125144
Ingredient ID: NPC124436
Ingredient ID: NPC119090
Ingredient ID: NPC115301
Ingredient ID: NPC114784
Ingredient ID: NPC114325
Ingredient ID: NPC11232
Ingredient ID: NPC108494
Ingredient ID: NPC108218
Ingredient ID: NPC1075
Ingredient ID: NPC105329
Ingredient ID: NPC104514
Ingredient ID: NPC100980
Ingredient ID: NPC100551
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
| Therapeutic Target | Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Therapeutic Target | Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 67 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00001986 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00016679 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00080366 | Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00102596 | Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00299559 | Kinetics of Etheric Oils, Smart Textiles vs. Ointment | common cold | Menthol (NPC223468) | NP level |
| NCT00361322 | Efficacy and Safety of a Preparation Containing an Antibiotic and Anti-Inflammatory Agent in Acne Vulgaris | acne | Salicylic Acid (NPC100551) | NP level |
| NCT00425074 | Pharmacodynamic-pharmacokinetic Trial, of Slow Release ASA, in the Platelet Functionalism. | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT00501059 | A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT00501254 | Pharmacodynamic Trial, of Slow Release ASA, in Platelet Functionalism, a Long Term Treatment Period | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT00848172 | Double-Blind, Placebo Controlled Pilot Study of Octanoic Acid in Essential Tremor | essential tremor | Octanoic Acid (NPC301696) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
NCT03832647,NCT00361322,NCT01706250,NCT04490967,NCT02755545,NCT01706263,NCT02524665 |
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT02289768
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
FFAR1
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT01294462
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53,NFKB1
NCT02472626 |
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,ACHE,TSHR,MMP9,CA9,MMP1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,SNCA,LMNA,MMP2,OR51E2,CA9,MMP1,NAPRT
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2,FABP5
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
MMP1,MMP9
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
