CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Hypoxis Nyasica

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO15748
Plant Latin Name: Hypoxis Nyasica
Taxonomy Genus: Hypoxis
Taxonomy Family: Hypoxidaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: 65498-1

Used in Medicines

Unknown.

Geographical Distribution

Tanzania; Zimbabwe; Mozambique; Malawi; Zambia

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

115 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

88 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

45 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC96613

Ingredient ID: NPC90232

Ingredient ID: NPC85813

Ingredient ID: NPC84771

Ingredient ID: NPC83702

Ingredient ID: NPC77249

Ingredient ID: NPC76314

Ingredient ID: NPC71394

Ingredient ID: NPC69871

Ingredient ID: NPC68267

Ingredient ID: NPC57801

Ingredient ID: NPC56448

Ingredient ID: NPC4465

Ingredient ID: NPC43520

Ingredient ID: NPC43360

Ingredient ID: NPC37132

Ingredient ID: NPC3707

Ingredient ID: NPC34903

Ingredient ID: NPC307945

Ingredient ID: NPC3016

Ingredient ID: NPC301585

Ingredient ID: NPC299505

Ingredient ID: NPC298802

Ingredient ID: NPC297117

Ingredient ID: NPC29678

Ingredient ID: NPC294548

Ingredient ID: NPC293249

Ingredient ID: NPC292825

Ingredient ID: NPC28657

Ingredient ID: NPC286052

Ingredient ID: NPC283011

Ingredient ID: NPC279974

Ingredient ID: NPC274729

Ingredient ID: NPC27407

Ingredient ID: NPC27349

Ingredient ID: NPC27243

Ingredient ID: NPC26974

Ingredient ID: NPC267741

Ingredient ID: NPC266359

Ingredient ID: NPC264833

Ingredient ID: NPC263785

Ingredient ID: NPC26229

Ingredient ID: NPC261831

Ingredient ID: NPC260691

Ingredient ID: NPC258220

Ingredient ID: NPC257383

Ingredient ID: NPC255647

Ingredient ID: NPC249578

Ingredient ID: NPC249194

Ingredient ID: NPC247835

Ingredient ID: NPC243728

Ingredient ID: NPC23925

Ingredient ID: NPC238041

Ingredient ID: NPC233481

Ingredient ID: NPC230923

Ingredient ID: NPC23046

Ingredient ID: NPC230301

Ingredient ID: NPC229216

Ingredient ID: NPC228906

Ingredient ID: NPC22260

Ingredient ID: NPC222153

Ingredient ID: NPC222147

Ingredient ID: NPC220759

Ingredient ID: NPC219560

Ingredient ID: NPC217914

Ingredient ID: NPC216630

Ingredient ID: NPC216187

Ingredient ID: NPC216127

Ingredient ID: NPC2114

Ingredient ID: NPC209970

Ingredient ID: NPC207632

Ingredient ID: NPC202651

Ingredient ID: NPC201950

Ingredient ID: NPC201844

Ingredient ID: NPC199773

Ingredient ID: NPC196924

Ingredient ID: NPC196370

Ingredient ID: NPC196227

Ingredient ID: NPC19404

Ingredient ID: NPC189092

Ingredient ID: NPC187445

Ingredient ID: NPC179798

Ingredient ID: NPC17599

Ingredient ID: NPC168030

Ingredient ID: NPC163755

Ingredient ID: NPC162742

Ingredient ID: NPC158963

Ingredient ID: NPC155461

Ingredient ID: NPC154186

Ingredient ID: NPC153958

Ingredient ID: NPC151250

Ingredient ID: NPC149184

Ingredient ID: NPC148403

Ingredient ID: NPC145444

Ingredient ID: NPC145277

Ingredient ID: NPC143008

Ingredient ID: NPC142349

Ingredient ID: NPC142027

Ingredient ID: NPC139473

Ingredient ID: NPC138222

Ingredient ID: NPC136932

Ingredient ID: NPC126750

Ingredient ID: NPC126503

Ingredient ID: NPC123965

Ingredient ID: NPC120151

Ingredient ID: NPC119802

Ingredient ID: NPC119036

Ingredient ID: NPC116726

Ingredient ID: NPC113733

Ingredient ID: NPC107860

Ingredient ID: NPC107629

Ingredient ID: NPC106770

Ingredient ID: NPC105354

Ingredient ID: NPC105267

Ingredient ID: NPC104050

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

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Search:

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Enzyme	AKR1C3	Aldo-keto-reductase family 1 member C3	P42330	CHEMBL4681
Therapeutic Target	Fatty acid binding protein family	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Therapeutic Target	Fatty acid binding protein family	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Therapeutic Target	Nuclear hormone receptor subfamily 1	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Therapeutic Target	Nuclear hormone receptor subfamily 1	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Therapeutic Target	Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Therapeutic Target	Oxidoreductase	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Therapeutic Target	Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Therapeutic Target	Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 10 of 10 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	13

Clinical trial details

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Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00009841	Gene Therapy in Treating Patients With Advanced Head and Neck Cancer	head and neck malignant neoplasia	Cholesterol (NPC28657)	NP level
NCT00029679	Borage Oil and Ginkgo Biloba (EGb 761) in Asthma	asthma	Linoleic Acid (NPC85813)	NP level
NCT00204932	Effects of CLA Supplements on Body Weight and Fat Oxidation	obesity	Linoleic Acid (NPC85813)	NP level
NCT00272844	Treatment of the Cholesterol Defect in Smith-Lemli-Opitz Syndrome	Smith-Lemli-Opitz syndrome	Cholesterol (NPC28657)	NP level
NCT00607945	Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus	type 2 diabetes mellitus	Linoleic Acid (NPC85813)	NP level
NCT00638196	Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS	multiple sclerosis	Oleic Acid (NPC261831)	NP level
NCT00908791	Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue	breast cancer	Linoleic Acid (NPC85813)	NP level
NCT00951158	A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors	neoplasm	Linoleic Acid (NPC85813)	NP level
NCT00965068	Cholesterol in ASD: Characterization and Treatment	Asperger syndrome;autism	Cholesterol (NPC28657)	NP level
NCT01661764	Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention	colorectal adenoma	Oleic Acid (NPC261831)	NP level

Showing 1 to 10 of 13 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Show entries

Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	FFAR1,PPARA
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	F2,TSHR,AKR1C3,NR1I2
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	OR51E2,F2,FFAR4,AKR1C3,NR1I2,PTGS2,FABP3,ALOX15,LMNA
Adenocarcinoma of prostate Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82.0	OR51E2,ALOX15,FABP5
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	F2,ALOX15
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	PTGS2
Angina pectoris Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA40	F2
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	PTGS2,F2 NCT00029679
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	PTGS2
Autism spectrum disorder without disorder of intellectual development and with mild or no impairment of functional language Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A02.0	NCT00965068

Showing 1 to 10 of 108 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Hypoxis Nyasica

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

115 All known Ingredients in Total

88 Ingredients with Acceptable Bioavailablity

45 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Acute diabete complication

Adenocarcinoma of bronchus or lung

Adenocarcinoma of pancreas

Adenocarcinoma of prostate

Adenocarcinoma of stomach

Alzheimer disease

Angina pectoris

Asthma

Atopic eczema

Autism spectrum disorder without disorder of intellectual development and with mild or no impairment of functional language

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities