Collective Molecular Activities of the Plant: Luffa Aegyptiaca
Country/Region:
Brazil; Madagascar; Angola; South Africa; Indonesia; India; Congo; Zimbabwe; Jordan; Swaziland; Thailand; South KoreaTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Ayurveda; SiddhaBrazil; Madagascar; Bangladesh; Liberia; Sudan; Guinea; Cambodia; Malawi; Ethiopia; Rwanda; Somalia; Swaziland; Vanuatu; Nigeria; Bolivia; Cameroon; Cote d'Ivoire; Benin; Ghana; Cuba; Thailand; Venezuela; Senegal; Burkina Faso; Zimbabwe; China; Jordan; Dominican Republic; Sierra Leone; Eritrea; Netherlands; Uganda; Gambia; Tanzania; Indonesia; New Caledonia; Mauritius; Trinidad and Tobago; Mauritania; Gabon; South Korea; Guinea-Bissau; Mali; Yemen; Haiti; Jamaica; Albania; Angola; Chad; Mexico; South Africa; India; Djibouti; Congo; Mozambique; Colombia; Burundi; Kenya; Niger; Fiji; Zambia
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
59 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
28 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
32 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC94167
Ingredient ID: NPC85813
Ingredient ID: NPC84113
Ingredient ID: NPC81010
Ingredient ID: NPC75871
Ingredient ID: NPC74259
Ingredient ID: NPC73143
Ingredient ID: NPC72260
Ingredient ID: NPC68357
Ingredient ID: NPC60056
Ingredient ID: NPC5785
Ingredient ID: NPC55412
Ingredient ID: NPC489907
Ingredient ID: NPC48357
Ingredient ID: NPC41586
Ingredient ID: NPC32977
Ingredient ID: NPC328447
Ingredient ID: NPC308492
Ingredient ID: NPC298869
Ingredient ID: NPC293714
Ingredient ID: NPC288816
Ingredient ID: NPC279121
Ingredient ID: NPC270946
Ingredient ID: NPC269919
Ingredient ID: NPC261831
Ingredient ID: NPC242580
Ingredient ID: NPC237067
Ingredient ID: NPC236357
Ingredient ID: NPC231518
Ingredient ID: NPC221144
Ingredient ID: NPC216802
Ingredient ID: NPC211662
Ingredient ID: NPC210080
Ingredient ID: NPC208193
Ingredient ID: NPC20791
Ingredient ID: NPC199039
Ingredient ID: NPC197901
Ingredient ID: NPC193893
Ingredient ID: NPC187770
Ingredient ID: NPC17810
Ingredient ID: NPC177059
Ingredient ID: NPC173555
Ingredient ID: NPC169749
Ingredient ID: NPC1682
Ingredient ID: NPC167400
Ingredient ID: NPC167072
Ingredient ID: NPC15598
Ingredient ID: NPC150950
Ingredient ID: NPC147983
Ingredient ID: NPC147543
Ingredient ID: NPC146787
Ingredient ID: NPC138125
Ingredient ID: NPC136781
Ingredient ID: NPC136014
Ingredient ID: NPC133856
Ingredient ID: NPC130683
Ingredient ID: NPC120635
Ingredient ID: NPC117706
Ingredient ID: NPC117445
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO4C1 | Solute carrier organic anion transporter family member 4C1 | Q6ZQN7 | CHEMBL2073690 |
| Therapeutic Target | Cysteine protease | CASP6 | Caspase-6 | P55212 | CHEMBL3308 |
| Therapeutic Target | Enzyme | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 495 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | NP level |
| NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract | Beta Carotene (NPC17810);Ascorbate (NPC187770) | NP level |
| NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | macular degeneration | Ascorbate (NPC187770);Beta Carotene (NPC17810) | NP level |
| NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | NP level |
| NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Ascorbate (NPC187770) | NP level |
| NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction | Folic Acid (NPC147983);Beta Carotene (NPC17810);Ascorbate (NPC187770);Pyridoxine (NPC269919) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT03090048,NCT03522922
|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT03684772
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
FFAR1,DPP4,AURKB,KDR,PPARA,AKR1B1
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53,SRC,AXL,AURKB,FLT3,GSK3B,TOP2A,PIM1,MAPT
NCT00184054,NCT00329498,NCT03113071 |
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT03624270
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT03718507,NCT04404387
|
Acute upper respiratory infectionDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA07 |
STAT3
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
NPSR1,CA7,AKR1C3,MMP12,CA12,SLCO1B1,AURKB,TOP2A,ACHE,CDK1,XDH
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ALOX5,CYP1B1,NPSR1,ITGAL,CA7,FFAR4,ALOX15,AKR1C3,FABP3,APP,ABCG2,SNCA,PIM1,RECQL,DPP4,NPC1,POLB,HIF1A,PAX8,CA2,LMNA,AXL,HCAR2,AURKB,MET,ACHE,GSTP1,XDH
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
