Collective Molecular Activities of the Plant: Angelica Decursiva
Plant ID: NPO15394
Plant Latin Name: Angelica Decursiva
Taxonomy Genus: Angelica
Taxonomy Family: Apiaceae
Plant External Links:
NCBI TaxonomyDB:
52491
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Analgesic; Antiarthritic; Antiseptic; Antispasmodic; Carminative; Expectorant; Lenitive; Stimulant; Stomachic; Tonic
China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
101 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
90 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
54 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98179
Ingredient ID: NPC98028
Ingredient ID: NPC93241
Ingredient ID: NPC91226
Ingredient ID: NPC88461
Ingredient ID: NPC86892
Ingredient ID: NPC86412
Ingredient ID: NPC85295
Ingredient ID: NPC78094
Ingredient ID: NPC76753
Ingredient ID: NPC76336
Ingredient ID: NPC7526
Ingredient ID: NPC74539
Ingredient ID: NPC71853
Ingredient ID: NPC63355
Ingredient ID: NPC55615
Ingredient ID: NPC55149
Ingredient ID: NPC49074
Ingredient ID: NPC47163
Ingredient ID: NPC40070
Ingredient ID: NPC37708
Ingredient ID: NPC33320
Ingredient ID: NPC325450
Ingredient ID: NPC323861
Ingredient ID: NPC32095
Ingredient ID: NPC319389
Ingredient ID: NPC312881
Ingredient ID: NPC31194
Ingredient ID: NPC308383
Ingredient ID: NPC306858
Ingredient ID: NPC305007
Ingredient ID: NPC301224
Ingredient ID: NPC301055
Ingredient ID: NPC300274
Ingredient ID: NPC297472
Ingredient ID: NPC296624
Ingredient ID: NPC296377
Ingredient ID: NPC294707
Ingredient ID: NPC294456
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC289785
Ingredient ID: NPC281398
Ingredient ID: NPC281014
Ingredient ID: NPC279325
Ingredient ID: NPC276761
Ingredient ID: NPC267412
Ingredient ID: NPC253574
Ingredient ID: NPC248884
Ingredient ID: NPC247553
Ingredient ID: NPC243728
Ingredient ID: NPC243688
Ingredient ID: NPC24355
Ingredient ID: NPC243546
Ingredient ID: NPC243509
Ingredient ID: NPC234536
Ingredient ID: NPC232548
Ingredient ID: NPC230301
Ingredient ID: NPC230091
Ingredient ID: NPC225804
Ingredient ID: NPC225106
Ingredient ID: NPC224194
Ingredient ID: NPC222843
Ingredient ID: NPC222036
Ingredient ID: NPC218482
Ingredient ID: NPC216630
Ingredient ID: NPC215519
Ingredient ID: NPC215512
Ingredient ID: NPC215179
Ingredient ID: NPC214224
Ingredient ID: NPC212124
Ingredient ID: NPC206490
Ingredient ID: NPC206452
Ingredient ID: NPC204353
Ingredient ID: NPC199658
Ingredient ID: NPC198381
Ingredient ID: NPC195343
Ingredient ID: NPC187145
Ingredient ID: NPC184861
Ingredient ID: NPC183054
Ingredient ID: NPC175941
Ingredient ID: NPC175051
Ingredient ID: NPC169510
Ingredient ID: NPC165967
Ingredient ID: NPC165641
Ingredient ID: NPC164269
Ingredient ID: NPC163533
Ingredient ID: NPC160240
Ingredient ID: NPC156461
Ingredient ID: NPC149209
Ingredient ID: NPC148638
Ingredient ID: NPC139891
Ingredient ID: NPC138460
Ingredient ID: NPC137115
Ingredient ID: NPC135295
Ingredient ID: NPC135073
Ingredient ID: NPC133956
Ingredient ID: NPC128633
Ingredient ID: NPC113733
Ingredient ID: NPC102511
Ingredient ID: NPC100285
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2A13 | Cytochrome P450 2A13 | Q16696 | CHEMBL3542436 |
| Therapeutic Target | Cysteine protease | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Therapeutic Target | Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Therapeutic Target | Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Therapeutic Target | Enzyme | BRCA1 | Breast cancer type 1 susceptibility protein | P38398 | CHEMBL5990 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Hydrolase | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 90 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00004359 | Phase II Pilot Study of Extracorporeal Phototherapy for Epidermolysis Bullosa Acquisita | epidermolysis bullosa acquisita | Methoxsalen (NPC33320) | NP level |
| NCT00030589 | Chemotherapy and Photodynamic Therapy in Treating Patients With Cutaneous T-Cell Lymphoma | lymphoma | Methoxsalen (NPC33320) | NP level |
| NCT00054600 | Safety and Efficacy Study of Photopheresis With UVADEX to Prevent Graft-versus-Host Disease | graft versus host disease | Methoxsalen (NPC33320) | NP level |
| NCT00054613 | Safety and Efficacy Study of Photopheresis Plus Standard Therapy to Treat Chronic Graft-versus-Host Disease | graft versus host disease | Methoxsalen (NPC33320) | NP level |
| NCT00056056 | Ultraviolet Light Therapy Using Methoxsalen With or Without Bexarotene in Treating Patients With Mycosis Fungoides | lymphoma | Methoxsalen (NPC33320) | NP level |
| NCT00056355 | Extracorporeal Photopheresis to Maintain Symptoms Remission During Steroid Withdrawal in Patients With Steroid-Dependent Crohn's Disease | Crohn's disease | Methoxsalen (NPC33320) | NP level |
| NCT00113854 | Mannitol as Adjunct Therapy for Childhood Cerebral Malaria | malaria | Mannitol (NPC86412) | NP level |
| NCT00117208 | Comparison of Inhaled Mannitol and rhDNase in Children With Cystic Fibrosis | cystic fibrosis | Mannitol (NPC86412) | NP level |
| NCT00179010 | AMP as a Better Delivery System of Adenosine | ischemia | Adenosine (NPC156461) | NP level |
| NCT00189007 | Antenatal Allopurinol During Fetal Hypoxia | fetal hypoxia | Mannitol (NPC86412) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TERT,TP53
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00781404
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04588441
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT01747174,NCT00284323
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,CA12,CA9,TERT,BRCA1,F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ADORA3,ACHE,CYP1B1,CA9,TERT,ADORA2A,OR51E2,BRCA1,NPC1,CA14,CASP1,F2,CES2,LMNA
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
TERT,OR51E2,FABP5
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
TERT,BRCA1,F2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
NCT01123525,NCT00751491 |
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
