Collective Molecular Activities of the Plant: Actaea Dahurica
Plant ID: NPO15373
Plant Latin Name: Actaea Dahurica
Taxonomy Genus: Actaea
Taxonomy Family: Ranunculaceae
Plant External Links:
NCBI TaxonomyDB:
64029
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
206 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
137 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
118 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99886
Ingredient ID: NPC97260
Ingredient ID: NPC96835
Ingredient ID: NPC96630
Ingredient ID: NPC94885
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Ingredient ID: NPC90232
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Ingredient ID: NPC78500
Ingredient ID: NPC75158
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Ingredient ID: NPC70744
Ingredient ID: NPC68889
Ingredient ID: NPC68842
Ingredient ID: NPC68438
Ingredient ID: NPC67761
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Ingredient ID: NPC65871
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Ingredient ID: NPC301696
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Ingredient ID: NPC184145
Ingredient ID: NPC183683
Ingredient ID: NPC183285
Ingredient ID: NPC182840
Ingredient ID: NPC18205
Ingredient ID: NPC180871
Ingredient ID: NPC180684
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Ingredient ID: NPC178382
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Ingredient ID: NPC174368
Ingredient ID: NPC171783
Ingredient ID: NPC169222
Ingredient ID: NPC168855
Ingredient ID: NPC166894
Ingredient ID: NPC1656
Ingredient ID: NPC165163
Ingredient ID: NPC164706
Ingredient ID: NPC163556
Ingredient ID: NPC161617
Ingredient ID: NPC161097
Ingredient ID: NPC159606
Ingredient ID: NPC158707
Ingredient ID: NPC155263
Ingredient ID: NPC154792
Ingredient ID: NPC154186
Ingredient ID: NPC152899
Ingredient ID: NPC151675
Ingredient ID: NPC150420
Ingredient ID: NPC14917
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Ingredient ID: NPC133600
Ingredient ID: NPC130059
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Ingredient ID: NPC125144
Ingredient ID: NPC124436
Ingredient ID: NPC119090
Ingredient ID: NPC115301
Ingredient ID: NPC114784
Ingredient ID: NPC114325
Ingredient ID: NPC114268
Ingredient ID: NPC11232
Ingredient ID: NPC108494
Ingredient ID: NPC108218
Ingredient ID: NPC107907
Ingredient ID: NPC1075
Ingredient ID: NPC105329
Ingredient ID: NPC104514
Ingredient ID: NPC100980
Ingredient ID: NPC100551
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
| Therapeutic Target | Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Therapeutic Target | Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Therapeutic Target | Oxidoreductase | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Therapeutic Target | Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Therapeutic Target | Serine protease | EPHX2 | Epoxide hydratase | P34913 | CHEMBL2409 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 67 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00001986 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00016679 | 1-Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00080366 | Octanol to Treat Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00102596 | Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor | essential tremor | Octanol (NPC163556) | NP level |
| NCT00299559 | Kinetics of Etheric Oils, Smart Textiles vs. Ointment | common cold | Menthol (NPC223468) | NP level |
| NCT00361322 | Efficacy and Safety of a Preparation Containing an Antibiotic and Anti-Inflammatory Agent in Acne Vulgaris | acne | Salicylic Acid (NPC100551) | NP level |
| NCT00425074 | Pharmacodynamic-pharmacokinetic Trial, of Slow Release ASA, in the Platelet Functionalism. | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT00501059 | A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT00501254 | Pharmacodynamic Trial, of Slow Release ASA, in Platelet Functionalism, a Long Term Treatment Period | cardiovascular disease | Salicylic Acid (NPC100551) | NP level |
| NCT00848172 | Double-Blind, Placebo Controlled Pilot Study of Octanoic Acid in Essential Tremor | essential tremor | Octanoic Acid (NPC301696) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
NCT02755545,NCT04490967,NCT00361322,NCT03832647,NCT01706250,NCT01706263,NCT02524665 |
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT02289768
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
FFAR1
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT01294462
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,TP53
NCT02472626 |
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,TSHR,CA9,MMP9,ACHE,MMP1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
OR51E2,MMP2,CA9,ALOX5,ACHE,SNCA,NAPRT,MMP1,LMNA
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2,FABP5
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
MMP9,MMP1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
