Collective Molecular Activities of the Plant: Jatropha Gossypiifolia
Plant ID: NPO1534
Plant Latin Name: Jatropha Gossypiifolia
Taxonomy Genus: Jatropha
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
454931
Plant-of-the-World-Online:
n.a.
Country/Region:
Ghana; Malaysia; Philippines; Indonesia; India; Togo; Vietnam; Laos; ThailandTraditional Medicine System:
Ghana; Togo; Philippines; Indonesia; India; Malaysia; Vietnam; Laos; Thailand
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
112 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
79 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
26 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99182
Ingredient ID: NPC94758
Ingredient ID: NPC90062
Ingredient ID: NPC88382
Ingredient ID: NPC8621
Ingredient ID: NPC81316
Ingredient ID: NPC80448
Ingredient ID: NPC79571
Ingredient ID: NPC78631
Ingredient ID: NPC75844
Ingredient ID: NPC7278
Ingredient ID: NPC7059
Ingredient ID: NPC70081
Ingredient ID: NPC67650
Ingredient ID: NPC664
Ingredient ID: NPC61954
Ingredient ID: NPC59668
Ingredient ID: NPC58865
Ingredient ID: NPC55233
Ingredient ID: NPC53119
Ingredient ID: NPC483332
Ingredient ID: NPC483331
Ingredient ID: NPC483330
Ingredient ID: NPC483329
Ingredient ID: NPC483328
Ingredient ID: NPC483327
Ingredient ID: NPC483326
Ingredient ID: NPC483325
Ingredient ID: NPC483324
Ingredient ID: NPC483323
Ingredient ID: NPC483322
Ingredient ID: NPC43160
Ingredient ID: NPC41728
Ingredient ID: NPC41689
Ingredient ID: NPC40000
Ingredient ID: NPC36922
Ingredient ID: NPC36856
Ingredient ID: NPC36352
Ingredient ID: NPC34687
Ingredient ID: NPC33406
Ingredient ID: NPC309655
Ingredient ID: NPC30896
Ingredient ID: NPC30654
Ingredient ID: NPC306418
Ingredient ID: NPC300342
Ingredient ID: NPC296558
Ingredient ID: NPC295723
Ingredient ID: NPC293201
Ingredient ID: NPC280284
Ingredient ID: NPC278556
Ingredient ID: NPC27838
Ingredient ID: NPC277205
Ingredient ID: NPC274152
Ingredient ID: NPC273423
Ingredient ID: NPC269207
Ingredient ID: NPC265411
Ingredient ID: NPC264428
Ingredient ID: NPC263337
Ingredient ID: NPC256899
Ingredient ID: NPC25257
Ingredient ID: NPC25141
Ingredient ID: NPC244088
Ingredient ID: NPC242383
Ingredient ID: NPC241202
Ingredient ID: NPC238428
Ingredient ID: NPC23695
Ingredient ID: NPC232977
Ingredient ID: NPC231410
Ingredient ID: NPC230301
Ingredient ID: NPC225178
Ingredient ID: NPC221774
Ingredient ID: NPC221661
Ingredient ID: NPC211074
Ingredient ID: NPC210934
Ingredient ID: NPC210688
Ingredient ID: NPC210450
Ingredient ID: NPC208392
Ingredient ID: NPC207362
Ingredient ID: NPC205468
Ingredient ID: NPC205125
Ingredient ID: NPC204868
Ingredient ID: NPC200505
Ingredient ID: NPC197219
Ingredient ID: NPC194208
Ingredient ID: NPC188947
Ingredient ID: NPC187870
Ingredient ID: NPC184049
Ingredient ID: NPC181540
Ingredient ID: NPC180300
Ingredient ID: NPC171505
Ingredient ID: NPC164727
Ingredient ID: NPC159362
Ingredient ID: NPC157776
Ingredient ID: NPC149203
Ingredient ID: NPC144054
Ingredient ID: NPC141944
Ingredient ID: NPC130913
Ingredient ID: NPC125269
Ingredient ID: NPC125108
Ingredient ID: NPC12483
Ingredient ID: NPC124588
Ingredient ID: NPC120744
Ingredient ID: NPC119663
Ingredient ID: NPC118968
Ingredient ID: NPC114014
Ingredient ID: NPC110396
Ingredient ID: NPC110250
Ingredient ID: NPC107662
Ingredient ID: NPC106047
Ingredient ID: NPC10331
Ingredient ID: NPC102895
Ingredient ID: NPC101680
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Therapeutic Target | Secreted protein | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 1215 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000122 | Fluorouracil Filtering Surgery Study (FFSS) | glaucoma | Fluorouracil (NPC75844) | NP level |
| NCT00000758 | A Phase III Randomized Trial of Topical Vaginal Fluorouracil (5-Fluorouracil, 5-FU) Maintenance Therapy Versus Observation After Standard Treatment for High-Grade Cervical Dysplasia in HIV-Infected Women | dysplasia of cervix | Fluorouracil (NPC75844) | NP level |
| NCT00001428 | A Phase II Study of 5-Fluorouracil Administered as a One Hour Infusion in Combination With Calcium Leucovorin and Interferon Alpha-2A in Advanced Colorectal Cancer | colorectal neoplasm | Fluorouracil (NPC75844) | NP level |
| NCT00001498 | A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With Peripheral Blood Progenitor Cell Support, and Intensification With Paclitaxel and Doxorubicin for Patients With High-Risk Breast Cancer | breast cancer | Fluorouracil (NPC75844) | NP level |
| NCT00001569 | Phase I Trial of Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin Plus Early Postoperative Intraperitoneal Paclitaxel and 5-FU for Peritoneal Carcinomatosis | peritoneal neoplasm;carcinoma | Fluorouracil (NPC75844) | NP level |
| NCT00001579 | A Phase I Trial of 5-Fluorouracil Given With 776C85 (GW776) and Low-Dose Leucovorin in Adult Patients With Solid Tumors | lymphoma | Fluorouracil (NPC75844) | NP level |
| NCT00002476 | Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Head and Neck Cancer | head and neck malignant neoplasia | Fluorouracil (NPC75844) | NP level |
| NCT00002496 | Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Cancer of the Larynx | head and neck malignant neoplasia | Fluorouracil (NPC75844) | NP level |
| NCT00002498 | Combination Chemotherapy Compared With Mitoxantrone in Treating Older Patients With Advanced Breast Cancer | breast cancer | Fluorouracil (NPC75844) | NP level |
| NCT00002523 | Radiation Therapy, Surgery, and Chemotherapy in Treating Patients With Rectal Cancer That Can Be Surgically Removed | colorectal carcinoma | Fluorouracil (NPC75844) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT05078827,NCT00377273,NCT01354717,NCT02281682,NCT00696488,NCT01525329,NCT02019355,NCT02289768,NCT04875026,NCT02616601,NCT03037541
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
THPO,TSHR,F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,F2
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
NCT01567618,NCT03959293,NCT05268510,NCT02545504,NCT02625610,NCT04675983,NCT02494583,NCT04908566,NCT04510064,NCT00183911,NCT03281369,NCT04523818 |
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT04752696,NCT02468557,NCT03806309,NCT05314998,NCT01676259,NCT02178709,NCT00307723,NCT05132504,NCT04821284,NCT04927780,NCT04481204,NCT02243007,NCT03970252,NCT04793932,NCT01893294,NCT03977233,NCT00548548,NCT05472259,NCT04292743,NCT01526135,NCT03331640,NCT02440958,NCT00054873,NCT04539808,NCT05257993,NCT04469556,NCT04990037,NCT02795988,NCT02959879,NCT05209074
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
Basal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C32 |
NCT03541252
|
Biliary tract cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C17 |
NCT03524508,NCT04722133,NCT03110510,NCT04005339,NCT03778593,NCT04217954,NCT01127555,NCT00090025,NCT03291899,NCT05052099,NCT01494363,NCT03785873,NCT01572324
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
