Collective Molecular Activities of the Plant: Ficus Simplicissima
Country/Region:
ChinaTraditional Medicine System:
TCMNepal; Bangladesh; Myanmar; Indonesia; India; Cambodia; Vietnam; China; Laos; Thailand
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
66 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
34 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
38 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC98163
Ingredient ID: NPC86642
Ingredient ID: NPC80302
Ingredient ID: NPC76662
Ingredient ID: NPC75384
Ingredient ID: NPC73219
Ingredient ID: NPC6913
Ingredient ID: NPC57429
Ingredient ID: NPC51146
Ingredient ID: NPC50880
Ingredient ID: NPC49103
Ingredient ID: NPC46335
Ingredient ID: NPC38343
Ingredient ID: NPC36999
Ingredient ID: NPC33338
Ingredient ID: NPC310342
Ingredient ID: NPC305307
Ingredient ID: NPC302857
Ingredient ID: NPC294558
Ingredient ID: NPC292345
Ingredient ID: NPC286956
Ingredient ID: NPC282812
Ingredient ID: NPC279406
Ingredient ID: NPC278906
Ingredient ID: NPC277510
Ingredient ID: NPC272552
Ingredient ID: NPC264084
Ingredient ID: NPC261324
Ingredient ID: NPC256849
Ingredient ID: NPC255246
Ingredient ID: NPC254474
Ingredient ID: NPC236202
Ingredient ID: NPC234222
Ingredient ID: NPC227491
Ingredient ID: NPC226315
Ingredient ID: NPC226108
Ingredient ID: NPC224161
Ingredient ID: NPC223548
Ingredient ID: NPC219876
Ingredient ID: NPC219143
Ingredient ID: NPC204353
Ingredient ID: NPC203468
Ingredient ID: NPC202600
Ingredient ID: NPC195952
Ingredient ID: NPC188563
Ingredient ID: NPC185755
Ingredient ID: NPC185392
Ingredient ID: NPC185231
Ingredient ID: NPC174246
Ingredient ID: NPC159451
Ingredient ID: NPC157417
Ingredient ID: NPC156654
Ingredient ID: NPC152451
Ingredient ID: NPC139940
Ingredient ID: NPC136014
Ingredient ID: NPC129800
Ingredient ID: NPC126681
Ingredient ID: NPC126029
Ingredient ID: NPC119133
Ingredient ID: NPC118284
Ingredient ID: NPC11433
Ingredient ID: NPC112890
Ingredient ID: NPC11016
Ingredient ID: NPC108811
Ingredient ID: NPC10781
Ingredient ID: NPC106551
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
| Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Therapeutic Target | Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Therapeutic Target | Protein Kinase | SRC | Tyrosine-protein kinase SRC | P12931 | CHEMBL267 |
| Therapeutic Target | Protein Kinase | IGF1R | Insulin-like growth factor I receptor | P08069 | CHEMBL1957 |
| Therapeutic Target | Protein Kinase | AXL | Tyrosine-protein kinase receptor UFO | P30530 | CHEMBL4895 |
| Therapeutic Target | Protein Kinase | PTK2 | Focal adhesion kinase 1 | Q05397 | CHEMBL2695 |
| Therapeutic Target | Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 167 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00000372 | Glycine and D-Cycloserine in Schizophrenia | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00005092 | Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer | leukemia;multiple myeloma;myelodysplastic syndrome | Psoralen (NPC51146) | NP level |
| NCT00005658 | Glycine to Treat Psychotic Disorders in Children | schizophrenia | Glycine (NPC126681) | NP level |
| NCT00052715 | Biological Therapy and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme | Central Nervous System Neoplasm | Lysine (NPC112890) | NP level |
| NCT00058123 | Poly-ICLC in Treating Patients With Recurrent or Progressive Anaplastic Glioma | Central Nervous System Neoplasm | Lysine (NPC112890) | NP level |
| NCT00108589 | S-Adenosylmethionine Therapy for Non-Alcoholic Steatohepatitis | Hepatitis | Methionine (NPC152451) | NP level |
| NCT00133406 | Long-term Impact and Intervention for Diarrhea in Brazil | diarrheal disease | Glycine (NPC126681) | NP level |
| NCT00133562 | HIAS II - Study of Nutritional Supplementation in Hospitalized Children With Persistent Diarrhea or Malnutrition | malnutrition | Glycine (NPC126681) | NP level |
| NCT00215878 | D-serine for Posttraumatic Stress Disorder Treatment | post-traumatic stress disorder | Serine (NPC219143) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
NCT00694564
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
KDR,AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AXL,NFKB1,SRC
NCT01842139 |
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888
|
Acute upper respiratory infectionDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA07 |
DRD3
|
Acute viral hepatitisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50 |
NCT00108589
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
SNCA,AXL,OR51E2,CA14,CA2,LMNA,ALK
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
OR51E2
|
Adrenal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
ALK
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
