CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Lepidophorum Repandum

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO14965
Plant Latin Name: Lepidophorum Repandum
Taxonomy Genus: Lepidophorum
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 133251
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

55 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

7 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

19 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC96257

Ingredient ID: NPC88811

Ingredient ID: NPC886

Ingredient ID: NPC88218

Ingredient ID: NPC83963

Ingredient ID: NPC81211

Ingredient ID: NPC78363

Ingredient ID: NPC77217

Ingredient ID: NPC75161

Ingredient ID: NPC72615

Ingredient ID: NPC66090

Ingredient ID: NPC64160

Ingredient ID: NPC64141

Ingredient ID: NPC55666

Ingredient ID: NPC51700

Ingredient ID: NPC47182

Ingredient ID: NPC45844

Ingredient ID: NPC45360

Ingredient ID: NPC39322

Ingredient ID: NPC38136

Ingredient ID: NPC35880

Ingredient ID: NPC34927

Ingredient ID: NPC307583

Ingredient ID: NPC301802

Ingredient ID: NPC29883

Ingredient ID: NPC287597

Ingredient ID: NPC282779

Ingredient ID: NPC270215

Ingredient ID: NPC26229

Ingredient ID: NPC258477

Ingredient ID: NPC255195

Ingredient ID: NPC230301

Ingredient ID: NPC216110

Ingredient ID: NPC213561

Ingredient ID: NPC202498

Ingredient ID: NPC197316

Ingredient ID: NPC183459

Ingredient ID: NPC18335

Ingredient ID: NPC170416

Ingredient ID: NPC170364

Ingredient ID: NPC159981

Ingredient ID: NPC146792

Ingredient ID: NPC14490

Ingredient ID: NPC141014

Ingredient ID: NPC139156

Ingredient ID: NPC138899

Ingredient ID: NPC136699

Ingredient ID: NPC130683

Ingredient ID: NPC127639

Ingredient ID: NPC117764

Ingredient ID: NPC113733

Ingredient ID: NPC113416

Ingredient ID: NPC111888

Ingredient ID: NPC105025

Ingredient ID: NPC100998

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Therapeutic Target	Enzyme	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Therapeutic Target	Enzyme	CES1	Acyl coenzyme A:cholesterol acyltransferase	P23141	CHEMBL2265
Therapeutic Target	Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Therapeutic Target	Nuclear hormone receptor subfamily 1	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Therapeutic Target	Nuclear hormone receptor subfamily 1	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Therapeutic Target	Protein Kinase	PRKCA	Protein kinase C alpha	P17252	CHEMBL299
Therapeutic Target	Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Therapeutic Target	Transcription factor	RELA	Nuclear factor NF-kappa-B p65 subunit	Q04206	CHEMBL5533

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	23

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT03216876	A Study Of Ursolic Acid For Primary Sclerosing Cholangitis	sclerosing cholangitis	Ursolic Acid (NPC51700)	NP level
NCT01190995	Role of Repeated Painful Procedures in Preterm Neonates on Short Term Neurobehavioural Outcome	pain	Sucrose (NPC130683)	NP level
NCT00949104	Role of Oral Sucrose in Reducing the Pain to Orogastric Tube Insertion in Preterm Neonates	pain	Sucrose (NPC130683)	NP level
NCT02174705	Rotavirus vs. Sucrose for Vaccine Injection Pain	pain	Sucrose (NPC130683)	NP level
NCT00787059	AC6 Gene Transfer for CHF	congestive heart failure	Sucrose (NPC130683)	NP level
NCT00218946	Nasogastric Tube in Premature Babies - Pain and Treatment	premature birth	Sucrose (NPC130683)	NP level
NCT04403568	Testing the Synergism of Phytonutrients, Curcumin and Ursolic Acid, to Target Molecular Pathways in the Prostate	prostate cancer	Ursolic Acid (NPC51700)	NP level
NCT02662283	Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy	IGA glomerulonephritis	Acetoside (NPC197316)	NP level
NCT01485315	Transfusion-requirements in Septic Shock Trial	septic shock	Adenine (NPC18335)	NP level
NCT01561547	Trial of Repeated Analgesia With Kangaroo Care	pain	Sucrose (NPC130683)	NP level
NCT03718507	Study on the Effects of Different Premedication for LISA on Stress and Cerebral Tissue Oxygenation in Preterm Infants	acute respiratory distress syndrome	Sucrose (NPC130683)	NP level
NCT02086864	A Placebo Controlled Study of Homeopathic Treatment of Children and Youth With ADHD	attention deficit hyperactivity disorder	Sucrose (NPC130683)	NP level
NCT00519207	Evaluation of Topical Liposomal Lidocaine and Oral Sucrose for Treatment of Pain in Newborns Undergoing Venipuncture	pain	Sucrose (NPC130683)	NP level
NCT03272594	The Influence of Breastfeeding on Cortical Activity During Procedures	pain	Sucrose (NPC130683)	NP level
NCT00482560	Analgesic Effect of Breast Feeding vs Sucrose in Neonatal Screening	pain	Sucrose (NPC130683)	NP level
NCT01201954	Pain Relief of Newborn Preterm Infants During Endotracheal Suctioning	pain	Sucrose (NPC130683)	NP level
NCT02337933	Effect of Ursolic Acid Administration on Insulin Sensitivity and Metabolic Syndrome	metabolic syndrome	Ursolic Acid (NPC51700)	NP level
NCT01503060	Effectiveness of Parent-Led Interventions in Reducing Infant Hypersensitivity to Pain	pain	Sucrose (NPC130683)	NP level
NCT01238471	Oral Propranolol Versus Placebo for Early Stages of Retinopathy of Prematurity: A Randomized and Prospective Study	retinopathy of prematurity	Sucrose (NPC130683)	NP level
NCT04855266	Iron Sucrose in Patients With Iron Deficiency and POTS	orthostatic hypotension	Sucrose (NPC130683)	NP level
NCT03082001	Sucrose to Reduce Pain During Initiation of Venipuncture in Extremely Low Birth Weight Babies	pain	Sucrose (NPC130683)	NP level
NCT03745963	The Influence of Skin-to-skin Contact on Cortical Activity During Painful Procedures on Preterm Infants in the NICU	pain	Sucrose (NPC130683)	NP level
NCT02990364	Combination Analgesia for Neonatal Circumcision	pain	Sucrose (NPC130683)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	F2,DRD1,RECQL,CES1
Multiple sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A40	RELA,F2,RORC
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	DRD1,PRKCA,RECQL
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	RORC,RELA
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	RELA,F2
Solid tumour/cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00-2F9Z	RORC,RELA
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	L3MBTL1,PRKCA
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	F2,DRD1
Tetralogy of Fallot Disease Category: 20.Developmental anomalies Disease ICD-11 Code: LA88.2	F2,RORC
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	F2,DRD1
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	NCT02990364,NCT00949104,NCT01201954,NCT03745963,NCT00519207,NCT01561547,NCT01190995,NCT03082001,NCT01503060,NCT00482560,NCT03272594,NCT02174705
Autoimmune disease Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40-4A45	RORC
Choreiform disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A01	RELA
Dementia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6D80-6D8Z	DRD1
Indeterminate colitis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD72	RELA
Tic disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A05	DRD1
Coagulation defect Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3B10	F2
Crohn disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD70	RORC
Muscular atrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B61	PRKCA
Cocaine use disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C45	DRD1
Parkinsonism Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A00	DRD1
Cardiovascular disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA00-BE2Z	F2
Pulmonary hypertension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BB01	DRD1
Thrombosis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB61-GB90	F2
Psychotic disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A20-6A25	DRD1
Hyper-lipoproteinaemia Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C80	CES1
Skin and skin-structure infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F28-1G0Z	RELA
Nutritional deficiency Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B50-5B71	F2
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	F2
Cerebral ischaemic stroke Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B11	F2
Synthesis disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C52-5C59	CES1
Irritable bowel syndrome Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD91	RELA
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	RELA
Acute/subacute hepatic failure Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB91	RELA
Lupus erythematosus Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A40	RELA
Myocardial infarction Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA41-BA43	F2
Fungal infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F29-1F2F	RELA
Rheumatoid arthritis Disease Category: 15.Diseases of the musculoskeletal system or connective tissue Disease ICD-11 Code: FA20	RELA
Ischaemic/haemorrhagic stroke Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B20	F2
Schizophrenia Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A20	DRD1
Chronic arterial occlusive disease Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD4Z	CES1
Thrombocytopenia Disease Category: 03.Diseases of the blood or blood-forming organs Disease ICD-11 Code: 3B64	F2
Transplant rejection Disease Category: 22.Injury, poisoning or certain other consequences of external causes Disease ICD-11 Code: NE84	PRKCA
Lung cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25	RORC
Coronary thrombosis Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA43	F2
Muscular dystrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C70	RELA
Abortion Disease Category: 18.Pregnancy, childbirth or the puerperium Disease ICD-11 Code: JA00	DRD1
Diabetes mellitus, type unspecified Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A14	RELA
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	RELA
Peroxisomal disease Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C57	CES1
Allergic/hypersensitivity disorder Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A80-4A8Z	DRD1
Bleeding disorder Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA20-GA21	F2
Angina pectoris Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA40	F2
Prostate cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82	NCT04403568
Preterm newborn, unspecified Disease Category: 19.Certain conditions originating in the perinatal period Disease ICD-11 Code: KA21.4Z	NCT00218946
Acute respiratory distress syndrome Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB00	NCT03718507
Primary sclerosing cholangitis Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB96.2	NCT03216876
Nephritic syndrome Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GB40	NCT02662283
Orthostatic hypotension Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BA21	NCT04855266
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	NCT02086864
Septic shock Disease Category: X.Extension Codes Disease ICD-11 Code: XS26	NCT01485315
Congestive heart failure Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BD10	NCT00787059
Retinopathy of prematurity Disease Category: 09.Diseases of the visual system Disease ICD-11 Code: 9B71.3	NCT01238471
Metabolic disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C50-5D2Z	NCT02337933
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	RORC
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	RORC
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	RORC
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	L3MBTL1
Malignant neoplasm metastasis in lymph nodes of head, face or neck Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60.0	F2
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	RECQL
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	F2
Other specified malignant neoplasms ofcolon Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B90.Y	F2
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	F2
Melanoma of skin Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C30	PRKCA
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	L3MBTL1
Superficial ovarian endometriosis Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GA10.B4	PRKCA
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	F2
Malignant neoplasms of corpus uteri, unspecified Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.Z	F2
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	DRD1
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	PRKCA

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Lepidophorum Repandum

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

55 All known Ingredients in Total

7 Ingredients with Acceptable Bioavailablity

19 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Adenocarcinoma of pancreas

Multiple sclerosis

Mesothelioma of pleura

Psoriasis

Type 2 diabetes mellitus

Solid tumour/cancer

Malignant neoplasms of biliary tract, distal bile duct

Adenocarcinoma of stomach

Tetralogy of Fallot

Germ cell tumour of testis

Pain, unspecified

Autoimmune disease

Choreiform disorder

Dementia

Indeterminate colitis

Tic disorder

Coagulation defect

Crohn disease

Muscular atrophy

Cocaine use disorder

Parkinsonism

Cardiovascular disease

Pulmonary hypertension

Thrombosis

Psychotic disorder

Hyper-lipoproteinaemia

Skin and skin-structure infection

Nutritional deficiency

Asthma

Cerebral ischaemic stroke

Synthesis disorder

Irritable bowel syndrome

Acute myeloid leukaemia

Acute/subacute hepatic failure

Lupus erythematosus

Myocardial infarction

Fungal infection

Rheumatoid arthritis

Ischaemic/haemorrhagic stroke

Schizophrenia

Chronic arterial occlusive disease

Thrombocytopenia

Transplant rejection

Lung cancer

Coronary thrombosis

Muscular dystrophy

Abortion

Diabetes mellitus, type unspecified

Atopic eczema

Peroxisomal disease

Allergic/hypersensitivity disorder

Bleeding disorder

Angina pectoris

Prostate cancer

Preterm newborn, unspecified

Acute respiratory distress syndrome

Primary sclerosing cholangitis

Nephritic syndrome

Orthostatic hypotension

Attention deficit hyperactivity disorder

Septic shock

Congestive heart failure

Retinopathy of prematurity

Metabolic disorder