Collective Molecular Activities of the Plant: Fritillaria Unibracteata
Plant ID: NPO14849
Plant Latin Name: Fritillaria Unibracteata
Taxonomy Genus: Fritillaria
Taxonomy Family: Liliaceae
Plant External Links:
NCBI TaxonomyDB:
152095
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCMChina
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
46 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
23 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
18 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC89195
Ingredient ID: NPC8821
Ingredient ID: NPC71339
Ingredient ID: NPC68204
Ingredient ID: NPC66700
Ingredient ID: NPC65597
Ingredient ID: NPC62927
Ingredient ID: NPC61198
Ingredient ID: NPC5952
Ingredient ID: NPC59314
Ingredient ID: NPC54320
Ingredient ID: NPC44611
Ingredient ID: NPC43246
Ingredient ID: NPC326134
Ingredient ID: NPC323434
Ingredient ID: NPC312637
Ingredient ID: NPC305224
Ingredient ID: NPC28224
Ingredient ID: NPC27699
Ingredient ID: NPC271632
Ingredient ID: NPC263034
Ingredient ID: NPC262431
Ingredient ID: NPC249045
Ingredient ID: NPC246527
Ingredient ID: NPC242385
Ingredient ID: NPC238829
Ingredient ID: NPC23733
Ingredient ID: NPC220111
Ingredient ID: NPC214237
Ingredient ID: NPC209970
Ingredient ID: NPC209525
Ingredient ID: NPC189719
Ingredient ID: NPC18335
Ingredient ID: NPC174117
Ingredient ID: NPC166097
Ingredient ID: NPC164700
Ingredient ID: NPC163105
Ingredient ID: NPC160913
Ingredient ID: NPC157927
Ingredient ID: NPC156461
Ingredient ID: NPC145029
Ingredient ID: NPC14330
Ingredient ID: NPC128494
Ingredient ID: NPC117527
Ingredient ID: NPC111897
Ingredient ID: NPC105255
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Hydrolase | CDA | Cytidine deaminase | P32320 | CHEMBL4502 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA1 | Adenosine A1 receptor | P30542 | CHEMBL226 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA2A | Adenosine A2a receptor | P29274 | CHEMBL251 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
| Therapeutic Target | Transferase | TK1 | Thymidine kinase, cytosolic | P04183 | CHEMBL2883 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 96 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000699 | A Phase I/II Trial of Ribavirin (With Escalation) + Isoprinosine in Asymptomatic HIV-Viremic Patients | HIV infection | Inosine (NPC54320) | NP level |
| NCT00002604 | O(6)-Benzylguanine and Carmustine in Treating Patients With Solid Tumors | neoplasm | Guanine (NPC59314) | NP level |
| NCT00002801 | Combination Chemotherapy and Radiation Therapy in Treating Patients With Colorectal Cancer | colorectal carcinoma | Uracil (NPC27699) | NP level |
| NCT00002971 | O(6)-Benzylguanine in Treating Patients With Malignant Glioma | Central Nervous System Neoplasm | Guanine (NPC59314) | NP level |
| NCT00003348 | Carmustine Plus O(6)-Benzylguanine in Treating Patients With Recurrent or Progressive Gliomas of the Brain | Central Nervous System Neoplasm | Guanine (NPC59314) | NP level |
| NCT00003567 | Gene Therapy and Chemotherapy in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma | lymphoma;Central Nervous System Neoplasm | Guanine (NPC59314) | NP level |
| NCT00003613 | O6-benzylguanine and Carmustine in Treating Patients With Stage IA-IIA Cutaneous T-cell Lymphoma | Cutaneous T-cell lymphoma | Guanine (NPC59314) | NP level |
| NCT00003765 | O6-benzylguanine and Carmustine in Treating Children With Refractory CNS Tumors | Central Nervous System Neoplasm | Guanine (NPC59314) | NP level |
| NCT00003766 | O6-benzylguanine Followed by Surgery in Treating Patients With Solid Tumors That Can Be Removed During Surgery | neoplasm | Guanine (NPC59314) | NP level |
| NCT00003925 | Combination Chemotherapy In Treating Patients With Advanced Cancer | neoplasm | Uracil (NPC27699) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TK1
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT00271765,NCT00781404
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04588441
|
Acute ST elevation myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41.0 |
NCT00284323,NCT01747174
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
TK1,CDA
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
TK1,ADORA3,ADORA2A
|
Amyotrophic lateral sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60.0 |
NCT03168711,NCT02288091
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
NCT00751491,NCT01123525
|
Astrocytoma, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH6PH6 |
NCT00389090
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
NCT01932112,NCT03032965
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
