Collective Molecular Activities of the Plant: Orthosiphon Aristatus
Country/Region:
Philippines; Indonesia; Malaysia; Vietnam; Laos; ThailandTraditional Medicine System:
Australia; Bangladesh; Myanmar; Philippines; Indonesia; India; Cambodia; Malaysia; Vietnam; China; Laos; Sri Lanka; Thailand; Taiwan; Fiji
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
73 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
13 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
34 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9634
Ingredient ID: NPC90769
Ingredient ID: NPC88740
Ingredient ID: NPC85376
Ingredient ID: NPC82847
Ingredient ID: NPC81698
Ingredient ID: NPC77719
Ingredient ID: NPC7095
Ingredient ID: NPC69394
Ingredient ID: NPC6332
Ingredient ID: NPC60509
Ingredient ID: NPC57030
Ingredient ID: NPC35659
Ingredient ID: NPC306799
Ingredient ID: NPC304876
Ingredient ID: NPC300414
Ingredient ID: NPC295835
Ingredient ID: NPC2907
Ingredient ID: NPC288230
Ingredient ID: NPC288056
Ingredient ID: NPC286146
Ingredient ID: NPC275861
Ingredient ID: NPC265395
Ingredient ID: NPC26033
Ingredient ID: NPC257213
Ingredient ID: NPC256142
Ingredient ID: NPC251407
Ingredient ID: NPC250696
Ingredient ID: NPC250046
Ingredient ID: NPC249983
Ingredient ID: NPC249471
Ingredient ID: NPC249375
Ingredient ID: NPC242262
Ingredient ID: NPC241278
Ingredient ID: NPC237549
Ingredient ID: NPC233806
Ingredient ID: NPC233196
Ingredient ID: NPC228204
Ingredient ID: NPC221482
Ingredient ID: NPC213552
Ingredient ID: NPC213285
Ingredient ID: NPC208380
Ingredient ID: NPC205522
Ingredient ID: NPC201773
Ingredient ID: NPC199067
Ingredient ID: NPC198539
Ingredient ID: NPC198455
Ingredient ID: NPC195727
Ingredient ID: NPC187861
Ingredient ID: NPC186708
Ingredient ID: NPC183542
Ingredient ID: NPC18074
Ingredient ID: NPC178177
Ingredient ID: NPC175580
Ingredient ID: NPC165260
Ingredient ID: NPC163699
Ingredient ID: NPC160951
Ingredient ID: NPC15917
Ingredient ID: NPC158333
Ingredient ID: NPC156913
Ingredient ID: NPC154819
Ingredient ID: NPC14958
Ingredient ID: NPC131698
Ingredient ID: NPC127857
Ingredient ID: NPC124578
Ingredient ID: NPC121712
Ingredient ID: NPC1173
Ingredient ID: NPC114410
Ingredient ID: NPC112523
Ingredient ID: NPC112216
Ingredient ID: NPC10776
Ingredient ID: NPC104863
Ingredient ID: NPC101043
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Therapeutic Target | Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Therapeutic Target | Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 Plant level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01293162 | The Role of a Combination of Nutraceuticals in the Control of Cardiovascular Risk | Metabolic Syndrome | Orthosiphon Aristatus | Plant level As recipes of formula |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKA,AURKB,KDR
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AURKB,AURKA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA7,CA5A,AURKA,AURKB,CA9,CA6
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CYP1B1,CA14,CA7,AURKA,AURKB,CA9
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
AURKA,AURKB,CA6
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
KDR
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA6,CA14
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
KDR
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
KDR,AURKA,CA14,CA9,CA6
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
