Collective Molecular Activities of the Plant: Lobelia Chinensis
Country/Region:
Thailand; China; IndiaTraditional Medicine System:
Indian Folk; TCMBangladesh; South Africa; Nepal; India; Cambodia; Vietnam; China; Laos; Sri Lanka; Japan; Taiwan; Thailand
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
123 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
91 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
69 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC95675
Ingredient ID: NPC85473
Ingredient ID: NPC82271
Ingredient ID: NPC79056
Ingredient ID: NPC75709
Ingredient ID: NPC75204
Ingredient ID: NPC7491
Ingredient ID: NPC67761
Ingredient ID: NPC67462
Ingredient ID: NPC66681
Ingredient ID: NPC65855
Ingredient ID: NPC62727
Ingredient ID: NPC59581
Ingredient ID: NPC52005
Ingredient ID: NPC51758
Ingredient ID: NPC50898
Ingredient ID: NPC49168
Ingredient ID: NPC49151
Ingredient ID: NPC46248
Ingredient ID: NPC44931
Ingredient ID: NPC44328
Ingredient ID: NPC43728
Ingredient ID: NPC42471
Ingredient ID: NPC41538
Ingredient ID: NPC39360
Ingredient ID: NPC37205
Ingredient ID: NPC3665
Ingredient ID: NPC33489
Ingredient ID: NPC329148
Ingredient ID: NPC325762
Ingredient ID: NPC323515
Ingredient ID: NPC32279
Ingredient ID: NPC32222
Ingredient ID: NPC321150
Ingredient ID: NPC312132
Ingredient ID: NPC310820
Ingredient ID: NPC307011
Ingredient ID: NPC305663
Ingredient ID: NPC30315
Ingredient ID: NPC301585
Ingredient ID: NPC29883
Ingredient ID: NPC298796
Ingredient ID: NPC297844
Ingredient ID: NPC297527
Ingredient ID: NPC294136
Ingredient ID: NPC293353
Ingredient ID: NPC292758
Ingredient ID: NPC290613
Ingredient ID: NPC290598
Ingredient ID: NPC29
Ingredient ID: NPC288932
Ingredient ID: NPC286774
Ingredient ID: NPC285394
Ingredient ID: NPC279121
Ingredient ID: NPC277907
Ingredient ID: NPC277439
Ingredient ID: NPC26906
Ingredient ID: NPC265498
Ingredient ID: NPC257885
Ingredient ID: NPC252230
Ingredient ID: NPC249801
Ingredient ID: NPC248726
Ingredient ID: NPC246358
Ingredient ID: NPC243728
Ingredient ID: NPC241721
Ingredient ID: NPC240722
Ingredient ID: NPC236709
Ingredient ID: NPC233533
Ingredient ID: NPC232132
Ingredient ID: NPC231738
Ingredient ID: NPC230301
Ingredient ID: NPC226944
Ingredient ID: NPC22140
Ingredient ID: NPC220239
Ingredient ID: NPC217226
Ingredient ID: NPC216630
Ingredient ID: NPC214584
Ingredient ID: NPC210831
Ingredient ID: NPC210003
Ingredient ID: NPC209970
Ingredient ID: NPC209296
Ingredient ID: NPC209279
Ingredient ID: NPC209275
Ingredient ID: NPC208757
Ingredient ID: NPC208075
Ingredient ID: NPC20791
Ingredient ID: NPC205999
Ingredient ID: NPC202956
Ingredient ID: NPC200837
Ingredient ID: NPC197811
Ingredient ID: NPC197783
Ingredient ID: NPC194586
Ingredient ID: NPC193335
Ingredient ID: NPC192872
Ingredient ID: NPC183950
Ingredient ID: NPC181939
Ingredient ID: NPC177874
Ingredient ID: NPC176521
Ingredient ID: NPC167336
Ingredient ID: NPC166692
Ingredient ID: NPC164706
Ingredient ID: NPC16157
Ingredient ID: NPC161555
Ingredient ID: NPC160931
Ingredient ID: NPC159963
Ingredient ID: NPC155209
Ingredient ID: NPC155182
Ingredient ID: NPC148039
Ingredient ID: NPC139548
Ingredient ID: NPC139416
Ingredient ID: NPC138811
Ingredient ID: NPC13789
Ingredient ID: NPC134732
Ingredient ID: NPC126682
Ingredient ID: NPC120253
Ingredient ID: NPC117355
Ingredient ID: NPC109813
Ingredient ID: NPC108494
Ingredient ID: NPC107482
Ingredient ID: NPC106250
Ingredient ID: NPC102091
Ingredient ID: NPC101285
Ingredient ID: NPC100039
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 32 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00330096 | Effects of Hesperidin on Bone Mineral Density and Bone Metabolism of Postmenopausal Women | osteoporosis | Hesperidin (NPC79056) | NP level |
| NCT00439504 | Ph1 Lobeline Interaction Study - 1 | methamphetamine dependence | (-)-Lobeline (NPC285394) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT00519259 | Tolerability and Safety of 30, 45, and 60 mg of Sublingual Lobeline. - 1 | methamphetamine dependence | (-)-Lobeline (NPC285394) | NP level |
| NCT00664703 | Effectiveness of Lobeline in Treating Symptoms of ADHD in Adult Patients | attention deficit hyperactivity disorder | (-)-Lobeline (NPC285394) | NP level |
| NCT01110512 | Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) | venous insufficiency | Diosmin (NPC209296) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
| NCT01438320 | Q-Trial in Patients With Hepatitis C | chronic hepatitis C virus infection | Quercetin (NPC20791) | NP level |
| NCT01597401 | A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subjects With Stable Sickle Cell Disease | sickle cell anemia | 5-Hydroxymethyl-Furfural (NPC107482) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AURKB,DPP4,KDR,AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
GSK3B,AXL,PIM1,FLT3,AURKB,SRC,TP53
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,CA7,MMP12,XDH,AURKB,CDK1,F2,CYP2D6,TTR,CA12,NPSR1,THPO
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,CA7,DPP4,POLB,XDH,DRD1,RECQL,AURKB,CYP1B1,HIF1A,F2,CNR2,TTR,MET,OR51E2,ALOX15,PIM1,ABCG2,AXL,NPSR1,ALOX5,LMNA
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,TTR,OR51E2,FABP5,ALOX15
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
AURKB,NOX4,MMP12,MET,NPSR1,CDK1,CYP19A1,ALOX15,F2,DRD1
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
HIF1A
|
Ageing associated decline in intrinsic capacityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG2A |
NCT05422885,NCT04946383
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
DRD1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
