Collective Molecular Activities of the Plant: Melochia Tomentosa
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PLANiTS DNA barcode
Taxonomic Information
Used in Medicines
Unknown.
Geographical Distribution
Brazil; Jamaica; Netherlands; Honduras; Cuba; Mexico; Bahamas; Trinidad and Tobago; Peru; Dominican Republic; Belize; Venezuela; Haiti
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary
Overview of Ingredients
15 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
7 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
12 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC85813
Ingredient ID: NPC294548
Ingredient ID: NPC286245
Ingredient ID: NPC261831
Ingredient ID: NPC256849
Ingredient ID: NPC255837
Ingredient ID: NPC250436
Ingredient ID: NPC244690
Ingredient ID: NPC176740
Ingredient ID: NPC173637
Ingredient ID: NPC167983
Ingredient ID: NPC160512
Ingredient ID: NPC126029
Ingredient ID: NPC119133
Ingredient ID: NPC102281
Classification of Human Proteins Collectively Targeted by the Plant
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Drug Transporter | ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Therapeutic Target | DNA methyltransferase | DNMT1 | DNA (cytosine-5)-methyltransferase 1 | P26358 | CHEMBL1993 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | AKR1C3 | Aldo-keto-reductase family 1 member C3 | P42330 | CHEMBL4681 |
| Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Therapeutic Target | Fatty acid binding protein family | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Therapeutic Target | Other nuclear protein | RAD52 | DNA repair protein RAD52 homolog | P43351 | CHEMBL2362978 |
| Therapeutic Target | Oxidoreductase | PGD | 6-phosphogluconate dehydrogenase | P52209 | CHEMBL3404 |
| Therapeutic Target | Oxidoreductase | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Therapeutic Target | Protein Kinase | DYRK1A | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Q13627 | CHEMBL2292 |
| Therapeutic Target | Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Threonine protease | PSMB5 | Proteasome Macropain subunit MB1 | P28074 | CHEMBL4662 |
| Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Clinical Trials Summary
Overview
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 142 | |
Clinical trial details
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00951158 | A Molecular Pharmacodynamic Dose-titration Trial of Conjugated Linoleic Acid (CLA; Clarinol®) in Patients With Advanced Solid Tumors | neoplasm | Linoleic Acid (NPC85813) | NP level |
| NCT00003197 | Green Tea Extract in Treating Patients With Advanced Solid Tumors | neoplasm | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT04553666 | Reducing Frailty for Older Cancer Survivors Using Supplements | inflammation | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00676793 | A Study of the Effect of Polyphenon E (Green Tea Extract) on Breast Cancer Progression | breast cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01596647 | Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors | neoplasm | Caffeine (NPC256849) | NP level |
| NCT02627898 | Effect of Green Tea Extract on Arterial Stiffness in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00461942 | Efficacy and Safety of Green Tea Polyphenol in De Novo Parkinson's Disease Patients | Parkinson disease | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03864042 | Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors | metastatic melanoma | Caffeine (NPC256849) | NP level |
| NCT00625391 | Green Tea and Tai Chi for Bone Health | osteoporosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00377975 | "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat | obesity | Caffeine (NPC256849) | NP level |
| NCT00951834 | Sunphenon EGCg (Epigallocatechin-Gallate) in the Early Stage of Alzheimer´s Disease | Alzheimer disease | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01855971 | "Using Epigallocatechin Gallate (EGCG) and Cognitive Training to Modulate Cognitive Performance in Patients With Fragile X Syndrome" (TESFX) | fragile X syndrome | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00437632 | Study To Investigate If Repeat Doses Of GSK598809 Are Safe And Well Tolerated And To Evaluate Blood Levels Of GSK598809 | substance dependence | Caffeine (NPC256849) | NP level |
| NCT02048215 | Effect on Energy Metabolism at Cellular Level of Diet Plus Treatment With Ephedrine and Caffeine in Obesity | obesity | Caffeine (NPC256849) | NP level |
| NCT00733993 | Caffeine and Cocaine | cocaine dependence | Caffeine (NPC256849) | NP level |
| NCT01999829 | Prevention of Atrial Fibrillation Following Valvular Replacement With Cardiopulmonary Bypass: a Prospective, Randomized Clinical Study Comparing Oral Caffeine With Placebo | atrial fibrillation | Caffeine (NPC256849) | NP level |
| NCT02832336 | The Effect of Caffeine on the Narcoleptic Patients | narcolepsy | Caffeine (NPC256849) | NP level |
| NCT00432887 | Experimental Studies of the Effects of Caffeine on Glucose Regulation | type 2 diabetes mellitus | Caffeine (NPC256849) | NP level |
| NCT04425902 | Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults | HIV infection | Caffeine (NPC256849) | NP level |
| NCT00495092 | Efficacy of Caffeine, With and Without Biperiden, in the Detoxification of Cocaine Dependent Patients | cocaine dependence | Caffeine (NPC256849) | NP level |
| NCT01060345 | A Pilot Study of Chemo-prevention of Green Tea in Women With Ductal Carcinoma in Situ | breast ductal carcinoma in situ | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02863575 | A Dental Pain Study Comparing The Analgesic Efficacy Of Ibuprofen/Caffeine | pain | Caffeine (NPC256849) | NP level |
| NCT02520752 | A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors | neoplasm | Caffeine (NPC256849) | NP level |
| NCT02647086 | Open Label, Drug-Drug Interaction (DDI) Study of Dupilumab (REGN668/SAR231893) in Patients With Moderate to Severe Atopic Dermatitis (AD) | atopic eczema | Caffeine (NPC256849) | NP level |
| NCT02225093 | A Study to Evaluate How Daily Dosing With Enzalutamide Affects the Metabolism of Caffeine and Dextromethorphan in Men With Prostate Cancer | prostate cancer | Caffeine (NPC256849) | NP level |
| NCT01686646 | Effects of Two Doses of a Common Cold Treatment on Alertness | common cold | Caffeine (NPC256849) | NP level |
| NCT03333824 | Effects of AZD1775 on the PK Substrates for CYP3A, CYP2C19, CYP1A2 and on QT Interval in Patients With Advanced Cancer | neoplasm | Caffeine (NPC256849) | NP level |
| NCT02582996 | Cefalium® Compared to Tylenol® in the Treatment of Migraine Attacks | migraine disorder | Caffeine (NPC256849) | NP level |
| NCT01912820 | Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery | prostate adenocarcinoma | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01394796 | Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals. | Down syndrome | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01738178 | Caffeine as a Therapy for Parkinson's Disease | Parkinson disease | Caffeine (NPC256849) | NP level |
| NCT04132336 | Study to Find Out the Optimal Dose of Caffeine in the Combination Tablet of Naproxen Sodium and Caffeine in Patients Experiencing Moderate to Severe Pain After Having Wisdom Teeth Removed | pain | Caffeine (NPC256849) | NP level |
| NCT00930306 | AZD2066 Cocktail Study | Chronic pain | Caffeine (NPC256849) | NP level |
| NCT01183767 | Sunphenon Epigallocatechin-Gallate (EGCg) in Duchenne Muscular Dystrophy | Duchenne muscular dystrophy | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT05445232 | A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants | obesity | Caffeine (NPC256849) | NP level |
| NCT00607945 | Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Linoleic Acid (NPC85813) | NP level |
| NCT00233935 | Defined Green Tea Catechin Extract in Preventing Esophageal Cancer in Patients With Barrett's Esophagus | Barrett's esophagus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00262743 | Green Tea Extract in Treating Patients With Stage 0, Stage I, or Stage II Chronic Lymphocytic Leukemia | leukemia | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00638196 | Placebo vs. Linoleic Acid Controlled Assessment of Treatment Efficacy in MS | multiple sclerosis | Oleic Acid (NPC261831) | NP level |
| NCT00707252 | Study of Polyphenon E in Addition to Erlotinib in Advanced Non Small Cell Lung Cancer | non-small cell lung carcinoma | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01289561 | Combined Effects of Alcohol and Caffeine | alcohol dependence | Caffeine (NPC256849) | NP level |
| NCT00471952 | Maxalt 10mg Plus Caffeine 75mg in the Acute Treatment of Migraine Headache | migraine with aura;migraine without aura | Caffeine (NPC256849) | NP level |
| NCT01744587 | Epstein-Barr Virus Reactivation and the Effect of EGCG on Virus Reactivation in Remission Patients | nasopharyngeal neoplasm | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02974114 | Exploratory Study to Investigate Cognition Function and Mobility in Individuals With Pain | pain | Caffeine (NPC256849) | NP level |
| NCT01172405 | Efficacy and Safety Study to Compare Ibuprofen + Caffeine With Ibuprofen Alone in the Treatment of Headache | Headache | Caffeine (NPC256849) | NP level |
| NCT02015312 | A Trial for the Treatment of Cardiac AL-Amyloidosis With the Green Tea Compound Epigallocatechin-3-gallate (TAME-AL) | AL amyloidosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02772601 | This Study Tests the Effect of Risankizumab on the Metabolism in the Liver of Five Additional Drugs to Study Possible Drug Interactions in Patients With Psoriasis With or Without Psoriatic Arthritis | psoriasis | Caffeine (NPC256849) | NP level |
| NCT04504045 | Metformin's Effect on Drug Metabolism in Patients With Type 2 Diabetes | type 2 diabetes mellitus | Caffeine (NPC256849) | NP level |
| NCT05364008 | FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate | uterine fibroid | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00091325 | Green Tea Extract (Polyphenon E) in Preventing Cancer in Healthy Participants | neoplasm | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00564824 | The Impact of Caffeine on Brachial Endothelial Function in Healthy Subjects and in Patients With Ischemic Heart Disease | coronary artery disease | Caffeine (NPC256849) | NP level |
| NCT00516243 | Defined Green Tea Catechin Extract in Treating Women With Hormone Receptor Negative Stage I-III Breast Cancer | breast cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00666562 | Green Tea Extract in Treating Patients With Nonmetastatic Bladder Cancer | urinary bladder cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00942422 | Green Tea Extract in Treating Patients With Monoclonal Gammopathy of Undetermined Significance and/or Smoldering Multiple Myeloma | multiple myeloma | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00029679 | Borage Oil and Ginkgo Biloba (EGb 761) in Asthma | asthma | Linoleic Acid (NPC85813) | NP level |
| NCT03970798 | A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or Rosuvastatin | Parkinson disease | Caffeine (NPC256849) | NP level |
| NCT03187496 | Drug-drug Interaction Study Between EDP-305, Midazolam, Caffeine and Rosuvastatin in Healthy Volunteers. | non-alcoholic steatohepatitis | Caffeine (NPC256849) | NP level |
| NCT00459407 | Defined Green Tea Catechins in Treating Patients With Prostate Cancer Undergoing Surgery to Remove the Prostate | prostate adenocarcinoma | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT04246762 | Study in Subjects With Rheumatoid Arthritis to Evaluate the Effect of a Single Dose of Olokizumab on the Pharmacokinetics of Substrates for CYP1A2, CYP2C9, CYP2C19 and CYP3A4 | rheumatoid arthritis | Caffeine (NPC256849) | NP level |
| NCT02875691 | Effect of Green Tea on Treatment of Lupus | systemic lupus erythematosus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT05485805 | A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo | toothache | Caffeine (NPC256849) | NP level |
| NCT00951964 | Treatment of Epidermolysis Bullosa Dystrophica by Polyphenon E (Epigallocatechin 3 Gallate) | Dystrophic epidermolysis bullosa | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01190735 | Caffeine for Motor Manifestations of Parkinson's Disease | Parkinson disease | Caffeine (NPC256849) | NP level |
| NCT01699711 | Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool | Down syndrome | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01875159 | Effects of Caffeine on Intermittent Hypoxia in Infants Born Preterm | hypoxia | Caffeine (NPC256849) | NP level |
| NCT01517399 | Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer Subjects | neoplasm | Caffeine (NPC256849) | NP level |
| NCT00676780 | Green Tea Extract and Prostate Cancer | prostate cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02985671 | To Evaluate the Superiority of Fixed Combination (Orfenadrine 35mg, Acetaminophen 325mg, Caffeine 65mg and Diclofenac Sodium 50mg) Compared to Voltaren® (Diclofenac Sodium 50mg) in the Treatment of Acute Postural Low Back Pain. | Low back pain | Caffeine (NPC256849) | NP level |
| NCT03533556 | Effects of L-theanine and Caffeine on Attention and Attention-related Brain Activity of Children With Attention Deficit Hyperactivity Disorder | attention deficit hyperactivity disorder | Caffeine (NPC256849) | NP level |
| NCT01661764 | Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention | colorectal adenoma | Oleic Acid (NPC261831) | NP level |
| NCT03768492 | Study of the Safety and Efficacy of a Caffeine-based Antifibrosis Cream in Patients With Breast Cancer Undergoing Radiation Therapy | breast carcinoma | Caffeine (NPC256849) | NP level |
| NCT01462318 | An Open-Label Immunogenicity and Pharmacokinetics Study of Daclizumab High Yield Process Prefilled Syringe in Relapsing Remitting Multiple Sclerosis | relapsing-remitting multiple sclerosis | Caffeine (NPC256849) | NP level |
| NCT02183688 | Acetylsalicylic Acid (ASA) + Paracetamol + Caffeine Combination Compared With ASA + Paracetamol as Well as ASA, Paracetamol, and Caffeine in Headache Patients | migraine disorder | Caffeine (NPC256849) | NP level |
| NCT01275170 | A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005) | infectious disease | Caffeine (NPC256849) | NP level |
| NCT01629329 | Prochlorperazine Versus Acetaminophen, Aspirin, and Caffeine for the Treatment of Acute Migraine | migraine disorder | Caffeine (NPC256849) | NP level |
| NCT00459420 | Caffeine for Excessive Daytime Somnolence in Parkinson's Disease | Parkinson disease | Caffeine (NPC256849) | NP level |
| NCT03321734 | Intermittent Hypoxia and Caffeine in Infants Born Preterm | hypoxia | Caffeine (NPC256849) | NP level |
| NCT01435837 | Interaction of Caffeine and Hydration on Voice | voice disorders | Caffeine (NPC256849) | NP level |
| NCT00363805 | Green Tea or Polyphenon E in Preventing Lung Cancer in Former Smokers With Chronic Obstructive Pulmonary Disease | lung cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00223691 | Treatment of Orthostatic Hypotension in Autonomic Failure | orthostatic hypotension | Caffeine (NPC256849) | NP level |
| NCT01880866 | (-)-Epicatechin and Pulmonary Arterial Hypertension | pulmonary arterial hypertension | (-)-Epicatechin (NPC126029) | NP level |
| NCT02740712 | Pharmacokinetic Drug-Drug Interaction Study of Rucaparib | neoplasm | Caffeine (NPC256849) | NP level |
| NCT01340599 | Defined Green Tea Catechin Extract in Treating Patients With Localized Prostate Cancer Undergoing Surgery | prostate cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02063802 | Metformin vs Conjugated Linoleic Acid and an Intervention Program With Healthy Habits in Obese Children | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT03358706 | A Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing in Participants With Active Crohn's Disease or Ulcerative Colitis | Crohn's disease;ulcerative colitis | Caffeine (NPC256849) | NP level |
| NCT03003000 | Ibuprofen/Caffeine Lower Back or Neck Pain Study | Back pain;Neck pain | Caffeine (NPC256849) | NP level |
| NCT04570085 | Effect of CAFfeine on Cognition in Alzheimer's Disease | Alzheimer disease | Caffeine (NPC256849) | NP level |
| NCT01842633 | Clinical Study to Evaluate Efficacy of New Paracetamol Formulation Compared to Ibuprofen in Headache | pain | Caffeine (NPC256849) | NP level |
| NCT02311088 | Trial of Caffeine to Alleviate Dyspnea Related to Ticagrelor | Dyspnea | Caffeine (NPC256849) | NP level |
| NCT04643249 | Drug-drug Interaction Study of KL1333 in Healthy Subjects | mitochondrial disease | Caffeine (NPC256849) | NP level |
| NCT01755702 | Paracetamol With Caffeine to Treat Episodic Tension Type Headache | Tension-type headache | Caffeine (NPC256849) | NP level |
| NCT02329600 | Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus | oral lichen planus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02594358 | Caffeine in Amblyopia Study | amblyopia | Caffeine (NPC256849) | NP level |
| NCT00908791 | Proof of Principle Trial to Determine if Nutritional Supplement Conjugated Linoleic Acid (CLA) Can Modulate the Lipogenic Pathway in Breast Cancer Tissue | breast cancer | Linoleic Acid (NPC85813) | NP level |
| NCT03278925 | Defined Green Tea Catechin Extract in Preventing Liver Cancer in Participants With Cirrhosis | cirrhosis of liver | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00836719 | Safety of Polyphenon E in Multiple Sclerosis Pilot Study | multiple sclerosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00302289 | B181: Stimulation of Thermogenesis by Bio-Active Food Ingredients | obesity | Caffeine (NPC256849) | NP level |
| NCT02008721 | Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach | multiple system atrophy | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00726726 | Drug Interaction Study With a Potential Alzheimer's Disease Compound | Alzheimer disease | Caffeine (NPC256849) | NP level |
| NCT00525668 | Sunphenon Epigallocatechin-gallate (EGCg) in Relapsing-remitting Multiple Sclerosis (SuniMS Study) | relapsing-remitting multiple sclerosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02655614 | A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis | amyotrophic lateral sclerosis | Caffeine (NPC256849) | NP level |
| NCT01856868 | Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study) | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
| NCT03928847 | Fibroblast Specific Inhibition of LOXL2 and TGFbeta1 Signaling in Patients With Pulmonary Fibrosis. | idiopathic pulmonary fibrosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00388128 | Caffeine and Intermittent Claudication | intermittent vascular claudication | Caffeine (NPC256849) | NP level |
| NCT03556592 | Drug-drug Interaction Trial With Tralokinumab in Moderate to Severe Atopic Dermatitis - ECZTRA 4 | atopic eczema | Caffeine (NPC256849) | NP level |
| NCT01525628 | Drug Drug Interaction Study Between BI 201335 and BI 207127 in Chronic Hepatitis C Infected Patients | chronic hepatitis C virus infection | Caffeine (NPC256849) | NP level |
| NCT01080677 | Caffeine/Propranolol Intervention for Acute Migraine | migraine disorder | Caffeine (NPC256849) | NP level |
| NCT01433289 | Study to Evaluate Safety and Toxicity of Polyphenon E (EGCG) in HIV-1-Infected Individuals | HIV infection | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02323698 | Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury | Spinal cord injury | Caffeine (NPC256849) | NP level |
| NCT01416480 | Clinical Trial to Evaluate the Safety and Efficacy of "Theobromine Capsule" as an Antitussive in Acute Cougher | bronchial disease | Theobromine (NPC119133) | NP level |
| NCT00917735 | Green Tea and Reduction of Breast Cancer Risk | breast cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02862977 | Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine and Caffeine in Osteomuscular Treatment | pain | Caffeine (NPC256849) | NP level |
| NCT05170464 | The Acute Effects of Exercise and Caffeine on Working Memory During Acute Caffeine Deprivation | memory impairment | Caffeine (NPC256849) | NP level |
| NCT00005828 | Green Tea Extract in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy | prostate cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03022838 | The Effects of Caffeine Withdrawal on Migraine | migraine disorder | Caffeine (NPC256849) | NP level |
| NCT00799890 | Sunphenon in Progressive Forms of Multiple Sclerosis | multiple sclerosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00443170 | A Placebo-controlled Study to Investigate the Safety, and Pharmacokinetics of Oral GSK626616AC in Healthy Subjects | anemia (phenotype) | Caffeine (NPC256849) | NP level |
| NCT04177693 | Pharmacokinetics and Hepatic Safety of EGCG | uterine fibroid | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01636557 | A Study to Evaluate the Effect of a Single Dose of CNTO 136 (Sirukumab) on CYP450 Enzyme Activities After Subcutaneous Administration in Patients With Rheumatoid Arthritis | rheumatoid arthritis | Caffeine (NPC256849) | NP level |
| NCT00449982 | Efficacy and Safety Study of Polyphenon E to Treat External Genital Warts | anogenital venereal wart | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02832271 | Green Tea Extract for Endometriosis Treatment | endometriosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00567905 | Effect of Green Tea Extract on Type 2 Diabetes | type 2 diabetes mellitus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02891538 | Chemopreventive Effects of Epigallocatechin Gallate (EGCG) in Colorectal Cancer (CRC) Patients | malignant colon neoplasm | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03236662 | (-)- Epicatechin Becker Muscular Dystrophy | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
| NCT04898023 | Zinc and Green Tea Extract for Community Respiratory Viral Infections | viral disease | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT04872270 | Pain Management After Shoulder Arthroplasty | pain | Caffeine (NPC256849) | NP level |
| NCT01248468 | Efficacy and Safety of Acetaminophen, Aspirin and Caffeine With Sumatriptan in the Acute Treatment of Migraine | migraine disorder | Caffeine (NPC256849) | NP level |
| NCT00692510 | Drug Interaction Study Between AZD3480 and Cytochrome P450 | Alzheimer disease | Caffeine (NPC256849) | NP level |
| NCT01792310 | A Phase 1/2A Study of LAM561 in Adult Patients With Advanced Solid Tumours | glioma | Oleic Acid (NPC261831) | NP level |
| NCT01462370 | Study to Assess the Safety and Efficacy of Etoricoxib Versus Ibuprofen in the Treatment of Dysmenorrhea (MK-0663-145 AM1) | Dysmenorrhea | Caffeine (NPC256849) | NP level |
| NCT02397382 | Pharmacokinetic Study to Evaluate the Effect of a Single Dose of Guselkumab (CNTO 1959) on CYP 450 Enzyme Activities After Subcutaneous Administration in Participants With Psoriasis | psoriasis | Caffeine (NPC256849) | NP level |
| NCT01426971 | Ibuprofen Versus Ibuprofen Plus Caffeine in the Treatment of Migraine. | pain | Caffeine (NPC256849) | NP level |
| NCT00596011 | Study of Polyphenon E in Men With High-grade Prostatic Intraepithelial Neoplasia | benign prostatic hyperplasia | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00088946 | Erlotinib and Green Tea Extract (Polyphenon® E) in Preventing Cancer Recurrence in Former Smokers Who Have Undergone Surgery for Bladder Cancer | urinary bladder cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03131973 | Effects of Concomitant Administration of BMS-986195 on Methotrexate, Caffeine, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin | rheumatoid arthritis | Caffeine (NPC256849) | NP level |
| NCT00204932 | Effects of CLA Supplements on Body Weight and Fat Oxidation | obesity | Linoleic Acid (NPC85813) | NP level |
| NCT01357681 | Effects of EGCG (Epigallocatechin Gallate) in Huntington's Disease (ETON-Study) | Huntington disease | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01705652 | Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients | prostate cancer | Rutin (NPC176740) | NP level |
| NCT01451723 | Safety and Neuroprotective Effects of Polyphenon E in MS | multiple sclerosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02731495 | Effect of Epigallocatechin -3-gallate Supplementation in Traumatic Brain Injury Patients | brain injury | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00513110 | A Possible Therapeutic Role for Adenosine During Inflammation | serum lipopolysaccharide activity | Caffeine (NPC256849) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
AKR1B1,ACHE
NCT04132336,NCT01426971,NCT01842633,NCT02863575,NCT02974114,NCT04872270,NCT02862977 |
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
MAPK1,ABCB1,POLB,APP,TERT,PPARA,BCL2,NFKB1,DNMT1
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
AKR1B1,HSD17B10,DNMT1,NFKB1,FABP5,ACHE,FFAR4,ALOX15,PSMB5
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
APP,ACHE,SNCA,BACE1
NCT00692510,NCT00726726,NCT00951834,NCT04570085 |
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
PPARA,NFKB1,FFAR1
NCT02627898,NCT00432887,NCT00567905,NCT00607945,NCT04504045 |
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
BCL2,TERT,AKR1C3
NCT00005828,NCT02225093,NCT01705652,NCT00676780,NCT01340599 |
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT00003197,NCT00951158,NCT00091325,NCT01517399,NCT02520752,NCT01596647,NCT02740712,NCT03333824
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
ACHE,SNCA
NCT00459420,NCT00461942,NCT03970798,NCT01738178,NCT01190735 |
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA,AKR1B1,FABP5,DNMT1,BCL2,TERT,ELAVL3
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
FABP5,ACHE,FFAR4,TERT,FFAR4,TERT,FABP5
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
FABP5,AKR1C3,DNMT1,TERT,FABP4,TERT,AKR1C3
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
TERT,BCL2
NCT00516243,NCT00908791,NCT00917735,NCT00676793 |
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
NCT05445232,NCT00204932,NCT00302289,NCT00377975,NCT02048215,NCT02063802
|
Migraine disorder(TM1)Disease Category: 26.Supplementary Chapter Traditional Medicine Conditions - Module IDisease ICD-11 Code: SD10 |
NCT01080677,NCT02183688,NCT03022838,NCT01248468,NCT02582996,NCT01629329
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
APP,FABP5,ACHE,BCL2,ELAVL3,SNCA
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
APP,BCL2,TERT,NR1I2,FABP3,FFAR1
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
AKR1B1,NFKB1
NCT04246762,NCT01636557,NCT03131973 |
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
BCL2,NFKB1
FABP5 NCT02397382,NCT02772601 |
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
TERT,BCL2,DNMT1,ABCB1
NCT00363805 |
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
NFKB1
NCT00799890,NCT00638196,NCT00836719,NCT01451723 |
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
FABP5,TERT,ALOX15
NCT01912820,NCT00459407 |
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA,PGAM1,ACHE,FABP3,SNCA
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
FABP5,FFAR1,TERT,FABP3,SNCA
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
DNMT1,BCL2,MAPK1,TERT
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TERT,DNMT1,BCL2,NFKB1
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
FABP5,AKR1B1,FABP3,FABP4
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ABCB1,ACHE,ELAVL3,ALOX15
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
AKR1C3,ACHE,TERT,NR1I2
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
TERT,PGD,ALOX15,ALPL
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
DNMT1,TERT,BCL2
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
TERT,BCL2
NCT00942422 |
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
DNMT1,TERT,BCL2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
FFAR1,AKR1B1,PPARA
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
MAPK1,TERT,BCL2
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
TERT,AKR1B1,ACHE
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
PPARA
FABP4 NCT03187496 |
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
NFKB1
NCT02647086,NCT03556592 |
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
FFAR1,ACHE
NCT02875691 |
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
AKR1C3,TERT,FABP4
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
AKR1C3,TERT,PGD
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
ALOX15,TERT,ACHE
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
BCL2,TERT
|
Diffuse large B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
BCL2,DNMT1
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
TERT
NCT01661764 |
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
NFKB1,PPARA
|
Dystrophic epidermolysis bullosaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EC32 |
APP
NCT00951964 |
Follicular lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A80 |
BCL2
NCT00455416 |
AmyloidosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5D00 |
APP
NCT02015312 |
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ACHE
NCT00437632 |
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT01433289,NCT04425902
|
Becker muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70.0 |
NCT01856868,NCT03236662
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
ALPL
NCT03358706 |
Uterine fibroidDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E66 |
NCT05364008,NCT04177693
|
Malignant neoplasms of bladder, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.Z |
NCT00666562,NCT00088946
|
Tension-type headacheDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A81 |
NCT01172405,NCT01755702
|
Cocaine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C45 |
NCT00733993,NCT00495092
|
Relapsing-remitting multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40.0 |
NCT01462318,NCT00525668
|
AsphyxiaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD11.1 |
NCT03321734,NCT01875159
|
Complete trisomy 21Disease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD40.0 |
NCT01394796,NCT01699711
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT04553666,NCT00388128
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
ALPL,AKR1B1
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
TERT,ALOX15
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
NFKB1,ACHE
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
TERT,AKR1B1
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
FFAR1,ALPL
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA,FFAR1
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
TERT,ELAVL3
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA,FABP5
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
HSD17B10,DNMT1,ACHE,TERT,PSMB5,LMNA,TDP1,AKR1B1,NR1I2,FABP3,MAPKAPK5,PPARA,FABP5,BCL2,FFAR1,FABP4
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
TDP1,POLB,HSD17B10,AKR1B1,FABP5,PGAM1,FFAR1,FFAR4,TERT,NR1I2,PGD,ELAVL3,ALOX15,ALPL,PSMB5
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,APP,POLB,ABCB1,AKR1C3,PGAM1,ACHE,FFAR4,TERT,NR1I2,PGD,FABP3,ALOX15,SNCA
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
TDP1,FABP5,DNMT1,ALOX15,FFAR4,TERT,NR1I2,PGD,ELAVL3,FABP3,ALPL,PSMB5
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
LMNA,TDP1,ABCB1,DNMT1,FFAR1,BACE1,FFAR4,TERT,PGD,ALOX15,SNCA
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
APP,AKR1B1,FABP5,PGAM1,ACHE,RAD52,MAPK1,PGD,FABP3,MAPKAPK5,SNCA
|
Parasitic infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D0Y-1G2Z |
ALPL
|
HyperlipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARA
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
NFKB1
|
Genetic prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E02 |
ALPL
|
Ovarian dysfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80 |
BCL2
|
Female pelvic painDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA34 |
AKR1C3
|
GoutDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA25 |
PPARA
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
NFKB1
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
TERT
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
AKR1B1
|
RetinopathyDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B71 |
APP
|
DyslipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80-5C81 |
PPARA
|
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
ACHE
|
Diagnostic imagingDisease Category: NADisease ICD-11 Code: N.A. |
APP
|
Chronic myelomonocytic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A40 |
BCL2
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
NFKB1
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
ABCB1
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
ACHE
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
PPARA
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
TERT
|
Desmoid tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F7C |
APP
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
BCL2
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
NFKB1
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
FFAR1
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
ACHE
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
BCL2
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
BCL2
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
PGD
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
ACHE
|
Oesophageal/gastroduodenal disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD90 |
ACHE
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
NFKB1
|
Kaposi sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B57 |
DNMT1
|
Arteries/arterioles disorderDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD52 |
MAPK1
|
Parasitic worm infestationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F90 |
ACHE
|
BCR-ABL1-negative chronic myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A41 |
BCL2
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
PPARA
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
AKR1B1
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
BCL2
|
PediculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G00 |
ACHE
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
NFKB1
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
TERT
|
Skin and skin-structure infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G0Z |
NFKB1
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
DNMT1
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
AKR1B1
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARA
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
AKR1B1
|
Colon cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
ALPL
|
ThrombocytosisDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B63 |
TERT
|
Motor neuron diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60 |
BCL2
|
LeukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60-2B33 |
NCT00262743
|
Amyotrophic lateral sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60.0 |
NCT02655614
|
coronary artery diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Y-BA8Z |
NCT00564824
|
Migraine with auraDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80.1 |
NCT00471952
|
Other specified disorders of teeth and supporting structuresDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA0A.Y |
NCT05485805
|
Malignant neoplasms of colonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
NCT02891538
|
Glioma, malignantDisease Category: X.Extension CodesDisease ICD-11 Code: XH4RQ3 |
NCT01792310
|
AnemiaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A00-3A9Z |
NCT00443170
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
NCT01880866
|
Duchenne muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70.1 |
NCT01183767
|
Malignant neoplasms of nasopharynxDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
NCT01744587
|
Bacterial infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C41 |
NCT00513110
|
Common cold disorder(TM1)Disease Category: 26.Supplementary Chapter Traditional Medicine Conditions - Module IDisease ICD-11 Code: SA60 |
NCT01686646
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
NCT03928847
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
NCT01999829
|
Voice disturbances, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MA82.Z |
NCT01435837
|
Multiple system atrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87.0 |
NCT02008721
|
Malignant neoplasm metastasis, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E2Z |
NCT03864042
|
Injury of spinal cord, level unspecifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: ND51.2 |
NCT02323698
|
Alcohol dependenceDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40.2 |
NCT01289561
|
OsteoporosisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83.1 |
NCT00625391
|
Migraine without auraDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80.0 |
NCT00471952
|
DysmenorrhoeaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA34.3 |
NCT01462370
|
Other specified diseases of the respiratory systemDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB40.Y |
NCT01416480
|
Low back painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME84.2 |
NCT02985671
|
Spinal painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME84 |
NCT03003000
|
Impairment of binocular functionsDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9D46 |
NCT02594358
|
Ulcerative colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD71 |
NCT03358706
|
Cervical spine painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME84.0 |
NCT03003000
|
Ductal carcinoma in situ of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E65.2 |
NCT01060345
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
NCT00707252
|
Lichen planusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA91 |
NCT02329600
|
Chronic hepatitis CDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E51.1 |
NCT01525628
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
NCT00930306
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
NCT02832271
|
Other specified inborn errors of energy metabolismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C53.Y |
NCT04643249
|
Orthostatic hypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA21 |
NCT00223691
|
Infection, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1H0Z |
NCT01275170
|
Anogenital wartsDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A95 |
NCT00449982
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
NCT03533556
|
Breast in situ carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E65 |
NCT03768492
|
Columnar metaplastic epithelium of the oesophagus, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA23.Z |
NCT00233935
|
Prostate hyperplasiaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA90 |
NCT00596011
|
Huntington diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01.10 |
NCT01357681
|
Intracranial injury, unspecifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NA07.Z |
NCT02731495
|
Hepatic fibrosis/cirrhosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB93 |
NCT03278925
|
Fragile X chromosomeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD55 |
NCT01855971
|
Unspecified viral infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D9Z |
NCT04898023
|
Age-associated cognitive declineDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB21.0 |
NCT05170464
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
NCT00029679
|
DyspnoeaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD11.5 |
NCT02311088
|
NarcolepsyDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A20 |
NCT02832336
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
ALPL
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
ACHE
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
ALPL
|
Dengue fever, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D2Z |
NR1I2
|
Malignant neoplasms of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
FABP4
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
AKR1C3
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
FABP4
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
FABP4
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
FFAR4
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
FFAR1
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
TERT
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
FFAR4
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
ACHE
|
Malignant neoplasm of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
FABP4
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
AKR1C3
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
Plant-Targeted Human Disease Network
>> Targets derived from weak experimental activities
