Collective Molecular Activities of the Plant: Lespedeza Davidii
Plant ID: NPO14318
Plant Latin Name: Lespedeza Davidii
Taxonomy Genus: Lespedeza
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
701534
Plant-of-the-World-Online:
n.a.
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
122 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
97 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
12 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99605
Ingredient ID: NPC98340
Ingredient ID: NPC97965
Ingredient ID: NPC97632
Ingredient ID: NPC97455
Ingredient ID: NPC92573
Ingredient ID: NPC92056
Ingredient ID: NPC89102
Ingredient ID: NPC88150
Ingredient ID: NPC86541
Ingredient ID: NPC7934
Ingredient ID: NPC77338
Ingredient ID: NPC74923
Ingredient ID: NPC68637
Ingredient ID: NPC66962
Ingredient ID: NPC63632
Ingredient ID: NPC61535
Ingredient ID: NPC61076
Ingredient ID: NPC58579
Ingredient ID: NPC57781
Ingredient ID: NPC55602
Ingredient ID: NPC51743
Ingredient ID: NPC46072
Ingredient ID: NPC46056
Ingredient ID: NPC37965
Ingredient ID: NPC37818
Ingredient ID: NPC310491
Ingredient ID: NPC309778
Ingredient ID: NPC306418
Ingredient ID: NPC305932
Ingredient ID: NPC303693
Ingredient ID: NPC302416
Ingredient ID: NPC301632
Ingredient ID: NPC300561
Ingredient ID: NPC299401
Ingredient ID: NPC298215
Ingredient ID: NPC290864
Ingredient ID: NPC290598
Ingredient ID: NPC290495
Ingredient ID: NPC289032
Ingredient ID: NPC288656
Ingredient ID: NPC285391
Ingredient ID: NPC282635
Ingredient ID: NPC281220
Ingredient ID: NPC280381
Ingredient ID: NPC279870
Ingredient ID: NPC27765
Ingredient ID: NPC276673
Ingredient ID: NPC276516
Ingredient ID: NPC27460
Ingredient ID: NPC271450
Ingredient ID: NPC270348
Ingredient ID: NPC270028
Ingredient ID: NPC26960
Ingredient ID: NPC263662
Ingredient ID: NPC261962
Ingredient ID: NPC259459
Ingredient ID: NPC257610
Ingredient ID: NPC255488
Ingredient ID: NPC2514
Ingredient ID: NPC249910
Ingredient ID: NPC249012
Ingredient ID: NPC248703
Ingredient ID: NPC246172
Ingredient ID: NPC238520
Ingredient ID: NPC236224
Ingredient ID: NPC233221
Ingredient ID: NPC230747
Ingredient ID: NPC230301
Ingredient ID: NPC228401
Ingredient ID: NPC227750
Ingredient ID: NPC223186
Ingredient ID: NPC221778
Ingredient ID: NPC220053
Ingredient ID: NPC219852
Ingredient ID: NPC219306
Ingredient ID: NPC216692
Ingredient ID: NPC215835
Ingredient ID: NPC214907
Ingredient ID: NPC212442
Ingredient ID: NPC207379
Ingredient ID: NPC20550
Ingredient ID: NPC200294
Ingredient ID: NPC198706
Ingredient ID: NPC196795
Ingredient ID: NPC196636
Ingredient ID: NPC195334
Ingredient ID: NPC191474
Ingredient ID: NPC190027
Ingredient ID: NPC180855
Ingredient ID: NPC174812
Ingredient ID: NPC171538
Ingredient ID: NPC165973
Ingredient ID: NPC164935
Ingredient ID: NPC163970
Ingredient ID: NPC160525
Ingredient ID: NPC158961
Ingredient ID: NPC156433
Ingredient ID: NPC15447
Ingredient ID: NPC149300
Ingredient ID: NPC149115
Ingredient ID: NPC145294
Ingredient ID: NPC143591
Ingredient ID: NPC142752
Ingredient ID: NPC137797
Ingredient ID: NPC133671
Ingredient ID: NPC131713
Ingredient ID: NPC131489
Ingredient ID: NPC128425
Ingredient ID: NPC128174
Ingredient ID: NPC126368
Ingredient ID: NPC125359
Ingredient ID: NPC12421
Ingredient ID: NPC123034
Ingredient ID: NPC122121
Ingredient ID: NPC108348
Ingredient ID: NPC107325
Ingredient ID: NPC105539
Ingredient ID: NPC102889
Ingredient ID: NPC101733
Ingredient ID: NPC100395
Ingredient ID: NPC100037
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 5 | TBXAS1 | Thromboxane-A synthase | P24557 | CHEMBL1835 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
| Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Therapeutic Target | Protein Kinase | LCK | Tyrosine-protein kinase LCK | P06239 | CHEMBL258 |
| Therapeutic Target | Protein Kinase | FYN | Tyrosine-protein kinase FYN | P06241 | CHEMBL1841 |
| Therapeutic Target | Protein Kinase | MAPK14 | MAP kinase p38 alpha | Q16539 | CHEMBL260 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 2 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT02280759 | Efficacy of Gelatin Tannate in Treatment Acute Gastroenteritis in Children. | gastroenteritis | Tannic Acid (NPC149300) | NP level |
| NCT02644200 | Gelatin Tannate as Treatment for Acute Childhood Gastroenteritis | gastroenteritis | Tannic Acid (NPC149300) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,CA7,F2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
TBXAS1,FYN,CA2,F2,LCK,CA7
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAPK14
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2,TBXAS1
|
Arteries/arterioles disorderDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD52 |
MAPK1
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2,TBXAS1
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA2,CA12
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
