Collective Molecular Activities of the Plant: Physalis Alkekengi
Plant ID: NPO14304
Plant Latin Name: Physalis Alkekengi
Taxonomy Genus: Physalis
Taxonomy Family: Solanaceae
Plant External Links:
NCBI TaxonomyDB:
33120
Plant-of-the-World-Online:
n.a.
Country/Region:
China; South Korea; IndiaTraditional Medicine System:
Unani; TCM; Homeopathy; AyurvedaMedicinal Functions:
Antiphlogistic; Antirheumatic; Antitussive; Aperient; Diuretic; Expectorant; Febrifuge; Homeopathy; Lithontripic
India; South Korea; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
127 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
40 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
64 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC97444
Ingredient ID: NPC95389
Ingredient ID: NPC95381
Ingredient ID: NPC93080
Ingredient ID: NPC91529
Ingredient ID: NPC89096
Ingredient ID: NPC85799
Ingredient ID: NPC85550
Ingredient ID: NPC81936
Ingredient ID: NPC81544
Ingredient ID: NPC76128
Ingredient ID: NPC70744
Ingredient ID: NPC69266
Ingredient ID: NPC67850
Ingredient ID: NPC65530
Ingredient ID: NPC6274
Ingredient ID: NPC60942
Ingredient ID: NPC60666
Ingredient ID: NPC58628
Ingredient ID: NPC53168
Ingredient ID: NPC50898
Ingredient ID: NPC5029
Ingredient ID: NPC48367
Ingredient ID: NPC47549
Ingredient ID: NPC46191
Ingredient ID: NPC3845
Ingredient ID: NPC3672
Ingredient ID: NPC3357
Ingredient ID: NPC33378
Ingredient ID: NPC312929
Ingredient ID: NPC30767
Ingredient ID: NPC305818
Ingredient ID: NPC304638
Ingredient ID: NPC30432
Ingredient ID: NPC303422
Ingredient ID: NPC29874
Ingredient ID: NPC293378
Ingredient ID: NPC290437
Ingredient ID: NPC289346
Ingredient ID: NPC288089
Ingredient ID: NPC282923
Ingredient ID: NPC279121
Ingredient ID: NPC277678
Ingredient ID: NPC276222
Ingredient ID: NPC274087
Ingredient ID: NPC273557
Ingredient ID: NPC272865
Ingredient ID: NPC272423
Ingredient ID: NPC271385
Ingredient ID: NPC264192
Ingredient ID: NPC263620
Ingredient ID: NPC26080
Ingredient ID: NPC260508
Ingredient ID: NPC257472
Ingredient ID: NPC254847
Ingredient ID: NPC254614
Ingredient ID: NPC254603
Ingredient ID: NPC254146
Ingredient ID: NPC252169
Ingredient ID: NPC251369
Ingredient ID: NPC250042
Ingredient ID: NPC248949
Ingredient ID: NPC248573
Ingredient ID: NPC247450
Ingredient ID: NPC245584
Ingredient ID: NPC243014
Ingredient ID: NPC242712
Ingredient ID: NPC242486
Ingredient ID: NPC235784
Ingredient ID: NPC233007
Ingredient ID: NPC228093
Ingredient ID: NPC22697
Ingredient ID: NPC226906
Ingredient ID: NPC225710
Ingredient ID: NPC22563
Ingredient ID: NPC223004
Ingredient ID: NPC221090
Ingredient ID: NPC219913
Ingredient ID: NPC219876
Ingredient ID: NPC217373
Ingredient ID: NPC21030
Ingredient ID: NPC206331
Ingredient ID: NPC205756
Ingredient ID: NPC204071
Ingredient ID: NPC203468
Ingredient ID: NPC200740
Ingredient ID: NPC196851
Ingredient ID: NPC194508
Ingredient ID: NPC192916
Ingredient ID: NPC19256
Ingredient ID: NPC191011
Ingredient ID: NPC190457
Ingredient ID: NPC190078
Ingredient ID: NPC189142
Ingredient ID: NPC188291
Ingredient ID: NPC181999
Ingredient ID: NPC179950
Ingredient ID: NPC178852
Ingredient ID: NPC178851
Ingredient ID: NPC176740
Ingredient ID: NPC173637
Ingredient ID: NPC168879
Ingredient ID: NPC165264
Ingredient ID: NPC164487
Ingredient ID: NPC161571
Ingredient ID: NPC160687
Ingredient ID: NPC158565
Ingredient ID: NPC157517
Ingredient ID: NPC156654
Ingredient ID: NPC15215
Ingredient ID: NPC150340
Ingredient ID: NPC142153
Ingredient ID: NPC139508
Ingredient ID: NPC137949
Ingredient ID: NPC13674
Ingredient ID: NPC124436
Ingredient ID: NPC118284
Ingredient ID: NPC117237
Ingredient ID: NPC116657
Ingredient ID: NPC113788
Ingredient ID: NPC111772
Ingredient ID: NPC109879
Ingredient ID: NPC108167
Ingredient ID: NPC106407
Ingredient ID: NPC102316
Ingredient ID: NPC100911
Ingredient ID: NPC100390
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 85 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00098969 | UMCC 2003-064 Resveratrol in Preventing Cancer in Healthy Participants | neoplasm | Resveratrol (NPC161571) | NP level |
| NCT00249951 | Alkaline Citrate Treatment to Lower the Risk of Nephrocalcinosis in Preterm Infants | Nephrocalcinosis | Citric Acid (NPC293378) | NP level |
| NCT00256334 | Resveratrol for Patients With Colon Cancer | malignant colon neoplasm | Resveratrol (NPC161571) | NP level |
| NCT00433576 | Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery | colorectal adenocarcinoma;malignant colon neoplasm;rectum cancer | Resveratrol (NPC161571) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791);Resveratrol (NPC161571) | NP level |
| NCT00567931 | 1-Methyl-D-Tryptophan in Treating Patients With Metastatic or Refractory Solid Tumors That Cannot Be Removed By Surgery | neoplasm | Tryptophan (NPC203468) | NP level |
| NCT00654667 | Mechanisms of Metabolic Regulation of Resveratrol on Humans With Metabolic Syndrome | insulin resistance | Resveratrol (NPC161571) | NP level |
| NCT01012349 | Efficacy and Safety Clinical Trial of the Combination of Acetylsalicylic Acid, Sodium Bicarbonate and Citric Acid, Produced by Geolab Pharmaceutical Industries Ltd., Compared to Acetylsalicylic Acid (Aspirin ® - Bayer) in Patients With Episodic Tension-type Headache. | Tension-type headache | Citric Acid (NPC293378) | NP level |
| NCT01042535 | Vaccine Therapy and 1-MT in Treating Patients With Metastatic Breast Cancer | male breast carcinoma | Tryptophan (NPC203468) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
KDR,DPP4,AURKB,AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
FLT3,SRC,GSK3B,PIM1,KDM1A,AURKB,AXL,TP53
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,CA7,AURKB,TTR,CA9,MMP12,TRPA1,CA12,NPSR1,THPO,CDK1,XDH
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,CA7,TRPA1,GLI1,DPP4,POLB,CA2,XDH,RECQL,AURKB,CYP1B1,HIF1A,SNCA,TTR,CA9,MET,ALOX15,PIM1,ABCG2,AXL,PTGS1,FUT7,NPSR1,ALOX5,CA14,PTGS2,LMNA,CYP2C19
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,TTR,ALOX15
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
AURKB,NOX4,MMP12,MET,NPSR1,CDK1,CYP19A1,ALOX15
|
Adrenal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
ESR1
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
HIF1A
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
