Collective Molecular Activities of the Plant: Uncaria Rhynchophylla
Plant ID: NPO14112
Plant Latin Name: Uncaria Rhynchophylla
Taxonomy Genus: Uncaria
Taxonomy Family: Rubiaceae
Plant External Links:
NCBI TaxonomyDB:
43575
Plant-of-the-World-Online:
n.a.
Country/Region:
ChinaTraditional Medicine System:
TCM; KampoMedicinal Functions:
Antidiarrhoeal; Antiemetic; Antispasmodic; Carminative; Febrifuge; Hepatic
China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
175 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
92 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
107 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99886
Ingredient ID: NPC97553
Ingredient ID: NPC97380
Ingredient ID: NPC94234
Ingredient ID: NPC92774
Ingredient ID: NPC85985
Ingredient ID: NPC85127
Ingredient ID: NPC84073
Ingredient ID: NPC82070
Ingredient ID: NPC80801
Ingredient ID: NPC7543
Ingredient ID: NPC74591
Ingredient ID: NPC731
Ingredient ID: NPC71853
Ingredient ID: NPC649
Ingredient ID: NPC63210
Ingredient ID: NPC61477
Ingredient ID: NPC59159
Ingredient ID: NPC57879
Ingredient ID: NPC54591
Ingredient ID: NPC54379
Ingredient ID: NPC51700
Ingredient ID: NPC49818
Ingredient ID: NPC486470
Ingredient ID: NPC486469
Ingredient ID: NPC486468
Ingredient ID: NPC486467
Ingredient ID: NPC486466
Ingredient ID: NPC486465
Ingredient ID: NPC486464
Ingredient ID: NPC486463
Ingredient ID: NPC486462
Ingredient ID: NPC486461
Ingredient ID: NPC486460
Ingredient ID: NPC486459
Ingredient ID: NPC486458
Ingredient ID: NPC486457
Ingredient ID: NPC486456
Ingredient ID: NPC486455
Ingredient ID: NPC486454
Ingredient ID: NPC486453
Ingredient ID: NPC486452
Ingredient ID: NPC486451
Ingredient ID: NPC486450
Ingredient ID: NPC486449
Ingredient ID: NPC486448
Ingredient ID: NPC486447
Ingredient ID: NPC486446
Ingredient ID: NPC486445
Ingredient ID: NPC486444
Ingredient ID: NPC486443
Ingredient ID: NPC486442
Ingredient ID: NPC486441
Ingredient ID: NPC486440
Ingredient ID: NPC486439
Ingredient ID: NPC486438
Ingredient ID: NPC486437
Ingredient ID: NPC486436
Ingredient ID: NPC47993
Ingredient ID: NPC476114
Ingredient ID: NPC475627
Ingredient ID: NPC475457
Ingredient ID: NPC475454
Ingredient ID: NPC475346
Ingredient ID: NPC475311
Ingredient ID: NPC47475
Ingredient ID: NPC473680
Ingredient ID: NPC473579
Ingredient ID: NPC468994
Ingredient ID: NPC40703
Ingredient ID: NPC40552
Ingredient ID: NPC36769
Ingredient ID: NPC3247
Ingredient ID: NPC324489
Ingredient ID: NPC322058
Ingredient ID: NPC319597
Ingredient ID: NPC312996
Ingredient ID: NPC312684
Ingredient ID: NPC310729
Ingredient ID: NPC309982
Ingredient ID: NPC308583
Ingredient ID: NPC306277
Ingredient ID: NPC305074
Ingredient ID: NPC302857
Ingredient ID: NPC302136
Ingredient ID: NPC299480
Ingredient ID: NPC298932
Ingredient ID: NPC29726
Ingredient ID: NPC294902
Ingredient ID: NPC293255
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC289227
Ingredient ID: NPC288590
Ingredient ID: NPC288537
Ingredient ID: NPC278068
Ingredient ID: NPC276993
Ingredient ID: NPC275463
Ingredient ID: NPC274330
Ingredient ID: NPC273374
Ingredient ID: NPC271686
Ingredient ID: NPC268160
Ingredient ID: NPC267691
Ingredient ID: NPC264711
Ingredient ID: NPC263709
Ingredient ID: NPC261619
Ingredient ID: NPC256923
Ingredient ID: NPC255696
Ingredient ID: NPC25529
Ingredient ID: NPC254240
Ingredient ID: NPC253627
Ingredient ID: NPC252635
Ingredient ID: NPC251619
Ingredient ID: NPC248056
Ingredient ID: NPC245312
Ingredient ID: NPC244753
Ingredient ID: NPC244572
Ingredient ID: NPC243728
Ingredient ID: NPC243673
Ingredient ID: NPC237532
Ingredient ID: NPC236202
Ingredient ID: NPC230301
Ingredient ID: NPC227138
Ingredient ID: NPC220765
Ingredient ID: NPC220151
Ingredient ID: NPC219876
Ingredient ID: NPC21752
Ingredient ID: NPC213711
Ingredient ID: NPC213066
Ingredient ID: NPC212143
Ingredient ID: NPC211755
Ingredient ID: NPC211525
Ingredient ID: NPC210415
Ingredient ID: NPC206728
Ingredient ID: NPC206232
Ingredient ID: NPC202407
Ingredient ID: NPC201287
Ingredient ID: NPC199851
Ingredient ID: NPC199607
Ingredient ID: NPC194130
Ingredient ID: NPC193410
Ingredient ID: NPC19019
Ingredient ID: NPC18982
Ingredient ID: NPC180804
Ingredient ID: NPC179787
Ingredient ID: NPC176740
Ingredient ID: NPC176006
Ingredient ID: NPC175612
Ingredient ID: NPC174788
Ingredient ID: NPC169318
Ingredient ID: NPC167976
Ingredient ID: NPC166456
Ingredient ID: NPC160125
Ingredient ID: NPC158956
Ingredient ID: NPC158733
Ingredient ID: NPC15658
Ingredient ID: NPC1556
Ingredient ID: NPC153694
Ingredient ID: NPC153585
Ingredient ID: NPC153095
Ingredient ID: NPC152489
Ingredient ID: NPC150310
Ingredient ID: NPC148468
Ingredient ID: NPC14515
Ingredient ID: NPC141782
Ingredient ID: NPC140008
Ingredient ID: NPC126029
Ingredient ID: NPC123625
Ingredient ID: NPC118958
Ingredient ID: NPC113989
Ingredient ID: NPC111602
Ingredient ID: NPC108811
Ingredient ID: NPC107782
Ingredient ID: NPC1075
Ingredient ID: NPC103585
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Therapeutic Target | 5HT3 receptor | HTR3A | Serotonin 3a (5-HT3a) receptor | P46098 | CHEMBL1899 |
| Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Therapeutic Target | Enzyme | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Isomerase | TOP2A | DNA topoisomerase II alpha | P11388 | CHEMBL1806 |
| Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Therapeutic Target | Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 22 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01690676 | Effect of an Apple Polyphenol Extract on Brachial Artery Flow-mediated Vasodilatory Function | hypertension | (+)-Epicatechin (NPC261619) | NP level |
| NCT01697579 | Study of the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Fosaprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Children (MK-0517-029) | Chemotherapy-induced nausea and vomiting | Serotonin (NPC220765) | NP level |
| NCT01705652 | Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients | prostate cancer | Rutin (NPC176740) | NP level |
| NCT01856868 | Use of (-)-Epicatechin in the Treatment of Becker Muscular Dystrophy (Pilot Study) | Becker muscular dystrophy | (-)-Epicatechin (NPC126029) | NP level |
| NCT01880866 | (-)-Epicatechin and Pulmonary Arterial Hypertension | pulmonary arterial hypertension | (-)-Epicatechin (NPC126029) | NP level |
| NCT02136342 | Phase 1 Trial of Chlorogenic Acid in Patients With Advanced Cancer | cancer | Chlorogenic Acid (NPC302857) | NP level |
| NCT02245204 | Phase I Studies of Chlorogenic Acid for Injection for Tolerance and Pharmacokinetic of Advanced Cancers | cancer | Chlorogenic Acid (NPC302857) | NP level |
| NCT02330276 | Early Phase Pre-Clinical and Initial Clinical Research on Epicatechin | prediabetes syndrome | (+)-Epicatechin (NPC261619) | NP level |
| NCT02337933 | Effect of Ursolic Acid Administration on Insulin Sensitivity and Metabolic Syndrome | metabolic syndrome | Ursolic Acid (NPC51700) | NP level |
| NCT02351622 | Caffeic Acid Tablets as a Second-line Therapy for ITP | autoimmune thrombocytopenic purpura | Caffeic Acid (NPC294902) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
HTR2C,AKR1B1,HTR2A
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,MAPT,TP53,TOP2A,RELA
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Acute upper respiratory infectionDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA07 |
DRD3,DRD2
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
RELA,NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,HTR1D,MMP1,CA7,F2,CA9,CA6,CA5A,HTR2B,HTR2C,TOP2A,CA12,TSHR,MMP9,ADRA2A,HTR3A
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,SNCA,HTR1D,MMP1,CA7,HTR2A,F2,CA9,RECQL,HTR1B,HTR2B,CES1,MMP2,HTR7,DRD2,DRD1,CA14,HTR3C
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
DRD1,HTR2C,MMP9,F2,MMP1,CA6,TOP2A
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
