Plant ID: NPO137
Plant Latin Name: Nepeta Multifida
Taxonomy Genus: Nepeta
Taxonomy Family: Lamiaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
452600-1
Unknown.
China; Russia; Mongolia; South Africa
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Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
Cytochrome P450 | Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Therapeutic Target | Oxidoreductase | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Therapeutic Target | Transcription factor | AHR | Aryl hydrocarbon receptor | P35869 | CHEMBL3201 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials |
---|
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CYP1B1,CA2,CYP2C9,CISD1,DPP4,CA7,CA14,LMNA,HSD17B2
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
AHR,CSNK2A2,CA12,DPP4,CA7,TYR,LMNA,HSD17B2
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CSNK2A3,AHR,CA12,CA2,CISD1,CYP1A2,HSD17B2
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CA2,DPP4,CISD1,CA7,CA14,HSD17B2
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CSNK2A3,CYP1B1,CA12,CA2,DPP4,LMNA
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
AHR,CA12,DPP4,CYP2C9,CA14,HSD17B2
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
CA14,CA2,CSNK2A1,AHR,CA12
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
CSNK2A2,CA12,CISD1,LMNA,AHR
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CYP1B1,DPP4,CYP2C9,CISD1,HSD17B2
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA14,CA12,CA2,CYP2C9
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CYP1A1,CA2,CYP2C9,CA14
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CA12,DPP4,CYP1B1,CA7
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CYP1A1,CA2,CYP2C9,HSD17B2
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP1A1,CA12,CA2,CYP1A2
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CA12,DPP4,CA7,HSD17B2
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA14,CA12,CA2
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
DPP4,CYP2A6,AHR
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
CA7,CA12,CYP2C9
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
CA2,DPP4,LMNA
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CA2,CYP2C9,CYP1A2
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA7,CA12,CYP2C9
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA12,CA2
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
CA2,CA14
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
CA12,HSD17B2
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
CSNK2A3,LMNA
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
CYP2C9,TYR
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CYP1A1,TYR
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CA12,CA12
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CA12,CYP2A6
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
CYP1B1,DPP4
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
CA2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
TYR
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
DPP4
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
AHR
|
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
CSNK2A1
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
CA2
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
DPP4
|
Metabolic disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5D2Z |
DPP4
|
Coronavirus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D92 |
CSNK2A1
|
Duodenal ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA63 |
CA2
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
AHR
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CA2
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
CA2
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
CA2
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
AHR
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
AHR
|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
DPP4
|
Ureteral cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C92 |
AHR
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
DPP4
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
DPP4
|
Inborn metabolism deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5C59 |
CA14
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
DPP4
|
Mycosis fungoidesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B01 |
CYP2A6
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
CA2
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
CYP1A1
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
CYP2C9
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
CA12
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
DPP4
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
CYP1A1
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
DPP4
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
CA14
|
Pneumonia due to PseudomonasaeruginosaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40.05 |
DPP4
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
CA12
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CYP1A1
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
CYP1A1
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
CYP1B1
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
HSD17B2
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
AHR
|