Brazil; Bangladesh; Kenya; Sudan; Guinea; Costa Rica; Cambodia; Malawi; Ethiopia; Somalia; Peru; Nigeria; Bolivia; Cameroon; Cote d'Ivoire; Benin; Ghana; Cuba; Venezuela; Zambia; Burkina Faso; Togo; Zimbabwe; China; Thailand; Dominican Republic; Belize; Sierra Leone; Liberia; Netherlands; Uganda; Oman; Tanzania; Indonesia; Trinidad and Tobago; Gabon; Guinea-Bissau; Guyana; Honduras; Haiti; Jamaica; Seychelles; Angola; Suriname; Mexico; India; Senegal; Congo; Mozambique; Colombia; Burundi; French Guiana; Taiwan; Fiji; Comoros
Ingredient ID: NPC476058
Ingredient ID: NPC475000
Ingredient ID: NPC474965
Ingredient ID: NPC43940
Ingredient ID: NPC34770
Ingredient ID: NPC312872
Ingredient ID: NPC283791
Ingredient ID: NPC273813
Ingredient ID: NPC26872
Ingredient ID: NPC26850
Ingredient ID: NPC206201
Ingredient ID: NPC204385
Ingredient ID: NPC166884
Ingredient ID: NPC162689
Ingredient ID: NPC148140
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials |
---|
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CYP1A2
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP1A2
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP1A2
|