Collective Molecular Activities of the Plant: Thalictrum Foliolosum
Country/Region:
China; IndiaTraditional Medicine System:
Indian Folk; TCM; Ayurveda; SiddhaMedicinal Functions:
Antiperiodic; Diuretic; Febrifuge; Ophthalmic; Purgative; Salve; Stomachic; Tonic
India; Nepal; China; Myanmar; Thailand
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
52 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
23 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
25 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC91382
Ingredient ID: NPC88864
Ingredient ID: NPC87364
Ingredient ID: NPC86469
Ingredient ID: NPC81218
Ingredient ID: NPC79549
Ingredient ID: NPC77572
Ingredient ID: NPC73199
Ingredient ID: NPC67978
Ingredient ID: NPC59567
Ingredient ID: NPC49075
Ingredient ID: NPC46470
Ingredient ID: NPC428
Ingredient ID: NPC326451
Ingredient ID: NPC32572
Ingredient ID: NPC317145
Ingredient ID: NPC303581
Ingredient ID: NPC291352
Ingredient ID: NPC281457
Ingredient ID: NPC2706
Ingredient ID: NPC263883
Ingredient ID: NPC251735
Ingredient ID: NPC248109
Ingredient ID: NPC23367
Ingredient ID: NPC229373
Ingredient ID: NPC220268
Ingredient ID: NPC215124
Ingredient ID: NPC207786
Ingredient ID: NPC202605
Ingredient ID: NPC200555
Ingredient ID: NPC199402
Ingredient ID: NPC183485
Ingredient ID: NPC171409
Ingredient ID: NPC16452
Ingredient ID: NPC164203
Ingredient ID: NPC154351
Ingredient ID: NPC153319
Ingredient ID: NPC15025
Ingredient ID: NPC150006
Ingredient ID: NPC147390
Ingredient ID: NPC13826
Ingredient ID: NPC130704
Ingredient ID: NPC121400
Ingredient ID: NPC12053
Ingredient ID: NPC119333
Ingredient ID: NPC11708
Ingredient ID: NPC116007
Ingredient ID: NPC115096
Ingredient ID: NPC113961
Ingredient ID: NPC111488
Ingredient ID: NPC10908
Ingredient ID: NPC106786
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials |
|---|
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
CYP2D6
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CYP2D6
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
LMNA
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CYP2D6
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CYP2D6
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
