Collective Molecular Activities of the Plant: Plumbago Zeylanica
Country/Region:
South Africa; Tanzania; Indonesia; India; Laos; Congo; Malaysia; Rwanda; China; Vietnam; Kenya; Thailand; Nigeria; PhilippinesTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCMBrazil; Italy; Bangladesh; Liberia; Sudan; Guinea; Costa Rica; Bahamas; Ethiopia; Rwanda; Tanzania; Somalia; Peru; Laos; Nigeria; Bolivia; Cameroon; Burkina Faso; Ecuador; Benin; Ghana; Australia; Cuba; Togo; Thailand; Venezuela; Cape Verde; Cote d'Ivoire; Sri Lanka; Trinidad and Tobago; Zimbabwe; China; Oman; Senegal; Dominican Republic; Sierra Leone; Eritrea; Netherlands; Swaziland; Gambia; Philippines; Indonesia; New Caledonia; Zambia; Mauritius; Paraguay; Vietnam; Namibia; Guinea-Bissau; Mali; Honduras; Malawi; Haiti; Jamaica; Angola; Chad; Mexico; South Africa; India; Malaysia; Djibouti; Congo; Mozambique; Uganda; Burundi; Kenya; Niger; Fiji; Botswana
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
70 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
51 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
36 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99693
Ingredient ID: NPC94874
Ingredient ID: NPC85346
Ingredient ID: NPC82623
Ingredient ID: NPC80561
Ingredient ID: NPC798
Ingredient ID: NPC70154
Ingredient ID: NPC64093
Ingredient ID: NPC59462
Ingredient ID: NPC55949
Ingredient ID: NPC54123
Ingredient ID: NPC50898
Ingredient ID: NPC4936
Ingredient ID: NPC471263
Ingredient ID: NPC471262
Ingredient ID: NPC471261
Ingredient ID: NPC471260
Ingredient ID: NPC471259
Ingredient ID: NPC471258
Ingredient ID: NPC471257
Ingredient ID: NPC471256
Ingredient ID: NPC471255
Ingredient ID: NPC42372
Ingredient ID: NPC37984
Ingredient ID: NPC37548
Ingredient ID: NPC3604
Ingredient ID: NPC34414
Ingredient ID: NPC304454
Ingredient ID: NPC299972
Ingredient ID: NPC285829
Ingredient ID: NPC282043
Ingredient ID: NPC270483
Ingredient ID: NPC267520
Ingredient ID: NPC266441
Ingredient ID: NPC257188
Ingredient ID: NPC254407
Ingredient ID: NPC248429
Ingredient ID: NPC246246
Ingredient ID: NPC244699
Ingredient ID: NPC242712
Ingredient ID: NPC239564
Ingredient ID: NPC238853
Ingredient ID: NPC234890
Ingredient ID: NPC229958
Ingredient ID: NPC227211
Ingredient ID: NPC220432
Ingredient ID: NPC219913
Ingredient ID: NPC214648
Ingredient ID: NPC213613
Ingredient ID: NPC209177
Ingredient ID: NPC205856
Ingredient ID: NPC199696
Ingredient ID: NPC193358
Ingredient ID: NPC192721
Ingredient ID: NPC183950
Ingredient ID: NPC18260
Ingredient ID: NPC179787
Ingredient ID: NPC176491
Ingredient ID: NPC173350
Ingredient ID: NPC161637
Ingredient ID: NPC154176
Ingredient ID: NPC147238
Ingredient ID: NPC142636
Ingredient ID: NPC137674
Ingredient ID: NPC131406
Ingredient ID: NPC13007
Ingredient ID: NPC127471
Ingredient ID: NPC12455
Ingredient ID: NPC120619
Ingredient ID: NPC111494
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Therapeutic Target | Other cytosolic protein | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Therapeutic Target | Oxidoreductase | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | P14061 | CHEMBL3181 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 1 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT04677855 | Study of PCUR-101 in Combination With ADT in Patients With mCRPC | prostate cancer | Plumbagin (NPC285829) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
MAPT,TP53
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CDC25A,THPO,CA9,CA12,ACHE,TRPA1,XDH,TTR
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CDC25A,CYP1B1,CA9,DPP4,ACHE,TRPA1,XDH,TTR
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
TTR
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CDC25A,CYP19A1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE,ESR2,MAPT
|
AmyloidosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5D00 |
TTR
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
DPP4
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA12
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
