Collective Molecular Activities of the Plant: Tacca Chantrieri
Country/Region:
Thailand; ChinaTraditional Medicine System:
TCMBangladesh; Myanmar; India; Cambodia; Vietnam; China; Laos; Thailand
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
94 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
12 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
33 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99530
Ingredient ID: NPC9824
Ingredient ID: NPC97002
Ingredient ID: NPC94975
Ingredient ID: NPC94188
Ingredient ID: NPC93226
Ingredient ID: NPC91461
Ingredient ID: NPC91014
Ingredient ID: NPC88515
Ingredient ID: NPC82988
Ingredient ID: NPC80248
Ingredient ID: NPC79715
Ingredient ID: NPC76863
Ingredient ID: NPC7456
Ingredient ID: NPC67441
Ingredient ID: NPC65858
Ingredient ID: NPC64769
Ingredient ID: NPC54872
Ingredient ID: NPC53042
Ingredient ID: NPC52277
Ingredient ID: NPC485986
Ingredient ID: NPC485985
Ingredient ID: NPC485984
Ingredient ID: NPC485983
Ingredient ID: NPC485982
Ingredient ID: NPC474320
Ingredient ID: NPC474272
Ingredient ID: NPC474214
Ingredient ID: NPC473853
Ingredient ID: NPC44563
Ingredient ID: NPC44400
Ingredient ID: NPC43252
Ingredient ID: NPC306379
Ingredient ID: NPC297977
Ingredient ID: NPC296334
Ingredient ID: NPC288494
Ingredient ID: NPC286334
Ingredient ID: NPC282489
Ingredient ID: NPC274324
Ingredient ID: NPC273247
Ingredient ID: NPC267822
Ingredient ID: NPC264633
Ingredient ID: NPC252191
Ingredient ID: NPC250436
Ingredient ID: NPC250415
Ingredient ID: NPC242473
Ingredient ID: NPC240451
Ingredient ID: NPC237634
Ingredient ID: NPC236781
Ingredient ID: NPC231607
Ingredient ID: NPC230318
Ingredient ID: NPC227415
Ingredient ID: NPC220397
Ingredient ID: NPC215966
Ingredient ID: NPC207732
Ingredient ID: NPC204012
Ingredient ID: NPC20145
Ingredient ID: NPC201333
Ingredient ID: NPC200566
Ingredient ID: NPC199459
Ingredient ID: NPC197984
Ingredient ID: NPC194674
Ingredient ID: NPC187583
Ingredient ID: NPC184651
Ingredient ID: NPC18220
Ingredient ID: NPC179002
Ingredient ID: NPC177035
Ingredient ID: NPC176224
Ingredient ID: NPC174918
Ingredient ID: NPC17359
Ingredient ID: NPC172896
Ingredient ID: NPC171869
Ingredient ID: NPC171069
Ingredient ID: NPC169818
Ingredient ID: NPC161571
Ingredient ID: NPC160900
Ingredient ID: NPC160854
Ingredient ID: NPC157574
Ingredient ID: NPC157046
Ingredient ID: NPC153453
Ingredient ID: NPC149634
Ingredient ID: NPC147545
Ingredient ID: NPC14704
Ingredient ID: NPC142718
Ingredient ID: NPC141425
Ingredient ID: NPC140592
Ingredient ID: NPC135038
Ingredient ID: NPC120773
Ingredient ID: NPC118754
Ingredient ID: NPC117482
Ingredient ID: NPC111701
Ingredient ID: NPC108659
Ingredient ID: NPC103935
Ingredient ID: NPC102060
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Drug Transporter | ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Therapeutic Target | DNA methyltransferase | DNMT1 | DNA (cytosine-5)-methyltransferase 1 | P26358 | CHEMBL1993 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Isomerase | PTGES | Prostaglandin E synthase | O14684 | CHEMBL5658 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Therapeutic Target | Miscellaneous ion channel | BCL2 | Apoptosis regulator Bcl-2 | P10415 | CHEMBL4860 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
| Therapeutic Target | Other nuclear protein | RAD52 | DNA repair protein RAD52 homolog | P43351 | CHEMBL2362978 |
| Therapeutic Target | Oxidoreductase | PTGS2 | Cyclooxygenase-2 | P35354 | CHEMBL230 |
| Therapeutic Target | Oxidoreductase | NQO2 | Quinone reductase 2 | P16083 | CHEMBL3959 |
| Therapeutic Target | Oxidoreductase | PGD | 6-phosphogluconate dehydrogenase | P52209 | CHEMBL3404 |
| Therapeutic Target | Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Therapeutic Target | Phosphodiesterase | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Therapeutic Target | Protein Kinase | DYRK1A | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Q13627 | CHEMBL2292 |
| Therapeutic Target | Serine protease | DPP4 | Dipeptidyl peptidase IV | P27487 | CHEMBL284 |
| Therapeutic Target | Surface antigen | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
| Therapeutic Target | Threonine protease | PSMB5 | Proteasome Macropain subunit MB1 | P28074 | CHEMBL4662 |
| Therapeutic Target | Transferase | PIK3CA | PI3-kinase p110-alpha subunit | P42336 | CHEMBL4005 |
| Therapeutic Target | Transferase | PIK3CB | PI3-kinase p110-beta subunit | P42338 | CHEMBL3145 |
| Therapeutic Target | Transient receptor potential channel | TRPA1 | Transient receptor potential cation channel subfamily A member 1 | O75762 | CHEMBL6007 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 95 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00676780 | Green Tea Extract and Prostate Cancer | prostate cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01183767 | Sunphenon Epigallocatechin-Gallate (EGCg) in Duchenne Muscular Dystrophy | Duchenne muscular dystrophy | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00625391 | Green Tea and Tai Chi for Bone Health | osteoporosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02314208 | Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5 | Spastic paraplegia | Resveratrol (NPC161571) | NP level |
| NCT03743636 | Nicotinamide Riboside With and Without Resveratrol to Improve Functioning in Peripheral Artery Disease | peripheral arterial disease | Resveratrol (NPC161571) | NP level |
| NCT04177693 | Pharmacokinetics and Hepatic Safety of EGCG | uterine fibroid | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00799890 | Sunphenon in Progressive Forms of Multiple Sclerosis | multiple sclerosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02329600 | Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus | oral lichen planus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT04542993 | Can SARS-CoV-2 Viral Load and COVID-19 Disease Severity be Reduced by Resveratrol-assisted Zinc Therapy | COVID-19;severe acute respiratory syndrome | Resveratrol (NPC161571) | NP level |
| NCT02832271 | Green Tea Extract for Endometriosis Treatment | endometriosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03253913 | Resveratrol and Sirolimus in Lymphangioleiomyomatosis Trial | lymphangioleiomyomatosis | Resveratrol (NPC161571) | NP level |
| NCT05364008 | FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate | uterine fibroid | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT05062486 | A Study to Evaluate the Safety and Efficacy of RQC for AMD | age-related macular degeneration | Resveratrol (NPC161571) | NP level |
| NCT00363805 | Green Tea or Polyphenon E in Preventing Lung Cancer in Former Smokers With Chronic Obstructive Pulmonary Disease | lung cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00449982 | Efficacy and Safety Study of Polyphenon E to Treat External Genital Warts | anogenital venereal wart | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00516243 | Defined Green Tea Catechin Extract in Treating Women With Hormone Receptor Negative Stage I-III Breast Cancer | breast cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00951834 | Sunphenon EGCg (Epigallocatechin-Gallate) in the Early Stage of Alzheimer´s Disease | Alzheimer disease | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00262743 | Green Tea Extract in Treating Patients With Stage 0, Stage I, or Stage II Chronic Lymphocytic Leukemia | leukemia | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02030977 | The Effects of Resveratrol Supplement on Biochemical Factors and Hepatic Fibrosis in Patients With Nonalcoholic Steatohepatitis | non-alcoholic fatty liver disease | Resveratrol (NPC161571) | NP level |
| NCT02409537 | Effects of Dietary Antioxidants to Prevent Cardiovascular Disease | Hypercholesterolemia | Resveratrol (NPC161571) | NP level |
| NCT00666562 | Green Tea Extract in Treating Patients With Nonmetastatic Bladder Cancer | urinary bladder cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT04898023 | Zinc and Green Tea Extract for Community Respiratory Viral Infections | viral disease | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02008721 | Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach | multiple system atrophy | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02731495 | Effect of Epigallocatechin -3-gallate Supplementation in Traumatic Brain Injury Patients | brain injury | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03091543 | Tolerability, Safety and Pharmacokinetics of Four Single-doses of BIA 6-512 (Trans-resveratrol) and Their Effect on the Levodopa Pharmacokinetics | Parkinson disease | Resveratrol (NPC161571) | NP level |
| NCT00942422 | Green Tea Extract in Treating Patients With Monoclonal Gammopathy of Undetermined Significance and/or Smoldering Multiple Myeloma | multiple myeloma | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT04553666 | Reducing Frailty for Older Cancer Survivors Using Supplements | inflammation | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01060345 | A Pilot Study of Chemo-prevention of Green Tea in Women With Ductal Carcinoma in Situ | breast ductal carcinoma in situ | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02062190 | Resveratrol, Cardiovascular Risk Markers And Cognitive Performance In Patients With Schizophrenia | schizophrenia | Resveratrol (NPC161571) | NP level |
| NCT02891538 | Chemopreventive Effects of Epigallocatechin Gallate (EGCG) in Colorectal Cancer (CRC) Patients | malignant colon neoplasm | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00461942 | Efficacy and Safety of Green Tea Polyphenol in De Novo Parkinson's Disease Patients | Parkinson disease | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00088946 | Erlotinib and Green Tea Extract (Polyphenon® E) in Preventing Cancer Recurrence in Former Smokers Who Have Undergone Surgery for Bladder Cancer | urinary bladder cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT04867252 | Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine Parameters and Perceived Stress in Patients With Polycystic Ovarian Syndrome | polycystic ovary syndrome | Resveratrol (NPC161571) | NP level |
| NCT01842399 | Resveratrol and Cardiovascular Health in the Elderly | hypertension | Resveratrol (NPC161571) | NP level |
| NCT00525668 | Sunphenon Epigallocatechin-gallate (EGCg) in Relapsing-remitting Multiple Sclerosis (SuniMS Study) | relapsing-remitting multiple sclerosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03095105 | Pharmacokinetic Profile of BIA 6-512 in Healthy Elderly Subjects Versus Healthy Young Subjects | Parkinson disease | Resveratrol (NPC161571) | NP level |
| NCT02219906 | Resveratrol in Metabolic Syndrome: Effect on Platelet Hyper-reactivity and HDL Lipid Peroxidation | metabolic syndrome | Resveratrol (NPC161571) | NP level |
| NCT03928847 | Fibroblast Specific Inhibition of LOXL2 and TGFbeta1 Signaling in Patients With Pulmonary Fibrosis. | idiopathic pulmonary fibrosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01504854 | Resveratrol for Alzheimer's Disease | Alzheimer disease | Resveratrol (NPC161571) | NP level |
| NCT02549924 | Effect of Administration of Resveratrol on Glycemic Variability in Individuals With Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Resveratrol (NPC161571) | NP level |
| NCT00707252 | Study of Polyphenon E in Addition to Erlotinib in Advanced Non Small Cell Lung Cancer | non-small cell lung carcinoma | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02261844 | Resveratrol and Human Hepatocyte Function in Cancer | liver cancer | Resveratrol (NPC161571) | NP level |
| NCT01394796 | Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals. | Down syndrome | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00098969 | UMCC 2003-064 Resveratrol in Preventing Cancer in Healthy Participants | neoplasm | Resveratrol (NPC161571) | NP level |
| NCT00951964 | Treatment of Epidermolysis Bullosa Dystrophica by Polyphenon E (Epigallocatechin 3 Gallate) | Dystrophic epidermolysis bullosa | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT04400890 | Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of Resveratrol, a Plant Polyphenol, for COVID-19 | COVID-19 | Resveratrol (NPC161571) | NP level |
| NCT01855971 | "Using Epigallocatechin Gallate (EGCG) and Cognitive Training to Modulate Cognitive Performance in Patients With Fragile X Syndrome" (TESFX) | fragile X syndrome | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03093389 | Tolerability and Steady-state Pharmacokinetics of BIA 6-512 | Parkinson disease | Resveratrol (NPC161571) | NP level |
| NCT00917735 | Green Tea and Reduction of Breast Cancer Risk | breast cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02627898 | Effect of Green Tea Extract on Arterial Stiffness in Type 2 Diabetes Mellitus | type 2 diabetes mellitus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT03095092 | Effect of Food on BIA 6-512 (Trans-resveratrol) | Parkinson disease | Resveratrol (NPC161571) | NP level |
| NCT01357681 | Effects of EGCG (Epigallocatechin Gallate) in Huntington's Disease (ETON-Study) | Huntington disease | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02905799 | Resveratrol in Knee Osteoarthritis | osteoarthritis | Resveratrol (NPC161571) | NP level |
| NCT03278925 | Defined Green Tea Catechin Extract in Preventing Liver Cancer in Participants With Cirrhosis | cirrhosis of liver | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00091325 | Green Tea Extract (Polyphenon E) in Preventing Cancer in Healthy Participants | neoplasm | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00005828 | Green Tea Extract in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy | prostate cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01492114 | Anti-inflammatory and Antioxidant Effects of Resveratrol on Healthy Adults. | inflammation | Resveratrol (NPC161571) | NP level |
| NCT03446625 | Resveratrol as a Preventive Treatment of OHSS | infertility | Resveratrol (NPC161571) | NP level |
| NCT02523274 | Resveratrol and Exercise to Treat Functional Limitations in Late Life | aging | Resveratrol (NPC161571) | NP level |
| NCT01744587 | Epstein-Barr Virus Reactivation and the Effect of EGCG on Virus Reactivation in Remission Patients | nasopharyngeal neoplasm | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00433576 | Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery | colorectal adenocarcinoma;malignant colon neoplasm;rectum cancer | Resveratrol (NPC161571) | NP level |
| NCT00567905 | Effect of Green Tea Extract on Type 2 Diabetes | type 2 diabetes mellitus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Epigalocatechin Gallate (NPC250436);Resveratrol (NPC161571) | NP level |
| NCT01677611 | Effects of Resveratrol in Patients With Type 2 Diabetes | type 2 diabetes mellitus | Resveratrol (NPC161571) | NP level |
| NCT00836719 | Safety of Polyphenon E in Multiple Sclerosis Pilot Study | multiple sclerosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02704494 | Resveratrol's Effects in Diabetic Nephropathy | diabetic nephropathy | Resveratrol (NPC161571) | NP level |
| NCT01914081 | Resveratrol: A Potential Anti- Remodeling Agent in Heart Failure, From Bench to Bedside | dilated cardiomyopathy | Resveratrol (NPC161571) | NP level |
| NCT00459407 | Defined Green Tea Catechins in Treating Patients With Prostate Cancer Undergoing Surgery to Remove the Prostate | prostate adenocarcinoma | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01912820 | Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery | prostate adenocarcinoma | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT04449198 | Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1 | type 1 diabetes mellitus | Resveratrol (NPC161571) | NP level |
| NCT03933163 | Micronised Resveratrol as a Treatment for Friedreich Ataxia | Friedreich ataxia | Resveratrol (NPC161571) | NP level |
| NCT03091868 | Pharmacokinetics of Rising Single-doses of BIA 6-512 and Their Effect on the Levodopa Pharmacokinetics | Parkinson disease | Resveratrol (NPC161571) | NP level |
| NCT02245932 | Resveratrol In Chronic Obstructive Pulmonary Disease (COPD) Patients (CARMENS-trial) | chronic obstructive pulmonary disease | Resveratrol (NPC161571) | NP level |
| NCT01321151 | Use of Resveratrol to Decrease Acute Secondary Brain Injury Following Sports-Related Concussions in Boxers | concussion | Resveratrol (NPC161571) | NP level |
| NCT02336633 | Resveratrol and Huntington Disease | Huntington disease | Resveratrol (NPC161571) | NP level |
| NCT02114892 | Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion | metabolic syndrome | Resveratrol (NPC161571) | NP level |
| NCT02433925 | Resveratrol's Effects on Inflammation and Oxidative Stress in Chronic Kidney Disease | chronic kidney disease | Resveratrol (NPC161571) | NP level |
| NCT01699711 | Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool | Down syndrome | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01564381 | Effects of Resveratrol Supplements on Vascular Health in Postmenopausal Women | cardiovascular disease | Resveratrol (NPC161571) | NP level |
| NCT02130440 | Evaluation of the Beneficial Effects of a Nasal Spray of Resveratrol in Children With Seasonal Allergic Rhinitis | seasonal allergic rhinitis | Resveratrol (NPC161571) | NP level |
| NCT03094156 | Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics | Parkinson disease | Resveratrol (NPC161571) | NP level |
| NCT03097211 | Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics With a Single-dose of Levodopa/Benserazide 200/50 mg or With a Single-dose of Levodopa/Benserazide 200/50 mg Plus a Single-dose of Nebicapone 150 mg | Parkinson disease | Resveratrol (NPC161571) | NP level |
| NCT00003197 | Green Tea Extract in Treating Patients With Advanced Solid Tumors | neoplasm | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01433289 | Study to Evaluate Safety and Toxicity of Polyphenon E (EGCG) in HIV-1-Infected Individuals | HIV infection | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00256334 | Resveratrol for Patients With Colon Cancer | malignant colon neoplasm | Resveratrol (NPC161571) | NP level |
| NCT01339884 | A Study of Resveratrol as Treatment for Friedreich Ataxia | Friedreich ataxia | Resveratrol (NPC161571) | NP level |
| NCT01126229 | Resveratrol for Improved Performance in the Elderly | memory impairment | Resveratrol (NPC161571) | NP level |
| NCT00233935 | Defined Green Tea Catechin Extract in Preventing Esophageal Cancer in Patients With Barrett's Esophagus | Barrett's esophagus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00596011 | Study of Polyphenon E in Men With High-grade Prostatic Intraepithelial Neoplasia | benign prostatic hyperplasia | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01451723 | Safety and Neuroprotective Effects of Polyphenon E in MS | multiple sclerosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00654667 | Mechanisms of Metabolic Regulation of Resveratrol on Humans With Metabolic Syndrome | insulin resistance | Resveratrol (NPC161571) | NP level |
| NCT02015312 | A Trial for the Treatment of Cardiac AL-Amyloidosis With the Green Tea Compound Epigallocatechin-3-gallate (TAME-AL) | AL amyloidosis | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT01340599 | Defined Green Tea Catechin Extract in Treating Patients With Localized Prostate Cancer Undergoing Surgery | prostate cancer | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT02875691 | Effect of Green Tea on Treatment of Lupus | systemic lupus erythematosus | Epigalocatechin Gallate (NPC250436) | NP level |
| NCT00676793 | A Study of the Effect of Polyphenon E (Green Tea Extract) on Breast Cancer Progression | breast cancer | Epigalocatechin Gallate (NPC250436) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
PIK3CB,ESR1,MAOA,PIK3CA,TERT,BCL2
NCT00005828,NCT00676780,NCT01340599 |
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
F3,BCL2,LMNA,TRPA1,CA9,DNMT1,PTGES,TERT,PTGS1
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CYP1B1,CISD1,TRPA1,DPP4,CYP3A4,CA9,DNMT1,PTGES,PSMB5
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
PPARD,DPP4,PTGS1,PTGS2
NCT00567905,NCT01677611,NCT02549924,NCT02627898 |
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
DNMT1,CA9,CA12,PTGES,TERT,CA12,TERT,CA9
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
SNCA,DPP4,CYP3A4,CA9,CA12,PTGES,TERT,GLO1
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
NPSR1,PGD,TRPA1,CA9,CA12,PTGES,TERT
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
SNCA,PGAM1,PTGS2,PTGES,DPP4,NQO2,LMNA
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CYP1B1,PTGS2,DPP4,CA9,CA12,LMNA,PTGS1
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
CA14,SNCA,PTGS1,BCL2,APP,PTGES
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
TRPA1,CA9,TERT,TRPA1,CA9,TERT
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
NPSR1,TRPA1,CA9,CA12,PTGES,TERT
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
TERT,BCL2,DNMT1,ABCB1
NCT00363805 |
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
NPSR1,PTGS2,TRPA1,CA9,TERT
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
ESR1,TRPA1,CA9,CA12,TERT
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
PTGS2,ESR1,PTGS1
NCT02832271 |
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PTGS2,PTGS1,PPARD,ESR1
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
DNMT1,BCL2,F3,TERT
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
PIK3CB,PTGS1,PIK3CA,TERT
|
Metabolic disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5D2Z |
DPP4,PPARD
NCT02219906,NCT02114892 |
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
ESR1
NCT01451723,NCT00836719,NCT00799890 |
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
NPSR1,PGD,CA9,TERT
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
CYP1B1,ESR1,TRPA1,DPP4
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
TERT,BCL2,DNMT1
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
PTGS1,PTGS2,CYP3A4
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA14,ABCB1,CA12
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
PTGS1,PTGS2,PIK3CB
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
PTGS1,PTGS2
NCT02905799 |
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
PTGS2,PTGS1
NCT01564381 |
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
PTGS2,PTGS1,DPP4
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
BCL2,TERT,DNMT1
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
TERT,BCL2
NCT00942422 |
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
PIK3CA,BCL2,DPP4
|
Female pelvic painDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA34 |
PTGS2,PTGS1,ESR1
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
TERT,BCL2,DNMT1
|
Follicular lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A80 |
BCL2,PIK3CA
NCT00455416 |
Malignant neoplasms of colonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90 |
NCT02891538,NCT00433576,NCT00256334
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
TERT
NCT00459407,NCT01912820 |
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT00003197,NCT00091325,NCT00098969
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
TRPA1,CA12,PTGES
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
TERT,BCL2,APP
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
NPSR1,TERT,PTGES
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP3A4,CA9,TERT
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CA14,PIK3CB,ABCB1
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CA12,CYP1B1,DPP4
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
F3,PTGES,LMNA
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP3A4,CA12,TERT
|
Urinary system diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GC2Z |
PTGS2,PTGS1
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
PTGS1,PTGS2
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA12,PTGS1
|
Unspecified viral infection of unspecified siteDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D9Z |
ESR1
NCT04898023 |
AmyloidosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5D00 |
APP
NCT02015312 |
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
DPP4,BCL2
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
PGD,ESR1
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
PTGS2,PTGS1
|
MigraineDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80 |
PTGS2,PTGS1
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
TERT,BCL2
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
BCL2,TERT
|
Inflammatory spondyloarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA92 |
PTGS2,PTGS1
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
ESR1,TERT
|
Spinal painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME84 |
PTGS1,PTGS2
|
Joint painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME82 |
PTGS2,PTGS1
|
Reactive arthropathyDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA11 |
PTGS2,PTGS1
|
Cerebral ischaemiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B1Z |
PTGS1,PTGS2
|
Otitis mediaDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AA80-AB0Z |
PTGS1,PTGS2
|
Postoperative inflammationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-CA43 |
PTGS1,PTGS2
|
Inherited coagulation factor deficiencyDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B14 |
PTGS2,PTGS1
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
TRPA1,PTGS1
|
HIV-infected patients with tuberculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1B10-1B14 |
PTGS1,PTGS2
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
ESR1,DPP4
|
Diffuse large B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
BCL2,DNMT1
|
Male infertilityDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB04 |
ESR1
NCT03446625 |
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
PPARD
NCT02030977 |
Dystrophic epidermolysis bullosaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EC32 |
APP
NCT00951964 |
Liver cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12 |
TERT
NCT02261844 |
Complete trisomy 21Disease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD40.0 |
NCT01699711,NCT01394796
|
Uterine fibroidDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E66 |
NCT04177693,NCT05364008
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT04553666,NCT01492114
|
Friedreich ataxiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A03.10 |
NCT01339884,NCT03933163
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04400890,NCT04542993
|
Malignant neoplasms of bladder, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.Z |
NCT00666562,NCT00088946
|
Huntington diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01.10 |
NCT01357681,NCT02336633
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
F3
NCT02875691 |
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
CA12,PTGES
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
TRPA1,DPP4
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
NPSR1,TERT
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
PTGS2,DPP4
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
F3,CA14
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
NPSR1,CA9
|
Pneumonia due to PseudomonasaeruginosaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40.05 |
TRPA1,DPP4
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
CA12,CA9
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
CYP1B1,PTGS2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
NPSR1,PGAM1,PTGS2,PGD,PTGES,PTGS1,PPARD,POLB,APP,TRPA1,CA9,LMNA,ABCB1,CA14,CISD1,CYP1B1,SNCA,DPP4,TERT
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
TERT,POLB,F3,PIK3CA,PTGS2,BCL2,PIK3CB,APP,CA12,ESR1,CYP3A4,PTGS1,ABCB1,CA14,CA9,DNMT1,NQO2
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
NPSR1,PGAM1,PTGS2,PGD,PTGES,PTGS1,TDP1,POLB,TRPA1,CA9,PSMB5,GLO1,CA14,CISD1,DPP4,TERT
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
CA12,PTGES,F3,TDP1,TRPA1,CA9,DNMT1,LMNA,PSMB5,GLO1,CISD1,BCL2,MAPKAPK5,TERT
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
TDP1,SNCA,PGD,LMNA,TRPA1,DNMT1,DPP4,CA9,BACE1,CA12,ABCB1,PTGES,TERT,PTGS1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
CA14,NPSR1,RAD52,SNCA,PGAM1,PGD,APP,TRPA1,GLO1,DPP4,PIK3CB,MAPKAPK5,CA12,PTGS1
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA12,TERT,CA14,PIK3CB,NQO2,ESR1,PIK3CA,BCL2,CA9
NCT00917735,NCT00676793,NCT00516243 |
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
PTGS1,SNCA,PTGS2,MAOA
NCT03097211,NCT00461942,NCT03095092,NCT03091868,NCT03095105,NCT03091543,NCT03093389,NCT03094156 |
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
ESR1,CISD1,TDP1,PGD,DNMT1,PIK3CB,CA9,CA12,PTGES,TERT,PSMB5,GLO1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
PTGS2,PTGES,APP,PPARD,BACE1,MAOA,SNCA,PTGS1
NCT01504854,NCT00951834 |
Mood disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60-6E23 |
MAOA
|
Knee osteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA01 |
PTGS2
|
Chronic myelomonocytic leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A40 |
BCL2
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
NQO2
|
Ovarian dysfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80 |
BCL2
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
PTGS1
|
Breast in situ carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E65 |
ESR1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
DPP4
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
DPP4
|
Metastatic tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D50-2E2Z |
ESR1
|
Menopausal disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA30 |
ESR1
|
Motor neuron diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60 |
BCL2
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
MAOA
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
MAOA
|
Upper respiratory tract disorderDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0Z |
TRPA1
|
Acquired prion diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E01 |
ESR1
|
Eye anterior segment structural developmental anomalyDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA11 |
PTGS1
|
Female genital tract noninflammatory disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA1Y |
ESR1
|
Menstrual cycle bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20 |
ESR1
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
PPARD
|
DyspareuniaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA12 |
ESR1
|
Ulcerative colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD71 |
PTGS1
|
Skin tag/polypDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK71 |
MAOA
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F3
|
Ataxic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A03 |
PTGS1
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
BCL2
|
Autoimmune liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB96 |
PPARD
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
TERT
|
Metastatic lymph node neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60 |
PIK3CB
|
Adrenal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
ESR1
|
Inborn metabolism deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5C59 |
CA14
|
ThrombocytosisDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B63 |
TERT
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
PTGS2
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
CA9
|
RetinopathyDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B71 |
APP
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
ESR1
|
Skeletal anomalyDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD24 |
ESR1
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
BCL2
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
VasculitisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A44 |
PTGS1
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
PTGS1
|
BCR-ABL1-negative chronic myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A41 |
BCL2
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
ESR1
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
MAOA
|
VaginitisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA02 |
ESR1
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
CA9
|
Nutritional deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B50-5B71 |
PTGS1
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
TERT
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
DNMT1
|
DyslipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80-5C81 |
PPARD
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
GLO1
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
DPP4
|
Diagnostic imagingDisease Category: NADisease ICD-11 Code: N.A. |
APP
|
Kaposi sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B57 |
DNMT1
|
Mature B-cell leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A82 |
BCL2
|
Female infertilityDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA31 |
ESR1
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
PTGS2
|
Desmoid tumourDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F7C |
APP
|
Intracranial injury, unspecifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NA07.Z |
NCT02731495
|
Ductal carcinoma in situ of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E65.2 |
NCT01060345
|
Severe acute respiratory syndromeDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D65 |
NCT04542993
|
Prostate hyperplasiaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA90 |
NCT00596011
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
NCT02245932
|
Macular degenerationDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B75 |
NCT05062486
|
Age-associated cognitive declineDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB21.0 |
NCT01126229
|
LymphangioleiomyomatosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB07 |
NCT03253913
|
HypercholesterolaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80.0 |
NCT02409537
|
OsteoporosisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83.1 |
NCT00625391
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
NCT02062190
|
Anogenital wartsDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A95 |
NCT00449982
|
ParaplegiaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB56 |
NCT02314208
|
Relapsing-remitting multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40.0 |
NCT00525668
|
Chronic kidney disease, stage unspecifiedDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61.Z |
NCT02704494
|
Fragile X chromosomeDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD55 |
NCT01855971
|
Malignant neoplasms of nasopharynxDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
NCT01744587
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
NCT00707252
|
Vasomotor/allergic rhinitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA08 |
NCT02130440
|
LeukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60-2B33 |
NCT00262743
|
CardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43 |
NCT01914081
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
NCT02433925
|
Multiple system atrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87.0 |
NCT02008721
|
Insulin-resistance syndromesDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A44 |
NCT00654667
|
Rectum cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B92 |
NCT00433576
|
Lichen planusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA91 |
NCT02329600
|
Type1diabetesmellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A10 |
NCT04449198
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
NCT03928847
|
Ageing associated decline in intrinsic capacityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG2A |
NCT02523274
|
Chronic arterial occlusive disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
NCT03743636
|
ConcussionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NA07.0 |
NCT01321151
|
Columnar metaplastic epithelium of the oesophagus, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA23.Z |
NCT00233935
|
Duchenne muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70.1 |
NCT01183767
|
Hepatic fibrosis/cirrhosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB93 |
NCT03278925
|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT01433289
|
Other specified malignant neoplasms of colonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
NCT00433576
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
NCT01842399
|
Polycystic ovary syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A80.1 |
NCT04867252
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
PTGS2
|
Non-alcoholic steatohepatitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92.1 |
PTGS2
|
Dengue fever, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D2Z |
MAOA
|
Malignant neoplasms of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
PTGS2
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CA9
|
Malaria, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F4Z |
PTGES
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
PTGS2
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
PTGS1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
