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Collective Molecular Activities of the Plant: Teucrium Yemense


Example Image
PLANiTS DNA barcode

Click for details-----ITS

NA

Click for details-----ITS1

NA

Click for details-----ITS2

NA
Taxonomic Information

Plant ID: NPO13237
Plant Latin Name: Teucrium Yemense
Taxonomy Genus: Teucrium
Taxonomy Family: Lamiaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary

Overview of Ingredients

68 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.


29 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

38 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.





Ingredient Structrual Cards

Ingredient ID: NPC97444

Ingredient ID: NPC85799

Ingredient ID: NPC76128

Ingredient ID: NPC69266

Ingredient ID: NPC65530

Ingredient ID: NPC58628

Ingredient ID: NPC53168

Ingredient ID: NPC50898

Ingredient ID: NPC5029

Ingredient ID: NPC488189

Ingredient ID: NPC488188

Ingredient ID: NPC488187

Ingredient ID: NPC488186

Ingredient ID: NPC488185

Ingredient ID: NPC488184

Ingredient ID: NPC488183

Ingredient ID: NPC48367

Ingredient ID: NPC3845

Ingredient ID: NPC3357

Ingredient ID: NPC312929

Ingredient ID: NPC30432

Ingredient ID: NPC29874

Ingredient ID: NPC293378

Ingredient ID: NPC289346

Ingredient ID: NPC288089

Ingredient ID: NPC282923

Ingredient ID: NPC276222

Ingredient ID: NPC273557

Ingredient ID: NPC272865

Ingredient ID: NPC271385

Ingredient ID: NPC26080

Ingredient ID: NPC254847

Ingredient ID: NPC254603

Ingredient ID: NPC252169

Ingredient ID: NPC248949

Ingredient ID: NPC248573

Ingredient ID: NPC245584

Ingredient ID: NPC242712

Ingredient ID: NPC235784

Ingredient ID: NPC22697

Ingredient ID: NPC226906

Ingredient ID: NPC225710

Ingredient ID: NPC22563

Ingredient ID: NPC223004

Ingredient ID: NPC221090

Ingredient ID: NPC219876

Ingredient ID: NPC20791

Ingredient ID: NPC203468

Ingredient ID: NPC192916

Ingredient ID: NPC19256

Ingredient ID: NPC191011

Ingredient ID: NPC190457

Ingredient ID: NPC190078

Ingredient ID: NPC189142

Ingredient ID: NPC179950

Ingredient ID: NPC178851

Ingredient ID: NPC176740

Ingredient ID: NPC173637

Ingredient ID: NPC161571

Ingredient ID: NPC157517

Ingredient ID: NPC156654

Ingredient ID: NPC142153

Ingredient ID: NPC139508

Ingredient ID: NPC13674

Ingredient ID: NPC118284

Ingredient ID: NPC111772

Ingredient ID: NPC109879

Ingredient ID: NPC108167

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Target Type: Individual Protein of Homo sapiens
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.

Detailed Information of Target Proteins

Target Type Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Cytochrome P450 Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 Cytochrome P450 family 3 CYP3A4 Cytochrome P450 3A4 P08684 CHEMBL340
Therapeutic Target Enzyme POLB DNA polymerase beta P06746 CHEMBL2392
Therapeutic Target Enzyme NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Therapeutic Target Enzyme ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Therapeutic Target Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Therapeutic Target Lyase CA14 Carbonic anhydrase XIV Q9ULX7 CHEMBL3510
Therapeutic Target Lyase CA9 Carbonic anhydrase IX Q16790 CHEMBL3594
Therapeutic Target Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Therapeutic Target Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Therapeutic Target Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Therapeutic Target Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Therapeutic Target Lysine demethylase KDM4E Lysine-specific demethylase 4D-like B2RXH2 CHEMBL1293226
Therapeutic Target Nuclear hormone receptor subfamily 3 ESR1 Estrogen receptor alpha P03372 CHEMBL206
Therapeutic Target Nuclear hormone receptor subfamily 3 ESR2 Estrogen receptor beta Q92731 CHEMBL242
Therapeutic Target Oxidoreductase PTGS2 Cyclooxygenase-2 P35354 CHEMBL230
Therapeutic Target Oxidoreductase HSD17B1 Estradiol 17-beta-dehydrogenase 1 P14061 CHEMBL3181
Therapeutic Target Oxidoreductase NQO2 Quinone reductase 2 P16083 CHEMBL3959
Therapeutic Target Oxidoreductase HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Q99714 CHEMBL4159
Therapeutic Target Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor Q6W5P4 CHEMBL5162
Therapeutic Target Phosphodiesterase TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Therapeutic Target Protein Kinase AXL Tyrosine-protein kinase receptor UFO P30530 CHEMBL4895
Therapeutic Target Protein Kinase CSNK2A1 Casein kinase II alpha P68400 CHEMBL3629
Therapeutic Target Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Therapeutic Target Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 P11309 CHEMBL2147
Therapeutic Target Protein Kinase MKNK2 MAP kinase signal-integrating kinase 2 Q9HBH9 CHEMBL4204
Therapeutic Target Protein Kinase YES1 Tyrosine-protein kinase YES P07947 CHEMBL2073
Therapeutic Target Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B Q96GD4 CHEMBL2185
Therapeutic Target Protein Kinase CDK1 Cyclin-dependent kinase 1 P06493 CHEMBL308
Therapeutic Target Protein Kinase MET Hepatocyte growth factor receptor P08581 CHEMBL3717
Therapeutic Target Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 P36888 CHEMBL1974
Therapeutic Target Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Therapeutic Target Secreted protein TTR Transthyretin P02766 CHEMBL3194
Therapeutic Target Secreted protein THPO Thrombopoietin P40225 CHEMBL1293256
Therapeutic Target Serine protease DPP4 Dipeptidyl peptidase IV P27487 CHEMBL284
Therapeutic Target Structural protein LMNA Prelamin-A/C P02545 CHEMBL1293235
Therapeutic Target Threonine protease PSMB1 Proteasome component C5 P20618 CHEMBL4208
Therapeutic Target Transferase PIK3CB PI3-kinase p110-beta subunit P42338 CHEMBL3145
Therapeutic Target Transferase FUT7 Alpha-(1,3)-fucosyltransferase 7 Q11130 CHEMBL3596077
Therapeutic Target Transferase PIK3CA PI3-kinase p110-alpha subunit P42336 CHEMBL4005
Therapeutic Target Transient receptor potential channel TRPA1 Transient receptor potential cation channel subfamily A member 1 O75762 CHEMBL6007
Clinical Trials Summary
Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type Number of clinical trials
NP level85
Clinical trial details
NCT ID Title Condition Form in clinical use Associated by plant or compound
NCT03989271 Biological Effects of Quercetin in COPD chronic obstructive pulmonary disease Quercetin (NPC20791) NP level
NCT01705652 Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients prostate cancer Rutin (NPC176740) NP level
NCT01839344 Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes. type 2 diabetes mellitus Quercetin (NPC20791) NP level
NCT02314208 Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5 Spastic paraplegia Resveratrol (NPC161571) NP level
NCT02130440 Evaluation of the Beneficial Effects of a Nasal Spray of Resveratrol in Children With Seasonal Allergic Rhinitis seasonal allergic rhinitis Resveratrol (NPC161571) NP level
NCT05422885 Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease aging Quercetin (NPC20791) NP level
NCT01375101 Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus oral lichen planus Quercetin (NPC20791) NP level
NCT02114892 Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion metabolic syndrome Resveratrol (NPC161571) NP level
NCT01504854 Resveratrol for Alzheimer's Disease Alzheimer disease Resveratrol (NPC161571) NP level
NCT03097211 Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics With a Single-dose of Levodopa/Benserazide 200/50 mg or With a Single-dose of Levodopa/Benserazide 200/50 mg Plus a Single-dose of Nebicapone 150 mg Parkinson disease Resveratrol (NPC161571) NP level
NCT04733534 An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer childhood cancer Quercetin (NPC20791) NP level
NCT00654667 Mechanisms of Metabolic Regulation of Resveratrol on Humans With Metabolic Syndrome insulin resistance Resveratrol (NPC161571) NP level
NCT01348204 Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators cystic fibrosis Quercetin (NPC20791) NP level
NCT01602068 Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Delivery Prior to Implantation of a Posterior Chamber IOL cataract Citric Acid (NPC293378) NP level
NCT02261844 Resveratrol and Human Hepatocyte Function in Cancer liver cancer Resveratrol (NPC161571) NP level
NCT02067975 Tryptophan MRI in People With Schizophrenia and Healthy Controls schizophrenia Tryptophan (NPC203468) NP level
NCT04449198 Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1 type 1 diabetes mellitus Resveratrol (NPC161571) NP level
NCT01042535 Vaccine Therapy and 1-MT in Treating Patients With Metastatic Breast Cancer male breast carcinoma Tryptophan (NPC203468) NP level
NCT01754779 Treatment for Calcium Phosphate Kidney Stone Disease nephrolithiasis Citric Acid (NPC293378) NP level
NCT02523274 Resveratrol and Exercise to Treat Functional Limitations in Late Life aging Resveratrol (NPC161571) NP level
NCT02433925 Resveratrol's Effects on Inflammation and Oxidative Stress in Chronic Kidney Disease chronic kidney disease Resveratrol (NPC161571) NP level
NCT04622865 Masitinib Combined With Isoquercetin and Best Supportive Care in Hospitalized Patients With Moderate and Severe COVID-19 COVID-19 Isoquercetin (NPC179950) NP level
NCT04400890 Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of Resveratrol, a Plant Polyphenol, for COVID-19 COVID-19 Resveratrol (NPC161571) NP level
NCT02446795 Isoquercetin as an Adjunct Therapy in Patients With Kidney Cancer Receiving First-line Sunitinib: a Phase I/II Trial renal cell carcinoma Isoquercetin (NPC179950) NP level
NCT02219906 Resveratrol in Metabolic Syndrome: Effect on Platelet Hyper-reactivity and HDL Lipid Peroxidation metabolic syndrome Resveratrol (NPC161571) NP level
NCT00256334 Resveratrol for Patients With Colon Cancer malignant colon neoplasm Resveratrol (NPC161571) NP level
NCT00433576 Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery colorectal adenocarcinoma;malignant colon neoplasm;rectum cancer Resveratrol (NPC161571) NP level
NCT04542993 Can SARS-CoV-2 Viral Load and COVID-19 Disease Severity be Reduced by Resveratrol-assisted Zinc Therapy COVID-19;severe acute respiratory syndrome Resveratrol (NPC161571) NP level
NCT01339884 A Study of Resveratrol as Treatment for Friedreich Ataxia Friedreich ataxia Resveratrol (NPC161571) NP level
NCT03095105 Pharmacokinetic Profile of BIA 6-512 in Healthy Elderly Subjects Versus Healthy Young Subjects Parkinson disease Resveratrol (NPC161571) NP level
NCT02905799 Resveratrol in Knee Osteoarthritis osteoarthritis Resveratrol (NPC161571) NP level
NCT04733651 Study to Investigate the Clinical Efficacy of Isoquercetin in Patients With COVID-19 COVID-19 Isoquercetin (NPC179950) NP level
NCT01191216 1-Methyl-D-Tryptophan and Docetaxel in Treating Patients With Metastatic Solid Tumors neoplasm Tryptophan (NPC203468) NP level
NCT04514510 Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease sickle cell anemia Isoquercetin (NPC179950) NP level
NCT02226484 Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD? gastroesophageal reflux disease Quercetin (NPC20791) NP level
NCT02245932 Resveratrol In Chronic Obstructive Pulmonary Disease (COPD) Patients (CARMENS-trial) chronic obstructive pulmonary disease Resveratrol (NPC161571) NP level
NCT03091868 Pharmacokinetics of Rising Single-doses of BIA 6-512 and Their Effect on the Levodopa Pharmacokinetics Parkinson disease Resveratrol (NPC161571) NP level
NCT03933163 Micronised Resveratrol as a Treatment for Friedreich Ataxia Friedreich ataxia Resveratrol (NPC161571) NP level
NCT00249951 Alkaline Citrate Treatment to Lower the Risk of Nephrocalcinosis in Preterm Infants Nephrocalcinosis Citric Acid (NPC293378) NP level
NCT00567931 1-Methyl-D-Tryptophan in Treating Patients With Metastatic or Refractory Solid Tumors That Cannot Be Removed By Surgery neoplasm Tryptophan (NPC203468) NP level
NCT02552888 Nitrite, Isoquercetin and Endothelial Dysfunction (NICE) Trial chronic kidney disease Isoquercetin (NPC179950) NP level
NCT05456022 Therapeutic Efficacy of Quercetin Versus Its Encapsulated Nanoparticle on Tongue Squamous Cell Carcinoma Cell Line mouth neoplasm Quercetin (NPC20791) NP level
NCT01126229 Resveratrol for Improved Performance in the Elderly memory impairment Resveratrol (NPC161571) NP level
NCT01677611 Effects of Resveratrol in Patients With Type 2 Diabetes type 2 diabetes mellitus Resveratrol (NPC161571) NP level
NCT01842399 Resveratrol and Cardiovascular Health in the Elderly hypertension Resveratrol (NPC161571) NP level
NCT04867252 Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine Parameters and Perceived Stress in Patients With Polycystic Ovarian Syndrome polycystic ovary syndrome Resveratrol (NPC161571) NP level
NCT04853199 Quercetin In The Treatment Of SARS-COV 2 COVID-19 Quercetin (NPC20791) NP level
NCT04946383 Safety and Effectivness of Quercetin & Dasatinib on Epigenetic Aging aging Quercetin (NPC20791) NP level
NCT01912820 Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery prostate adenocarcinoma Quercetin (NPC20791) NP level
NCT03743636 Nicotinamide Riboside With and Without Resveratrol to Improve Functioning in Peripheral Artery Disease peripheral arterial disease Resveratrol (NPC161571) NP level
NCT03943459 Sirtuin-1 and Advanced Glycation End-products in Postmenopausal Women With Coronary Disease coronary artery disease Quercetin (NPC20791) NP level
NCT03446625 Resveratrol as a Preventive Treatment of OHSS infertility Resveratrol (NPC161571) NP level
NCT02030977 The Effects of Resveratrol Supplement on Biochemical Factors and Hepatic Fibrosis in Patients With Nonalcoholic Steatohepatitis non-alcoholic fatty liver disease Resveratrol (NPC161571) NP level
NCT01321151 Use of Resveratrol to Decrease Acute Secondary Brain Injury Following Sports-Related Concussions in Boxers concussion Resveratrol (NPC161571) NP level
NCT02704494 Resveratrol's Effects in Diabetic Nephropathy diabetic nephropathy Resveratrol (NPC161571) NP level
NCT02612259 A Phase II, Randomized, Double-blind, Placebo-controlled, in Parallel Groups Clinical Trial to Assess the Safety and Efficacy of Dietary Supplementation With Tryptophan to Achieve Weight Loss, and Its Neuropsychological Effects in Adolescents With Obesity obesity Tryptophan (NPC203468) NP level
NCT01720147 Quercetin in Children With Fanconi Anemia; a Pilot Study Fanconi anemia Quercetin (NPC20791) NP level
NCT01012349 Efficacy and Safety Clinical Trial of the Combination of Acetylsalicylic Acid, Sodium Bicarbonate and Citric Acid, Produced by Geolab Pharmaceutical Industries Ltd., Compared to Acetylsalicylic Acid (Aspirin ® - Bayer) in Patients With Episodic Tension-type Headache. Tension-type headache Citric Acid (NPC293378) NP level
NCT01708278 Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) chronic obstructive pulmonary disease Quercetin (NPC20791) NP level
NCT01421160 Regulating Urine pH Levels to Alleviate Chronic Joint Pain osteoarthritis Citric Acid (NPC293378) NP level
NCT05062486 A Study to Evaluate the Safety and Efficacy of RQC for AMD age-related macular degeneration Quercetin (NPC20791);Resveratrol (NPC161571) NP level
NCT01438320 Q-Trial in Patients With Hepatitis C chronic hepatitis C virus infection Quercetin (NPC20791) NP level
NCT00455416 Dietary Intervention in Follicular Lymphoma follicular lymphoma Resveratrol (NPC161571);Quercetin (NPC20791) NP level
NCT04474626 Isoquercetin in Sickle Cell Anemia sickle cell anemia Isoquercetin (NPC179950) NP level
NCT03253913 Resveratrol and Sirolimus in Lymphangioleiomyomatosis Trial lymphangioleiomyomatosis Resveratrol (NPC161571) NP level
NCT04536090 Study of Isoquercetin (IQC-950AN) Plus Standard of Care Versus Standard of Care Only for the Treatment of COVID-19 COVID-19 Isoquercetin (NPC179950) NP level
NCT04851821 The Effectiveness of Phytotherapy in SARS-COV2(COVID-19) COVID-19 Quercetin (NPC20791) NP level
NCT02618824 Role of Terminal Warm Blood Cardioplegia as Myocardial Protection in the Use of Histidine-Tryptophan-Ketoglutarate Cardioplegia in Complex Congenital Heart Surgery congenital heart disease Tryptophan (NPC203468) NP level
NCT00000324 Tryptophan and Behavior Therapy for Cocaine Abuse - 1 cocaine dependence Tryptophan (NPC203468) NP level
NCT05276895 Effect of Natural Senolytic Agents & NLRP3 Inhibitors on Osteoarthritis osteoarthritis Quercetin (NPC20791) NP level
NCT02549924 Effect of Administration of Resveratrol on Glycemic Variability in Individuals With Type 2 Diabetes Mellitus type 2 diabetes mellitus Resveratrol (NPC161571) NP level
NCT02848131 Senescence in Chronic Kidney Disease chronic kidney disease Quercetin (NPC20791) NP level
NCT03091543 Tolerability, Safety and Pharmacokinetics of Four Single-doses of BIA 6-512 (Trans-resveratrol) and Their Effect on the Levodopa Pharmacokinetics Parkinson disease Resveratrol (NPC161571) NP level
NCT01492114 Anti-inflammatory and Antioxidant Effects of Resveratrol on Healthy Adults. inflammation Resveratrol (NPC161571) NP level
NCT03095092 Effect of Food on BIA 6-512 (Trans-resveratrol) Parkinson disease Resveratrol (NPC161571) NP level
NCT01564381 Effects of Resveratrol Supplements on Vascular Health in Postmenopausal Women cardiovascular disease Resveratrol (NPC161571) NP level
NCT01914081 Resveratrol: A Potential Anti- Remodeling Agent in Heart Failure, From Bench to Bedside dilated cardiomyopathy Resveratrol (NPC161571) NP level
NCT02409537 Effects of Dietary Antioxidants to Prevent Cardiovascular Disease Hypercholesterolemia Resveratrol (NPC161571) NP level
NCT03094156 Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics Parkinson disease Resveratrol (NPC161571) NP level
NCT00098969 UMCC 2003-064 Resveratrol in Preventing Cancer in Healthy Participants neoplasm Resveratrol (NPC161571) NP level
NCT04907253 Quercetin in Coronary Artery By-pass Surgery coronary artery disease Quercetin (NPC20791) NP level
NCT02336633 Resveratrol and Huntington Disease Huntington disease Resveratrol (NPC161571) NP level
NCT02062190 Resveratrol, Cardiovascular Risk Markers And Cognitive Performance In Patients With Schizophrenia schizophrenia Resveratrol (NPC161571) NP level
NCT03093389 Tolerability and Steady-state Pharmacokinetics of BIA 6-512 Parkinson disease Resveratrol (NPC161571) NP level
NCT01962116 Citrate Versus Heparin for the Lock of Non-tunneled Hemodialysis Catheters in Patients Hospitalised in ICU Renal insufficiency Citric Acid (NPC293378) NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

 How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
 ❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant
Association Type & Detailed Evidence
Lung cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25
 CDK1,FLT3,ALOX5,KDM1A,EGFR,KDR,MET,AXL,IGF1R
Hepatoblastoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.01
 CA12,CDK1,CA4,SRC,AKR1B1,AURKB,IGF1R,CYP19A1,NOX4
Superficial ovarian endometriosis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA10.B4
 DPP4,LMNA,CA4,SRC,CA2,ACHE,NQO2,PTGS2,HSD17B1
Urothelial carcinoma of bladder
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94.2
 CDK1,AKR1B1,AURKB,HSD17B1,CYP3A4,CA2,CA9,CYP1A2,TTR
Malignant haematopoietic neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B33
 CDK1,KDM1A,PIK3CA,TP53,FLT3,AURKB,SRC,DPP4
Alzheimer disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A20
 FLT3,KDR,ESR2,MET,PTGS2,ACHE,PTGS1
 NCT01504854
Malignant neoplasms of thyroid gland, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D10.Z
 CA12,DPP4,XDH,CYP1B1,CA7,ALOX5,MET,NOX4
Malignant neoplasms of corpus uteri, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.Z
 CDK1,AURKB,CA2,XDH,NPSR1,CA9,ALOX15,CYP1A1
Invasive carcinoma of breast
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C61
 CA12,CDK1,THPO,AURKB,TRPA1,FUT7,ESR1,CA9
Renal cell carcinoma, chromophobe type
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH6153
 TTR,MET,CA12,AURKB,CYP3A4,CYP1A2,CA2,CYP1A1
Liver cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12
 CSNK2A1,KDR,MKNK2,MET,IGF1R,EGFR
 NCT02261844
Acute myeloid leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A60
 KDM1A,SRC,FLT3,AXL,PIM1,TP53,AURKB
Pain, unspecified
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG3Z
 IGF1R,PIK3CB,PTGS2,AKR1B1,PTGS1,ACHE,ALOX5
COVID-19
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D6Y
 NCT04542993,NCT04400890,NCT04851821,NCT04853199,NCT04622865,NCT04536090,NCT04733651
Adenocarcinoma of stomach
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B72.0
 CDK1,AURKB,NPSR1,ALOX15,CYP19A1,MET,NOX4
Carpal tunnel syndrome
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C10.0
 DPP4,THPO,TRPA1,FUT7,ESR1,CYP1B1,NOX4
Brain cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00
 KDR,ESR1,SRC,TP53,EGFR,MET
Rheumatoid arthritis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA20
 ABCG2,AKR1B1,PTGS2,CA2,ALOX5,PTGS1
Cardiovascular disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA00-BE2Z
 PTGS2,SRC,MET,KDR,PTGS1
 NCT01564381
Prostate cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C82
 ESR2,PIK3CA,AURKB,PIK3CB,ESR1
 NCT01705652
Type 2 diabetes mellitus
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A11
 PTGS2,PTGS1,DPP4
 NCT02549924,NCT01839344,NCT01677611
Leishmaniasis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F54
 DPP4,AKR1B1,TRPA1,FLT3,FUT7,NOX4
Malignant neoplasm metastasis in lymph nodes of head, face or neck
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D60.0
 AURKB,TRPA1,PTGS2,NPSR1,CA9,NOX4
West Nile virus infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D46
 DPP4,AXL,ACHE,PTGS2,CYP19A1,MET
Other specified malignant neoplasms of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.Y
 CA12,CDK1,AURKB,XDH,CA9,HSD17B1
Malignant neoplasms of oesophagus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B70
 CDK1,AURKB,ALOX15,ACHE,NPSR1,NOX4
Multiple myeloma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A83
 IGF1R,FLT3,KDR,SRC,AXL
Renal cell carcinoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90
 MET,EGFR,CA9,KDR
 NCT02446795
Osteoarthritis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA00-FA05
 PTGS2,PTGS1
 NCT01421160,NCT02905799,NCT05276895
Ovarian cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C73
 TP53,KDR,SRC,MET,FLT3
Glaucoma
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9C61
 ACHE,AKR1B1,CA4,MET,CA2
Myelodysplastic syndrome
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A37
 TP53,KDM1A,EGFR,AXL,KDR
Chronic kidney disease
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB61
 XDH,IGF1R
 NCT02552888,NCT02848131,NCT02433925
Other specified malignant neoplasms ofcolon
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90.Y
 NPSR1,CA9,MET,NOX4,CYP1A1
Melanoma of skin
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30
 IGF1R,ABCG2,FUT7,TTR,NOX4
Chikungunya virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D40
 LMNA,EGFR,AXL,XDH,CYP19A1
Pancreatic cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10
 EGFR,TP53,SRC,IGF1R
Metastatic lymph node neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D60
 MET,KDR,EGFR,PIK3CB
Chronic pain
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG30
 FLT3,EGFR,PTGS2,KDR
Peritoneal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C51
 KDR,TP53,FLT3,SRC
Postoperative inflammation
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A00-CA43
 ALOX5,SRC,PTGS2,PTGS1
Acute diabete complication
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A2Y
 AKR1B1,KDR,AURKB,DPP4
Endometriosis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA10
 CYP19A1,ESR1,PTGS1,PTGS2
Head and neck cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D42
 KDR,MET,TP53,EGFR
Seborrhoeic dermatitis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA81
 CA12,CA2,CA4,PTGS1
Atopic eczema
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA80
 PTGS1,ALOX5,PTGS2,CYP3A4
Bacterial infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1A00-1C4Z
 CA4,CA14,CA12,CA2
Stomach cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B72
 EGFR,MET,KDR,TP53
Myocardial infarction
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA41-BA43
 PTGS2,PTGS1,DPP4,THPO
Neuropathy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C0Z
 AKR1B1,TRPA1,PTGS1,CYP19A1
Mature T-cell lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A90
 MKNK2,CA9,KDM1A,EGFR
Hyper-lipoproteinaemia
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C80
 ESR2,PTGS1,PTGS2,ESR1
Mature B-cell leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A82
 EGFR,AXL,SRC,TP53
Adenocarcinoma of prostate
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C82.0
 ALOX15,TTR,NOX4
 NCT01912820
Human immunodeficiency virus disease without mention of tuberculosis or malaria
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1C62
 AXL,MET,FLT3,PTGS2
Solid tumour/cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00-2F9Z
 NQO2,CA14,AURKB,AXL,CYP3A4,POLB,KDM1A,ALOX5,IGF1R,CA9,FLT3,TP53,EGFR,ESR1,CA2,PTGS2,PIM1,PIK3CA,CA12,CSNK2A1,CA4,SRC,MET,MKNK2,PTGS1,XDH,KDR,CDK1,PIK3CB,YES1
Nasopharyngeal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B6B
 ALOX5,CDK1,EGFR
Psoriasis
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA90
 ALOX5,DPP4,FLT3
Non-small cell lung cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25
 KDR,EGFR,MET
Female pelvic pain
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA34
 PTGS2,PTGS1,ESR1
Melanoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C30
 MET,EGFR,KDR
NA
Disease Category: NA
Disease ICD-11 Code: NA
 MET,NOX4
 NCT01492114
Indeterminate colitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD72
 ESR2,PTGS2,PTGS1
Myeloproliferative neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A20
 KDM1A,SRC,FLT3
Pleomorphic sarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B54
 MET,KDR,SRC
Pituitary gland disorder
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A60-5A61
 ESR1,IGF1R,ALOX5
Chronic arterial occlusive disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD4Z
 DPP4,MET,TP53
Metabolic disorder
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C50-5D2Z
 DPP4
 NCT02114892,NCT02219906
Asthma
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA23
 PTGS2,CA4,ALOX5
Schizophrenia
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A20
 AKR1B1
 NCT02067975,NCT02062190
Neoplasms
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 02
 NCT00098969,NCT00567931,NCT01191216
Chronic obstructive pulmonary disease
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA22
 NCT01708278,NCT02245932,NCT03989271
Ageing associated decline in intrinsic capacity
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MG2A
 NCT04946383,NCT05422885,NCT02523274
Osteoarthritis, unspecified
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA0Z
 CA12,CDK1,TRPA1
Tetralogy of Fallot
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LA88.2
 CA14,CA4,ABCG2
Systemic lupus erythematosus
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A40.0
 ACHE,YES1,CYP1A1
Heart failure, unspecified
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD1Z
 ABCG2,CYP1B1,PTGS2
Ebola virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D60.01
 AXL,ACHE,MET
Diffuse large B-cell lymphomas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A81
 RECQL,THPO,HSD17B10,EGFR,ACHE,KDM1A,MET,PSMB5,CA12,CDK1,LMNA,TDP1,AKR1B1,AURKB,TP53,TRPA1,KDR,ESR2,SRC,PSMB1,CSNK2A2,CSNK2A1,AXL,CA9,NOX4
Adenocarcinoma of pancreas
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C10.0
 CA14,RECQL,POLB,ACHE,XDH,PTGS1,CYP2C19,TTR,MET,LMNA,AURKB,TRPA1,PIM1,CYP1B1,CA7,DPP4,CA2,FUT7,NPSR1,ALOX15,ALOX5,AXL,PTGS2,CA9,ABCG2
Carcinosarcoma of uterus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76.43
 CA14,POLB,HSD17B10,XDH,PTGS1,KDM1A,MET,PSMB5,TDP1,TP53,AKR1B1,AURKB,TRPA1,YES1,CA7,DPP4,CA2,FUT7,NPSR1,ALOX15,CYP19A1,PTGS2,CA9
Mesothelioma of pleura
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C26.0
 RECQL,EGFR,XDH,FLT3,PTGS1,MET,CA12,CDK1,LMNA,TDP1,AURKB,TRPA1,PIM1,KDR,CA7,DPP4,SRC,CSNK2A2,FUT7,ALOX15,ALOX5,AXL,CA9
Germ cell tumour of testis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C80.2
 CA14,ALOX12,ACHE,XDH,PTGS1,TTR,MET,CA12,CDK1,CA4,AKR1B1,TRPA1,PIK3CB,KDR,DPP4,FUT7,NPSR1,ALOX5,ABCG2,NOX4
Reactive arthropathy
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA11
 PTGS2,PTGS1
Diabetes mellitus, type unspecified
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A14
 ESR1,DPP4
Low bone mass disorder
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FB83
 ESR1,CA2
Unspecific body region injury
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: ND56
 EGFR,MET
Joint pain
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: ME82
 PTGS2,PTGS1
Unspecified viral infection of unspecified site
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D9Z
 FLT3,ESR1
Malignant digestive organ neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C11
 SRC,KDR
Fallopian tube cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C74
 TP53,SRC
Cervical cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C77
 SRC,TP53
Menopausal disorder
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA30
 ESR1,ESR2
Spinal pain
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: ME84
 PTGS1,PTGS2
Inflammatory spondyloarthritis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA92
 PTGS1,PTGS2
Thyroid cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D10
 KDR,MET
Inherited coagulation factor deficiency
Disease Category: 03.Diseases of the blood or blood-forming organs
Disease ICD-11 Code: 3B14
 PTGS1,PTGS2
HIV-infected patients with tuberculosis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1B10-1B14
 PTGS2,PTGS1
Systemic sclerosis
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A42
 PTGS1
 NOX4
Migraine
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A80
 PTGS1,PTGS2
Cushing syndrome
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A70
 CYP19A1,ESR2
Heart failure
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD10-BD1Z
 CA2,XDH
Cardiomyopathy
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BC43
 TTR
 NCT01914081
Idiopathic interstitial pneumonitis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CB03
 ALOX5,FLT3
Gastrointestinal stromal tumour
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B5B
 SRC,KDR
Mature B-cell lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A85
 FLT3,CDK1
Otitis media
Disease Category: 10.Diseases of the ear or mastoid process
Disease ICD-11 Code: AA80-AB0Z
 PTGS2,PTGS1
Cataract
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B10
 AKR1B1
 NCT01602068
Thrombocytopenia
Disease Category: 03.Diseases of the blood or blood-forming organs
Disease ICD-11 Code: 3B64
 ALOX5,KDR
Urinary system disease
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GC2Z
 PTGS1,PTGS2
Cerebral ischaemia
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B1Z
 PTGS1,PTGS2
Male infertility
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB04
 ESR1
 NCT03446625
Insomnia
Disease Category: 07.Sleep-wake disorders
Disease ICD-11 Code: 7A00-7A0Z
 NQO2,CA2
Multiple sclerosis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A40
 SRC,ESR1
Motor neuron disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B60
 SRC,IGF1R
Endometrial cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C76
 TP53,SRC
Influenza
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1E30-1E32
 XDH,ALOX5
Ischemia
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B10-8B11
 SRC,EGFR
BCR-ABL1-negative chronic myeloid leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A41
 FLT3,SRC
Hepatitis virus infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1E50-1E51
 EGFR,ESR2
Follicular lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A80
 PIK3CA
 NCT00455416
Vasomotor/allergic rhinitis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA08
 ESR2
 NCT02130440
coronary artery disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA8Y-BA8Z
 NCT04907253,NCT03943459
Polycystic ovary syndrome
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A80.1
 FUT7
 NCT04867252
Sickle-cell disorder
Disease Category: 03.Diseases of the blood or blood-forming organs
Disease ICD-11 Code: 3A51
 NCT04474626,NCT04514510
Friedreich ataxia
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A03.10
 NCT01339884,NCT03933163
Malignant neoplasms of colon
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90
 NCT00433576,NCT00256334
Coeliac disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA95
 CDK1,CYP1A1
Zika virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D48
 AXL,ACHE
Dengue fever, unspecified
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D2Z
 ABCG2,AURKB
Pneumonia due to Pseudomonasaeruginosa
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA40.05
 DPP4,TRPA1
Chronic rhinosinusitis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA0A
 CA9,CYP1A1
Gliomas of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.0
 PTGS1,NOX4
Breast cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C60-2C6Y
 PIK3CA,CA12,PIK3CB,CA14,KDR,EGFR,CDK1,MET,ESR1,CA2,CA9,CA4,NQO2,MKNK2,CYP19A1,AXL,ESR2,SRC,IGF1R
Serous cystadenoma,borderline malignancy of ovary
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C73.4
 ALOX12,XDH,MET,PSMB5,CA12,CSNK2A3,TDP1,TP53,PIK3CB,YES1,ESR1,CYP1A2,CA2,FUT7,ALOX15,ALOX5,CSNK2A1,CA9,NOX4
Malignant neoplasms of biliary tract, distal bile duct
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C15
 ALOX12,IGF1R,PTGS1,CSNK2A3,CDK1,LMNA,CA4,TP53,AKR1B1,AURKB,TRPA1,ESR2,SRC,ALOX5,CSNK2A1,CA9,NOX4
Other specified malignant neoplasms of kidney, except renal pelvis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C90.Y
 ALOX5,AURKB,ACHE,XDH,TRPA1,MET,CA9,CYP19A1,AURKB,TRPA1,FUT7,CA9,ALOX5
Hepatocellular carcinoma of liver
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C12.02
 CA12,CDK1,CA4,AURKB,CA9,CYP19A1,NOX4,CA12,CDK1,SRC,AURKB,CA9,CYP19A1
Malignant neoplasms of thymus
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C27
 HSD17B10,ACHE,FLT3,PSMB5,AKR1B1,CYP3A4,TRPA1,CYP1B1,DPP4,PSMB1,FUT7,ALOX15,CA9
Glioblastoma of brain
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A00.00
 CA12,CSNK2A3,DPP4,LMNA,CA2,PTGS2,PTGS1,MET,CYP1B1,KDR,CA9,CYP19A1
Malignant neoplasms of adrenal gland
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D11
 CA12,CDK1,DPP4,CA4,AURKB,CYP3A4,FUT7,MET,CA9,CA7,CYP19A1,NOX4
Parkinsonism
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A00
 ACHE,PTGS1,SRC,PTGS2
 NCT03091543,NCT03094156,NCT03091868,NCT03093389,NCT03095092,NCT03097211,NCT03095105
Adenocarcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.0
 CA12,CDK1,THPO,AURKB,ACHE,XDH,TRPA1,NPSR1,CA9,CA7,TTR
Colorectal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B91
 PIK3CB,MET,FLT3,IGF1R,MKNK2,EGFR,TP53,PIK3CA,PTGS1,KDR
Pheochromocytoma
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH3854
 CA14,ACHE,XDH,PTGS1,TTR,MET,CA4,CA2,FUT7,NOX4
Squamous cell carcinoma of bronchus or lung
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C25.2
 CA12,CDK1,ALOX12,AURKB,HSD17B1,TRPA1,XDH,NPSR1,CA9,CA7
Cytomegaloviral disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D82
 CA14,THPO,KDM4E,CA2,ACHE,PIK3CB,ALOX15,CYP2C19,ESR2,CYP1A1
Female infertility
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA31
 ESR1
Kidney failure
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB60-GB6Z
 TP53
Menstrual cycle bleeding disorder
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA20
 ESR1
Malignant mesenchymal neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B5D-2B5Y
 EGFR
Leiomyosarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B58
 SRC
Dementia
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6D80-6D8Z
 ACHE
Filariasis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F66
 ALOX5
Dyspareunia
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA12
 ESR1
Upper respiratory tract disorder
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA0Z
 TRPA1
Testicular cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C80
 EGFR
Acne vulgaris
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: ED80
 ESR1
Inborn purine/pyrimidine/nucleotide metabolism error
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C55
 XDH
Myasthenia gravis
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C6Y
 ACHE
Breast in situ carcinoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2E65
 ESR1
Bladder cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94
 TP53
Carcinoid syndrome
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5B10
 ALOX5
Ischaemic/haemorrhagic stroke
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B20
 THPO
Gout
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA25
 XDH
Sepsis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1G40-1G41
 ESR2
Thyrotoxicosis
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A02
 IGF1R
Amyloidosis
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5D00
 TTR
Coronavirus infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D92
 CSNK2A1
Pediculosis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1G00
 ACHE
Substance abuse
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6C40
 ACHE
Transplanted organ/tissue
Disease Category: 24.Factors influencing health status or contact with health services
Disease ICD-11 Code: QB63
 FLT3
Acquired prion disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8E01
 ESR1
Metastatic tumour
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D50-2E2Z
 ESR1
Knee osteoarthritis
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA01
 PTGS2
Transplant rejection
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: NE84
 TP53
Encephalopathy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8E47
 XDH
Epidermal dysplasias
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EK90
 SRC
Skeletal anomaly
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LD24
 ESR1
Phakomatoses/hamartoneoplastic syndrome
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LD2D
 FLT3
Metastatic liver/bile duct neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D80
 TP53
Duodenal ulcer
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA63
 CA2
Oesophageal/gastroduodenal disorder
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD90
 ACHE
Anxiety
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MB24.3
 CYP3A4
Biliary tract cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C17
 MET
Ewing sarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B52
 KDM1A
Liver disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB90-DB9Z
 MET
Esophageal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B70
 TP53
Diabetic foot ulcer
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD54
 EGFR
Ischemic heart disease
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA40-BA6Z
 MET
Inborn metabolism deficiency
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C50-5C59
 CA14
Skin postprocedural disorder
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EL8Y
 EGFR
Ataxic disorder
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A03
 PTGS1
Chronic myelomonocytic leukaemia
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A40
 FLT3
Human immunodeficiency virus disease
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1C60-1C62
 FLT3
Ovarian dysfunction
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A80
 TP53
Metastatic malignant neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D50-2E09
 AXL
Thrombosis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB61-GB90
 AKR1B1
Hypopharyngeal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B6D
 EGFR
Oesophagitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA24
 CYP19A1
Vaginitis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA02
 ESR1
Vasculitis
Disease Category: 04.Diseases of the immune system
Disease ICD-11 Code: 4A44
 PTGS1
Liposarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B59
 TP53
Angina pectoris
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA40
 EGFR
Metastatic digestive system neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D8Y
 SRC
Retinopathy
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B71
 IGF1R
Eye anterior segment structural developmental anomaly
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LA11
 PTGS1
Lip/oral cavity/pharynx neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B6E
 TP53
Synovial sarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B5A
 SRC
Multiple structural anomalies syndrome
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LD2F
 IGF1R
Autism spectrum disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6A02
 DPP4
Diffuse large B-cell lymphoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A81
 FLT3
Metastatic biliary tract neoplasms
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C14-2C17
 EGFR
Essential hypertension
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BA00
 CA2
Colon cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90
 EGFR
Extraocular muscle disorder
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9C82
 IGF1R
Unspecific substance harmful effect
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: NE6Z
 ACHE
Intracerebral haemorrhage
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8B00
 EGFR
Osteosarcoma
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B51
 SRC
Muscular dystrophy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C70
 PTGS1
Bone/articular cartilage neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2F7B
 FLT3
Urethral cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C93
 EGFR
Mastocytosis
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A21
 FLT3
Ulcerative colitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD71
 PTGS1
Mild neurocognitive disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6D71
 ACHE
Irritable bowel syndrome
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD91
 ABCG2
Adrenal cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D11
 ESR1
Mineral deficiency
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5B5K
 XDH
Nutritional deficiency
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5B50-5B71
 PTGS1
Prostate hyperplasia
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA90
 ESR2
Parasitic worm infestation
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F90
 ACHE
Inflammatory arthropathy
Disease Category: 15.Diseases of the musculoskeletal system or connective tissue
Disease ICD-11 Code: FA2Z
 FLT3
Spinal cord/cranial nerve neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A02
 EGFR
Digestive organ benign neoplasm
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2E92
 KDR
Fungal infection
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1F29-1F2F
 ALOX5
Female genital tract noninflammatory disorder
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GA1Y
 ESR1
Concussion
Disease Category: 22.Injury, poisoning or certain other consequences of external causes
Disease ICD-11 Code: NA07.0
 NCT01321151
Pulmonary hypertension
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BB01
 NCT01842399
Chronic hepatitis C
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1E51.1
 NCT01438320
Structural developmental anomaly of heart or great vessels, unspecified
Disease Category: 20.Developmental anomalies
Disease ICD-11 Code: LA8Z
 NCT02618824
Type1diabetesmellitus
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A10
 NCT04449198
Nephrocalcinosis
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB57
 NCT00249951
Macular degeneration
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9B75
 NCT05062486
Gastro-oesophageal reflux disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DA22
 NCT02226484
Insulin-resistance syndromes
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5A44
 NCT00654667
Congenital aplastic anaemia
Disease Category: 03.Diseases of the blood or blood-forming organs
Disease ICD-11 Code: 3A70.0
 NCT01720147
Huntington disease
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A01.10
 NCT02336633
Other specified malignant neoplasms of colon
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B90.Y
 NCT00433576
Severe acute respiratory syndrome
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1D65
 NCT04542993
Chronic kidney disease, stage unspecified
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB61.Z
 NCT02704494
Obesity
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5B80-5B81
 NCT02612259
Cystic fibrosis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CA25
 NCT01348204
Unspecified malignant neoplasms of unspecified sites
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2D4Z
 NCT04733534
Lichen planus
Disease Category: 14.Diseases of the skin
Disease ICD-11 Code: EA91
 NCT01375101
Carcinoma of male breast
Disease Category: X.Extension Codes
Disease ICD-11 Code: XH5KW8
 NCT01042535
Cholelithiasis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DC11
 NCT01754779
Cocaine use disorder
Disease Category: 06.Mental, behavioural or neurodevelopmental disorders
Disease ICD-11 Code: 6C45
 NCT00000324
Rectum cancer
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B92
 NCT00433576
Age-associated cognitive decline
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MB21.0
 NCT01126229
Chronic arterial occlusive disease, unspecified
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BD4Z
 NCT03743636
Non-alcoholic fatty liver disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB92
 NCT02030977
Malignant neoplasms of other or unspecified parts of mouth
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2B66
 NCT05456022
Tension-type headache
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8A81
 NCT01012349
Paraplegia
Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified
Disease ICD-11 Code: MB56
 NCT02314208
Kidney failure, unspecified
Disease Category: 16.Diseases of the genitourinary system
Disease ICD-11 Code: GB6Z
 NCT01962116
Hypercholesterolaemia
Disease Category: 05.Endocrine, nutritional or metabolic diseases
Disease ICD-11 Code: 5C80.0
 NCT02409537
Lymphangioleiomyomatosis
Disease Category: 12.Diseases of the respiratory system
Disease ICD-11 Code: CB07
 NCT03253913
Crohn disease
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD70
 PTGS2
Non-alcoholic steatohepatitis
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DB92.1
 PTGS2
Myelodysplastic syndromes, unspecified
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2A3Z
 PIM1
Inflammatory bowel diseases, unspecified
Disease Category: 13.Diseases of the digestive system
Disease ICD-11 Code: DD7Z
 NOX4
Atrial fibrillation
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BC81.3
 CA7
Myotonic dystrophy
Disease Category: 08.Diseases of the nervous system
Disease ICD-11 Code: 8C71.0
 CYP1A1
Malignant neoplasms of bladder
Disease Category: 02.Neoplasms
Disease ICD-11 Code: 2C94
 PTGS2
Keratoconus
Disease Category: 09.Diseases of the visual system
Disease ICD-11 Code: 9A78.50
 CA4
Pre-eclampsia
Disease Category: 18.Pregnancy, childbirth or the puerperium
Disease ICD-11 Code: JA24
 CA4
Dilated cardiomyopathy
Disease Category: 11.Diseases of the circulatory system
Disease ICD-11 Code: BC43.0
 ABCG2
Lyme borreliosis
Disease Category: 01.Certain infectious or parasitic diseases
Disease ICD-11 Code: 1C1G
 MET

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network 
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Plant Ingredients  
3. Collective Molecular Proteins  
4. Collective Enriched Activities  
5. Plant molecular targets overlapping with DEGs  
6. Associated clinical trials  
7. Associated Human Diseases  
>> Targets derived from weak experimental activities
About Us

The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD) and School of Pharmacy, Fudan University.

CMAUP

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Principle Investigator:
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chenyuzong@sz.tsinghua.edu.cn
Prof. Zeng Xian
zengxian@fudan.edu.cn

Developer & Maintainer:
Ph.D. Student Dongyue Hou
dyhou22@m.fudan.edu.cn
Mr. Hanbo Lin
hblin19@fudan.edu.cn
Ms. Yuhan Feng
yhfeng22@m.fudan.edu.cn

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