Plant ID: NPO1320
Plant Latin Name: Thalictrum Ichangense
Taxonomy Genus: Thalictrum
Taxonomy Family: Ranunculaceae
NCBI TaxonomyDB:
1084677
Plant-of-the-World-Online:
n.a.
Ingredient ID: NPC78222
Ingredient ID: NPC50100
Ingredient ID: NPC291545
Ingredient ID: NPC285749
Ingredient ID: NPC272902
Ingredient ID: NPC271027
Ingredient ID: NPC270625
Ingredient ID: NPC255550
Ingredient ID: NPC235251
Ingredient ID: NPC224584
Ingredient ID: NPC216630
Ingredient ID: NPC204820
Ingredient ID: NPC199137
Ingredient ID: NPC155767
Ingredient ID: NPC154298
Ingredient ID: NPC138925
Ingredient ID: NPC136996
Ingredient ID: NPC12231
Ingredient ID: NPC109163
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
Therapeutic Target | Transient receptor potential channel | TRPV1 | Vanilloid receptor | Q8NER1 | CHEMBL4794 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 48 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT03794388 | Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery | breast cancer | Capsaicin (NPC255550) | NP level |
NCT02570841 | Pain Thresholds Under High-dose Topical Capsaicin | pain | Capsaicin (NPC255550) | NP level |
NCT03348735 | Localized Neuropathic Pain: Topical Treatment Versus Systemic Treatment | neuropathic pain | Capsaicin (NPC255550) | NP level |
NCT03113448 | 0.075% Capsaicin Lotion for the Treatment of Painful Diabetic Neuropathy | diabetic neuropathy | Capsaicin (NPC255550) | NP level |
NCT01699854 | Capsaicin Patch 8 % for the Treatment of Persistent Pain After Inguinal Herniotomy | pain | Capsaicin (NPC255550) | NP level |
NCT00008476 | Capsaicin to Control Pain Following Third Molar Extraction | facial pain | Capsaicin (NPC255550) | NP level |
NCT01125215 | Capsaicin Nanoparticle in Patient With Painful Diabetic Neuropathy | diabetic neuropathy | Capsaicin (NPC255550) | NP level |
NCT00064623 | Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy | peripheral nervous system disease;pain | Capsaicin (NPC255550) | NP level |
NCT01260454 | The Qutenza Patch as Treatment for Disabling Treprostinil (Remodulin) Infusion Site Pain | pulmonary arterial hypertension | Capsaicin (NPC255550) | NP level |
NCT03223350 | Topical Capsaicin for Cyclical Vomiting | Vomiting | Capsaicin (NPC255550) | NP level |
NCT05226299 | Cough Desensitization Therapy: Pilot 2 | Cough | Capsaicin (NPC255550) | NP level |
NCT01478607 | A Study to Evaluate the Long-term Safety of Repeated QUTENZA Administration for Treatment of Pain Caused by Nerve Damage in Diabetic Patients | diabetic neuropathy | Capsaicin (NPC255550) | NP level |
NCT02769910 | Effects of High-concentration Topical Capsaicin on Histaminergic and Non-histaminergic Itch | Pruritus | Capsaicin (NPC255550) | NP level |
NCT04545892 | Capsaicin for Cerebral Perfusion Augmentation. | stroke | Capsaicin (NPC255550) | NP level |
NCT00321672 | Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy | peripheral nervous system disease;pain | Capsaicin (NPC255550) | NP level |
NCT05029297 | Study With Two Capsaicin Topic Treatments in Diabetic Neuropathy. | diabetic neuropathy | Capsaicin (NPC255550) | NP level |
NCT03317613 | Clinical Trial Assessing the Efficacy of Capsaicin Patch (Qutenza®) in Cancer Patients With Neuropathic Pain | neuropathic pain | Capsaicin (NPC255550) | NP level |
NCT00300222 | Study of NGX-4010 for the Treatment of Postherpetic Neuralgia | neuralgia;pain | Capsaicin (NPC255550) | NP level |
NCT00916942 | Study of NGX-4010 With the Use of Open Label Lidocaine (2.5%)/Prilocaine (2.5%) Cream for the Treatment of Postherpetic Neuralgia (PHN) | postherpetic neuralgia | Capsaicin (NPC255550) | NP level |
NCT04967664 | Comparison of Qutenza (8% Capsaicin) With a Low-dose Capsaicin for Treatment of Nerve Pain After Surgery | neuropathic pain | Capsaicin (NPC255550) | NP level |
NCT00130949 | ALGRX 4975 in the Treatment of Tennis Elbow | lateral epicondylitis | Capsaicin (NPC255550) | NP level |
NCT02710110 | Respiratory Strength Training in Persons With Amyotrophic Lateral Sclerosis (ALS) | amyotrophic lateral sclerosis | Capsaicin (NPC255550) | NP level |
NCT05093478 | The Prevalence of Local Immunoglobulin E (IgE) Elevation and Its Effect on Intranasal Capsaicin Therapy in the Non-allergic Rhinitis Population | non-allergic rhinitis | Capsaicin (NPC255550) | NP level |
NCT01595620 | Cannabinoid Modulation of Pain | pain | Capsaicin (NPC255550) | NP level |
NCT01231750 | Efficacy of Topical Capsaicin Cream for Stable Angina | angina pectoris | Capsaicin (NPC255550) | NP level |
NCT02695745 | Experimental Biomarker Study for Pain Thresholds | pain | Capsaicin (NPC255550) | NP level |
NCT01883102 | The Effect of Ablation of Epidermal Nerve Fibers Using Capsaicin Cream | pain | Capsaicin (NPC255550) | NP level |
NCT00528216 | Study of Three Capsaicin Dermal Liquid Formulations on Epidermal Nerve Fiber Immunostaining and Sensory Function | pain | Capsaicin (NPC255550) | NP level |
NCT00130962 | ALGRX 4975 in the Treatment of Patients With Morton's Neuroma | neuroma | Capsaicin (NPC255550) | NP level |
NCT00471055 | Efficacy Study on Symptomatic Control of Patient With Knee Osteoarthritis Between 0.0125% of Capsaicin to Placebo | osteoarthritis, knee | Capsaicin (NPC255550) | NP level |
NCT02766517 | Biomarker Study in Participants With Migraine | migraine disorder | Capsaicin (NPC255550) | NP level |
NCT03472677 | The Effect of Injection Site Cooling on Pain Experienced After the Administration of CNTX-4975-05 Into the Knee | osteoarthritis, knee | Capsaicin (NPC255550) | NP level |
NCT00061152 | Pilot Study of High-Concentration Capsaicin Patches in the Treatment of Painful HIV-Associated Neuropathy | HIV infection | Capsaicin (NPC255550) | NP level |
NCT02240329 | Assessment of Dystussia in Traumatic Brain Injury | brain injury | Capsaicin (NPC255550) | NP level |
NCT00993070 | Efficacy and Safety Study of Topical Capsaicin in Painful Diabetic Neuropathy | diabetic polyneuropathy | Capsaicin (NPC255550) | NP level |
NCT00068081 | Controlled Study of NGX-4010 for the Treatment of Postherpetic Neuralgia | neuralgia;pain | Capsaicin (NPC255550) | NP level |
NCT00912262 | A Study to Investigate the Tolerability and Effects on Epidermal Nerve Fiber Density of Multiple Low-Concentrations of NGX-1998 in Healthy Volunteers | pain | Capsaicin (NPC255550) | NP level |
NCT04256733 | Cough Desensitization Therapy for Cough Hypersensitivity Syndrome | Cough | Capsaicin (NPC255550) | NP level |
NCT03153813 | Capsaicin Patches In Knee Osteoarthritis In Obese Patients | pain | Capsaicin (NPC255550) | NP level |
NCT04918069 | Capsaicin to Prevent Delayed Chemotherapy Induced Nausea and Vomiting (CapCIN) | Chemotherapy-induced nausea and vomiting | Capsaicin (NPC255550) | NP level |
NCT00133133 | Efficacy and Safety of ALGRX 4975 in the Treatment of Postoperative Pain After Gall Bladder Removal | pain | Capsaicin (NPC255550) | NP level |
NCT02700815 | Capsaicin + Diclofenac Gel in Acute Back Pain or Neck Pain | pain | Capsaicin (NPC255550) | NP level |
NCT00795106 | Trial to Evaluate the Efficacy of Topical Capsaicin to Reduce Pain and Improve Health-related Quality of Life in Adults With Chronic Myofascial Neck Pain | myofascial pain syndrome | Capsaicin (NPC255550) | NP level |
NCT00146198 | Efficacy and Safety of ALGRX 4975 in Treatment of Postoperative Pain After Hernia Repair | pain | Capsaicin (NPC255550) | NP level |
NCT00085761 | Study of NGX-4010 for Treatment of Painful HIV-Associated Neuropathy | peripheral nervous system disease;pain | Capsaicin (NPC255550) | NP level |
NCT00003610 | Capsaicin Lozenges in Treating Patients With Mucositis Caused by Radiation Therapy | head and neck malignant neoplasia | Capsaicin (NPC255550) | NP level |
NCT03576508 | A Study to Compare Levels of Capsaicin After Intra-Articular Injection and Topical Application in Patients With Painful Knee Osteoarthritis | osteoarthritis | Capsaicin (NPC255550) | NP level |
NCT00115310 | Study of NGX-4010 for the Treatment of Postherpetic Neuralgia | Herpes Zoster;neuralgia;pain | Capsaicin (NPC255550) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Diabetic polyneuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C03.0 |
NCT00993070,NCT01125215,NCT03113448,NCT01478607,NCT05029297
|
Neuropathic painDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43.0 |
NCT03317613,NCT04967664,NCT03348735
|
Chronic neuropathic pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30.5Z |
NCT00115310,NCT00300222,NCT00068081
|
Central and peripheral nervous diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04-8E7Z |
NCT00085761,NCT00321672,NCT00064623
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
OR51E2,FABP5,FABP4
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
OR51E2,FABP5,FABP4
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
FABP5,FABP5,OR51E2
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
OR51E2,FABP5,FABP4
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
TRPV1
NCT03576508 |
CoughDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD12 |
NCT04256733,NCT05226299
|
Osteoarthritis of kneeDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA01 |
NCT00471055,NCT03472677
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
FABP5,OR51E2
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
FABP5,OR51E2
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
FABP5,OR51E2
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
FABP5,OR51E2
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
TRPV1
NCT00068081,NCT00300222,NCT00085761,NCT01883102,NCT02695745,NCT03153813,NCT00064623,NCT00912262,NCT00528216,NCT00115310,NCT00321672,NCT02700815,NCT00133133,NCT02570841,NCT01595620,NCT01699854,NCT00146198 |
Visual system diseaseDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9E1Z |
TRPV1
|
MigraineDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80 |
TRPV1
|
Lower limb mononeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C11 |
TRPV1
|
Knee osteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA01 |
TRPV1
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
TRPV1
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
TRPV1
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
TRPV1
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
TRPV1
|
Functional bladder disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GC50 |
TRPV1
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
TRPV1
|
Postherpetic polyneuropathyDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E91.5 |
NCT00916942
|
Neuroma, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH4UE6 |
NCT00130962
|
Nausea/vomitingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD90 |
NCT04918069
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
NCT00003610
|
Amyotrophic lateral sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60.0 |
NCT02710110
|
Migraine disorder(TM1)Disease Category: 26.Supplementary Chapter Traditional Medicine Conditions - Module IDisease ICD-11 Code: SD10 |
NCT02766517
|
Chronic widespread painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30.01 |
NCT00795106
|
VomitingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD90.1 |
NCT03223350
|
Non-allergic rhinitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA08.1 |
NCT05093478
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
NCT01231750
|
Painful cranial neuropathies or other facial painsDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A85 |
NCT00008476
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
NCT03794388
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
NCT04545892
|
PruritusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EC90 |
NCT02769910
|
Intracranial injury, unspecifiedDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NA07.Z |
NCT02240329
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
NCT01260454
|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT00061152
|
Herpes simplex infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00 |
NCT00115310
|
Lateral epicondylitis of elbowDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB55.1 |
NCT00130949
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
FABP5
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
FABP5
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
FABP5
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
FABP4
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
FABP4
|
Malignant neoplasms of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
FABP4
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
OR51E2
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
OR51E2
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
OR51E2
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
FABP4
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
FABP4
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
FABP5
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
FABP5
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
FABP5
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
OR51E2
|
Malignant neoplasm of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
FABP4
|