Plant ID: NPO13199
Plant Latin Name: Syzygium Jambos
Taxonomy Genus: Syzygium
Taxonomy Family: Myrtaceae
NCBI TaxonomyDB:
334483
Plant-of-the-World-Online:
n.a.
India; Vietnam; China; Laos
Ingredient ID: NPC98872
Ingredient ID: NPC94167
Ingredient ID: NPC94101
Ingredient ID: NPC91580
Ingredient ID: NPC90689
Ingredient ID: NPC8203
Ingredient ID: NPC80854
Ingredient ID: NPC80837
Ingredient ID: NPC76376
Ingredient ID: NPC72652
Ingredient ID: NPC66802
Ingredient ID: NPC63020
Ingredient ID: NPC55412
Ingredient ID: NPC5280
Ingredient ID: NPC50114
Ingredient ID: NPC489907
Ingredient ID: NPC47301
Ingredient ID: NPC39966
Ingredient ID: NPC37502
Ingredient ID: NPC34700
Ingredient ID: NPC310957
Ingredient ID: NPC307063
Ingredient ID: NPC304423
Ingredient ID: NPC298395
Ingredient ID: NPC290598
Ingredient ID: NPC279461
Ingredient ID: NPC2789
Ingredient ID: NPC27786
Ingredient ID: NPC265077
Ingredient ID: NPC246654
Ingredient ID: NPC242580
Ingredient ID: NPC233395
Ingredient ID: NPC233122
Ingredient ID: NPC231063
Ingredient ID: NPC230920
Ingredient ID: NPC228523
Ingredient ID: NPC227925
Ingredient ID: NPC227139
Ingredient ID: NPC224883
Ingredient ID: NPC224072
Ingredient ID: NPC217781
Ingredient ID: NPC203981
Ingredient ID: NPC200684
Ingredient ID: NPC192864
Ingredient ID: NPC192744
Ingredient ID: NPC192638
Ingredient ID: NPC187770
Ingredient ID: NPC187021
Ingredient ID: NPC181587
Ingredient ID: NPC180391
Ingredient ID: NPC178383
Ingredient ID: NPC17810
Ingredient ID: NPC176025
Ingredient ID: NPC167400
Ingredient ID: NPC167240
Ingredient ID: NPC153344
Ingredient ID: NPC150950
Ingredient ID: NPC149203
Ingredient ID: NPC139545
Ingredient ID: NPC131709
Ingredient ID: NPC127624
Ingredient ID: NPC119555
Ingredient ID: NPC114822
Ingredient ID: NPC110699
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
Therapeutic Target | Membrane receptor | APP | Beta amyloid A4 protein | P05067 | CHEMBL2487 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Therapeutic Target | Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
Therapeutic Target | Small molecule receptor (family A GPCR) | HCAR2 | Hydroxycarboxylic acid receptor 2 | Q8TDS4 | CHEMBL3785 |
Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2B | Alpha-2b adrenergic receptor | P18089 | CHEMBL1942 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Therapeutic Target | Transferase | GSTP1 | Glutathione S-transferase Pi | P09211 | CHEMBL3902 |
Therapeutic Target | Unclassified protein | SNCA | Alpha-synuclein | P37840 | CHEMBL6152 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
![]() | 250 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | retinitis pigmentosa | Retinol (NPC55412) | ![]() |
NCT00000116 | Randomized Trial of DHA for Retinitis Pigmentosa Patients Receiving Vitamin A | retinitis pigmentosa | Retinol (NPC55412) | ![]() |
NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | ![]() |
NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | macular degeneration | Ascorbate (NPC187770);Beta Carotene (NPC17810) | ![]() |
NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract | Beta Carotene (NPC17810);Ascorbate (NPC187770) | ![]() |
NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | Myocardial Ischemia | Niacin (NPC167400) | ![]() |
NCT00000482 | Coronary Drug Project | Myocardial Ischemia;myocardial infarction | Niacin (NPC167400) | ![]() |
NCT00000512 | Familial Atherosclerosis Treatment Study | Myocardial Ischemia | Niacin (NPC167400) | ![]() |
NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction | Beta Carotene (NPC17810);Ascorbate (NPC187770) | ![]() |
NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | Myocardial Ischemia | Ascorbate (NPC187770) | ![]() |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT03090048,NCT03522922
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT00855257
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NCT00184054,NCT00329498
|
Acute promyelocytic leukaemiaDisease Category: X.Extension CodesDisease ICD-11 Code: XH1A50 |
NCT03624270
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT04404387
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
SLCO1B1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,APP,CES1,HCAR2,GSTP1,SNCA
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SLCO1B1
NCT01080352 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
SLCO1B1
|
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT03697239,NCT03908333,NCT03410030
|