Antirheumatic; Aromatic; Poultice; Stomachic
Australia; Bangladesh; Myanmar; Philippines; Nepal; India; Vietnam; China; Laos; Sri Lanka; Thailand
Ingredient ID: NPC98717
Ingredient ID: NPC96769
Ingredient ID: NPC93287
Ingredient ID: NPC91594
Ingredient ID: NPC83268
Ingredient ID: NPC82979
Ingredient ID: NPC76406
Ingredient ID: NPC66924
Ingredient ID: NPC64141
Ingredient ID: NPC472854
Ingredient ID: NPC472853
Ingredient ID: NPC472852
Ingredient ID: NPC472850
Ingredient ID: NPC472849
Ingredient ID: NPC472848
Ingredient ID: NPC472847
Ingredient ID: NPC44512
Ingredient ID: NPC38269
Ingredient ID: NPC300894
Ingredient ID: NPC293378
Ingredient ID: NPC273560
Ingredient ID: NPC264317
Ingredient ID: NPC258320
Ingredient ID: NPC246543
Ingredient ID: NPC242071
Ingredient ID: NPC23845
Ingredient ID: NPC227339
Ingredient ID: NPC215089
Ingredient ID: NPC213696
Ingredient ID: NPC206800
Ingredient ID: NPC198311
Ingredient ID: NPC197503
Ingredient ID: NPC197316
Ingredient ID: NPC193180
Ingredient ID: NPC189853
Ingredient ID: NPC17810
Ingredient ID: NPC177747
Ingredient ID: NPC171280
Ingredient ID: NPC157773
Ingredient ID: NPC155129
Ingredient ID: NPC142836
Ingredient ID: NPC134405
Ingredient ID: NPC133809
Ingredient ID: NPC133389
Ingredient ID: NPC133253
Ingredient ID: NPC107709
Ingredient ID: NPC106764
Ingredient ID: NPC102206
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 13 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT01602068 | Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Delivery Prior to Implantation of a Posterior Chamber IOL | cataract | Citric Acid (NPC293378) | NP level |
NCT00249951 | Alkaline Citrate Treatment to Lower the Risk of Nephrocalcinosis in Preterm Infants | Nephrocalcinosis | Citric Acid (NPC293378) | NP level |
NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810) | NP level |
NCT01421160 | Regulating Urine pH Levels to Alleviate Chronic Joint Pain | osteoarthritis | Citric Acid (NPC293378) | NP level |
NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction;Myocardial Ischemia | Beta Carotene (NPC17810) | NP level |
NCT01012349 | Efficacy and Safety Clinical Trial of the Combination of Acetylsalicylic Acid, Sodium Bicarbonate and Citric Acid, Produced by Geolab Pharmaceutical Industries Ltd., Compared to Acetylsalicylic Acid (Aspirin ® - Bayer) in Patients With Episodic Tension-type Headache. | Tension-type headache | Citric Acid (NPC293378) | NP level |
NCT01962116 | Citrate Versus Heparin for the Lock of Non-tunneled Hemodialysis Catheters in Patients Hospitalised in ICU | Renal insufficiency | Citric Acid (NPC293378) | NP level |
NCT00701987 | Safety, Tolerability, and Preliminary Efficacy Study of ALS-357 in Patients With Cutaneous Metastatic Melanoma | melanoma | Betulinic Acid (NPC264317) | NP level |
NCT01754779 | Treatment for Calcium Phosphate Kidney Stone Disease | nephrolithiasis | Citric Acid (NPC293378) | NP level |
NCT02662283 | Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy | IGA glomerulonephritis | Acetoside (NPC197316) | NP level |
NCT00275418 | Beta Carotene From Natural Source for Patients With Non-Active Crohn's Disease | Crohn's disease | Beta Carotene (NPC17810) | NP level |
NCT00346502 | Evaluation of 20% Betulinic Acid Ointment for Treatment of Dysplastic Nevi (Moderate to Severe Dysplasia) | dysplastic nevus | Betulinic Acid (NPC264317) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
NCT01602068,NCT00000161
|
Macular degenerationDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B75 |
NCT00000161,NCT00000152
|
Ovarian cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73 |
TNKS
|
Tension-type headacheDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A81 |
NCT01012349
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
NCT00275418
|
CholelithiasisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC11 |
NCT01754779
|
OsteoarthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA00-FA05 |
NCT01421160
|
Nephritic syndromeDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB40 |
NCT02662283
|
Dysplastic naevusDisease Category: X.Extension CodesDisease ICD-11 Code: XH9035 |
NCT00346502
|
NephrocalcinosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB57 |
NCT00249951
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
NCT00701987
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
NCT00000541
|
Ischaemic heart diseases, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA6Z |
NCT00000541
|
Kidney failure, unspecifiedDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB6Z |
NCT01962116
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
SLCO1B1
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
SLCO1B1
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
SLCO1B1
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
SLCO1B1
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
SLCO1B1
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
SLCO1B1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SLCO1B1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
SLCO1B1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
SLCO1B1
|