Collective Molecular Activities of the Plant: Toona Ciliata
Plant ID: NPO13083
Plant Latin Name: Toona Ciliata
Taxonomy Genus: Toona
Taxonomy Family: Meliaceae
Plant External Links:
NCBI TaxonomyDB:
67918
Plant-of-the-World-Online:
n.a.
Country/Region:
ThailandTraditional Medicine System:
Thailand
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
55 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
26 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
35 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC8638
Ingredient ID: NPC73583
Ingredient ID: NPC71114
Ingredient ID: NPC67917
Ingredient ID: NPC6201
Ingredient ID: NPC486217
Ingredient ID: NPC486216
Ingredient ID: NPC486215
Ingredient ID: NPC486214
Ingredient ID: NPC486213
Ingredient ID: NPC486212
Ingredient ID: NPC486211
Ingredient ID: NPC486210
Ingredient ID: NPC486209
Ingredient ID: NPC486208
Ingredient ID: NPC486207
Ingredient ID: NPC486206
Ingredient ID: NPC486205
Ingredient ID: NPC486204
Ingredient ID: NPC486203
Ingredient ID: NPC486202
Ingredient ID: NPC486201
Ingredient ID: NPC486200
Ingredient ID: NPC486199
Ingredient ID: NPC470420
Ingredient ID: NPC470419
Ingredient ID: NPC470418
Ingredient ID: NPC470417
Ingredient ID: NPC41405
Ingredient ID: NPC3755
Ingredient ID: NPC330683
Ingredient ID: NPC304103
Ingredient ID: NPC293704
Ingredient ID: NPC284326
Ingredient ID: NPC281372
Ingredient ID: NPC269823
Ingredient ID: NPC269275
Ingredient ID: NPC261925
Ingredient ID: NPC249780
Ingredient ID: NPC245020
Ingredient ID: NPC239716
Ingredient ID: NPC237423
Ingredient ID: NPC234042
Ingredient ID: NPC225227
Ingredient ID: NPC210956
Ingredient ID: NPC210268
Ingredient ID: NPC176867
Ingredient ID: NPC166746
Ingredient ID: NPC15858
Ingredient ID: NPC146462
Ingredient ID: NPC130329
Ingredient ID: NPC122967
Ingredient ID: NPC113157
Ingredient ID: NPC104806
Ingredient ID: NPC102117
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 84 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000776 | Dexamethasone in Cryptococcal Meningitis | intracranial hypertension;cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
| NCT00001017 | Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDS | cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
| NCT00001107 | Comparison of Two Treatments to Prevent Invasive Fungal Infections in Patients Who Have Received Liver Transplants | candidiasis | Amphotericin B (NPC67917) | NP level |
| NCT00001646 | Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis | aspergillosis | Amphotericin B (NPC67917) | NP level |
| NCT00002159 | A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis | blastomycosis;histoplasmosis | Amphotericin B (NPC67917) | NP level |
| NCT00002277 | A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections | fungal infectious disease | Amphotericin B (NPC67917) | NP level |
| NCT00002316 | The Safety and Effectiveness of RMP-7 Plus Amphotericin B in Patients With HIV and Cryptococcal Meningitis | cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
| NCT00002742 | Antifungal Therapy for Fever and Neutropenia in Patients Receiving Treatment for Hematologic Cancer | chronic myeloproliferative disorder;leukemia;multiple myeloma;myelodysplastic syndrome;infection | Amphotericin B (NPC67917) | NP level |
| NCT00002850 | Antibiotic Therapy in Preventing Early Infection in Patients With Multiple Myeloma Who Are Receiving Chemotherapy | infection | Ofloxacin (NPC330683) | NP level |
| NCT00003031 | Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis | aspergillosis | Amphotericin B (NPC67917) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NCT03187691,NCT00418951,NCT00451711
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA
|
AspergillosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F20 |
NCT00158730,NCT00047827,NCT00334412,NCT00003031,NCT03327727,NCT04267497,NCT00263315,NCT00001646,NCT00986713,NCT00076869
|
Aspergillus-induced allergic or hypersensitivity conditionsDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA82.4 |
NCT01857479
|
BlastomycosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F22 |
NCT00002159
|
CandidosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F23 |
NCT00815516,NCT00001107,NCT01945281,NCT00106288,NCT00163111
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Chronic mucocutaneous candidosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F23.14 |
NCT02629419
|
Diabetic foot ulcerDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD54 |
NCT00563394,NCT00563433
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
