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Collective Molecular Activities of the Plant: Rumex Crispus


Example Image
PLANiTS DNA barcode

Click for details-----ITS

TCGAAACCTGCTCAAAGCAGACTGACCCGCGAACCCGTTCCTAACACAAAGGCGCCCCCGGGCGCCGCCAACCCAACCCCGGCGCGGATTGCGCCAAGGACCACGAACAAAATCGCCCCCCGAGCGGCCCGGTCCTCCGGAGCCCGCGCGGCGGCGGCGTGTCGTTTCTACTTAACTAAAACGACTCTCGGCAACGGATATCTCGGCTCTCGCATCGATGAAGAACGTAGCGAAATGCGATACTTGGTGTGAATTGCAGAATCCCGTGAACCATCGAGTCTTTGAACGCAAGTTGCGCCCGAGGCCTTCTGGCCGAGGGCACGTCTGTCTGGGCGTCACGCACCGCGTCGCCCCCCACCCCCCCCCTCCGGGGGGGATCGGGGGCGGAGACTGGCCCCCCGTGCGCCCCGGCGCGCGGCCGGCCTAAACGCAGACCCCGCGGCCGCGAGAACGGCGCGACGATTGGTGGCGTACTTCATGGCATCGCGTCGCGCCCTCTGCGGCCCCCCGGGAGATCATCGGCCCACAAAGCGGACCCCGGTCCACCGTTGCGACCCCAGA

Click for details-----ITS1

GGAGGATTGTCGAAACCTGCTCAGAGCAGACTGACCCGCGAACCCGTTCCTAACACAAACGGCGCCCCCGGGCGCCGCCAACCCACCCCCGGCGCGGATTGCGCCAAGGACCACGAACAAAATCGCCCCCCGGGCGGCCCGGTCCTCCGGAGCCCGCGCGGCGCGGCGTGTCGTTTCTACCTAACAAAAA

Click for details-----ITS2

ACCGCGTCGCCCCCCACCCCCCCCCCCTCCGGGGGGGGGGGATCGGGGGCGGAGACTGGCCCCCCGTGCGCCCCGGCGCGCGGCCGGCCTAAACCCAGACCCCGCGGCCGCGAGAACGGCGCGACGATTGGTGGCGTACTTCATGGCATCGCGTCGCGCCCTCTGCGGCCCCCCGGGAGATCATCGGCCCACAAAGCGGACCCCGGTCCACCGTT
Taxonomic Information

Plant ID: NPO12955
Plant Latin Name: Rumex Crispus
Taxonomy Genus: Rumex
Taxonomy Family: Polygonaceae

Plant External Links:

NCBI TaxonomyDB: 174649
Plant-of-the-World-Online: 224413-2

Used in Medicines

Country/Region:
Turkey; Italy; Portugal; South Africa; Mexico; India; South Korea; Russia

Traditional Medicine System:


Medicinal Functions:

Alterative; Antiscorbutic; Astringent; Cancer; Cholagogue; Depurative; Homeopathy; Laxative; Poultice; Salve; Tonic

Geographical Distribution

Brazil; Turkey; Italy; Peru; Sudan; Costa Rica; France; Bahamas; Ethiopia; Norway; Ireland; Bolivia; Cameroon; Ecuador; Belarus; Algeria; Cuba; Iceland; Venezuela; Cape Verde; Russia; United States; Zimbabwe; Germany; Chile; Belgium; Dominican Republic; Spain; Ukraine; Eritrea; Netherlands; Libya; Denmark; Poland; Finland; New Caledonia; Mauritius; Morocco; Sweden; Namibia; Kenya; Switzerland; Honduras; Haiti; Bulgaria; Jamaica; Romania; Albania; Angola; Portugal; Mexico; Egypt; Fiji; South Africa; India; United Kingdom; Lesotho; Austria; Mozambique; Tunisia; Colombia; Greece; Hungary; South Korea; Cyprus; Zambia

Geographical Distribution
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See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary

Overview of Ingredients

11 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.


9 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

6 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.





Ingredient Structrual Cards

Ingredient ID: NPC92229

Ingredient ID: NPC80128

Ingredient ID: NPC67037

Ingredient ID: NPC3224

Ingredient ID: NPC278329

Ingredient ID: NPC267205

Ingredient ID: NPC254848

Ingredient ID: NPC227668

Ingredient ID: NPC176893

Ingredient ID: NPC13758

Ingredient ID: NPC103540

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Target Type: Individual Protein of Homo sapiens
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
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Detailed Information of Target Proteins

Target TypeProtein ClassGene IDProtein NameUniprot IDTarget ChEMBL ID
No data available in table
Showing 0 to 0 of 0 entries
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Clinical Trials Summary
Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type Number of clinical trials
Clinical trial details
NCT IDTitleConditionForm in clinical useAssociated by plant or compound
No data available in table
Showing 0 to 0 of 0 entries
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❱❱❱ Associated Human Diseases and Detailed Association Evidence

 How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
 ❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant
Association Type & Detailed Evidence
No data available in table
Showing 0 to 0 of 0 entries
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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network 
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Plant Ingredients  
3. Collective Molecular Proteins  
4. Collective Enriched Activities  
5. Plant molecular targets overlapping with DEGs  
6. Associated clinical trials  
7. Associated Human Diseases  
>> Targets derived from weak experimental activities
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD) and School of Pharmacy, Fudan University.

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Principle Investigator:
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Prof. Zeng Xian
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Developer & Maintainer:
Ph.D. Student Dongyue Hou
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Mr. Hanbo Lin
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Ms. Yuhan Feng
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