Collective Molecular Activities of the Plant: Solanum Dulcamara
Country/Region:
Albania; India; Finland; Lebanon; Sweden; ChinaTraditional Medicine System:
TCM; Homeopathy; AyurvedaMedicinal Functions:
Alterative; Anodyne; Cancer; Depurative; Diuretic; Emetic; Expectorant; Hepatic; Homeopathy; Narcotic; Purgative
Brazil; Albania; Lebanon; Finland; India; United States; Sweden; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
69 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
22 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
15 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC91603
Ingredient ID: NPC85001
Ingredient ID: NPC80334
Ingredient ID: NPC58950
Ingredient ID: NPC5466
Ingredient ID: NPC51707
Ingredient ID: NPC43094
Ingredient ID: NPC41844
Ingredient ID: NPC327436
Ingredient ID: NPC326355
Ingredient ID: NPC322690
Ingredient ID: NPC322294
Ingredient ID: NPC320130
Ingredient ID: NPC313179
Ingredient ID: NPC311830
Ingredient ID: NPC311099
Ingredient ID: NPC299544
Ingredient ID: NPC299459
Ingredient ID: NPC283199
Ingredient ID: NPC267022
Ingredient ID: NPC264752
Ingredient ID: NPC26383
Ingredient ID: NPC260221
Ingredient ID: NPC258334
Ingredient ID: NPC255707
Ingredient ID: NPC253924
Ingredient ID: NPC247921
Ingredient ID: NPC24556
Ingredient ID: NPC242057
Ingredient ID: NPC241783
Ingredient ID: NPC241069
Ingredient ID: NPC235126
Ingredient ID: NPC232612
Ingredient ID: NPC222884
Ingredient ID: NPC222268
Ingredient ID: NPC214496
Ingredient ID: NPC210073
Ingredient ID: NPC204895
Ingredient ID: NPC201817
Ingredient ID: NPC198722
Ingredient ID: NPC196492
Ingredient ID: NPC194663
Ingredient ID: NPC190954
Ingredient ID: NPC18861
Ingredient ID: NPC186528
Ingredient ID: NPC186040
Ingredient ID: NPC183531
Ingredient ID: NPC18188
Ingredient ID: NPC173596
Ingredient ID: NPC171736
Ingredient ID: NPC169498
Ingredient ID: NPC167634
Ingredient ID: NPC164067
Ingredient ID: NPC159340
Ingredient ID: NPC158034
Ingredient ID: NPC155985
Ingredient ID: NPC150324
Ingredient ID: NPC149545
Ingredient ID: NPC149184
Ingredient ID: NPC147753
Ingredient ID: NPC143014
Ingredient ID: NPC133300
Ingredient ID: NPC132787
Ingredient ID: NPC124308
Ingredient ID: NPC119987
Ingredient ID: NPC119449
Ingredient ID: NPC115959
Ingredient ID: NPC105115
Ingredient ID: NPC10171
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | GABA-A receptor | GABRR1 | GABA receptor rho-1 subunit | P24046 | CHEMBL3561 |
| Therapeutic Target | Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Protein methyltransferase | KMT2A | Histone-lysine N-methyltransferase MLL | Q03164 | CHEMBL1293299 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 8 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00006202 | Lutein for Age-Related Macular Degeneration | macular degeneration | Lutein (NPC313179) | NP level |
| NCT00029289 | Effects of Lutein in Retinitis Pigmentosa | retinitis pigmentosa | Lutein (NPC313179) | NP level |
| NCT00121589 | Lutein/Zeaxanthin and Omega-3 Supplementation in Persons Over Age 60 | macular degeneration | Lutein (NPC313179) | NP level |
| NCT00346333 | Clinical Trial of Lutein for Patients With Retinitis Pigmentosa Receiving Vitamin A | retinitis pigmentosa | Lutein (NPC313179) | NP level |
| NCT01048476 | Effects of Lutein and Zeaxanthin Supplementation on Age-related Macular Degeneration | age-related macular degeneration | Lutein (NPC313179) | NP level |
| NCT02002130 | The Use of Glutamic Acid Decarboxylase (GAD) and Gamma-Amino Butyric Acid (GABA) in the Treatment of Type I Diabetes | type 1 diabetes mellitus | Gamma-Aminobutyric Acid (NPC18188) | NP level |
| NCT03750968 | Lutein & Zeaxanthin in Pregnancy - Carotenoid Supplementation During Pregnancy: Ocular and Systemic Effects | pregnancy | Lutein (NPC313179) | NP level |
| NCT03959592 | Macular Pigment and Visual Performance in Glaucoma Patients | glaucoma | Lutein (NPC313179) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Adaptive immunity immunodeficiencyDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01 |
GABRA5
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CA12,BLM,GABBR2,CA9,GABRA5,SLC6A11,GABRR1,GABRA3
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,BLM,GABBR2,CA9,GABRR1,GABRA3,GABRA2
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
BLM,GABRR1,GABRA3
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
GABRA5
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
GABRA3
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
GABBR2,GABRA5
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA12
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA12,CA9
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
GABBR2,CA9,GABRA5,GABRR1,GABRA3,GABRA2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
